1,248 results match your criteria: "British Columbia Centre for Disease Control.[Affiliation]"
Mol Diagn Ther
September 2024
The Consortium for Clinical Metagenomics in Infectious Diseases, Nashville, TN, USA.
Central nervous system (CNS) infections carry a substantial burden of morbidity and mortality worldwide, and accurate and timely diagnosis is required to optimize management. Metagenomic next-generation sequencing (mNGS) has proven to be a valuable tool in detecting pathogens in patients with suspected CNS infection. By sequencing microbial nucleic acids present in a patient's cerebrospinal fluid, brain tissue, or samples collected outside of the CNS, such as plasma, mNGS can detect a wide range of pathogens, including rare, unexpected, and/or fastidious organisms.
View Article and Find Full Text PDFProtein Sci
August 2024
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Antibiotic resistance is recognized as an imminent and growing global health threat. New antimicrobial drugs are urgently needed due to the decreasing effectiveness of conventional small-molecule antibiotics. Antimicrobial peptides (AMPs), a class of host defense peptides, are emerging as promising candidates to address this need.
View Article and Find Full Text PDFPLoS One
July 2024
British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
Background: In many jurisdictions, policies restrict access to Opioid Agonist Treatment (OAT) in correctional facilities. Receipt of OAT during incarceration is associated with reduced risk of fatal overdose after release but little is known about the effect on nonfatal overdose. This study aimed to examine the association between OAT use during incarceration and nonfatal overdose in the 30 days following release.
View Article and Find Full Text PDFCan J Public Health
August 2024
Medical Microbiology, Canadian Blood Services, Edmonton, AB, Canada.
J Adolesc Health
October 2024
Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; Centre for Gender and Sexual Health Equity, Vancouver, British Columbia, Canada; British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
J Viral Hepat
October 2024
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
We assessed the impact of the COVID-19 pandemic on hepatocellular carcinoma (HCC) surveillance among individuals with HCV diagnosed with cirrhosis in British Columbia (BC), Canada. We used data from the British Columbia Hepatitis Testers Cohort (BC-HTC), including all individuals in the province tested for or diagnosed with HCV from 1 January 1990 to 31 December 2015, to assess HCC surveillance. To analyse the impact of the pandemic on HCC surveillance, we used pre-policy (January 2018 to February 2020) and post-policy (March to December 2020) periods.
View Article and Find Full Text PDFCult Health Sex
June 2024
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Many Two-Spirit, gay, bisexual, transgender, and other queer Black, Indigenous, people of colour in Canada encounter racism when testing for sexually transmitted and blood-borne infections. Our objective in this study was to understand how racism shapes testing experiences for these communities in Ontario, Canada. Four peer researchers conducted recruitment and data collection in consultation with a community advisory board.
View Article and Find Full Text PDFLancet HIV
July 2024
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:
Background: Treatment as prevention and pre-exposure prophylaxis (PrEP) are key strategies in the control of HIV/AIDS. We aimed to characterise the longitudinal effects of antiretroviral therapy (ART), followed by treatment as prevention and the addition of PrEP, on the HIV effective reproduction number (R) in British Columbia, Canada.
Methods: This population-level programme evaluation used data from the Drug Treatment Program of the British Columbia Centre for Excellence in HIV/AIDS (Vancouver, British Columbia, Canada).
Am J Epidemiol
December 2024
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T1P8, Canada.
The prevalence and relative disparities of mental health outcomes and well-being indicators are often inconsistent across studies of sexual minority men (SMM) due to selection biases in community-based surveys (nonprobability sample), as well as misclassification biases in population-based surveys where some SMM often conceal their sexual orientation identities. The present study estimated the prevalence of mental health related outcomes (depressive symptoms, mental health service use, anxiety) and well-being indicators (loneliness and self-rated mental health) among SMM, broken down by sexual orientation using the adjusted logistic propensity score (ALP) weighting. We applied the ALP to correct for selection biases in the 2019 Sex Now data (a community-based survey of SMMs in Canada) by reweighting it to the 2015-2018 Canadian Community Health Survey (a population survey from Statistics Canada).
View Article and Find Full Text PDFCan Commun Dis Rep
May 2024
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.
Can Commun Dis Rep
May 2024
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.
Background: Invasive group A streptococcal (iGAS, ) disease has been a nationally notifiable disease in Canada since 2000. This report summarizes the demographics, types, and antimicrobial resistance of iGAS isolates collected in Canada in 2021 and 2022.
Methods: The Public Health Agency of Canada's National Microbiology Laboratory collaborates with provincial and territorial public health laboratories to conduct national surveillance of invasive .
Can J Public Health
August 2024
Environmental Health Services, British Columbia Centre for Disease Control, Vancouver, BC, Canada.
Setting: The potential for exposure to indoor radon varies dramatically across British Columbia (BC) due to varied geology. Individuals may struggle to understand their exposure risk and agencies may struggle to understand the value of population-level programs and policies to mitigate risk.
Intervention: The BC Centre for Disease Control (BCCDC) established the BC Radon Data Repository (BCRDR) to facilitate radon research, public awareness, and action in the province.
Lancet Infect Dis
October 2024
Unity Health Toronto, University of Toronto, Toronto, ON, Canada.
Vaccines (Basel)
April 2024
CIHR Canadian HIV Trials Network (CTN), Vancouver, BC V6Z 1Y6, Canada.
COVID-19 breakthrough infection (BTI) can occur despite vaccination. Using a multi-centre, prospective, observational Canadian cohort of people with HIV (PWH) receiving ≥2 COVID-19 vaccines, we compared the SARS-CoV-2 spike (S) and receptor-binding domain (RBD)-specific IgG levels 3 and 6 months post second dose, as well as 1 month post third dose, in PWH with and without BTI. BTI was defined as positivity based on self-report measures (data up to last study visit) or IgG data (up to 1 month post dose 3).
View Article and Find Full Text PDFWe investigated the impacts of the COVID-19 pandemic on hepatitis C (HCV) treatment initiation, including by birth cohort and injection drug use status, in British Columbia (BC), Canada. Using population data from the BC COVID-19 Cohort, we conducted interrupted time series analyses, estimating changes in HCV treatment initiation following the introduction of pandemic-related policies in March 2020. The study included a pre-policy period (April 2018 to March 2020) and three follow-up periods (April to December 2020, January to December 2021, and January to December 2022).
View Article and Find Full Text PDFInt J Drug Policy
June 2024
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada; Centre for Gender and Sexual Health Equity, Vancouver, British Columbia, Canada; École de Santé Publique de l'Université de Montréal, Montréal, Québec, Canada; Centre de recherche en santé publique (CReSP), Montréal, Québec, Canada.
Background: Despite well-established evidence showing that young sexual and gender minority (SGM) men experience disproportionate mental health and substance use inequities, few sexual health services provide mental health and substance use care. This qualitative study examined the experiences and perspectives about integrated care models within sexual health services among young SGM men experiencing mental health and substance use challenges.
Methods: Semi-structured interviews were conducted with 50 SGM men aged 18-30 years who reported using substances with sex in Vancouver, Canada.
Cancer Epidemiol Biomarkers Prev
July 2024
Women's Health Research Institute, BC Women's Hospital and Health Services, Vancouver, Canada.
ArXiv
May 2024
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
The COVID-19 pandemic led to a large global effort to sequence SARS-CoV-2 genomes from patient samples to track viral evolution and inform public health response. Millions of SARS-CoV-2 genome sequences have been deposited in global public repositories. The Canadian COVID-19 Genomics Network (CanCOGeN - VirusSeq), a consortium tasked with coordinating expanded sequencing of SARS-CoV-2 genomes across Canada early in the pandemic, created the Canadian VirusSeq Data Portal, with associated data pipelines and procedures, to support these efforts.
View Article and Find Full Text PDFBMJ Open Respir Res
May 2024
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Background: Many interstitial lung diseases (ILDs) have clear causal relationships with environmental and occupational exposures. Exposure identification can assist with diagnosis, understanding disease pathogenesis, prognostication and prevention of disease progression and occurrence in others at risk. Despite the importance of exposure identification in ILD, there is no standardised assessment approach.
View Article and Find Full Text PDFEcohealth
March 2024
Canadian Wildlife Health Cooperative British Columbia, Abbotsford, BC, Canada.
From July 2020 to June 2021, 248 wild house mice (Mus musculus), deer mice (Peromyscus maniculatus), brown rats (Rattus norvegicus), and black rats (Rattus rattus) from Texas and Washington, USA, and British Columbia, Canada, were tested for SARS-CoV-2 exposure and infection. Two brown rats and 11 house mice were positive for neutralizing antibodies using a surrogate virus neutralization test, but negative or indeterminate with the Multiplexed Fluorometric ImmunoAssay COVID-Plex, which targets full-length spike and nuclear proteins. Oro-nasopharyngeal swabs and fecal samples tested negative by RT-qPCR, with an indeterminate fecal sample in one house mouse.
View Article and Find Full Text PDFJ Infect Dis
December 2024
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Background: Current molecular diagnostics are limited in the number and type of detectable pathogens. Metagenomic next-generation sequencing (mNGS) is an emerging, and increasingly feasible, pathogen-agnostic diagnostic approach. Translational barriers prohibit the widespread adoption of this technology in clinical laboratories.
View Article and Find Full Text PDFAm J Med
April 2024
Data and Analytic Services, British Columbia Centre for Disease Control, Vancouver, British Columbia V5Z 4R4, Canada; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada; Centre for Advancing Health Outcomes, St. Paul's Hospital, Vancouver, British Columbia V6Z 1Y6, Canada. Electronic address:
Background: COVID-19 is associated with increased risk of post-acute cardiovascular outcomes. Population-based evidence for long periods of observation is still limited.
Methods: This population-based cohort study was conducted using data (2020-2021) from the British Columbia COVID-19 Cohort.
Clin Infect Dis
April 2024
Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Background: Lymphatic filariasis (LF) is a neglected tropical disease targeted for elimination as a public health problem by 2030. Although mass treatments have led to huge reductions in LF prevalence, some countries or regions may find it difficult to achieve elimination by 2030 owing to various factors, including local differences in transmission. Subnational projections of intervention impact are a useful tool in understanding these dynamics, but correctly characterizing their uncertainty is challenging.
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