2,523 results match your criteria: "Buffalo General Hospital; 49 Niagara Street.[Affiliation]"
Fatigue levels and associated factors in systemic sclerosis: a cross-sectional study of 2,385 SPIN Cohort participants.
Rheumatology (Oxford)
October 2024
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Article Synopsis
- A study compared fatigue levels in a large group of people with systemic sclerosis (SSc) to typical fatigue levels in the general population, finding that SSc patients experienced significantly more fatigue.
- Participants included 2,385 individuals, with a majority being female and averaging around 55 years old, and it was noted that 18% reported mild fatigue, 27% moderate fatigue, and 8% severe fatigue.
- Factors such as age, gender, marital status, fatigue-related lifestyle choices (like smoking and BMI), and specific disease features (like gastrointestinal issues and joint problems) were all linked to higher fatigue scores in SSc patients.
Validity and Reliability of the Korean Version of the Trauma-Informed Climate Scale-10.
Asian Nurs Res (Korean Soc Nurs Sci)
December 2024
College of Nursing, Seoul National University, Republic of Korea.
Purpose: The Trauma-Informed Climate Scale-10 is a short form developed to efficiently measure staff perceptions of the values of trauma-informed care within the service environment. This study aimed to evaluate the reliability and validity of the Korean version of the Trauma-Informed Climate Scale-10 (K-TICS-10) among Korean nurses.
Methods: The K-TICS-10 underwent a linguistic validation process, including translation, back-translation, and expert committee review.
Integrating priorities at the intersection of cancer and neuroscience.
Cancer Cell
January 2025
Department of Head and Neck Surgery and the Department of Genomic Medicine, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA; University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address:
Cancer neuroscience is a rapidly growing multidisciplinary field that conceptualizes tumors as tissues fully integrated into the nervous system. Recognizing the complexity and challenges in this field is of fundamental importance to achieving the goal of translational impact for cancer patients. Our commentary highlights key scientific priorities, optimal training settings, and roadblocks to translating scientific findings to the clinic in this emerging field, aiming to formulate a transformative and cohesive path forward.
View Article and Find Full Text PDFAssociations of Social Determinants and Community Resilience with Lung Cancer Incidence and Mortality in the United States.
Am J Respir Crit Care Med
December 2024
Division of Pulmonary, Critical Care, Sleep Medicine, University of Florida, Jacksonville, Florida.
Safety and Efficacy of Metformin for Idiopathic Intracranial Hypertension. A U.S-Based Real-World Data Retrospective Multicenter Cohort Study.
medRxiv
October 2024
Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Introduction: Idiopathic intracranial hypertension (IIH) remains a challenging condition to manage, with limited therapeutic options. This study investigated the potential of metformin as a novel treatment for IIH, exploring its effects on disease outcomes and safety profile.
Methods: We conducted a retrospective cohort study using the TriNetX database, analyzing data from 2009 to August 2024.
Initial patient characteristics of Thoracic Surgical Oncology Group 102: A multicenter prospective registry of active surveillance in patients with multiple ground-glass opacities.
J Thorac Cardiovasc Surg
October 2024
Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Article Synopsis
- The study investigated the feasibility and safety of active surveillance for patients with multiple ground glass opacities (GGOs) in the lungs, which are a common concern in medical imaging.
- A total of 337 patients, primarily older adults with a significant history of smoking, were enrolled and monitored over time, with each GGO documented via CT scans every 6 to 12 months.
- Preliminary findings suggest that active surveillance is a viable management option for patients, with ongoing assessments planned to evaluate long-term safety and outcomes over five years.
Data-driven, harmonised classification system for myelodysplastic syndromes: a consensus paper from the International Consortium for Myelodysplastic Syndromes.
Lancet Haematol
November 2024
Center for Accelerating Leukemia/Lymphoma Research at Comprehensive Cancer Center, IRCCS Humanitas Research Hospital, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy. Electronic address:
Article Synopsis
- The WHO and International Consensus Classification 2022 aim to improve diagnosis and treatment decisions for myelodysplastic syndromes, but disparities in their implementation exist.
- A panel of experts used a data-driven method and the Delphi consensus process to align the two classifications, focusing on genomic features to create harmonized labels for distinct clusters.
- Key findings identified nine genomic clusters, with the most significant linked to biallelic TP53 inactivation, and highlighted the inadequacy of traditional morphological assessments in capturing the complexity of these diseases.
Defining ideal middle cerebral artery bifurcation aneurysm size for Woven EndoBridge embolization.
J Neurosurg
October 2024
3Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.
Article Synopsis
- The study aimed to identify the optimal sizes for middle cerebral artery (MCA) bifurcation aneurysms that are most suitable for treatment with the Woven EndoBridge (WEB) device, focusing on aneurysm width and neck dimensions.
- Using a large retrospective database, the researchers analyzed unruptured MCA bifurcation aneurysms and established ideal cutoff values of 6.1 mm for width and 4.6 mm for neck size regarding treatment effectiveness.
- Findings indicated that aneurysms smaller than these cutoff values had significantly higher rates of occlusion (93% for width and 90% for neck) and lower retreatment rates compared to larger aneurysms, highlighting the importance of
Evaluation of Mortality Rate Disparities for Cardiac Arrest Between Urban and Rural Cohorts in the United States Using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) Database.
Cureus
September 2024
Department of Internal Medicine, Maharajah Institute of Medical Sciences, Vizianagaram, IND.
Introduction The United States includes diverse geographic areas with distinct urban and rural settings. Urban areas served with higher health services and the rural regions with restricted facilities. This disparity results in higher rural mortality rates.
View Article and Find Full Text PDFDemographic and Regional Trends of Cardiovascular Disease and Obesity-Related Mortality in the United States From 1999 to 2021.
Am J Cardiol
December 2024
Baylor Scott and White Research Institute, Dallas, Texas; The Heart Hospital Plano, Plano, Texas; Department of Medicine, Baylor College of Medicine, Temple, Texas. Electronic address:
Irritable Bowel Syndrome (IBS) and Smoking: An Evaluation of IBS symptom severity and anxiety sensitivity among adults in the United States.
Addict Behav
January 2025
Department of Medicine, Division of Behavioral Medicine, Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY, USA.
Article Synopsis
- Irritable bowel syndrome (IBS) affects gut-brain function and can lead to psychological distress, work impairment, and reduced quality of life, with limited research on its relationship with smoking.
- The study analyzed 263 adults with IBS who smoke, focusing on how IBS symptom severity and anxiety sensitivity influence smoking habits and challenges in quitting.
- Results showed that both anxiety sensitivity and IBS severity increased perceived difficulties in quitting smoking, especially highlighting that higher anxiety sensitivity amplified the negative expectations around quitting for those with more severe IBS symptoms.
Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label, multi-cohort, phase 1 trial.
Lancet Oncol
October 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- * The study, called KOMET-001, was conducted in multiple countries and involved dose-escalation and validation phases, with patients in specific molecular subtypes receiving varying doses of ziftomenib over 28-day cycles.
- * Results indicated that 83 patients were treated with ziftomenib from September 2019 to August 2022, and the findings are crucial for determining the drug's safety and effectiveness for future phases of clinical testing.
A Systematic Review of Early General Parenting Interventions: Long-term Effects in Underrepresented Populations and Implications for Obesity Prevention.
Curr Obes Rep
December 2024
Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, NY, USA.
Purpose Of Review: While some parenting interventions designed for early-life obesity prevention have demonstrated short-term success, there is limited evidence of longer-term impacts and feasibility with underrepresented populations. The goal of this review was to examine existing general parenting programs for parents of children 0-5 years that were not designed to target obesity but investigated long-term effects on parenting and/or were conducted with underrepresented populations to offer recommendations for the modification or development of parenting-focused obesity prevention programs.
Recent Findings: Most studies with sustained impacts on parenting in underrepresented populations were brief, group-based programs for parents of children 2-5 years.
Admission neutrophil-to-lymphocyte ratio to predict mortality in burn patients: a meta-analysis.
Intensive Care Med Exp
October 2024
Veterans Affairs Western New York Health Care System, 3495 Bailey Avenue, Buffalo, NY, 14215, USA.
Background: The neutrophil-to-lymphocyte ratio (NLR) proves to be a convenient and cost-effective marker with studies showing that a high NLR can serve as a mortality indicator in burn cases. We conducted a meta-analysis aiming to explore whether on-admission NLR values could serve as predictors of mortality in burn patients.
Methods: PubMed, Web of Science, Scopus and Embase were searched from inception until January 2024.
Transcriptomic Profiles of AKAP12 Deficiency in Mouse Corpus Callosum.
Bioinform Biol Insights
September 2024
Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
A-kinase anchor protein 12 (AKAP12), a scaffold protein, has been implicated in the central nervous system, including blood-brain barrier (BBB) function. Although its expression level in the corpus callosum is higher than in other brain regions, such as the cerebral cortex, the role of AKAP12 in the corpus callosum remains unclear. In this study, we investigate the impact of AKAP12 deficiency by transcriptome analysis using RNA-sequencing (RNA-seq) on the corpus callosum of AKAP12 knockout (KO) mice.
View Article and Find Full Text PDFComparison of intraoperative and postoperative outcomes between open, wiltse, and percutaneous approach to traumatic thoracolumbar spine fractures without neurological injury: A systematic review and meta-analysis.
N Am Spine Soc J
December 2024
Department of Neurosurgery, Duke University School of Medicine, Durham, NC, United States.
Article Synopsis
- - A systematic review compared different surgical approaches for fixing traumatic thoracolumbar fractures without neurological injury, focusing on traditional open, mini-open Wiltse, and percutaneous methods.
- - Results showed the Wiltse approach had advantages such as lower operative time, blood loss, and hospital stay compared to the traditional open method, while also performing better in certain metrics against the percutaneous approach.
- - The study concludes that minimally invasive techniques may reduce patient complications and improve care, recommending a prospective trial for better evaluation of outcomes and surgical choices.
Association Between Median Household Income and Perioperative Outcomes of Lumbar Spinal Fusion: An Analysis of the National Inpatient Sample (2009-2020).
World Neurosurg
December 2024
Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, Buffalo, New York, USA; Department of Neurosurgery, Buffalo General Medical Center, Kaleida Health, Buffalo, New York, USA. Electronic address:
Background: Relationships between low socioeconomic status and surgical outcomes are well established for certain procedures. However, scant literature has focused on relationships between median household income and lumbar fusion outcomes.
Methods: Patients who underwent fusion procedures between January 1, 2009 and December 31, 2020 were identified from the National Inpatient Sample database.
Contemporary Approach to the Diagnosis and Classification of Myelodysplastic Neoplasms/Syndromes-Recommendations From the International Consortium for Myelodysplastic Neoplasms/Syndromes (MDS [icMDS]).
Mod Pathol
December 2024
Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:
Article Synopsis
- Myelodysplastic neoplasms/syndromes (MDS) are a diverse set of diseases marked by ineffective blood cell production.
- Recent classification systems by the World Health Organization and the International Consensus have provided more detailed categorizations of MDS based on morphology and genetics.
- A comprehensive and systematic approach is essential for the accurate diagnosis and classification of MDS, as outlined by the International Consortium for MDS (icMDS).
Correlation of APOE polymorphism, expression, and plasma levels with cardiac comorbidities among lipodystrophy in HIV-infected patients.
Clin Chim Acta
January 2025
Department of Molecular Biology, National AIDS Research Institute Pune 411026, India. Electronic address:
Article Synopsis
- - The study examined the impact of ApoE gene polymorphisms on HIV-related lipodystrophy (HIVLD) and metabolic abnormalities in 200 HIV-infected patients, revealing that certain genotypes might influence the risk of developing these conditions.
- - Results indicated that ApoE alleles 2 and specific genotypes, like 4/4, were connected to a decreased risk of HIV-1 infection and a lower likelihood of severe HIVLD, whereas allele 2 was linked to increased risk of both HIV acquisition and HIVLD severity.
- - Additionally, the study found correlations between specific ApoE genotypes and impaired cholesterol and glucose levels in patients without HIVLD, highlighting the intricate relationship between genetics and metabolic health in the context
Find Your Perfect Match for Surgical Residency: Six Steps to Building your BRANDD from the Collaboration of Surgical Education Fellows.
Ann Surg Open
September 2024
From the Department of Surgery, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.
Diagnostic accuracy of hemodynamic assessment of intracranial atherosclerotic stenosis from a single angiographic view: a validation study.
J Neurointerv Surg
September 2024
Neurovascular Center, Changhai Hospital, Naval Medical Uniervisty, Shanghai, China
Article Synopsis
- The study investigates the use of angio-based fractional flow (FF) derived from a single angiographic view to evaluate the hemodynamic status of intracranial atherosclerotic stenosis (ICAS), compared to wire-based FF as a standard.
- A total of 100 ICAS patients were analyzed, showing a strong correlation between angio-based FF and wire-based FF, with high diagnostic accuracy for determining critical thresholds.
- The findings suggest that angio-based FF is a viable and effective method for assessing the functional state of cerebral arterial stenosis.
Analysis of more than 400,000 women provides case-control evidence for and variant classification.
medRxiv
September 2024
Biostatistics Unit, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.
Article Synopsis
- Clinical genetic testing helps find cancer risks by identifying gene changes, but some of these changes are confusing because we don't know what they mean (called VUS).
- Researchers studied a huge number of breast cancer patients and healthy people to understand these confusing gene changes better.
- They found that their method of analyzing data closely matches what other experts say about which gene changes are harmless or harmful, giving more information about 785 unclear changes.
Diagnostic performance of new BAST score versus FIB-4 index in predicating of the liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease.
Eur J Med Res
September 2024
Department of Tropical Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common liver issue, and the study compares the effectiveness of two tests, BAST and FIB-4, in predicting liver fibrosis in non-diabetic MASLD patients.* -
- The study involved 140 patients who underwent tests for fibrosis severity, and results showed that the BAST score had significantly higher sensitivity and specificity than the FIB-4 test for identifying advanced fibrosis.* -
- Overall, the BAST score outperformed FIB-4, making it a more reliable tool for predicting liver fibrosis in MASLD, particularly for patients with advanced stages.*
The impact of hypertension on clinical outcomes in moyamoya disease: a multicenter, propensity score-matched analysis.
Acta Neurochir (Wien)
September 2024
Department of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Article Synopsis
- - Moyamoya disease (MMD) is a rare brain disorder that causes narrowing of blood vessels, often accompanied by high blood pressure, which complicates the condition's outcomes; this study compares MMD patients with and without hypertension.
- - A total of 598 MMD patients were analyzed from multiple institutions, with hypertensive (292) and non-hypertensive (306) groups evaluated for clinical characteristics and outcomes using statistical adjustments to account for differences in their backgrounds.
- - Results indicated that although hypertensive patients showed higher rates of certain risk factors (like diabetes and smoking) and higher stroke rates before adjustments, post-matching analysis revealed no significant differences in stroke rates or recovery outcomes between the two groups, suggesting effective