4,513 results match your criteria: "Budd-Chiari Syndrome"

Direct Oral Anticoagulants in Budd-Chiari Syndrome.

Eur J Haematol

December 2024

Department of Medicine, Division of Hematology/Oncology, University of South Florida, Tampa, Florida, USA.

Aims: Budd-Chiari syndrome (BCS) is managed by interventions aimed at relieving hepatic venous obstruction and anticoagulation. Despite robust data supporting the tolerability and efficacy of direct oral anticoagulants (DOACs) in patients with other venous thromboembolism, its utility in BCS is not well documented. This study aims to evaluate the efficacy and tolerability of DOACs in Primary BCS from the available literature.

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Introduction/background: Budd-Chiari syndrome is a rare entity that is caused by an obstruction of the flow in the hepatic veins or inferior vena cava.

Case Presentation: Herein, we report a rare case of iatrogenic Budd-Chiari syndrome. A 52-year-old woman with chronic renal failure under hemodialysis, presented to our hospital for dyspnea caused by a large pleural effusion.

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Budd-Chiari syndrome (BCS), a rare hepatic vein obstruction condition, poses significant risks during gestation and the postpartum period. We present the case of a 30-year-old primigravida at 32 weeks gestation admitted with weakness and lethargy, which was diagnosed with impending uterine rupture, HELLP syndrome, and intrauterine fetal demise. An emergency cesarean section was performed, delivering a stillborn baby and uncovering 700 milliliters of blood clots in her abdominal cavity.

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Background: Budd-Chiari syndrome is a rare and severe vascular liver disease. We presented patient with fulminant liver failure secondary to leiomyosarcoma of the IVC and thrombosis.

Case Presentation: A 44-year-old female presented with fulminant liver failure secondary to inferior vena cava (IVC) thrombosis.

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Behçet's disease (BD) is characterized by skin lesions, uveitis, and recurrent oral and genital ulcers. Vascular problems, predominantly affecting veins, lead to thrombosis, increasing the risk of ruptured artery aneurysms and Budd-Chiari syndrome (BCS). Morbidity and mortality are significantly heightened by rare occurrences such as pulmonary artery aneurysms, cardiac involvement, and BCS.

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Unlabelled: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by the presence of antiphospholipid antibodies and venous and arterial thrombotic events, including obstetric complications. We describe the case of a 56-year-old female diagnosed with APS with triple antibody positivity and multiple disease-associated manifestations, namely recurrent purpuric lesions, adrenal insufficiency due to infarction, acalculous cholecystitis, and three spontaneous abortions. Her follow-up was marked by severe thrombotic and haemorrhagic events, notably splanchnic vein thrombosis and haemorrhagic shock after a renal biopsy, as well as the diagnosis of systemic lupus erythematosus 8 years after the APS diagnosis.

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Surgical Management of Infective Endocarditis Complicated by Budd-Chiari Syndrome.

Cureus

October 2024

Cardiac Surgery, International University of Health and Welfare, Narita Hospital, Chiba, JPN.

Budd-Chiari syndrome (BCS) is a relatively rare comorbidity, particularly in patients undergoing cardiac surgery. The difficulty arises when we try to drain blood from the obstructed lower body circulation to establish extracorporeal circulation. Herein, we describe a patient who developed a persistent fever after undergoing neurosurgery for a head arteriovenous fistula, wherein blood cultures confirmed infection.

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Article Synopsis
  • The study investigates the reasons behind early relaparotomies in living donor liver transplant recipients within the first 30 days post-surgery, emphasizing the ongoing prevalence of complications despite improved surgical practices.* -
  • Out of 535 patients analyzed between 2019 and 2021, 15.9% (85 patients) required early relaparotomy, with key factors like elevated creatinine and sodium levels, the use of left lobe grafts, and significant blood loss identified as independent risk factors.* -
  • Major causes for needing early relaparotomy included postoperative bleeding, biliary leakage, and vascular issues, highlighting the complexities of post-transplant care and the importance of monitoring at-risk patients.*
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Article Synopsis
  • * A thorough literature search was conducted, analyzing 29 studies involving 767 patients, focusing on various gastrointestinal problems associated with SLE and their treatments.
  • * The findings indicate that while treatments like intravenous methylprednisolone and oral prednisolone may benefit patients, the overall quality of evidence is low, emphasizing the necessity for better-defined disease standards and more robust clinical trials.
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Veins Tell the Tale: Visible Clues of Budd-Chiari Syndrome.

Am J Med

October 2024

Department of Emergency and General Medicine, Tokyo Metropolitan Tama Medical Center, Fuchu, Tokyo, Japan. Electronic address:

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Background: Postoperative complications like remnant hepatic vein (HV) outflow block and liver torsion can occur after right hepatectomy. Hepatic falciform ligament fixation is typically used to prevent liver torsion. We report a novel procedure to manage outflow block.

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Transjugular Intrahepatic Portosystemic Shunt for Budd-Chiari Syndrome: A Single-Centre Experience.

J Clin Med

October 2024

Department of Liver & Small Bowel Health Centre, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital & Research Centre, Riyadh 11451, Saudi Arabia.

: Despite several challenges in clinical management, there has been significant progress in understanding the aetiology, natural history and outcomes of Budd-Chiari syndrome (BCS) treatments. This study aims to evaluate the outcomes of transjugular intrahepatic portosystemic shunt (TIPS) using covered stent in management of BCS. : We conducted a retrospective analysis of 70 BCS patients who underwent TIPS using covered stents between January 2010 and December 2022 at a single tertiary liver transplant centre.

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Article Synopsis
  • Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare disorder that is difficult to diagnose due to diverse symptoms and a lack of awareness, often resulting in misdiagnosis.
  • This study explores the use of a machine learning model, specifically the XGBoost algorithm, to identify undiagnosed PNH patients using electronic health records from the UK, involving 131 PNH patients and over 593,000 controls.
  • The model achieved a recall rate of 27% for PNH patients, with a specificity of 99.99% for controls, and indicated that nearly 1 in 5 flagged patients may need further investigation for PNH, highlighting key symptoms like aplastic anemia and panc
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Article Synopsis
  • Budd-Chiari syndrome (BCS) involves blockage of the hepatic veins and is often linked to a condition that causes increased blood clotting.
  • Systemic amyloidosis is a disorder where misfolded proteins accumulate in the body, causing organ damage, and it typically leads to bleeding issues rather than clotting.
  • The case of a 40-year-old man illustrates how AL amyloidosis can lead to BCS, showing the importance of recognizing its varied and non-specific symptoms for accurate diagnosis.
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Article Synopsis
  • The text provides an English version of the 2018 guidelines for diagnosing and treating idiopathic portal hypertension, extrahepatic portal obstruction, and Budd-Chiari syndrome.
  • These guidelines were developed by the Aberrant Portal Hemodynamics Study Group and are overseen by Japan's Ministry of Health, Labor, and Welfare.
  • The full guidelines contain 86 clinical questions and explanations, spanning 183 pages in Japanese.
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Article Synopsis
  • A study investigated the utility of liver biopsy in diagnosing unexplained portal hypertension among 188 patients at the Second Hospital of Nanjing, revealing that 92.6% received a definitive diagnosis.
  • The most common causes identified were autoimmune hepatitis, autoimmune hepatitis-primary biliary cirrhosis overlap syndrome, and porto-sinusoidal vascular disease, with PSVD patients being younger and showing less severe liver function damage.
  • The research concluded that liver biopsy is a safe and effective tool for diagnosing unexplained portal hypertension, highlighting different clinical and pathological characteristics based on the underlying causes.
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Article Synopsis
  • Liver cirrhosis is a major health issue globally, causing around 2 million deaths annually, with various causes including viral infections, toxins, autoimmune diseases, and metabolic disorders.
  • Common symptoms of cirrhosis include jaundice, nausea, vomiting, and abnormal liver enzymes, with imaging often showing liver fibrosis.
  • A case study is presented of a 38-year-old woman with cirrhosis characterized by a mass compressing the inferior vena cava, which is an unusual manifestation compared to typical fibrotic changes.
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Article Synopsis
  • * Different regions have varying causes of BCS; in the West, hepatic vein thrombosis is common, while in Asia, membranous and short occlusions are more prevalent, impacting treatment strategies.
  • * Interventional treatments like angioplasty and shunting can alleviate the condition more effectively than surgery, although complications may arise, and some patients may ultimately need a liver transplant if therapies fail.
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Point-of-care ultrasound in the diagnosis and treatment of Budd-Chiari syndrome: A rare case report and literature review.

Heliyon

August 2024

Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

Budd-Chiari syndrome (BCS) is a life-threatening disease characterized by the partial or complete obstruction of hepatic venous outflow anywhere from the liver to the heart. In China, secondary BCS is rare. We present a case of secondary BCS caused by compression of the suprahepatic inferior vena cava (IVC), mainly due to local bile accumulation in the caudate lobe of the liver.

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