Tertiary lymphoid structures in colorectal cancer - organization and immune cell interactions.

Tertiary lymphoid structures (TLS), formerly recognized as Crohn's-like structures, serve as crucial biomarkers for evaluating the progression of colorectal cancer (CRC). Understanding their spatial distribution, cellular composition, and interactions within CRC is paramount for comprehending the immune response in the tumor microenvironment (TME). TLS are comprised of a T-cellular compartment and a B-cellular compartment, the latter encompassing follicular dendritic cells (FDCs), high endothelial venules (HEVs), and lymphatic vessels.

Transnational patterns, social networks and self-help organizations for migrant women.

Previous research shows the importance of building up self-help structures in a transnational perspective for the inclusion of migrant women who are fleeing their home countries because of war, violence, or different forms of vulnerability. The mobilization of self-help organizations through the intersection of transnationalism and gender is, in fact, a useful direction for a practice-oriented pedagogy directed both towards (1) the most vulnerable groups of women, or (2) those already empowered either as community leaders or network facilitators, other migrants and the whole native population. For this paper, we compare two video-interviews of refugee women collected in Bulgaria and Italy, which are important receiving countries either at the South-Eastern or Southern external border of the European Union.

The boost of force in unfused tetanic contractions at variable interpulse intervals in fast motor units of the rat medial gastrocnemius.

Previously, boost and sag effects seen in unfused tetanic contractions have been studied exclusively at constant stimulation frequency. However, intervals between successive discharges of motoneurons vary during voluntary movements. We therefore aimed to test whether the extra-efficient force production at the onset of contraction (boost) occurs during stimulation with variable intervals, and to what extent it depends on the level of interpulse interval (IPI) variability and history of stimulation.

Dynamic changes and future trend predictions of the global burden of anxiety disorders: analysis of 204 countries and regions from 1990 to 2021 and the impact of the COVID-19 pandemic.

Background: Anxiety disorders is a significant contributor to the Global Burden of Diseases (GBD), particularly in the aftermath of the COVID-19 pandemic, which has exacerbated the issue. Previous studies have not examined the impact of the COVID-19 pandemic on anxiety disorders over the entire time series, nor have they offered predictions regarding future trends of global anxiety disorders in the aftermath of the pandemic. This study aims to present the Age-Standardized Prevalence Rates (ASPR), Age-Standardized Incidence Rates (ASIR), and disability-adjusted life years (DALYs) associated with anxiety disorders from 1990 to 2021 across 204 countries and regions, emphasizing the age structure and the disease burden following the pandemic.

A Multicenter ICET-A Survey on Adherence to Annual Oral Glucose Tolerance Test (OGTT) Screening in Transfusion-Dependent Thalassemia (TDT) Patients - The Expert Clinicians' Opinion on Factors Influencing the Adherence and on Alternative Strategies for Adherence Optimization.

Background: Current guidelines for screening glucose dysregulation (GD) in patients with transfusion-dependent thalassemia (TDT) recommend an annual 2-hour oral glucose tolerance test (OGTT) starting at the age of 10 years.

Objective: Assessment of adherence to OGTT screening in patients with TDT.

Methods: A questionnaire was distributed to 18 Thalassemia Centers in 10 different countries, targeting factors influencing adherence to annual OGTT screening in specialized multidisciplinary pediatric and adult TDT units and identifying strategies to improve adherence to OGTT in TDT patients.

Prediction of Current and Future Distributions of (Coleoptera: Buprestidae) Under Climate Change Scenarios.

The consequences of climate change, accelerated by anthropogenic activities, have different effects on different ecosystems, and the severity of these effects is predicted to increase in the near future. The number of studies investigating how forest ecosystems respond to these changes is increasing. However, there remains a significant gap in research concerning how saproxylic organisms-one of the key contributors to the healthy functioning of these fragile ecosystems-will respond to the consequences of climate change.

Exploring a Novel Adsorbent for CO Capture and Gas Separation.

The urgent need to mitigate carbon emissions has spurred research into small-pore zeolites as cost-effective options for CO capture by solid adsorbents, particularly in postcombustion and biogas separation applications. In this study we investigate levyne (LEV-type) zeolite, a largely unexplored material for CO adsorption, as a novel adsorbent for CO capture and gas separation. Using seed-assisted synthesis approaches and different synthesis conditions, nanosized and micron-sized LEV zeolites were synthesized and characterized in terms of synthesis pathways, morphology, crystal size, and chemical composition.

Potential therapeutic applications of medical gases in cancer treatment.

Medical gases were primarily used for respiratory therapy and anesthesia, which showed promising potential in the cancer therapy. Several physiological and pathological processes were affected by the key gases, such as oxygen, carbon dioxide, nitric oxide, hydrogen sulfide, and carbon monoxide. Oxygen targets shrinking the tumor via hyperbaric oxygen therapy, and once combined with radiation therapy it enhances its effect.

The complexities of aeronautical transfer of acutely unwell neurosurgical patients.

Objective: Neurosurgical care is difficult to access in many scenarios. Aeromedical evacuation of acutely unwell neurosurgical patients from remote, isolated or poorly equipped locations can be considered. This article aims to provide a framework of logistical factors which deserve special consideration in the preparation of these patients for transfer.

Understanding drug solubilization in intestinal mixed micelles through molecular dynamics simulations.

Hypothesis: Solubilization is a fundamental process that underpins various technologies in the pharmaceutical and chemical industry. However, knowledge of the location, orientation and interactions of solubilized molecules in the micelles is still limited. We expect all-atom molecular dynamics simulations to improve the molecular-level understanding of solubilization and to enable its in silico prediction.

Exposure-response relationships between road traffic, railway, and aircraft noise and annoyangel.dzhambov@mu-plovdiv.bgance in Bulgarian cities.

This study aimed to develop exposure-response relationships (ERRs) between road, rail, and air traffic noise and high noise annoyance (HNA) and to assess the HNA disease burden. In 2023, 4 640 adults were cross-sectionally sampled from the five largest cities in Bulgaria. Participants' road, rail/tram, and air traffic HNA was defined as the top two categories (60% cut-off point) of a 5-point scale.

Self-perceived impact of COVID-19 and risk behaviors among adolescents: Results from the HBSC 2021/22 study in 21 European countries.

Aims: To investigate adolescents' perception of the impact of the COVID-19 pandemic on several aspects of their lives (mental health, well-being, family situation, peers, school, dieting, and physical activity) in relation to risk behaviors such as smoking, alcohol use, drunkenness, and cannabis use.

Methods: Data were used from the Health Behaviour in School-aged Children (HBSC) study conducted in 2021/2022, comprising 106,221 adolescents aged 11-15 (50.9% females) from 21 European countries.

Investigating the impact of Multiwalled Carbon Nanotubes exposure on enzymatic activities and histopathological variations in Swiss albino mice.

Present study was conducted to evaluate the detrimental impacts of exposure of Multi-walled Carbon Nanotubes (MWCNT-NP) on enzymatic activities and tissue structures in Swiss albino mice. The experimental groups of mice received MWCNT-NP for specific time period (seven or fourteen days). Two distinct doses of the MWCNT-NP solution were given orally: 0.

Semantic segmentation dataset of Land Use/Cover Area frame Survey (LUCAS) rural landscape Street View Images.

Urban focused semantically segmented datasets (e.g. ADE20k or CoCo) have been crucial in boosting research and applications in urban areas by providing rich sources of delineated objects in Street View Images (SVI).

An unusual variant of an accessory thoracic muscle.

Background: The anterior thoracic wall musculature presents significant morphological variability. The current literature describes a few accessory thoracic muscles (ATMs) and discusses possible clinical implications. The dissection report describes an unusual ATM variant.

Left ventricular elastance with resting volumetric transthoracic echocardiography identifies different phenotypes in heart failure with preserved ejection fraction: A retrospective analysis of a multicenter prospective observational study.

Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity including patients with different phenotypes of near normal, normal, and supernormal left ventricular (LV) function.

Objectives: To assess the value of resting LV elastance (also known as force) with transthoracic echocardiography (TTE) to identify HFpEF phenotypes.

Methods: In a prospective, observational, multicenter study, 2380 HFpEF patients were recruited from July 2016 to May 2024.

Demographic and Clinical Characteristics of Patients With Charcot Neuro-Osteoarthropathy in People With Diabetes Mellitus in Six Countries: A Multicenter Observational Study From 1996 to 2022.

To describe the demographic and clinical characteristics of patients with Charcot neuro-osteoarthropathy (CNO) and to examine for differences between participants with Type 1 diabetes mellitus (DM) (T1DM) and Type 2 diabetes mellitus (T2DM). Multicenter observational study in eight diabetic foot clinics in six countries between January 1, 1996, and December 31, 2022. Demographic, clinical, and laboratory parameters were obtained from the medical records.

Effect of roasting on the chemical and lipid composition of pine nuts in two regions in Russia.

The impact of thermal treatment for roasting on pine nuts from two geographical regions in Russia (Vladivostok and Baikal) was studied. They were roasted at 180 °C for 20 min in an oven. The aim was to establish the changes that occurred in the chemical (proteins, lipids, carbohydrates, ash, fibers), lipid composition (fatty acids, tocopherols, sterols, phospholipids), and physicochemical characteristics (peroxide value, acid value, iodine value, conjugated dienes and trienes) after roasting of the pine nuts.

DNA-elucidated life cycle of a highly pathogenic avian nematode: (Spirurida: Acuariidae) and its morphological development from infective third-stage larva to adult.

Gibson, 1968 is an acuariid nematode associated with lethal cases of streptocarosis of diverse aquatic birds in North America and Europe. This study reports as an agent causing severe and fatal necrosis of the oesophagus and proventriculus of anatids, i.e.

Unveiling Cryptic Diversity in Hylomys: A Commentary on Recent Taxonomic Revisions.

The genus Hylomys now comprises seven species instead of two; the Hylomys species in China should be classified as Hylomys peguensis.

The Polygenic Nature of Multiple Sclerosis: Genetic Variants, Immunological Modulation, and Environmental Connections.

Multiple Sclerosis (MS), a debilitating inflammatory disorder of the central nervous system characterized by demyelination, is significantly influenced by polygenic variations. Although the precise cause of MS remains unclear, it is believed to arise from a complex interplay of genetic and environmental factors. Recent investigations have focused on the polygenic nature of genetic alterations linked to MS risk.

Germanium Atoms Exceed the Tetrahedral Coordination in MFI Zeolite.

Germanium is known to occupy tetrahedral sites by substituting silicon in germanosilicate zeolites. In this study, we present pioneering findings regarding the synthesis of zeolites with an MFI structure (GeMFI) incorporating a high germanium amount (16% Ge). Remarkably, the germanium atoms feature a slight electron deficiency with respect to GeO, and the typical coordination number of 4, as usually reported for the germanosilicate zeolites, is exceeded, giving rise to Ge dimers in a double-bridge configuration.

Sutureless FOCUS harmonic scalpel versus clamp-and-tie techniques for thyroidectomy: a meta-analysis of 43 randomized controlled trials.

Background: One of the most important surgical steps during thyroidectomy is the safe ligation of vessels. In fact, it is crucial to avoid postoperative bleeding and nerves' injury. The "clamp and tie" technique was first introduced in the 19th century.

Direct microbial production of 2,3-Butanediol from inulin by Bacillus velezensis R22 through the synergistic action of membrane and cytoplasmic inulinases.

The present study investigates the natural ability of Bacillus velezensis R22 to produce 2,3-BD from two inulin-rich substrates - insoluble and soluble chicory flour. After complex optimization of the media content and process parameters by consecutive application of Plackett-Burman design and response surface methodology, the strain R22 was capable of producing 71.2 g/L (95.