507 results match your criteria: "Brigham and Women's Hospital Heart and Vascular Center[Affiliation]"
Bariatric surgery versus intensive medical therapy for diabetes--3-year outcomes.
N Engl J Med
May 2014
From the Bariatric and Metabolic Institute (P.R.S., S.A.B., A.A.), Lerner Research Institute (J.P.K.), Heart and Vascular Institute (K.W., C.E.P., E.S.H.K., S.E.N.), Urological and Kidney Institute (S.D.N.), and Endocrinology Institute (S.R.K.), Cleveland Clinic, Cleveland; and Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School - both in Boston (D.L.B.).
Background: In short-term randomized trials (duration, 1 to 2 years), bariatric surgery has been associated with improvement in type 2 diabetes mellitus.
Methods: We assessed outcomes 3 years after the randomization of 150 obese patients with uncontrolled type 2 diabetes to receive either intensive medical therapy alone or intensive medical therapy plus Roux-en-Y gastric bypass or sleeve gastrectomy. The primary end point was a glycated hemoglobin level of 6.
A controlled trial of renal denervation for resistant hypertension.
N Engl J Med
April 2014
From Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School (D.L.B., L.M.), Boston University School of Public Health (R.D.), and Harvard Clinical Research Institute (R.D., L.M.) - all in Boston; Piedmont Heart Institute, Atlanta (D.E.K.); the Division of Cardiology, Henry Ford Hospital (W.W.O.), and Wayne State University and the Detroit Medical Center (J.M.F.) - all in Detroit; Baptist Cardiac and Vascular Institute, Miami (B.T.K.); New York Presbyterian Hospital, Columbia University Medical Center, and Cardiovascular Research Foundation, New York (M.B.L.); Medtronic CardioVascular, Santa Rosa, CA (M.L., M.N., S.A.C.); University of Alabama at Birmingham, Birmingham (S.O.); Prairie Heart Institute, Springfield, IL (K.R.-S.); Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.A.C., R.R.T.); and University of Chicago Medicine, Chicago (G.L.B.).
Background: Prior unblinded studies have suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resistant hypertension.
Methods: We designed a prospective, single-blind, randomized, sham-controlled trial. Patients with severe resistant hypertension were randomly assigned in a 2:1 ratio to undergo renal denervation or a sham procedure.
Endovascular therapy for stroke: getting to the "heart" of the matter.
Circulation
March 2014
Department of Neurology, Emory University School of Medicine, Grady Memorial Hospital, Atlanta, GA (C.-H.J.S., R.G.N.); Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA (D.L.B); and Wellstar Neurosurgery, Kennestone Hospital, Marietta, GA (R.G.).
Unintentional overestimation of an expected antihypertensive effect in drug and device trials: mechanisms and solutions.
Int J Cardiol
March 2014
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, UK.
In clinical practice we pay close attention to choosing an appropriate intervention for patients and performing it safely. We may put less thought into how to measure the effect without bias. Clinical practice involving noisy values such as blood pressure requires intelligent processing to avoid confusing patients, but applying such discretion in clinical trials may inadvertently disrupt quantification of the benefit of the intervention, in unblinded trials.
View Article and Find Full Text PDFThe burden of advanced heart failure is reaching epidemic proportions. Generally considered for cardiac transplantation, patients often cannot receive this therapy because of their advanced age, comorbidity or the scarcity of donors. Most transplants are concentrated in North America and Europe, with the average center performing fewer than 20 annual transplants.
View Article and Find Full Text PDFContinuous flow left ventricular assist device related aortic root thrombosis complicated by left main coronary artery occlusion.
J Heart Lung Transplant
January 2014
Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA. Electronic address:
The vexing problem of thrombosis in long-term mechanical circulatory support.
J Heart Lung Transplant
January 2014
The Daniel K. Inouye College of Pharmacy, University of Hawaii, Hilo, Hawaii.
Durable left ventricular assist devices (LVADs) have not only enhanced longevity but also conferred sustained improvements in quality of life, symptom control, and functional capacity in patients with medically refractory advanced heart failure. Problems with device-related infection, bleeding, neurologic events, right-sided heart failure, and device malfunction have dominated the clinical care of patients living on mechanical support. Even as adoption of durable LVADs accelerated globally, we began to encounter a growing dilemma of pump malfunction caused by thrombosis.
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