135,809 results match your criteria: "British Columbia; British Columbia Women's and Children's Hospital[Affiliation]"
Microbiology (Reading)
January 2025
Department of Zoology, University of British Columbia, Vancouver, Canada.
Microbiome-animal host symbioses are ubiquitous in nature. Animal-associated microbiomes can play a crucial role in host physiology, health and resilience to environmental stressors. As climate change drives rising global temperatures and increases the frequency of thermal extremes, microbiomes are emerging as a new frontier in buffering vulnerable animals against temperature fluctuations.
View Article and Find Full Text PDFMol Biol Evol
January 2025
Shmunis School of Biomedicine and Cancer Research, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Bats have adapted to pathogens through diverse mechanisms, including increased resistance - rapid pathogen elimination, and tolerance - limiting tissue damage following infection. In the Egyptian fruit bat (an important model in comparative immunology) several mechanisms conferring disease tolerance were discovered, but mechanisms underpinning resistance remain poorly understood. Previous studies on other species suggested that elevated basal expression of innate immune genes may lead to increased resistance to infection.
View Article and Find Full Text PDFPediatr Radiol
January 2025
Hospital for Sick Children, University of Toronto, 175 Elizabeth Street, Toronto, Ontario, M5G2G3, Canada.
Dev Psychol
January 2025
Department of Psychology, University of British Columbia.
Communal values (i.e., valuing care for and connection with others) are important to individual well-being and societal functioning yet show marked gender differences, with girls valuing communion more than boys do.
View Article and Find Full Text PDFDev Psychol
January 2025
Department of Psychology, Stanford University.
Overcoming challenges to achieve success involves being able to spontaneously come up with effective strategies to address different task demands. Research has linked individual differences in such strategy generation and use to optimal development over time and greater success across many areas of life. Yet, there is surprisingly little experimental evidence that tests how we might help young children to spontaneously generate and apply effective strategies across different challenging tasks.
View Article and Find Full Text PDFAm J Respir Crit Care Med
January 2025
The University of Alabama at Birmingham, Division of Pulmonary, Allergy, and Critical Care Medicine, Birmingham, Alabama, United States.
Am J Respir Cell Mol Biol
January 2025
University of Groningen, University Medical Center Groningen, Department of Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, Groningen, Netherlands.
Asthma is a genetically complex inflammatory airway disease associated with over 200 Single nucleotide polymorphisms (SNPs). However, the functional effects of many asthma-associated SNPs in lung and airway epithelial samples are unknown. Here, we aimed to conduct expression quantitative trait loci (eQTL) analysis using a meta-analysis of nasal and lung samples.
View Article and Find Full Text PDFJ Comp Eff Res
January 2025
ICON plc, Insights, Evidence & Value - Health Economics & Epidemiology, Langen, Germany.
To compare the efficacy and safety of lanadelumab versus other approved long-term prophylaxis (LTP) treatments in patients with pediatric hereditary angioedema (HAE) aged <12 years. A systematic literature review was conducted to identify studies of LTP in patients with HAE aged <12 years. Two studies met the inclusion criteria in an indirect treatment comparison of efficacy and safety data in pediatric HAE patients.
View Article and Find Full Text PDFJ Physiol
January 2025
Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, British Columbia, Canada.
Analyst
January 2025
Department of Chemistry, University of Victoria, Victoria, British Columbia, V8W 3V6, Canada.
Infrared absorption spectroscopy and surface-enhanced Raman spectroscopy were integrated into three data fusion strategies-hybrid (concatenated spectra), mid-level (extracted features from both datasets) and high-level (fusion of predictions from both models)-to enhance the predictive accuracy for xylazine detection in illicit opioid samples. Three chemometric approaches-random forest, support vector machine, and -nearest neighbor algorithms-were employed and optimized using a 5-fold cross-validation grid search for all fusion strategies. Validation results identified the random forest classifier as the optimal model for all fusion strategies, achieving high sensitivity (88% for hybrid, 92% for mid-level, and 96% for high-level) and specificity (88% for hybrid, mid-level, and high-level).
View Article and Find Full Text PDFMol Biol Evol
January 2025
Department of Botany and Beaty Biodiversity Centre, University of British Columbia, Canada.
The degree to which evolution repeats itself has implications regarding the major forces driving evolution and the potential for evolutionary biology to be a predictive (versus solely historical) science. To understand the factors that control evolutionary repeatability, we experimentally evolved four replicate hybrid populations of sunflowers at natural sites for up to 14 years and tracked ancestry across the genome. We found that there was very strong negative selection against introgressed ancestry in several chromosomes, but positive selection for introgressed ancestry in one chromosome.
View Article and Find Full Text PDFJ Adv Nurs
January 2025
School of Nursing, University of Victoria, Victoria, British Columbia, Canada.
Aim: This research aimed to explore nursing students' experiences and perspectives on discrimination within nursing programs across classroom and clinical contexts, as well as structural discrimination through institutional policies and processes.
Design: Convergent mixed methods.
Methods: Survey and individual interviews to capture students' experiences and perspectives on discrimination within nursing programs.
Clin Transl Gastroenterol
January 2025
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Background: Neutrophil-to-lymphocyte ratio (NLR) is a novel biomarker studied in several autoimmune diseases including inflammatory bowel diseases (IBD) in adults, but poorly characterized in pediatric IBD (pIBD). We aimed to primarily investigate the relationship between NLR and pIBD endoscopic disease severity. We also examined whether NLR predicted hospitalization, surgery, and therapy response by 52 weeks.
View Article and Find Full Text PDFJ Cutan Med Surg
January 2025
Windsor Clinical Research, Windsor, ON, Canada.
Acne vulgaris (AV) is a common skin condition that can cause substantial psychosocial impact. Treatments of AV target clearing and prevention of lesions and reducing scarring and dyspigmentation. Numerous medications are used to target one or more of the pathogenetic factors contributing to AV.
View Article and Find Full Text PDFAm J Surg Pathol
January 2025
Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver BC, Canada.
Fumarate hydratase tumor predisposition syndrome (FHTPS) is caused by germline fumarate hydratase (FH) pathogenic variants (PVs). Most women with FHTPS develop FH-deficient (FHD) uterine leiomyomas (ULs), which arise 10 to 15 years earlier than aggressive FHD-renal cell carcinoma. We evaluate a previously proposed FHTPS screening strategy for women with ULs.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Computational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Arequipa, Peru.
JFMS Open Rep
January 2025
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, CA, USA.
Case Summary: A 9-year-old male castrated domestic shorthair cat from northern California was evaluated for a 12-month history of dermal and subcutaneous dermatitis in the inguinal region. Histopathologic examination of a biopsy revealed severe, chronic, multifocal to coalescing pyogranulomatous dermatitis and panniculitis, accompanied by ulceration and central necrosis. Aerobic bacterial culture of lesions yielded mycobacterial growth.
View Article and Find Full Text PDFJ Exp Biol
January 2025
Department of Zoology, University of British Columbia, Vancouver, BC, Canada.
Cross-protection occurs when exposure to one stressor confers heightened tolerance against a different stressor. Alternatively, exposure to one stressor could result in reduced tolerance against other stressors. Although cross-protection has been documented in a wide range of taxa at juvenile and adult life stages, whether early developmental exposure to a stressor confers cross-protection or reduced tolerance to other stressors later in life through developmental plasticity remains largely unexplored.
View Article and Find Full Text PDFFam Pract
January 2025
Department of Obstetrics and Gynaecology, 2775 Laurel Street, University of British Columbia, Vancouver, British Columbia, V5Z 1M9, Canada.
Background: Healthcare providers often lack awareness, knowledge, and confidence in managing vulvodynia, which can lead to difficulties with diagnosis and treatment for individuals with the condition.
Objective: To develop and test an educational online toolkit tailored to supporting community-based primary care providers with diagnosis, treatment, and patient support for vulvodynia.
Methods: A sample of 19 community-based family physicians completed online surveys before and after testing the Vulvodynia Primary Care Toolkit (the toolkit hereafter) in their practice for 6 months.
BMC Proc
January 2025
Azrieli Centre for Autism Research, Montreal Neurological Hospital-Institute, McGill University Health Centre, Montreal, Canada.
As part of a participatory project to advance navigational service delivery systems for children with neurodevelopmental disability (NDD) and their families, this paper addresses proceedings from a capacity-building conference in Vancouver, Canada. A total of 29 invited key stakeholders attended the meeting with the following aims: knowledge sharing amongst provincial/territorial regions advancing NDD navigation capacity; sustainable action-oriented knowledge exchange; and operationalizing next steps to build navigation resources across Canadian regions. Regional representation included multiple and inter-sectoral partners (e.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
January 2025
Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada.
Background: Indigenous Peoples comprise the youngest and fastest growing demographic in Canada, with many living in urban-suburban areas. Given higher fertility rates, younger overall ages and higher adolescent pregnancy rates, perinatal research is needed-to inform policymaking and programming throughout pregnancy and childhood. Yet such data remain scarce in British Columbia (BC), Canada.
View Article and Find Full Text PDFPurinergic Signal
January 2025
Department of Biology, Faculty of Science, University of British Columbia Okanagan Campus, Kelowna, BC, V1V 1V7, Canada.
The two main glial cell types of the central nervous system (CNS), astrocytes and microglia, are responsible for neuroimmune homeostasis. Recent evidence indicates astrocytes can participate in removal of pathological structures by becoming phagocytic under conditions of neurodegenerative disease when microglia, the professional phagocytes, are impaired. We hypothesized that adenosine triphosphate (ATP), which acts as damage-associated molecular pattern (DAMP), when released at high concentrations into extracellular space, upregulates phagocytic activity of human astrocytes.
View Article and Find Full Text PDFNat Hum Behav
January 2025
Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Science is crucial for evidence-based decision-making. Public trust in scientists can help decision makers act on the basis of the best available evidence, especially during crises. However, in recent years the epistemic authority of science has been challenged, causing concerns about low public trust in scientists.
View Article and Find Full Text PDFBMJ Open Respir Res
January 2025
Division of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Introduction: Persistent lung abnormalities following COVID-19 infection are common. Similar parenchymal changes are observed in idiopathic pulmonary fibrosis (IPF). We investigated whether common genetic risk factors in IPF are associated with developing lung parenchymal abnormalities following severe COVID-19 disease.
View Article and Find Full Text PDFJMIR Diabetes
January 2025
Research Institute, BC Children's Hospital, Vancouver, BC, Canada.
Background: Beyond physical health, managing type 1 diabetes (T1D) also encompasses a psychological component, including diabetes distress, that is, the worries, fears, and frustrations associated with meeting self-care demands over the lifetime. While digital health solutions have been increasingly used to address emotional health in diabetes, these technologies may not uniformly meet the unique concerns and technological savvy across all age groups.
Objective: This study aimed to explore the mental health needs of adolescents with T1D, determine their preferred modalities for app-based mental health support, and identify desirable design features for peer-delivered mental health support modeled on an app designed for adults with T1D.