Association between psychosocial stressors and temporomandibular disorders in clinical dental students: a cross-sectional study.

Background: Temporomandibular disorders (TMDs) comprise an extensive spectrum of conditions that originate from diverse complex components of the temporomandibular joint. It is generally acknowledged that the biopsychosocial model is the preeminent framework for understanding the aetiology of TMDs. Anxiety, depression, and tension are among the psychological disorders that are commonly observed in dental students.

Systematic analysis of post-blast organic traces in soil, application of color tests, TLC, GC-MS, and ITMS.

The post-blast trace analysis of explosives is inherently complex, requiring the separation and identification of multiple unknown compounds within contaminated matrices. The study explores modified methods for the extraction, analysis, and detection of post-explosion residues, of the three main organic explosives groups, focusing on key explosives such as NC (Nitrocellulose), NG (Nitroglycerin), Tetryl, TNT, RDX, PETN, as well as sheet and plastic explosives. A comprehensive protocol was developed, involving sample extraction, filtration, and clean-up processes, followed by analysis using a range of analytical techniques.

Evaluating the structure-based virtual screening performance of SARS-CoV-2 main protease: A benchmarking approach and a multistage screening example against the wild-type and Omicron variants.

COVID-19 still poses a worldwide health threat due to continuous viral mutations and potential resistance to vaccination. SARS-CoV-2 viral multiplication hindrance by inhibiting the viral main protease (Mpro) deemed propitious. Structure-based virtual screening (SBVS) is a conventional strategy for discovering new inhibitors.

Digital CBT for insomnia and emotion regulation in the workplace: a randomised waitlist-controlled trial.

Background: Cognitive behavioural therapy for insomnia (CBT-I) is the recommended first-line treatment for insomnia. However, scaling this proven effective intervention to areas of high need remains a challenge, necessitating sensitive adaptation and evaluation.

Methods: A randomised waitlist-controlled trial evaluated the efficacy of a hybrid digital CBT-I and emotion regulation (dCBT-I + ER) intervention delivered through workplaces.

Enhancing warning signs of mental health literacy: Evaluating a digital base intervention for health profession students.

Background: Despite its importance, Mental health literacy (MHL) among nursing and other health profession students often remains inadequate, potentially impacting their future roles as healthcare providers. This inadequacy can lead to delayed or inappropriate care for individuals with mental health concerns, perpetuating adverse outcomes and increasing the burden on healthcare systems.

Aim: To evaluate a digital-based intervention designed to enhance the warning signs of mental health literacy among health profession students.

Biomechanical Evaluation of Cantilevered 2-Unit Implant-Supported Prostheses: A 3D Finite Element Study.

Objective: To assess the biomechanical performance of cantilevered 2-unit implant-supported prostheses with zirconia and polyetherketoneketone (PEKK) under 3 loading conditions.

Method: A cone beam computer tomography (CBCT) scan of an edentulous mandible was segmented using Mimics software and refined in 3-Matic software to create trabecular and cortical bone structures. Implant CAD files were integrated using SolidWorks software, generating 4 models with varying implant positions: M1 (first premolar implant supporting a second premolar), M2 (second premolar implant supporting a first premolar), M3 (second premolar implant supporting a first molar), and M4 (first molar implant supporting a second premolar).

Carboxymethyl cellulose assisted reforming of poly acrylic acid co methyl methacrylate composite for wastewater treatment and effective hosting of antimicrobial silver.

Herein, novel polymer composite is fabricated by hybridizing poly (acrylic acid-co-methyl methacrylate) filaments with carboxymethyl cellulose, which efficiently reorients and strictly ties the fibrous chains to form polymeric units of plate-like morphology. This innovative hybrid polymer composite is analyzed using XRD, FT-IR, swelling and contact angle studies, DLS, AFM, and SEM. Removal efficiency of such polymer composite is scrutinized in colored wastewater treatment.

Synergizing GIS and genetic algorithms to enhance road management and fund allocation with a comprehensive case study approach.

This study identifies a critical knowledge gap, revealing how the deterioration of roads, compounded by extensive usage and additional factors, poses significant risks to the road networks' functionality. Without a robust fund allocation and prioritization strategy, the extent of this risk may be overlooked, adversely affecting the performance of essential infrastructure elements. Our research introduces an integrated decision-making model for existing road infrastructures to address this gap.

Full Study, Model Verification, and Control of a Five Degrees of Freedom Hybrid Robotic-Assisted System for Neurosurgery.

Background: Neurosurgery demands high precision, and robotic-assisted systems are increasingly employed to enhance surgical outcomes. This study focuses on a hybrid robotic-assisted system for neurosurgery, addressing forward and inverse kinematics, Jacobian matrices, and system singularities.

Methods: The system is simulated using MATLAB/Simscape Multibody to achieve accurate kinematic and dynamic representations.

Fracture Resistance of Anterior Teeth Restored with Post-retained Ceramic Crown vs Ceramic Endocrowns.

Aim: To compare the fracture resistance of anterior teeth restored with either glass fiber post (GFP) and conventional lithium disilicate (LDS) crowns or endocrowns made of LDS or hybrid ceramics.

Materials And Methods: A total of 21 central incisors with 2-mm ferrule and 1-mm shoulder finish line were applied in this investigation. The teeth were divided into three main groups ( = 7) according to the type of restoration used: PC glass fiber post (GFP) and e-max crown, EE (LDS endocrown), and VE (Vita-Enamic endocrown).

Tissue-friendly dentin treatments as a potential element in revascularization protocol (ex-vivo study).

Background: Endodontic treatment aims to eliminate pulp tissue, microorganisms, and toxins while creating an environment conducive to tissue revitalization and regeneration. Sodium hypochlorite, the gold-standard irrigant, is effective but has significant cytotoxic effects, prompting the need for safer alternatives. This study investigates the cytotoxicity, cell proliferation, adhesion to dentin, and osteogenic differentiation of cells exposed to Dual Rinse HEDP, curcumin, and sodium hypochlorite (2.

Cuproptosis regulation by long noncoding RNAs: Mechanistic insights and clinical implications in cancer.

Although survival rates have been improved in recent years, the prognosis of many cancer types remains inadequate, mostly owing to treatment resistance. Moreover, there is a continued need for exploring novel and reliable tumor markers to achieve accurate diagnosis. Understanding the molecular complexity of cancer allows for the development of more effective and personalized treatments and facilitates the discovery of biomarkers that surpass traditional ones and assist in cancer diagnosis and monitoring disease progression and response to treatment.

The effect of cigarette smoking and heated tobacco products on different denture materials; an in vitro study.

Purpose: This study compares the effect of conventional cigarette smoke versus heated tobacco on the discoloration, surface roughness, and bacterial colonization of different oral prosthesis materials.

Materials And Methods: A total of one hundred and twenty disc-shaped samples made of four different denture base materials were prepared to represent different denture bases to assess the surface roughness and biofilm formation; group (CA): conventional heat-cured acrylic resin (Acrostone, Egypt), group (FA): flexible acrylic resin (Valplast International Corp, USA), group (TA): heat-cured acrylic resin reinforced with titanium nanoparticles (TA nanoparticles, Nanogate, Egypt), and group (PA): 3D printed acrylic resin (Nexdent, The Netherlands). Another sixty samples of artificial and 3D printed teeth were used to assess the color change: conventional ready-made acrylic resin teeth (Acrostone, Egypt) and 3D-printed acrylic resin teeth (Nexdent, The Netherlands).

New trends in potentiometric sensors: From design to clinical and biomedical applications.

Potentiometry, a well-established electrochemical technique, provides a powerful and versatile method for the sensitive and selective measurement of a variety of analytes by measuring the potential difference between two electrodes, allowing for a direct and rapid readout of ion concentrations. This makes it a valuable tool in a variety of applications including industry, agriculture, forensics, medical, environmental assessment, and pharmaceutical drug analysis, therefore it has received significant attention from the scientific community. Their broad implementation in sensing applications arises through their many benefits, including ease of design, fabrication, and modification; rapid response time; high selectivity; suitability for use with colored and/or turbid solutions; and potential for integration into embedded systems interfaces.

Measurement of multidifferential cross sections for dijet production in proton-proton collisions at .

A measurement of the dijet production cross section is reported based on proton-proton collision data collected in 2016 at by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of up to 36.3 . Jets are reconstructed with the anti- algorithm for distance parameters of and 0.

Predicting construction waste in Egyptian residential projects: a robust multiple regression model approach.

Effective construction waste (CW) management, mainly concrete, brick, and steel, is a critical challenge due to its significant environmental and economic impacts. This study addresses this challenge by proposing multiple linear regression models to predict waste generation in residential buildings within the Egyptian construction industry, considering the influence of factors such as building design and site management features. Using data from 25 case studies, the models demonstrated high predictive accuracy, with adjusted R² values of 0.

In silico and In vivo protective effect of biochanin-A mitigating doxorubicin- induced cognitive deficits and neuroinflammation: Insights to the role of p-Tau and miR-132.

Doxorubicin (DOX)-induced chemobrain has been reported in several studies. Its main culprit is the induction of massive amounts of reactive oxygen species (ROS), hence triggering damage to brain tissues and thus leading to neuroinflammation. Biochanin A (BIO-A) is known to be an antioxidant, anti-inflammatory, and neuroprotective agent.

Harnessing the ubiquitin proteasome system as a key player in stem cell biology.

Intracellular proteins take part in almost every body function; thus, protein homeostasis is of utmost importance. The ubiquitin proteasome system (UPS) has a fundamental role in protein homeostasis. Its main role is to selectively eradicate impaired or misfolded proteins, thus halting any damage that could arise from the accumulation of these malfunctioning proteins.

From model validation to biomechanical analysis: In silico study of multirooted root analogue implants using 3D finite element analysis.

Objectives: To create a validated 3D finite element model and employ it to examine the biomechanical behaviour of multirooted root analogue implants (RAIs).

Methods: A validated finite element model comprising either an RAI or a threaded implant (TI) and an idealised bone block was developed based on a previously conducted in vitro study. All the experimental boundary conditions and material properties were reproduced.

Unlocking the therapeutic potential of canagliflozin in NAFLD: Insights into AMPK/SIRT1-mediated lipophagy.

Unlabelled: Nonalcoholic fatty liver disease (NAFLD) is a rising global health problem. The antidiabetic canagliflozin (CANA) has been proposed to ameliorate the metabolic abnormalities in NAFLD.

Aim: This study aimed to explore the possible anti-NAFLD effects of CANA in rats and HepG2 cells, focusing on AMPK/SIRT1-mediated lipophagy.

The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients.

Introduction: COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis, yet the key players driving this association remain unclear. It is generally assumed that organ damage causes toxic acidosis, but since neutrophil numbers in severe COVID-19 can exceed 80% of the total circulating leukocytes, we asked if metabolic acidosis mediated by the glycolytic neutrophils is associated with lung damage and impaired oxygen delivery in critically ill patients.

Methods: Based on prospective mortality outcome, critically ill COVID-19 patients were divided into ICU- survivors and ICU-non-survivors.

Optimization and DFT study for boosted electooxidation of formic acid at NiOx modified Pt using urea derivatives as blending fuels.

This paper addresses the enhancement of formic acid electrooxidation (FAO) at Pt and Pt-NiOx nanoparticles based-catalysts assisted with urea derivatives as blending fuels. Blending formic acid with various ratios of urea derivatives showed noticeable enhancements of FAO as demonstrated by a favorable negative shift of its onset potential (E) and increase of its peak current density concurrently with suppression of the amount of CO poisoning reaction intermediate. Among all the used derivatives, phenyl urea (PU) showed superior enhancing effect towards the direct FAO with a minimal CO formation together with a favorable negative shift of E by 150 mV.

Economic impact and clinical benefits of clinical pharmacy interventions: A six-year multi-center study using an innovative medication management tool.

Background: Increasing healthcare costs, particularly in Low- and Middle-Income Countries (LMICs) like Egypt, highlight the need for rational economic strategies. Clinical pharmacy interventions offer potential benefits by reducing drug therapy problems and associated costs, thereby supporting healthcare system sustainability.

Objective: This study evaluates the economic impact and clinical benefits of clinical pharmacy interventions in four tertiary hospitals in Egypt by implementing an innovative tool for medication management, focusing on cost avoidance and return on investment (ROI), while accounting for case severity and drug therapy problem (DTP) resolution.

Revealing the impact of tadalafil-loaded proniosomal gel against dexamethasone-delayed wound healing via modulating oxido-inflammatory response and TGF-β/Macrophage activation pathway in rabbit model.

A serious challenge of the chronic administration of dexamethasone (DEX) is a delay in wound healing. Thus, this study aimed to investigate the potential of Tadalafil (TAD)-loaded proniosomal gel to accelerate the healing process of skin wounds in DEX-challenged rabbits. Skin wounds were induced in 48 rabbits of 4 groups (n = 12 per group) and skin wounds were treated by sterile saline (control), TAD-loaded proniosomal gel topically on skin wound, DEX-injected rabbits, and DEX+TAD-loaded proniosomal gel for 4 weeks.