1 results match your criteria: "Brigham and Women's Hospital and Harvard Institute for Human Genetics[Affiliation]"
Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries.
Surgery
August 2001
Division of Vascular Surgery, Brigham and Women's Hospital and Harvard Institute for Human Genetics, Boston, MA 02115, USA.
Background: CD39, the major endothelial nucleoside triphosphate diphosphohydrolase (NTPDase), plays an important role in local thromboregulation. We hypothesized that balloon injury (BI) leads to an acute reduction in arterial NTPDase activity that could be restored by a targeted gene delivery strategy.
Methods: Recombinant adenoviral vectors containing human CD39 (Ad-CD39) or beta-galactosidase (Ad-LacZ) were used.