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Matrix therapy with RGTA OTR4120 improves healing time and quality in hairless rats with deep second-degree burns.

Plast Reconstr Surg

February 2011

Tours, Créteil, and Paris, France From the Plastic, Reconstructive, and Cosmetic Surgery and Burn Center, Trousseau Hospital, CHRU de Tours; Laboratory CRRET, UMR CNRS 7149, Paris 12 University; OTR3 SAS; the Department of Pathology, Rothschild Hospital; and the Department of Cardiovascular Surgery, Broussais Hospital and Georges Pompidou Hospital.

Background: ReGeneraTing Agents (RGTAs) are biodegradable polymers engineered to mimic heparan-sulfate in the extracellular matrix of damaged tissue. RGTAs improve tissue healing in several animal models by stabilizing and protecting heparin-binding growth factors and matrix proteins. RGTA restores the normal matrix architecture and supports tissue regeneration.

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