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59,737 results match your criteria: "Bronchi"
Environ Mol Mutagen
March 2025
Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA.
Formaldehyde (FA) is a highly reactive aldehyde that is regarded as an inhalation hazard and human carcinogen. Herein, we report a follow-up study evaluating the effects of exposure duration on the toxicity and mutagenicity of FA using a human in vitro air-liquid-interface (ALI) airway tissue model. Previously we exposed ALI cultures to 7.
View Article and Find Full Text PDFActa Anaesthesiol Scand
March 2025
Department of Anesthesia and Intensive Care Medicine, St. Olav Hospital, Trondheim, Norway.
Background And Methods: Few guidelines address how to handle unanticipated ventilatory problems and hypoxemia in a successfully intubated patient. We will refer to this situation as "can intubate-cannot ventilate." The situation may occur immediately after intubation or later during general anaesthesia.
View Article and Find Full Text PDFEcotoxicol Environ Saf
March 2025
College of Pharmacy, Chungnam National University, Daejeon 34134, South Korea. Electronic address:
Inhalation exposure to polyhexamethylene guanidine phosphate (PHMG-p), a primary component of humidifier disinfectants, has been linked to interstitial lung disease and potential carcinogenic effects. This study aimed to investigate epithelial cell transformation and the underlying molecular mechanisms by examining the properties of epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) following prolonged exposure to PHMG-p. Beas-2B human bronchial epithelial cells were treated with 0.
View Article and Find Full Text PDFEcotoxicol Environ Saf
March 2025
Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTE UR 4651, Rouen F-76000, France. Electronic address:
The widespread use of disposable masks has sparked concerns about potential exposure to harmful chemicals, including the already ubiquitous phthalates. It has been demonstrated that there is a causal relationship between the exposure to phthalates and the onset of respiratory diseases. Moreover, there is an increasing body of evidence, which suggests that mitochondria contribute to significant impact to the epithelial function in respiratory diseases.
View Article and Find Full Text PDFSci Total Environ
March 2025
School of Food Science and Biotechnology, Kyungpook National University, Republic of Korea; Tailored Food Technology, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address:
Airborne pollutants, particularly nitro-polycyclic aromatic hydrocarbons (nitro-PAHs), are significant contributors to respiratory diseases. Among these, 1-NP, a nitro-PAH prevalent in diesel exhaust particles (DEPs), is known to induce lung damage. While studies on the respiratory toxicity of 1-NP remain limited, the underlying molecular mechanisms, particularly the roles of mitochondrial dysfunction and toxicity-related gene expression in lung cell death, are even less understood.
View Article and Find Full Text PDFEnviron Int
February 2025
Department of Environment, Climate Change and Health, World Health Organization, Geneva, Switzerland. Electronic address:
Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are the producers of the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury (WHO/ILO Joint Estimates). The WHO International Agency for Research on Cancer has classified welding fumes as carcinogenic to humans (Group 1). A previous systematic review and meta-analysis from the WHO/ILO Joint Estimates reported that there was "sufficient evidence of harmfulness" that compared with no (or low) occupational exposure to welding fumes, any (or high) occupational exposure to welding fumes increased the risk of developing trachea, bronchus, and lung cancer.
View Article and Find Full Text PDFFront Immunol
February 2025
Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Introduction: Complex respiratory models, including air-liquid interface (ALI) transwell cultures and airway organoids, have emerged as promising tools for studying human respiratory virus infections. These models address several limitations of conventional two-dimensional cell line and animal models. However, the lack of standardized protocols for the application of these models in infection studies limits the possibilities for comparing results across different research groups.
View Article and Find Full Text PDFEpigenetics
December 2025
Department of Pulmonary Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Lung carcinogenesis is causally linked to cigarette smoking, in part by epigenetic changes. We tested whether accumulated epigenetic change in smokers is apparent in bronchial basal cells as cells of origin of squamous cell carcinoma. Using an EM-seq platform covering 53.
View Article and Find Full Text PDFSci Rep
February 2025
College of Basic Medical sciences, Dali University, Dali, 671000, China.
Tracheal, bronchial, and lung cancer (TBL) is among the most common malignancies worldwide, with persistently high incidence and mortality rates, posing a significant threat to public health. However, existing studies on TBL disease burden are often limited to specific regions or short-term trends, lacking systematic and predictive analyses. This study comprehensively evaluated the global, regional, and national burden of TBL across 204 countries and territories from 1990 to 2021, utilizing predictive models to estimate trends from 2022 to 2035.
View Article and Find Full Text PDFJ Asthma
March 2025
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Objective: A subset of asthmatics suffers from frequent exacerbations. Various features of airway remodeling and the resultant elastic property of airway walls may play pathophysiological roles in these exacerbations. The aim of the study was to examine the collapsibility of airways and sputum biomarkers associated with airway remodeling with different frequencies of exacerbations.
View Article and Find Full Text PDFRespirol Case Rep
February 2025
Department of Respiratory Medicine Graduate School of Medicine, University of Yamanashi Chuo Yamanashi Japan.
Bronchial aspergilloma, an uncommon subtype of pulmonary aspergilloma, likely developed in the main bronchus due to airflow stagnation and dryness following lobectomy. Detailed imaging and bronchoscopy provided valuable diagnostic insights, underscoring the importance of considering fungal infections in surgically altered airways.
View Article and Find Full Text PDFIndian J Thorac Cardiovasc Surg
March 2025
Department of Cardiothoracic and Vascular Surgery, SMS Medical College & Attached Hospitals, J L N Marg, Jaipur, 302001 Rajasthan India.
Background: Foreign body aspiration is a critical surgical emergency among pediatric patients, carrying a substantial risk of mortality and contributing significantly to respiratory distress in children. Timely intervention by experts is crucial to mitigating cumulative morbidity. This study aims to evaluate the efficacy of bronchotomy as a secure alternative following unsuccessful attempts at bronchoscopic foreign body retrieval.
View Article and Find Full Text PDFJ Thorac Dis
January 2025
Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Sublobar surgeries involving the left anterior segment of the lung can be challenging due to its central location within the left upper lobe (LUL) and among multi-segments. However, there have been no reports specifically analysing the anatomical patterns of this segment. Therefore, this study aimed to comprehensively investigate the subsegmental bronchovascular patterns and relationship between variations and surgical strategies.
View Article and Find Full Text PDFFront Immunol
February 2025
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
The role of bronchus-associated lymphoid tissue (BALT) in the regulation of immune responses to transplanted lungs remains an area of interest and controversy. Early studies in a rat pulmonary transplant model suggested BALT may accelerate rejection of grafts by inducing a local and systemic inflammatory response. Such observations were corroborated in intrapulmonary tracheal transplant models in the rat.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
Department of Anesthesiology, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
Rationale: Life-threatening airway obstructions caused by tumors demand prompt and effective intervention. Traditional surgical methods are often complicated by bleeding risks, especially with the use of anticoagulation during extracorporeal membrane oxygenation (ECMO). This report investigates the innovative application of heparin-free veno-venous ECMO (VV-ECMO) to minimize bleeding risks while maintaining effective oxygenation during airway obstruction surgeries, thereby offering a safer alternative in high-risk scenarios.
View Article and Find Full Text PDFLancet Reg Health West Pac
February 2025
Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, China.
Background: Respiratory tract cancers emerged as a public health challenge with the highest incidence and mortality among all cancer types in China, despite many national policies in place, such as early cancer screening. It is of outmost importance to monitor the burden of respiratory tract cancers across China and its provinces for refining health strategies.
Methods: Based on Global Burden of Disease (GBD) estimates, the present study investigated the age-sex specific pattern alterations of incidence, prevalence, mortality, and disability adjusted life years (DALYs) of respiratory tract cancers in China from 1990 to 2021, as well as its Estimated Annual Percentage Change (EAPC), Age-Standardized Incidence Rate (ASIR), and Age-Standardized Mortality Rate (ASMR).
Background: Amid shifting tobacco policies and escalating air pollution levels, Lung Cancer (LC) risk factors have changed notably. Continuous assessment of these risk factors is necessary. This study compares trends in tobacco, air pollution, and asbestos-associated Age-Standardized Mortality Rates (ASMR) from Trachea, Bronchus, and Lung (TBL) Cancer across the top ten most populated countries (2023 censuses) and globally.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
February 2025
Department of Respiratory and Critical Care Medicine, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China.
Exosomes are critical mediators of intercellular crosstalk and play significant roles in the progression of various diseases including acute lung injury (ALI). However, the specific role of exosomes in ALI remains largely unexplored. In investigation, we demonstrated that exosomes released from cigarette smoke extract (CSE)-exposed bronchial epithelial cells (BEAS-2B) facilitated M1 macrophage polarization.
View Article and Find Full Text PDFIntraoperative tracheobronchial injury is one of the most serious complications of any thoracic surgery. Its management is really challenging both for the surgeons as well as for the anesthesiologists. We present a rare case of intraoperative tracheobronchial injury during esophagectomy and the management of the ventilation by intermittent manual occlusion of the rent as a rescue method.
View Article and Find Full Text PDFTransl Lung Cancer Res
January 2025
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Three-dimensional (3D) is a useful tool for visualizing computed tomography (CT) scans, facilitating a clearer understanding of the spatial relationships between pulmonary lesions and the branching architecture of the bronchi and blood vessels. Several studies have demonstrated the benefit of preoperative 3D reconstruction in terms of intraoperative safety and short-term surgical outcomes after thoracoscopic surgery. However, evidence regarding the impact of 3D reconstruction on surgical planning of anatomical partial lobectomy (APL) is still lacking.
View Article and Find Full Text PDFCureus
January 2025
Anesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore, SGP.
Standard double-lumen tubes (DLTs) are unsuitable in patients with end tracheostomy due to the shortened tracheal length and atypical stoma angulation. This case highlights the challenges of achieving one-lung ventilation (OLV) in patients with end tracheostomies due to anatomical changes following total laryngectomy. A 68-year-old male with a history of total pharyngo-laryngo-esophagectomy, gastric pull-up, and end tracheostomy underwent video-assisted thoracic surgery (VATS) for left lung wedge resection and lymph node dissection.
View Article and Find Full Text PDFJ Cardiothorac Surg
February 2025
Department of Cardiothoracic Surgery, Chongqing Key Laboratory of Emergency Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, The Fourth People's Hospital of Chongqing, No. 1 Health Road, Yuzhong District, Chongqing, 400014, China.
Background: Chest trauma may precipitate a spectrum of injuries, among which tracheal laceration represents an uncommon but critical sequela. The occurrence of tracheal laceration could significantly impair respiratory and cardiovascular homeostasis, thereby posing a life-threatening risk to the patient. Expeditious surgical intervention is paramount for therapeutic management, and in certain instances, the administration of venovenous extracorporeal membrane oxygenation (VV ECMO) may be necessitated to support the patient's respiratory function.
View Article and Find Full Text PDFA previously healthy woman in her 40s presented with a 6-month history of increasing cough and breathlessness following COVID-19 infection. She experienced vocal hoarseness and recurrent respiratory infections during this time, requiring several antibiotic courses. She was treated for gastro-oesophageal reflux and trialled on inhaled corticosteroids, without improvement.
View Article and Find Full Text PDFJ Glob Health
February 2025
Laboratory of Molecular Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Background: Viral mutations and immune dysfunction still lead to recurrent infections of COVID-19 in cancer patients. Our aim in this study was to explore the differences in cumulative risk of COVID-19 death from different cancer types and characterise clinical and demographic factors associated with COVID-19 death.
Methods: We conducted a population-based study using the National Cancer Database, which included all cancer types.
Radiol Case Rep
April 2025
Department of Radiology, Yokohama City University Medical Center, 4-57 Urafunecho Minami-ku, Yokohama-shi, Kanagawa-ken 232-0024, Japan.
Myeloid sarcoma is a malignancy characterized by the excessive proliferation of immature myeloid cells or myeloblasts, leading to tumor formation outside the bone marrow. This condition often manifests before or after the onset of acute myeloid leukemia or during a relapse following initial remission. Myeloid sarcoma develops in any organs or parts of the body, but its occurrence in the mediastinum is rare.
View Article and Find Full Text PDF