5 results match your criteria: "Brighton and Sussex Medical School and University Hospitals Sussex NHS Foundation Trust[Affiliation]"
The barriers and enablers to accessing sexual health and sexual well-being services for midlife women (aged 40-65 years) in high-income countries: A mixed-methods systematic review.
Womens Health (Lond)
September 2024
Global Health and Infection Department, Brighton and Sussex Medical School and University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
Article Synopsis
- Midlife for women, typically spans from ages 40 to 65, involves significant hormonal, physical, psychological, and social changes that impact their sexual health and well-being.
- Access to sexual health services is crucial for maintaining the health of midlife women, particularly in the context of managing sexually transmitted infections and supporting sexual function and safety.
- A systematic review identified barriers to accessing sexual health services, such as stigma, lack of knowledge, and the disadvantages faced by underserved groups, while also highlighting enablers like intergenerational learning, women-only services, and local support resources.
Background: Women living with HIV (WLWH) are at increased risk of human papillomavirus (HPV)-related cancers. Throughout Europe, there is great heterogeneity among guidelines for screening programmes, access to HPV testing and HPV vaccination. The aim of this systematic review is to summarize available data on screening and prevention measures for HPV-related anogenital cancers in WLWH across the WHO European Region (WER).
View Article and Find Full Text PDFPalliative clinical trials in advanced chronic liver disease: Challenges and opportunities.
J Hepatol
November 2023
Massachusetts General Hospital, Boston, MA, USA.
Patients with advanced chronic liver disease have a complex symptom burden and many are not candidates for curative therapy. Despite this, provision of palliative interventions remains woefully inadequate, with an insufficient evidence base being a contributory factor. Designing and conducting palliative interventional trials in advanced chronic liver disease remains challenging for a multitude of reasons.
View Article and Find Full Text PDFTandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.
Nat Commun
March 2023
Worldwide Research Development and Medical, Pfizer, USA.
Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in patients with DILI at onset (DO; n = 133) and follow-up (n = 120), acute non-DILI at onset (NDO; n = 63) and follow-up (n = 42), and healthy volunteers (HV; n = 104). Area under the receiver operating characteristic curve (AUC) for cytoplasmic aconitate hydratase, argininosuccinate synthase, carbamoylphosphate synthase, fumarylacetoacetase, fructose-1,6-bisphosphatase 1 (FBP1) across cohorts achieved near complete separation (range: 0.
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