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Am J Transplant
December 2007
Transplantation Research Center, Brigham and Women's Hospital and the Children's Hospital of Boston, Boston, MA, USA.
Programmed death-1 (PD-1) is a recently identified coinhibitory molecule that belongs to the CD28 superfamily. PD-1 has two ligands PD-L1 and PD-L2. There is some evidence that PD-L1 and PD-L2 serve distinct functions, but their exact function in alloimmunity remains unclear.
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