Optimizing extraction conditions for isolation of antioxidant compounds from black rice bran using ultrasonic-assisted extraction and response surface methodology.

Black rice bran (BRB), a valuable byproduct from the rice milling process, possesses numerous pharmacological activities, including antioxidant potential, but information regarding highly efficient extraction methods is scarce. To enhance the extraction efficiency, ultrasonic-assisted extraction coupled with Box-Behnken design (BBD) was used in this study to maximize the total phenolic content (TPC), total flavonoid content (TFC), total anthocyanin content (TAC), and antioxidant capacity of BRB extract. The BBD results showed that 57% ethanol at 50°C and pH 3.

The Alteration of Proteomic Profiles in Hippocampus of Type 2 Diabetic Mice Associated With Cognitive Impairment.

Clinical and experimental studies have demonstrated that type 2 diabetes mellitus (T2DM) affects the brain structure and function, in particular the hippocampus, leading to cognitive impairments. However, the molecular mechanisms underlying cognitive deficits induced by T2DM are not fully understood. In this study, we aimed to investigate the effects of T2DM on behavior, the proteome profile in the hippocampus, and the potential molecular pathways involved in the development of cognitive dysfunction in T2DM mice.

Effects of 4-week Eri silkworm cornflakes supplementation on oxidative stress and antioxidant status in male university athletes: A preliminary crossover study.

This study among moderately fit male athletes investigated changes in oxidative stress and antioxidant levels after supplementation with Eri silkworm cornflakes. Male university athletes ( = 18, age 19-21 years) were enrolled in a randomized crossover trial. They participated in either the supplementation period (consuming 0.

The Prevalence of 5-Fluorouracil and Capecitabine Cardiotoxicity: A Systematic Review and Meta-Analysis.

Background: The incidence of cardiotoxicity events in patients who use 5-fluorouracil (5-FU) and capecitabine monotherapy remains unclear since previous studies reported the prevalence in patients who used combination regimens. We aimed to systematically review and meta-analyze the incidence of cardiotoxicity in fluorouracil and capecitabine monotherapy users.

Methods: The study protocol was registered with PROSPERO (CRD42023441627).

Determinants of Self-Medication in Immigrants: A Systematic Review.

Immigrants intended to more rely on self-medication because of the difficulty of accessing formal healthcare in host countries. Negative consequences could occur when self-medication was inappropriate. This study aimed to systematically explore the prevalence, sources and determinants of immigrants' self-medication and the extent of their inappropriate self-medication episodes.

Associations between 6-min walk distance and cardiopulmonary parameter in non-obese older adults: An observational study.

Background: The 6-min walk test (6MWT) has established itself as a classical field-test for assessing exercise capacity across diverse populations, including older adults. Despite its widespread use, the specific contribution of cardiopulmonary factors to the 6-min walk distance (6MWD) remains relatively unexplored.

Objective: The primary objective of this investigation was to examine any potential associations between 6MWD and various cardiopulmonary parameters in older adults.

Application of Optical Coherence Tomography (OCT) to Evaluate the Adverse Effects of 2,4-D Dimethylammonium on Morphological Changes in Riceland Prawn (Macrobrachium lanchesteri).

2,4-D dimethylammonium, a widely used herbicide, accumulates in aquatic animals, posing risks to both their populations and human consumers. This study evaluated the effects of 2,4-D on Riceland prawn (Macrobrachium lanchesteri) using Optical Coherence Tomography (OCT) to assess morphological changes. The activity of acetylcholinesterase (AChE), catalase (CAT), and glutathione S-transferase (GST) was also measured.

Mental well-being model of Thai older adults: Comparing the aging in place and aging migrant groups.

Objective: Although aging well and aging in place policies have been encouraged in many countries, a consistent challenge is insufficient evidence on older migrants. This study compared mental well-being models of older adults between aging in place and aging migrant groups. The model included social factors (e.

Influence of DPYD gene polymorphisms on 5-Fluorouracil toxicities in Thai colorectal cancer patients.

DPYD polymorphisms have been widely found to be related to 5-FU-induced toxicities. The aim of this study was to establish significant associations between five single-nucleotide polymorphisms of DPYD and 5-FU hematological toxicities in Thai colorectal cancer patients. The toxicities were analyzed at the first and second cycles of 5-FU administration in 75 patients.

Advanced Drug Delivery Technologies for Enhancing Bioavailability and Efficacy of Risperidone.

Multidisciplinary research has been conducted on novel drug delivery technologies to maximize therapeutic advantages while curtailing undesirable reactions. Drugs under BCS Class II often have a low bioavailability because the dissolution phase limits the absorption efficiency. In this review, risperidone was used as a pharmacological model to examine the impact of solubility enhancement at the primary administration site for such pharmaceuticals.

Factors affecting quality of life among older adults with hypertension in Wenzhou, China: A cross-sectional study.

Background: In China, the incidence of hypertension rises significantly with age, resulting in a markedly reduced quality of life (QoL) among older patients compared to the general population. Therefore, it is essential for healthcare providers, particularly nurses, to identify the predictive factors that influence QoL in this demographic.

Objective: This study aimed to describe the QoL levels and investigate the predictive power of perceived health status, self-care behavior, and social support on QoL among older patients with hypertension in Wenzhou, China.

Correlations among flexibility, stiffness, strength and muscle ultrasound parameters in older males afflicted with hamstrings tightness.

Introduction: Age-induced inflexibility may lead to significant mobility impairments and declines in well-being. However, the relationship between the structural and mechanical properties of soft tissue and joint extensibility remains unclear. This study aimed to investigate the correlation between flexibility, muscle tendon unit (MTU) stiffness, muscle ultrasound characteristics, muscle strength, and hamstring flexibility prediction in older males with hamstring inflexibility.

Rise of implantable drugs: A chronicle of breakthroughs in drug delivery systems.

In recent years, implantable drug delivery systems (IDDSs) have undergone significant advancements because they offer many advantages to patients and health care professionals. Miniaturization has reduced the size of these devices, making them less invasive and easier to implant. Remote control provides more precise medication delivery and dosage.

Transition of new residents to nursing homes: A qualitative meta-synthesis.

Aim: To synthesize qualitative evidence on the transition experience of new residents to nursing homes.

Methods: A systematic literature search was conducted in PubMed, Embase, CINAHL, China National Knowledge Infrastructure, China Wanfang Database from inception to February 2024. The CASP evaluation for qualitative studies was used for quality appraisal, and meta-aggregation was used in data analysis.

Presence of Pseudomonas aeruginosa in feces exacerbate leaky gut in mice with low dose dextran sulfate solution, impacts of specific bacteria.

The impact of Pseudomonas aeruginosa (PA) was explored in a mouse model with non-diarrheal gut permeability defect using 1.5% dextran sulfate solution (DSS) plus antibiotics (ATB) with or without orally administered PA. As such, ATB+DSS+PA mice induced more severe intestinal injury as indicated by stool consistency and leaky gut (FITC-dextran assay, bacteremia, and endotoxemia) with an increase in serum cytokines, liver enzyme, and hepatocyte apoptosis when compared with ATB+DSS mice.

Potential Cryptic Diversity in the Genus (Carcharhiniformes: Carcharhinidae): Insights from Mitochondrial Genome Sequencing.

is a genus of small placental sharks living in offshore waters. For a long time, the genus was considered a monotypic genus until a valid species, , was confirmed in 2010. However, in the same study was not widely recognized because of the lack of evidence.

Curculigosides J-K and curcorchidihydrobenzofuran A, a dihydrobenzofuran with anti-proliferative properties from .

Phytochemical investigation of the rhizomes and the leaves of led to the isolation of fourteen compounds. They consist of one undescribed dihydrobenzofuran, curcorchidihydrobenzofuran A (), two undescribed benzyl benzoate glycosides, curculigoside J () and K (), and eleven known compounds (-). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data.

House cricket protein hydrolysates alleviate hypertension, vascular dysfunction, and oxidative stress in nitric oxide-deficient hypertensive rats.

Background And Aim: Edible insects with high protein content and bioactive peptides with health promotion against chronic disease. Deficiency of nitric oxide (NO) contributes to hypertension, a leading cause of cardiovascular diseases and death worldwide. This study assessed the antihypertensive effects of house cricket protein hydrolysates (HCPH) in NO-deficient hypertensive rats.

Ethanolic extract of pods exhibits antioxidant and anti-inflammatory properties in lipopolysaccharide-induced murine macrophages by inhibiting the p38 MAPK pathway.

Background: (PS) is commonly used in Southeast Asian cuisine and traditional medicine to treat diabetes, hypertension, dermatitis, and kidney diseases. PS has emerged as a subject of interest because of its potential antioxidation and anti-inflammatory properties. However, despite its historically long and wide usage, a comprehensive investigation of these properties in PS pods (PSp) have not been conducted.

Surgical Outcomes of Mitomycin-C Augmented Trabeculectomy in Neovascular Glaucoma and Prognostic Factors for Surgical Failure in Thailand.

Purpose: To evaluate the surgical outcomes and identify ocular and systemic prognostic factors of trabeculectomy with mitomycin C (MMC) in the eyes of patients with neovascular glaucoma (NVG) in Thailand.

Patients And Methods: This retrospective study was conducted by reviewing records of Thai patients with NVG who underwent trabeculectomy with MMC between 2013 and 2022. Criterion failure was defined as intraocular pressure (IOP) >21 mmHg or less than a 20% reduction below baseline on two consecutive study visits after 3 months, IOP ≤5 mmHg on two consecutive study visits after 3 months, reoperation for glaucoma, and loss of light perception.