2,231 results match your criteria: "Brown Medical School[Affiliation]"

Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and increased hospital and intensive care unit length of stay. Despite progressive improvements in overall cardiac surgical operative mortality and postoperative morbidity, the incidence of poAF has remained unchanged at 30% to 50%. A number of evidence-based recommendations regarding the perioperative management of atrial fibrillation (AF) have been released from leading cardiovascular societies in recent years; however, it is unknown how closely these guidelines are being followed by medical practitioners.

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Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and hospital and intensive care unit length of stay. Despite progressive improvements in overall cardiac surgical operative mortality and postoperative morbidity, the incidence of poAF has remained unchanged at 30%-50%. A number of evidence-based recommendations regarding the perioperative management of atrial fibrillation (AF) have been released from leading cardiovascular societies in recent years; however, it is unknown how closely these guidelines are being followed by medical practitioners.

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What is anxious depression? Overlap and agreement between different definitions.

J Psychiatr Res

February 2019

Department of Psychiatry and Human Behavior, Brown Medical School, and the Department of Psychiatry, Rhode Island Hospital, Providence, United States.

Anxiety is common in depressed patients. However, a problem with the research on the significance of anxiety in depressed patients is that anxiety has been characterized in different ways. Little research has examined the concordance and overlap between the various definitions of anxious depression.

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Introduction: Vöhringer et al. identified a triad of items on the Mood Disorder Questionnaire (MDQ) that best discriminated between borderline personality disorder (BPD) and bipolar disorder (BD) in a tertiary mood clinic setting [23]. The present study aimed to replicate and extend these findings by examining the performance of the triad across a range of cut-off scores and comparing the operating characteristics of the triad to the full MDQ.

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Clinical Evaluation of Amyloid-Related Imaging Abnormalities in Bapineuzumab Phase III Studies.

J Alzheimers Dis

November 2019

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, MA, USA; General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Amyloid-related imaging abnormalities with effusion or edema (ARIA-E) reported in patients with mild-to-moderate Alzheimer's disease in bapineuzumab phase III studies.

Objectives: Assess symptoms, clinical severity, and ARIA-E outcomes, and to evaluate effects on cognition and function.

Methods: A centralized systematic sequential locked procedure and scoring system for assessment of magnetic resonance imaging scans in 1,331 APOE ɛ4 noncarriers and 1,121 carriers was conducted by experienced and trained pairs of neuroradiologists.

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Reliability and validity of a self-report scale for daily assessments of the severity of depressive symptoms.

Psychiatry Res

December 2018

Department of Psychiatry and Human Behavior, Brown Medical School, USA; Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.

To evaluate the efficacy of rapidly effective treatments for depression it is necessary to use measures that are designed to assess symptom severity over short intervals. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we modified our previously published depression scale and examined the reliability and validity of a daily version of the Clinically Useful Depression Outcome Scale (CUDOS-D). One thousand one hundred and fifteen patients presenting for treatment of DSM-IV/DSM-5 major depressive disorder (MDD) to a partial hospital program completed the CUDOS-D as part of their initial paperwork and on a daily basis thereafter.

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Background: DSM-5 introduced the anxious distress specifier in recognition of the clinical significance of anxiety in depressed patients. Recent studies that supported the validity of the specifier did not use measures that were designed to assess the criteria of the specifier but instead approximated the DSM-5 criteria from scales that were part of an existing data base. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we examined the validity of the specifier diagnosed with a semistructured interview.

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Article Synopsis
  • * CDAF may share a common autoimmune or immune-related origin, suggesting that treatment could benefit from a more targeted approach rather than just managing symptoms.
  • * A reevaluation of how CFS and fibromyalgia are diagnosed is needed, encouraging more specific categorization within the CDAF framework to improve patient care and treatment outcomes.
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Understanding the severity of depression: Which symptoms of depression are the best indicators of depression severity?

Compr Psychiatry

November 2018

Department of Psychiatry and Human Behavior, Brown Medical School, Rhode Island Hospital, Providence, RI, United States.

Background: In DSM-5, all symptoms of depression are considered equal representations of severity. In ICD-10, the type of symptom is considered in classifying severity. It is important to better understand if the defining symptoms of depression are differentially associated with overall severity so that severity categorization in diagnostic systems is most valid.

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Self-reported Patient Motivations for Seeking Cosmetic Procedures.

JAMA Dermatol

October 2018

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: Despite the growing popularity of cosmetic procedures, the sociocultural and quality-of-life factors that motivate patients to undergo such procedures are not well understood.

Objective: To estimate the relative importance of factors that motivate patients to seek minimally invasive cosmetic procedures.

Design, Setting, And Participants: This prospective, multicenter observational study was performed at 2 academic and 11 private dermatology practice sites that represented all US geographic regions.

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Status of US State Laws Mandating Timely Reporting of Nonfatal Overdose.

Am J Public Health

September 2018

Corey S. Davis is with the Network for Public Health Law, Los Angeles, CA, and the Brody School of Medicine, East Carolina University, Greenville, NC. Traci C. Green is with the Department of Emergency Medicine, Boston University School of Medicine, Boston, MA, and the Departments of Medicine and Epidemiology, Brown Medical School, Providence, RI. Hector Hernandez-Delgado and Amy Judd Lieberman are with the Network for Public Health Law, Los Angeles, CA.

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Screening for Bipolar Disorder and Finding Borderline Personality Disorder: A Replication and Extension.

J Pers Disord

August 2019

Department of Psychiatry and Human Behavior, Brown Medical School, and the Department of Psychiatry, Rhode Island Hospital, Providence, Rhode Island.

The authors' group previously reported that patients who screened positive on the Mood Disorders Questionnaire (MDQ), the most frequently studied screening scale for bipolar disorder, were as likely to be diagnosed with borderline personality disorder (BPD) as with bipolar disorder. A limitation of that study was that the authors examined the performance of the MDQ in patients presenting for various psychiatric disorders, including depression. The recognition of bipolar disorder and its differential diagnosis with BPD is of greatest clinical relevance in depressed patients.

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Functional Significance of Epicardial Coronary Artery Disease in Women: One Piece of the Puzzle.

JACC Cardiovasc Interv

August 2018

Division of Cardiology, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island. Electronic address:

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Commentary: Augmentation of Fear Extinction by Transcranial Direct Current Stimulation (tDCS).

Front Behav Neurosci

June 2018

Department of Psychiatry and Human Behavior, Alpert Brown Medical School, Brown University, Providence, RI, United States.

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Article Synopsis
  • A 3-year extension study evaluated the long-term safety and efficacy of intravenous (IV) bapineuzumab in patients with mild-to-moderate Alzheimer's disease, focusing on both APOE ε4 carriers and noncarriers.
  • The study involved 1,462 patients, who were unaware of their previous treatment as either placebo or bapineuzumab, and found that over 81% experienced adverse events, with higher incidences of ARIA-E in new bapineuzumab recipients.
  • Overall, the treatment was deemed generally well tolerated, with cognitive function deterioration similar across different dosage groups and comparable to findings from previous studies.
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Screening for psychiatric disorders with self-administered questionnaires.

Psychiatry Res

December 2018

Department of Psychiatry and Human Behavior, Brown Medical School, USA; Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.

Given the time demands of clinical practice it is not surprising that diagnoses are sometimes missed. To improve diagnostic recognition, self-administered screening scales have been recommended. A problem with much of the research effort on screening scales is the confusion between diagnostic testing and screening.

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Making sense of endovascular therapies for femoropopliteal disease.

Catheter Cardiovasc Interv

June 2018

Division of Cardiology, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island.

The femoropoliteal segment is a common target for endovascular intervention and the unique biomechanical forces on the arteries increase the risk of restenosis This large meta-analysis supports drug coated balloons as the initial endovascular strategy due to lower risk of target lesion revascularization compared to other modalities Whether there are subgroups of patients or lesion types that benefit from an alternative revascularization approach is unclear and warrants investigation.

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There has been growing interest in studying attention-deficit/hyperactivity disorder (ADHD) in adulthood as a result of research indicating that ADHD often persists into adulthood and frequently is comorbid with other psychiatric disorders. Adult ADHD symptoms are most commonly assessed via self-report, but prior research examining the structure of self-reported adult ADHD symptoms has yielded discrepant results. Explicating the factor structure of ADHD symptom measures is essential to determine if such self-report measures assess symptom dimensions showing distinctive relations with other psychopathology and psychosocial functioning.

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Article Synopsis
  • IBD, including Crohn's disease (CD) and ulcerative colitis (UC), often leaves some patients classified as inflammatory bowel disease unclassified (IBD-U), impacting treatment decisions.
  • A study analyzing pediatric patients with IBD-U found that within 2 years, 26% were reclassified as UC and 14% as CD, while 60% remained IBD-U, with molecular features of IBD-U resembling those of UC.
  • Patients with IBD-U were significantly less likely to receive anti-TNFα therapy compared to those diagnosed with CD, highlighting the need for better classification to guide effective treatment options.
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Coronary Stents: History, Design, and Construction.

J Clin Med

May 2018

Department of Medicine, Division of Cardiology, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA.

The history of percutaneous coronary intervention (PCI) is marked by rapid technological advancements that have taken place over the past 40 years. After a period of balloon angioplasty, which was marred by risk of abrupt vessel closure and vessel recoil, balloon expandable metal alloy stents were the mainstay of PCI. The introduction of drug eluting stents (DES) targeted in-stent restenosis, a common mode of stent failure, and ushered in the current PCI era.

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More Than One Way to Close the Gender Gap.

J Am Coll Cardiol

May 2018

Section of Cardiovascular Medicine, Yale University School of Medicine, and Center for Outcomes Research and Evaluation, New Haven, Connecticut.

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Background: Patients undergoing percutaneous mechanical circulatory support (pMCS)-assisted percutaneous coronary intervention (PCI) represent a high-risk group vulnerable to complications and readmissions.

Hypothesis: Thirty-day readmissions after pMCS-assisted PCI are common among patients with comorbidities and account for a significant amount of healthcare spending.

Methods: Patients undergoing PCI and pMCS (Impella, TandemHeart, or intra-aortic balloon pump) for any indication between January 1, 2012, and November 30, 2014, were selected from the Nationwide Readmissions Database.

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Sample preparation in foodomic analyses.

Electrophoresis

July 2018

Department of Biotechnology, University of Rijeka, Rijeka, Croatia.

Representative sampling and adequate sample preparation are key factors for successful performance of further steps in foodomic analyses, as well as for correct data interpretation. Incorrect sampling and improper sample preparation can be sources of severe bias in foodomic analyses. It is well known that both wrong sampling and sample treatment cannot be corrected anymore.

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