80 results match your criteria: "Bullous Disease of Dialysis"
Interest of therapeutic plasmapheresis in a chronic hemodialysis patient with severe bullous pemphigoid.
J Clin Apher
June 2024
Service Néphrologie dialyse Aphérèse, Hôpital Universitaire de Nîmes, CHU Carémeau, France.
Article Synopsis
- Bullous pemphigoid is a common autoimmune blistering disease primarily affecting older adults, often linked to serious health conditions like diabetes and heart disease.
- It involves the body producing autoantibodies that attack proteins in the skin, leading to painful blisters and a high mortality rate within the first year.
- A case study is presented of a diabetic patient on hemodialysis with severe bullous pemphigoid who was successfully treated with double filtration plasmapheresis, which helped eliminate the need for systemic steroids.
An Unusual Presentation of Renal Failure: A Case of Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (MPO-ANCA) Vasculitis.
Cureus
January 2024
Internal Medicine, Bayonne Medical Center, Bayonne, USA.
Article Synopsis
- MPO-ANCA vasculitis is a disease that causes small vessel inflammation, significantly affecting organs like the lungs, kidneys, and skin, leading to serious health issues.
- The case discussed involves a 77-year-old woman with a history of type 2 diabetes who experienced rapid kidney failure, skin lesions, and respiratory issues, ultimately requiring dialysis.
- Early treatment with prednisone improved some symptoms, but due to extensive kidney damage, the patient ended up needing permanent dialysis, highlighting the critical need for prompt diagnosis and intervention to prevent life-threatening complications.
[Assoziation zwischen chronischer Nierenerkrankung und dem Risiko für bullöses Pemphigoid: eine nationale bevölkerungsbasierte Kohortenstudie].
J Dtsch Dermatol Ges
December 2023
Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Cutaneous manifestations in patients with end-stage renal disease on hemodialysis.
Caspian J Intern Med
January 2023
Department of Nephrology, Babol University of Medical Sciences, Babol, Iran.
Article Synopsis
- End-stage renal disease (ESRD) can lead to various skin issues that impact patients' quality of life, making early recognition and treatment important.
- A study involving 150 hemodialysis patients revealed common skin problems, including dry skin (84.7%), pallor (82.7%), and itching (67.3%), along with skin infections in 36% of cases.
- The research concluded that skin conditions are prevalent in ESRD patients and timely management may enhance their overall quality of life.
Association between chronic kidney disease and risk of bullous pemphigoid: a nationwide population-based cohort study.
J Dtsch Dermatol Ges
December 2023
Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Article Synopsis
- - Studies indicate a link between chronic kidney disease (CKD) and an increased risk of bullous pemphigoid (BP), but this association is still not fully understood.
- - Research involving over a million participants in Taiwan revealed that CKD significantly raises the risk of developing BP, with dialysis-dependent patients facing the highest risk.
- - The findings suggest that individuals with CKD have a 1.3 times greater risk of BP, while those on dialysis have a 1.8 times greater risk compared to those without CKD.
Risk of bullous pemphigoid and pemphigus in patients on chronic dialysis: A nationwide population-based cohort study.
J Dermatol
December 2023
Department of Dermatology, Cardinal Tien Hospital, New Taipei City, Taiwan.
Article Synopsis
- Bullous pemphigoid occurs more frequently in patients undergoing chronic dialysis, indicating that these individuals are at a significantly higher risk for developing this condition compared to a matched control group.
- A study analyzing data from Taiwan's National Health Insurance Research Database found that the incidence rate of bullous pemphigoid in dialysis patients was over two times higher than in controls, with younger dialysis patients (under 75 years) facing an even greater risk.
- In contrast, chronic dialysis did not appear to significantly increase the risk for pemphigus, emphasizing the need for physicians to monitor dialysis patients specifically for bullous pemphigoid.
New Frontiers in Autoimmune Diagnostics: A Systematic Review on Saliva Testing.
Int J Environ Res Public Health
May 2023
University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin, 10154 Turin, Italy.
Article Synopsis
- Immunological laboratory testing is complex and often performed in specialized centers, facing challenges like limited resources and difficulties in blood sample collection, especially in vulnerable populations.
- A systematic review was conducted to explore the feasibility of using saliva samples for immunological testing, analyzing 170 articles where 18 studies were relevant.
- Results indicated that saliva collection via passive drooling was common, with ELISA being the main detection method; there is evidence of good correlation between saliva and serum results, suggesting saliva testing could be a reliable alternative for diagnosing autoantibodies.
Calcific uraemic arteriolopathy presenting as cellulitis of the dorsal foot.
BMJ Case Rep
April 2023
Department of Internal Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Article Synopsis
- - Calcific uraemic arteriolopathy (CUA) is a rare condition that usually causes painful skin lesions, primarily in the fatty areas of the lower legs.
- - The case presented describes CUA mimicking cellulitis, showcasing an unexpected bullous lesion on the top part of the lower leg.
- - With the incidence of CUA likely rising due to its connection to advanced kidney disease, it's crucial to recognize its various manifestations to enhance understanding and find better treatment options.
Levofloxacin-Associated Bullous Pemphigoid in a Hemodialysis Patient After Kidney Transplant Failure.
Am J Case Rep
December 2022
Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- * The patient experienced improvement in her infection symptoms, but then developed a severe skin rash characterized by bullous lesions, leading to further medical evaluation which confirmed the diagnosis.
- * The report emphasizes the need for awareness of skin conditions in dialysis patients, the significance of accurate diagnosis through biopsy, and the effectiveness of timely treatment, as evidenced by the patient's recovery after starting prednisone.
Renal Transplantation Could Reverse Dialysis-Associated Porphyria.
Cureus
August 2022
Urology, Gauhati Medical College & Hospital, Guwahati, IND.
Article Synopsis
- Pseudoporphyria (PP) is a rare skin condition that mimics porphyria cutanea tarda but doesn't show porphyrin abnormalities, often affecting patients on dialysis.
- This condition is characterized by blistering skin lesions that appear in areas exposed to light, and while treatments have been ineffective, N-acetylcysteine has shown mixed results.
- In a case study, a patient developed severe skin lesions after starting hemodialysis, but these lesions completely healed within 22 days following a kidney transplant, indicating that renal transplantation is a potential cure for dialysis-induced pseudoporphyria.
Blisters and Milia around the Peritoneal Dialysis Catheter: A Case of Localized Bullous Pemphigoid.
Dermatopathology (Basel)
August 2022
Dermatology Clinic, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Article Synopsis
- - A 79-year-old woman undergoing peritoneal dialysis developed tense blisters around her Tenckhoff catheter, prompting investigation into potential causes such as dermatitis, bacterial infection, or herpes virus.
- - The presence of milia indicated the possibility of a subepidermal blistering disease, leading to further diagnostic testing.
- - Results from laboratory tests, histopathological examination, and direct immunofluorescence confirmed she had localized bullous pemphigoid, a condition often seen in the elderly that can be linked to various factors, including dialysis complications.
Cefixime-induced linear IgA bullous dermatosis: a rare cause of mucocutaneous bullous eruption in a patient on hemodialysis.
Int J Dermatol
June 2022
Department of Dermatology, Venereology, and Leprosy, RG Kar Medical College and Hospital, Kolkata, West Bengal, India.
Kidney and Urinary Tract Involvement in Epidermolysis Bullosa: Is Routine Follow-Up Necessary?
Dermatol Pract Concept
May 2021
Department of Pediatric Nephrology, Marmara University School of Medicine, Istanbul, Turkey.
Article Synopsis
- This study focused on the kidney and urinary tract issues in patients with epidermolysis bullosa, a rare skin condition.
- The research included 16 patients, mostly children, revealing that most had normal kidney function, although one patient had severe kidney disease.
- The findings suggest that routine kidney evaluations are important for all epidermolysis bullosa patients, particularly those with the recessive dystrophic form, to monitor for potential complications over time.
Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey.
Ren Fail
December 2021
Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan.
Article Synopsis
- Bullous pemphigoid (BP) is a blistering autoimmune disease that can occur in patients with kidney issues on dialysis, but its exact incidence in these patients is not well established.
- A study reported three cases of BP in patients receiving peritoneal dialysis, suggesting that skin injuries might have triggered the condition, and certain medications could play a role in its development.
- The research indicates a significant incidence of BP among dialysis patients, highlighting that the occurrence is much higher compared to the general population, with a rate of 3 cases per 478.3 person-years in 10 years of observation.
Reactive Perforating Collagenosis; An Uncontrolled Pruritus That Left You Scratching Your Head.
Cureus
July 2020
Internal Medicine, State University of New York Upstate Medical University, Syracuse, USA.
Article Synopsis
- - Acquired perforating collagenosis is a rare skin condition related to collagen issues, often found in patients with microvascular diseases like diabetes and chronic kidney disease (CKD).
- - The case study involves a 68-year-old male with stage IV CKD who developed a widespread skin rash, which was wrongly suspected to be caused by other conditions before confirming perforating collagenosis through biopsies.
- - This report highlights the need for healthcare providers to recognize skin issues associated with advanced CKD and the importance of performing repeat biopsies to avoid diagnostic errors.
Development of Bullous Pemphigoid after Tenckhoff Catheter Placement in a Peritoneal Dialysis Patient.
Case Rep Dermatol
March 2020
Division of Nephrology, Department of Internal Medicine, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Article Synopsis
- Bullous pemphigoid (BP) is a chronic autoimmune skin disease that causes blistering and has been linked to patients with end-stage renal disease on dialysis.
- A case is reported where BP developed for the first time in a patient following the placement of a peritoneal dialysis catheter.
- Treatment with systemic doxycycline and topical clobetasol propionate over three months resulted in rapid improvement, with the patient remaining symptom-free during follow-up.
Safety and efficacy of plasma exchange via direct femoral vein puncture in autoimmune blistering diseases.
J Clin Apher
June 2020
Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan.
Article Synopsis
- Plasma exchange (PE) is used for treating autoimmune blistering diseases, and this study compares two methods: direct femoral vein puncture (FVP) and double-lumen catheter (DLC).
- The safety issues like catheter occlusion and blood flow problems were similar for both methods, but infections at the access site were significantly lower in the FVP group.
- While FVP was found to be a safe method, its effectiveness in removing autoantibodies was similar or slightly lower compared to the DLC method.
Dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid, likely triggered by scabies, in a hemodialysis patient with human leukocyte antigen-DQB1*03:01.
CEN Case Rep
August 2020
Department of Nephrology and Rheumatology, Rakuwakai Otowa Hospital, 2, Otowa Chinji-cho, Yamashina-ku, Kyoto, 607-8062, Japan.
Bullous pemphigoid (BP) is the most common autoimmune subepidermal bullous diseases. Autoantibodies against hemidesmosomal adhesion proteins might be involved in the developing process. BP usually affects the elderly with high mortality whereas the drug-induced BP is often improved and rarely relapses after the withdrawal of the suspected drug.
View Article and Find Full Text PDFRenal histological findings in a patient with acute renal injury associated with purpura fulminans: a case report.
J Bras Nefrol
February 2020
Universidade Estadual de Londrina, Londrina, PR, Brasil.
Article Synopsis
- Purpura fulminans (PF) is a rapidly progressing blood clotting disorder that causes skin necrosis and can lead to acute kidney injury (AKI), but there are no documented kidney histology findings related to PF.
- A 20-year-old previously healthy woman experienced severe symptoms and skin lesions, requiring dialysis and plasmapheresis, as her kidney function diminished.
- A renal biopsy helped rule out thrombocytopenic microangiopathy and revealed the first known histological findings for PF, leading to her recovery and treatment for skin damage.
Facilitated subcutaneous immunoglobulin treatment in pemphigus vulgaris.
BMJ Case Rep
May 2018
Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, S. Giovanni Bosco Hospital, Turin, Italy.
Article Synopsis
- * A case study of a 56-year-old woman with pemphigus vulgaris and breast cancer is presented, highlighting her previous treatments and the introduction of fSCIG after traditional therapies were limited due to her cancer diagnosis.
- * After 18 months of treatment with fSCIG, the patient's breast cancer was successfully managed, and she experienced a significant reduction in the severity of her autoimmune symptoms, suggesting that fSCIG could be a valuable, steroid-sparing option for certain pemphigus vulgar
Vascular mapping for the decision of hemodialysis access method: Case report.
J Vasc Access
May 2019
Tokatsu-Clinic Hospital, Matsudo, Japan.
Article Synopsis
- Preoperative ultrasound vascular mapping was used to find suitable surgical methods for two patients when standard arteriovenous fistula options were unavailable.* * In case 1, previous access sites were compromised, and an allergy to contrast medium necessitated an alternative approach, which was informed by the ultrasound mapping.* * In case 2, complications from a skin disease and malnutrition prevented the use of synthetic grafts, so ultrasound mapping helped determine the best access method for hemodialysis.*
Mucocutaneous Manifestations in Patients with Chronic Kidney Disease: A Cross-sectional Study.
Indian Dermatol Online J
January 2018
Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Himachal Pradesh, India.
Article Synopsis
- * A study involved 122 CKD patients, examining the prevalence of skin and mucous membrane disorders, revealing conditions like xerosis, skin pallor, and pruritus as common symptoms regardless of the patients' dialysis status.
- * Key findings included a high occurrence of dry skin, nail abnormalities, and oral issues, suggesting that environmental factors, such as climate, may worsen these symptoms; ongoing follow-up for CKD patients is recommended to manage these problems.
New diagnosis of bullous pemphigoid after withdrawal of immunosuppressive therapy in a failed renal transplant recipient on hemodialysis.
Hemodial Int
April 2018
Division of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Article Synopsis
- * A patient experienced bullous lesions after stopping immunosuppressant drugs due to renal allograft failure, with a skin biopsy confirming the BP diagnosis.
- * Treatment with systemic corticosteroids effectively managed the BP lesions, highlighting the need for heightened awareness of autoimmune skin diseases in patients who halt immunosuppressant therapy post-transplant failure.
Treatment of severe drug reactions by hemodialysis.
Int J Dermatol
February 2018
Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- - Extracorporeal treatments like hemodialysis are usually lifesaving for drug poisoning but not typically used for severe skin and systemic drug reactions.
- - This study highlights three cases where hemodialysis effectively reversed serious drug reactions, including conditions like toxic epidermal necrolysis.
- - The findings suggest that hemodialysis could be a game-changer for severe drug reactions, though it's not widely recognized in current treatment guidelines, partly due to limited patient cases.
The Inpatient Burden of Autoimmune Blistering Disease in US Children: Analysis of Nationwide Inpatient Sample Data.
Am J Clin Dermatol
April 2017
Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
Article Synopsis
- * The research found that pemphigus is the most common primary condition in PAIBD admissions, while dermatitis herpetiformis is common as a secondary diagnosis, with various demographic and chronic health associations highlighted.
- * Overall, PAIBD results in significant hospital burden and is linked to multiple comorbidities, affecting different racial and insurance demographics in distinct ways.