Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.

Assessing the Linking Between the Orthopaedic In-Training Examination and the American Board of Orthopaedic Surgery Part I Certification Examination.

Introduction: Since 2020, the American Academy of Orthopaedic Surgeons (AAOS) and American Board of Orthopaedic Surgery (ABOS) have collaborated to link the AAOS Orthopaedic In-Training Examination (OITE) and the ABOS part I Certification Examination, allowing the identification of a minimum score on each annual OITE that corresponds to a minimum passing part I score. The purpose of this study is to assess the performance of this examination linking over these past 3 years.

Methods: From 2020 to 2022, the AAOS provided each graduating resident's OITE score; from 2021 to 2023, the ABOS provided each examinee's ABOS part I pass-fail result.

Mind the gap: pre-operative diastasis recti increases trocar site hernia risk after laparoscopic cholecystectomy.

Purpose: Trocar site hernias impact 1-10% of patients undergoing a laparoscopic cholecystectomy, typically at the 10 mm port site. Risk factors identified for trocar site hernias include obesity and age; however, little is known about the impact of pre-existing diastasis rectus abdominus (DRA) on trocar site hernia rates. Therefore, we aimed to determine the impact of pre-operative DRA on trocar site hernia rates after laparoscopic cholecystectomy.

Multi-level barriers to equitable postpartum permanent contraception.

Background: There are several barriers to fulfillment of desired postpartum permanent contraception (PC). Prior research has primarily focused on the federal Medicaid sterilization policy as a barrier to PC; however, other barriers need to be examined.

Objectives: To explore the levels and intersections of barriers to postpartum PC that exist external to the Medicaid policy.

Analytical Characterization and Validation of a Novel Automated Amino-Terminal proB-Type Natriuretic Peptide Assay.

Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement has class 1, level of evidence A recommendations in heart failure (HF) guidelines for diagnosis and prognosis. Analytical characterization of a novel automated NT-proBNP assay is necessary to examine its fitness for validation in pivotal clinical trials.

Methods: The Access NT-proBNP assay is an immunoenzymatic assay using monoclonal capture and detection reagents on the DxI 9000 Immunoassay Analyzer.

Improving Postpartum Follow-Up with Telehealth: Did the Pandemic Nudge Us in a Better Direction?

Objective: To investigate if a telehealth option as the initial postpartum visit would increase postpartum visit attendance.

Methods: This was a retrospective cohort study of women receiving prenatal care through a federally qualified health center, Westside Family Health in Delaware, comparing attendance at a postpartum visit before telehealth was an option (2018) versus after the onset of the pandemic (2021). Representative random samples were taken from one year of deliveries pre- and post-implementation of the telehealth visit option.

Chronic intestinal failure knowledge among a cohort of ASPEN registered dietitians: Response to a membership survey.

Background: Rare and nutritionally complex diseases, like chronic intestinal failure (CIF), are not encountered regularly by clinicians. Specialized centers with experience in intestinal failure are relatively sparse, leading many patients to rely on local clinicians. Previously published reports demonstrated lack of knowledge in intestinal failure among gastroenterologists in the United States, in Europe, and in the United Kingdom.

Generating New Meniscus Therapies via Recent Breakthroughs in Development, Model Systems, and Clinical Diagnostics.

Over 850,000 surgeries are performed to treat meniscal injuries each year in the United States. Even with repair, patients are likely to develop osteoarthritis (OA) within the next two decades. There is a pressing clinical need to improve meniscal repair procedures to restore tissue function and prevent joint degeneration later in life.

Characteristics of spontaneous anterior-posterior oscillation-frequency convergences in the alpha band.

Anterior-posterior interactions in the alpha band (8-12 Hz) have been implicated in a variety of functions including perception, attention, and working memory. The underlying neural communication can be flexibly controlled by adjusting phase relations when activities across anterior-posterior regions oscillate at a matched frequency. We thus investigated how alpha oscillation frequencies spontaneously converged along anterior-posterior regions by tracking oscillatory EEG activity while participants rested.

Screening for Food Insecurity: US Preventive Services Task Force Recommendation Statement.

Importance: According to survey data, 12.8% of households experienced food insecurity in 2022, with 7.7% of households experiencing low food security and 5.

Return to Work After Anterior Cervical Disc Replacement vs. Fusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Study Design: Systematic review and meta-analysis.

Objective: To compare return-to-work (RTW) outcomes between anterior cervical discectomy and fusion (ACDF) and anterior cervical disc replacement (CDR) in working-aged patients with degenerative cervical spine disease.

Summary Of Background: Degenerative cervical spine disease frequently affects individuals in their prime working years, causing physical and economic burden.

Transforaminal vs Anterior Lumbar Interbody Fusion at L5-S1 for Degenerative Spine Disease: A Meta-analysis.

Study Design: Meta-Analysis.

Objective: This meta-analysis will compare transforaminal lumbar interbody fusion (TLIF) to Anterior lumbar interbody fusion (ALIF) at L5-S1 in lumbar degenerative spine diseases (DSD).

Background: Interbody device placement is indicated for alignment correction, sustaining decompression, achieving fusion, and is an effective and widely performed surgical treatment for lumbar DSD.

xDev: a mixed-signal, software-defined neurotechnology interface platform for accelerated system development.

Advances in electronics and materials science have led to the development of sophisticated components for clinical and research neurotechnology systems. However, instrumentation to easily evaluate how these components function in a complete system does not yet exist. In this work, we set out to design and validate a software-defined mixed-signal routing fabric, 'xDev', that enables neurotechnology system designers to rapidly iterate, evaluate, and deploy advanced multi-component systems.

Hydrogel and scalp/skin conductivities impact dose from tumor treating fields.

Purpose: Tumor Treating Fields (TTFields) are delivered by transducer arrays applied to scalp or body surface for treatment of multiple malignancies. Dermatologic complications are thought to be related to hydrogel situated between the electrodes and scalp or skin to facilitate electric field penetration. High intensity of TTFields on these surfaces may also be a contributing factor.

Which spine surgery techniques are most appealing to the public? A survey examining public perception of spine surgery techniques and factors associated with procedure preference.

Background: Public awareness and understanding of spine surgery techniques can influence patient decision-making and outcomes. Healthcare organizations often market these techniques, but the public's comprehension and perceptions of these procedures remain unclear.

Methods: A cross-sectional survey study was conducted via an online platform.

Determination of KGa-1b and SHCa-1 Δ'O and δO via Laser Fluorination of Lithium Fluoride Clay Pellets.

Rationale: Stable oxygen isotope measurements in silicate clays, such as smectite and kaolinite, provide crucial information for understanding Earth's climate history and environmental changes. Despite a growing interest in the oxygen isotope analysis of silicate clays and clay-rich sediments, there lacks a consensus on the preparation and standardization of clay mineral samples. To improve the accuracy and interlaboratory comparisons of clay isotope measurements, especially those involving laser fluorination techniques, newly established kaolinite and smectite oxygen isotope standards are much needed.

Atrial Fibrillation as a Predictor of Age-Related Macular Degeneration.

Background: Aging of the population has resulted in more patients living with atrial fibrillation (AF) and age-related macular degeneration (AMD). AF is associated with macro- and micro-thromboembolism, microvascular dysfunction, and system inflammation. Organ systems sensitive to the long-term systemic and vascular disease associations of AF will likely develop dysfunction over time.

Gender norms and sexual violence among South African adolescents: discrepancies between personal attitudes and perceived peer norms.

Social norms, particularly those pertaining to gender equity, can shape attitudes and behaviors that contribute to adolescent sexual violence (SV). This study examines personal attitudes and perceived peer norms regarding gender equity and associations with perpetration of SV among 100 South Africans aged 13-17 in 2019. We assessed: (1) sexual activity and SV behaviors and (2) personal attitudes and perceived peer norms around gender equity.

Examining Practices for Youth Illegal Sexual Behaviors which May Warrant De-Implementation: Overview and Recommendations.

Youth problem sexual behaviors (PSBs), and particularly youth illegal sexual behaviors, have deleterious consequences for youth who engage in them, including removal from the home, perpetration of non-sexual offenses, and chronic involvement with the child welfare and juvenile legal systems (Lussier, Juvenile sex offending through a developmental life course criminology perspective: An agenda for policy and research). Further, individuals who are victims of youth PSBs also experience poor mental and physical health outcomes, resulting in a significant public health expenditure (Hailes et al., Long-term outcomes of childhood sexual abuse: An umbrella review).

Amyloid-Related Imaging Abnormalities With Donanemab in Early Symptomatic Alzheimer Disease: Secondary Analysis of the TRAILBLAZER-ALZ and ALZ 2 Randomized Clinical Trials.

Importance: Amyloid-related imaging abnormalities (ARIA) are the major adverse event associated with amyloid-targeting immunotherapy. Identifying clinical features and individual risk factors for ARIA could facilitate effective prediction and prevention strategies.

Objective: To characterize ARIA in participants treated with donanemab.

Evaluating the Effect of Video Source and Other Video Characteristics on the Quality, Reliability, Actionability, and Understandability of Videos on Acromioclavicular Joint Repair.

Purpose:  This study aims to evaluate video quality, reliability, actionability, and understandability differences based on length, popularity, and source credentials (physician versus non-physician). The hypothesis suggests that current videos are of low quality and limited usefulness to patients, highlighting significant disparities based on the credentials of the video source.

Methods:  The phrase "acromioclavicular joint separation" was searched on YouTube.