Clinical Manifestations.

Background: Informant reports can complement standardized cognitive assessment and improve accuracy of dementia diagnosis. Although informant reports correlate moderately with objective measures of decline, the influence of informant factors, such as gender, on these relationships is unclear. This study assessed the hypothesis that informant gender would emerge as an independent predictor in the relationship between informant ratings of cognitive function (i.

Development and initial validation of the implicit internalized sexual orientation stigma affect misattribution procedure.

Introduction: This article describes the development and initial validation of a measure of implicit internalized stigma among queer people, the Implicit Internalized Sexual Orientation Stigma Affect Misattribution Procedure (Internal-SOS-AMP), a computer-administered sequential priming procedure.

Methods: The creation of the Internal-SOS-AMP involved a mixed-methods approach, including a literature review, expert interviews, stimuli selection and pilot testing, data collection from a large sample, reliability testing, correlational analyses, and confirmatory factor analysis. Psychometric testing was conducted with a national sample of 500 queer adults who completed two waves of data collection.

Asian Americans' childhood emotional abuse, emotional neglect, and opioid use: Distress intolerance as moderator.

Asian Americans are highly underrepresented in opioid use research, despite recent studies demonstrating the presence of opioid use behaviors in Asian Americans and distinct negative outcomes of opioid use among Asian Americans in comparison to White adults. Emotional abuse and emotional neglect are important risk factors that may impact opioid use. Thus, the purpose of this study was to investigate (a) the associations between childhood emotional trauma (emotional abuse and emotional neglect) and opioid use, and (b) the role of distress intolerance as a moderator.

Amino Acid Residue-Specific Ramachandran Distributions Derived from a Simple Mean Field Potential.

Protein dynamics in the unfolded state, in the context of early stage protein folding or intrinsically disordered proteins (IDPs), is not well understood. The discovery of IDPs, and their sequence-dependent dynamics, has led to many computational and experimental investigations regarding the conformational preferences of short oligopeptides and individual amino acid residues in the unfolded state. As proteins consist of sequences of amino acid residues, characterizing the intrinsic conformational preferences of the individual residues in the unfolded state is crucial for understanding the emergent conformations of peptides and proteins.

Asian Americans' childhood emotional abuse, emotional neglect, and hazardous alcohol use: Resilience as moderator.

Asian Americans are highly underrepresented in alcohol use research, despite recent studies demonstrating the presence of hazardous alcohol use behaviors and increasing alcohol use rates among Asian Americans. Emotional abuse and emotional neglect serve as important individual factors that may impact hazardous alcohol use. The purpose of this study was thus to investigate (a) the association between childhood emotional trauma and hazardous alcohol use and (b) the role of resilience as a moderator.

Understanding Momentary Alcohol Use Cognitions Through the Lenses of Momentary Socioeconomic Identification, Unfair Treatment, and Strain.

Background: Studies suggest that socioeconomic status (SES) is related to alcohol use. SES may impact alcohol use exposures to financial stress, discriminatory experiences, identity threats, negative emotions, and perceived threats. These experiences could lead to alcohol use increases in alcohol use willingness.

Unconventional Anomalous Hall Effect Driven by Self-Intercalation in Covalent 2D Magnet CrTe.

Covalent 2D magnets such as CrTe, which feature self-intercalated magnetic cations located between monolayers of transition-metal dichalcogenide material, offer a unique platform for controlling magnetic order and spin texture, enabling new potential applications for spintronic devices. Here, it is demonstrated that the unconventional anomalous Hall effect (AHE) in CrTe, characterized by additional humps and dips near the coercive field in AHE hysteresis, originates from an intrinsic mechanism dictated by the self-intercalation. This mechanism is distinctly different from previously proposed mechanisms such as topological Hall effect, or two-channel AHE arising from spatial inhomogeneities.

Universal salt-assisted assembly of MXene from suspension on polymer substrates.

Two-dimensional carbides and nitrides, known as MXenes, are promising for water-processable coatings due to their excellent electrical, thermal, and optical properties. However, depositing hydrophilic MXene nanosheets onto inert or hydrophobic polymer surfaces requires plasma treatment or chemical modification. This study demonstrates a universal salt-assisted assembly method that produces ultra-thin, uniform MXene coatings with exceptional mechanical stability and washability on various polymers, including high-performance polymers for extreme temperatures.

"I find value in myself": Queer Asian American men's self-love and resistance in the face of White supremacy.

Queer (i.e., gay, bisexual, or another sexual minority identity) Asian American men experience unique challenges and strengths related to their social identities at the intersection of race and sexual orientation.

Affirmative Healthcare for Transgender and Gender Nonconforming Patients: A Guide to Patient Assessment.

This review article will discuss the impact of implicit and systematic bias on the health of transgender and gender nonconforming (TGNC) individuals and highlight barriers that TGNC people experience in accessing health care. The importance of affirmative care in improving the health of TGNC people will be described, followed by recommendations for gender inclusive practices that clinical laboratories can adopt to provide more inclusive care for TGNC people.

A Biofilm Channel Origin for Vermiform Microstructure in Carbonate Microbialites.

A three-dimensional tubular fabric known as "vermiform microstructure" in Phanerozoic and Neoproterozoic carbonate microbialites has been hypothesized to represent the body fossil of nonspicular keratose demosponges. If correct, this interpretation extends the sponge body fossil record and origin of animals to ~890 Ma. However, the veracity of the keratose sponge interpretation for vermiform microstructure remains in question, and the origin of the tubular fabric is enigmatic.

Parental Resilience in Contexts of Political Violence: A Systematic Scoping Review of 45 Years of Research.

Families suffer in particular ways during the violence and targeted deprivation of freedom and resources within political violence (PV), which includes wars, armed conflicts, and military occupations. While evidence is accumulating about the disproportionate impacts of PV on parents and children, we lack a clear, globally integrated understanding of how families suffer-and survive-PV. There is an urgent need to synthesize existing work to refine our understanding of parental experiences within PV-with particular attention to both how PV creates suffering for parents, and how parents strategize, caring for their families within the most horrendous of circumstances.

Novel insights into the role of TREM2 in cerebrovascular diseases.

Cerebrovascular diseases (CVDs) include conditions such as stroke, cerebral amyloid angiopathy (CAA) and cerebral small vessel disease (CSVD), which contribute significantly to global morbidity and healthcare burden. The pathophysiology of CVD is complex, involving inflammatory, cellular and vascular mechanisms. Recently, research has focused on triggering receptor expressed on myeloid cells 2 (TREM2), an immune receptor predominantly found on microglia.

Trends and Disparities in Mental Health Use Among Asian American Sub-groups, 2013-2019.

Objective: The objective of this study was to characterize and compare national estimates of mental healthcare use among White and Asian American groups to provide an update using post Affordable Care Act data.

Methods: We analyzed yearly cross-sectional data from the 2013-2019 Medical Expenditure Panel Survey, including White (n = 112,590) and Asian American (n = 10,210) individuals, and examined rates of mental healthcare use for Asian (overall), Asian Indian, Chinese, Filipino, and Other Asian individuals relative to White individuals. Using multivariable logistic regression models and predictive margin methods, we estimated overall Asian disparities and Asian subgroup disparities compared to White group rates in mental health care (outpatient, specialty, psychotropic medication) among adults with and without elevated risk for mental illness.

Pharmacovigilance in the Age of Legalized Cannabis: Using Social Media to Monitor Drug-Drug Interactions Between Immunosuppressants and Cannabis-Derived Products.

Introduction: A clinical trial of Epidiolex, the only US FDA-approved cannabis-derived consumer product (CDP), discovered an interaction with an immunosuppressant (tacrolimus) that led to drug toxicity, highlighting the unique intersection of prescription and commonly unregulated consumer products.

Objective: We aimed to identify if similar drug-drug interactions (DDIs) are occurring among the consumer CDP market, even though they cannot be identified through trials.

Methods: We searched Reddit for subreddits related to CDPs or health, resulting in 63,561,233 posts.

Genetically influenced tobacco and alcohol use behaviors impact erythroid trait variation.

Genome wide association studies (GWAS) have associated thousands of loci with quantitative human blood trait variation. Loci and related genes that impact blood trait variation may regulate blood cell-intrinsic biological processes, or alternatively impact blood cell development and function via systemic factors. Clinical observations have linked tobacco or alcohol use with altered blood traits, but these trait relationships have not been systematically explored at the genetic level.

Emotional support across adulthood: A 60-year study of men's social networks.

Past research shows that social networks get smaller with age. But not all types of relationships may shrink at the same rate or for similar reasons. In the present study, we used a unique data set from a sample of 235 men who were followed longitudinally for 71 years to examine how the general pattern of network shrinkage documented in previous research generalizes to the number of emotional support providers in people's networks.

Internalized racism, racial collective self-esteem, and Asian American adults' disordered eating: Psychological distress as mediator.

Research emphasizes the importance of considering how sociocultural factors affect the disordered eating behaviors of Asian American adults. The present study thus investigated how internalized racism and racial collective self-esteem are associated with disordered eating among Asian American adults, as well as the potential mediating role of psychological distress. A final sample of 796 Asian American adults completed a cross-sectional survey that contained the study's questionnaires.