Seroprevalence and risk factors of brucellosis in pastoralists and their livestock in Central Equatoria State, South Sudan.

Background: Brucellosis poses serious public health implications and substantial economic losses in pastoral rural settings in South Sudan. In humans, brucellosis is almost always originating from animals. Current literature provides scant data regarding the seroprevalence of brucellosis in South Sudan.

Identification of Brucella RS15060 as a novel type IV secretion system effector associated with bacterial virulence.

Brucella is an intracellular parasitic pathogen that causes the worldwide zoonotic disease brucellosis. The type IV secretion system (T4SS) is utilized to secrete various effectors to help Brucella form Brucella-containing vacuoles within the cell and accomplish intracellular trafficking and replication. Brucella has fewer recognized effector proteins than other intracellular parasites in the Proteobacteria, indicating that Brucella may contain a large number of unidentified effector proteins.

Human and animal brucellosis and risk factors for human infection in Ethiopia: a systematic review and meta-analysis (2015-2024).

Background And Objective: Brucellosis is a neglected zoonotic disease caused by Brucella species. Unlike most developed nations, the problem of brucellosis in Ethiopia remains a public and animal health concern. This study was conducted to determine the magnitude of brucellosis in animals (mainly cattle, sheep, goats, dogs and camels) and humans, and to identify the risk factors for human brucellosis.

Prevalence and herd-level risk factors associated with Brucella infection in smallholders keeping large ruminants.

Brucellosis is a disease that poses a higher risk of transmission to animals and people who have close interactions with them, such as farmers. Therefore, the present study was designed to determine the seroprevalence of bovine brucellosis and associated risk factors in Kasur, Punjab, Pakistan. One hundred pooled milk samples from 100 smallholder mixed herds of cows and buffaloes with a total study population of 425 animals (277 cattle and 148 buffalos) with a range of up to seven animals in each herd were collected and tested through a milk ring test (MRT).

Two rare cases of Brucella-induced endocarditis and myopericarditis: challenges in diagnosis.

Introduction: Brucellosis is one of the most common zoonotic infections in the world. Cardiac complications of the disease are usually in the form of endocarditis, and, to a lesser extent, in the form of myopericarditis.

Case: We report the case of a 34-year-old female admitted with signs of fever, nausea, and headache.

Sero-prevalence of human brucellosis and associated factors among febrile patients attending Moyale Primary Hospital, Southern Ethiopia, 2023: Evidences from pastoralist community.

Background: Brucellosis is a neglected zoonotic disease often contracted through contact with animals and consumption of unpasteurized dairy products. Despite being the most common cause of non-malarial acute febrile illness brucellosis is often misdiagnosed in healthcare setups. The global incidence of Brucella infection is reported to be over 2 million cases annually.

Cat scratch disease in children with nocturnal fever: A case report.

Background: Cat scratch disease (CSD) is the most common human infection caused by (). The main manifestation is self-limited lymphadenopathy that primarily affects adolescents, and typically resolves without treatment within 2-4 months. However, individuals with compromised immune systems or immunodeficiency require specific antibacterial therapy following diagnosis.

Modeling the impact of short-term displacement of domestic animals on the transmission dynamics of brucellosis.

Brucellosis, a prevalent zoonotic disease caused by bacteria from the genus , presents a substantial public health and economic challenges worldwide. In this paper, we formulate a two-patch deterministic model to investigate the impact of short-term displacement of domestic animals on the transmission dynamics of brucellosis within and between patches with heterogeneous risk of infection. The model analysis is performed, and the basic reproduction number is computed and used in the stability analysis of equilibria.

Prolonged fever in a 13-year-old girl misdiagnosed as Ochrobactrum spp. bacteremia-the pitfalls of diagnostic Brucella spondylitis in a non-endemic country.

Brucellosis is a zoonosis with non-specific clinical symptoms involving multiple systems and organs. Its prevalence is low in most of EU countries, which can lead to the difficulties in laboratory and clinical diagnostic. Due to its relationship to the Ochrobactrum spp.

Bovine Brucellosis: First Comprehensive Evaluation from Hamedan, an Endemic Area in Iran.

Brucellosis is an infectious zoonotic disease. The disease is one of the major concerns in developing societies due to its great importance for public health and economic losses in the animal industry. The principal target of the study was to detect the prevalence of brucellosis and associated risk factors in cattle from Hamedan (western Iran) using different laboratory techniques.

What Could Lead to the Production of Anti-Rheumatoid Antibodies in Patients with Brucellosis Spondylodiscitis: Possible Causes.

Background: High titers of specific antibodies to cyclic citrulline peptide (ACCP) are often present in the serum of patients with rheumatoid arthritis (RA) and, together with rheumatoid factor (RF), are a diagnostic marker of RA. Brucellosis is a zoonotic infection in which osteoarticular involvement occurs in 10-85% of patients. RF in brucellosis patients is significantly higher than in healthy people.

Vertebral osteomyelitis: a comparative, single-center study in northwestern China.

Background: Vertebral osteomyelitis (VO) is an infection of the spine with increasing prevalence due to improved diagnostics and aging populations. Multiple pathogens, including , spp., and pyogenic bacteria, can cause VO, making differential diagnosis complex, especially in regions with endemic brucellosis and tuberculosis.

Takayasu arteritis masquerading as brucellosis: a case report.

This study reports a unique case of a 19-year-old male with Takayasu arteritis initially misdiagnosed as brucellosis due to persistently positive brucella serology. Despite multiple anti-brucellosis treatments, symptoms persisted until the correct diagnosis of Takayasu arteritis was made, Subsequent immunosuppressive therapy for Takayasu arteritis led to symptom improvement and normalization of serological markers. This highlights the challenge of distinguishing between these conditions and the potential for immunosuppression to impact brucella serology in such cases.

Aspects of brucellosis vaccination in Maranhão state.

Bovine brucellosis is a zoonosis of great economic and public health relevance. Understanding the epidemiological aspects of this disease is a determining factor to help developing effective strategies and supporting decision-making processes. The aim of the present study is to carry out a situational vaccination diagnosis against brucellosis in Maranhão State's cattle in order to identify challenges set for vaccination operations and to help the Official Veterinary Service to plan health interventions.

Leptospira seroprevalence and associated risk factors among slaughterhouse workers in Western Bahr El Ghazal State, South Sudan.

Background: Leptospirosis is a neglected re-emerging and occupational zoonotic disease worldwide. In Africa, contact with livestock is postulated as a potential source of environmental contamination and a source of human Leptospira exposure, though pathways remain unknown. Recently, we confirmed Leptospira exposure and shedding among slaughtered cattle in Western Bahr El Ghazal.

Clinical and epidemiological aspects of spondylodiscitis in a tertiary care hospital in South India.

This study aims to bridge the informational gap regarding the clinical and epidemiological aspects of spondylodiscitis in India, addressing the dearth of substantial evidence in this domain. This study was conducted in a tertiary care hospital over three years, involving 145 adult patients diagnosed with spondylodiscitis. Among them, 28 (19.

The European Union One Health 2023 Zoonoses report.

This report by the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring and surveillance activities carried out in 2023 in 27 Member States (MSs), the United Kingdom (Northern Ireland) and 10 non-MSs. Key statistics on zoonoses and zoonotic agents in humans, food, animals and feed are provided and interpreted historically. In 2023, the first and second most reported zoonoses in humans were campylobacteriosis and salmonellosis, respectively.

Case report: diagnosis of neurobrucellosis in a non-endemic area child using metagenomic next-generation sequencing.

Brucellosis with neurological symptoms at onset is rare in children and is frequently misdiagnosed or overlooked due to nonspecific clinical presentations, particularly in non-endemic areas. We report a case of neurobrucellosis in a child from a non-pastoral area, diagnosed via metagenomic next-generation sequencing (mNGS). The patient presented with headache and altered consciousness, accompanied by fever, projectile vomiting, seizures, and urinary incontinence.

A Pathological Diagnosis Method for Fever of Unknown Origin Based on Multipath Hierarchical Classification: Model Design and Validation.

Background: Fever of unknown origin (FUO) is a significant challenge for the medical community due to its association with a wide range of diseases, the complexity of diagnosis, and the likelihood of misdiagnosis. Machine learning can extract valuable information from the extensive data of patient indicators, aiding doctors in diagnosing the underlying cause of FUO.

Objective: The study aims to design a multipath hierarchical classification algorithm to diagnose FUO due to the hierarchical structure of the etiology of FUO.

A Misdiagnosis of Brucellosis Leads to Prosthetic Valve Endocarditis Complicated by Cerebrovascular Accident.

Cardiovascular complications of Brucellosis are not common and affecting less than 2% of cases. In clinical practice, endocarditis is the most frequent cardiovascular complication and is responsible for most of the brucellosis-related mortality cases and usually diagnosed lately in the course of the disease with mostly aorta valve involvement. In this case report, we present the case of a 27-year-old woman who was admitted to the hospital with fever, sudden onset right side hemiparesis, and horizontal gaze palsy.

Immunoinformatic design of a multivalent vaccine against and its evaluation in a murine model using a DNA prime-protein boost strategy.

Introduction: The development of effective vaccines against is critical due to its significant impact on human and animal health. The objective of this study was to design and evaluate and a multivalent vaccine based on the immunogenic potential of three selected open reading frames (ORFs) of .

Methods: The designed construct, named S22, was analyzed to evaluate its physicochemical properties, antigenicity, allergenicity and toxicity.

Seroprevalance of Brucellosis and Q-fever in water buffaloes (Bubalus bubalis) in Haryana state, India.

Brucellosis and Q-fever are two highly contagious bacterial diseases with significant zoonotic potential and economic threats, yet they often remain underreported and neglected in low- and middle-income countries. The present study aimed to determine the seroprevalence of Brucellosis and Q-fever in water buffaloes in the Haryana state of India to implement effective preventive measures for disease control. The study covered all 22 districts of Haryana and involved 400 serum samples collected from female buffaloes belonging to two age groups and three distinct agro-climatic zones.

Serine/threonine protein kinase mediates rifampicin resistance in through interacting with ribosomal protein RpsD and affecting antioxidant capacity.

Unlabelled: Brucellosis, a zoonotic disease, has re-emerged in both humans and animals, causing significant economic losses globally. Recently, an increasing number of rifampicin-resistant strains have been isolated worldwide without detectable mutations in known antibiotic resistance genes. Here, this study identified the deletion of serine/threonine protein kinase (STPK) gene in as an efficient trigger for rifampicin resistance using bioinformatics predictions, a transposon mutant library, and gene mutation strains.

[Etiological characteristics of in Henan Province, 2013-2022].

To analyze the genus, drug resistance/virulence and phylogenetic characteristics of strains isolated from brucellosis surveillance sentinels in Henan Province from 2013 to 2022, and provide baseline data for the surveillance, early warning and outbreak tracing of brucellosis. Blood samples were collected from patients with infection for strain isolation, culture and species identification, drug susceptibility test, whole genome sequencing, splicing and assembly, functional/virulence/resistance gene prediction analysis and phylogenetic tree drawing based on single nucleotide polymorphism (SNP). In 36 brucellosis patients, the majority were men (86.

Clinical characteristics of human brucellosis in different age groups in the Republic of North Macedonia-A case series.

Background: Brucellosis is a zoonotic infection that presents a major challenge to public health worldwide.

Aim: This research compares demographic characteristics, clinical features, and outcomes across different age groups in patients with human brucellosis.

Material And Methods: Between 2003 and 2022 a total of 508 patients with brucellosis were subjected to diagnostics and treatment at the Clinic for Infectious Diseases in Skopje.