Spontaneous sigmoid perforation and subsequent ruptured hepatic aneurysms in suspected vascular type Ehlers-Danlos syndrome: a case report and comprehensive literature review.

Ehlers-Danlos syndrome (EDS) is an inherited disorder of collagen creation and function which can affect many organs. Surgical management of EDS spectrum remains a significant challenge for surgeons, including the vascular type of EDS (vEDS). There do not exist specific guidelines for the management of vEDS, which proves difficulty given the devastating pathology and potential outcomes.

Prospective Analysis Comparing the Asthma Control Test (ACT) to the New Subjective Asthma Questionnaire (SAQ-1) for Assessing Asthma Control.

Background Asthma affects millions of patients worldwide. The Global Initiative for Asthma (GINA) emphasizes the need for individualized treatment based on symptoms and risk of exacerbations. The Asthma Control Test (ACT) is a well-validated tool and considered standard-of-care for assessing asthma control.

Racial and Educational Isolation are Associated with Worse Outcomes in Congenital Heart Disease.

Background: Sociodemographic factors influence outcomes in children with congenital heart disease (CHD). We predict an association between measures of social isolation and outcomes in infants with complex CHD. These measures, racial (RI) and educational (EI) isolation range from 0 to 1, with 0 being no isolation and 1 being fully isolated within a specific population.

Loss of DOT1L function disrupts neuronal transcription, animal behavior, and leads to a novel neurodevelopmental disorder.

Individuals with monoallelic pathogenic variants in the histone lysine methyltransferase DOT1L display global developmental delay and varying congenital anomalies. However, the impact of monoallelic loss of remains unclear. Here, we present a largely female cohort of 11 individuals with variants with developmental delays and dysmorphic facial features.

Enabling systemic identification and functionality profiling for Cdc42 homeostatic modulators.

Maintaining body homeostasis is the ultimate key to health. There are rich resources of bioactive materials for the functionality of homeostatic modulators (HMs) from both natural and synthetic chemical repertories. HMs are powerful modern therapeutics for human diseases including neuropsychiatric diseases, mental disorders, and drug addiction (e.

Evaluating Fellowship Training for Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) Using the EBUS-Skills and Task Assessment Tool (STAT) and High-Fidelity Bronchoscopy Simulator.

Background: There are two approaches for endobronchial ultrasound (EBUS) training: the traditional apprenticeship approach involving 'see one, do one, teach one', and the computer-based simulation approach. In the traditional approach, the trainee learns under direct supervision from an expert preceptor while performing on patients. In the latter approach, trainees use a high-fidelity bronchoscopy simulator, undertake a skills assessment exam (Endobronchial Ultrasound Skills and Task Assessment Tool (EBUS-STAT)), and receive supervised patient-based training from experienced clinicians.

Demographic, Disease, and Treatment Characteristics of Primary Tracheal Cancers.

Background: Primary tracheal cancers (PTCs) are rare neoplasms underreported in the literature. No consensus guidelines exist for the treatment of these cancers and multimodal management of these cancers has not been adequately explored for cases diagnosed over the past 2 decades.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients with PTC.

Adamantinoma: A SEER-based Epidemiological Analysis.

Adamantinoma (AD) is a rare bone cancer accounting for less than 0.1-0.5% of all primary bone tumors.

Predictors and Outcomes of Mental Health Conditions Among Patients with Colorectal Cancer.

Purpose: Mental health (MH) conditions are common in patients with colorectal cancer (CRC) due to the unique challenges these patients encounter. The primary aim was to investigate predictors of new onset MH conditions after a diagnosis of CRC and determine the association of new MH conditions on survival.

Methods: A single institution, retrospective study was conducted.

Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.

Importance: Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations.

Objective: To evaluate how established POAG PRSs perform in African-ancestry samples from the Genetics in Glaucoma Patients of African Descent (GIGA), Genetics of Glaucoma in Individuals of African Descent (GGLAD), and Million Veteran Program (MVP) datasets and compare these with European-ancestry samples.

Design, Setting, And Participants: This was a multicenter, cross-sectional study of POAG cases and controls from Tanzania, South Africa, Nigeria, Ghana, and the US.

Drought stress mitigation and improved yield in Glycine max through foliar application of zinc oxide nanoparticles.

The impact of climate change on agricultural production is apparent due to declining irrigation water availability vis-à-vis rising drought stress, particularly affecting summer crops. Growing evidence suggests that zinc (Zn) supplementation may serve as a potential drought stress management strategy in agriculture. Field studies were conducted using soybean (Glycine max var.

Age at diagnosis of diabetes, obesity, and the risk of dementia among adult patients with type 2 diabetes.

Background: While Type 2 Diabetes Mellitus (T2DM) prevalence is increasing among younger individuals, few studies have examined how age at T2DM diagnosis relates to dementia risk in diabetic populations. We aimed to investigate the association between age at T2DM diagnosis and subsequent dementia risk, and to determine whether obesity moderates this relationship.

Methods: We conducted a prospective cohort study using data from the Health and Retirement Study (2002-2016) matched with its 2003 Diabetes Mail-Out Survey.

An overview of the non-procedural treatment options for peripheral neuropathic pain.

Peripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non-interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology, and lifestyle modification.

Under pressure: Supporting academic faculty in demanding times.

Medical education has long relied upon the inherent rewards of teaching to secure necessary educators. In an era of increasing emphasis upon clinical productivity, the expectation of faculty engagement in medical education has been upended. In addition, the demands and stressors of modern medical education has contributed to the perceived cost of teaching by faculty.

Demographic Differences in the Radiology Residency Match, 2022 to 2024.

Purpose: Ranking preferences by residency programs in the Match could shape the diversity of selective specialties. We investigated demographic characteristics of applicants and matched residents in radiology and other specialties to identify changes in representation.

Methods: Survey data from the National Resident Matching Program were obtained for applicants to radiology (diagnostic radiology, interventional radiology, and combined diagnostic radiology and nuclear medicine) and nonradiology programs in the 2022 to 2024 Main Residency Matches.

A distinct co-expressed sulfurtransferase extends the physiological role of mercaptopropionate dioxygenase in Pseudomonas aeruginosa PAO1.

Oxidation and assimilation of persulfides in bacteria is often catalyzed by a persulfide dioxygenase and sulfurtransferase in consecutive reactions. Enzymes responsible for the oxidation of persulfides have not been clearly defined in Pseudomonas aeruginosa PAO1. The characterized mercaptopropionate dioxygenase (MDO) in P.

Sarcoidosis Mortality in North Carolina: Role of Region, Race, and Other Sociodemographic Variables.

Background: There is regional variability in sarcoidosis mortality across the United States. North Carolina ranks highly in sarcoidosis-related mortality, especially among African Americans (AA). We sought to determine any regional variability of sarcoidosis-related mortality and the relationship to sociodemographic determinants of health in North Carolina.

Parity Moderates the Socioeconomic Predictors of Birth Setting Choice.

Background: The increase in the number of people choosing community birth has raised interest in understanding the factors that influence birth setting choices. This study investigates how parity influences the association between maternal socioeconomic factors and choice of community versus hospital birth.

Methods: We used 2009-2021 US birth certificate data to identify community births (planned home or birth center births), parity, and maternal characteristics, including Women, Infants, and Children (WIC) program participation, race, ethnicity, educational attainment, marital status, body mass index (BMI), and age.