2 results match your criteria: "Brest University and Regional Hospital[Affiliation]"
Background: Inflammation may increase stress, while stress may promote inflammation. Most dermatological conditions are chronic and inflammatory, while some, such as cancer, naevi and tumours are non-inflammatory, but may cause stress because of the fear of malignancy and the necessity for surgical and other invasive treatments. Stress among patients with skin diseases is little explored.
View Article and Find Full Text PDFTranslocation t(2;7)(p11;q21) associated with the CDK6/IGK rearrangement is a rare but recurrent abnormality in B-cell lymphoproliferative malignancies.
Cancer Genet
March 2014
Laboratory of Histology, Embryology and Cytogenetics, Faculty of Medicine and Health Sciences, Université de Bretagne Occidentale, Brest, France; National Institute of Health and Medical Research (INSERM), Brest, France; Department of Cytogenetics and Reproductive Biology, Morvan Hospital, Brest University and Regional Hospital, Brest, France. Electronic address:
Article Synopsis
- Structural abnormalities on chromosome 7q are commonly found in chronic B-cell lymphoproliferative disorders, specifically involving the CDK6 gene due to translocations.
- Three notable translocations (t(7;14), t(7;22), and t(2;7)) have been identified that enhance the expression of CDK6 by positioning it near immunoglobulin gene enhancers during B-cell development.
- Recent studies have linked these genetic rearrangements to lymphoproliferative malignancies in patients, showing that increased CDK6 expression can affect the cell cycle, particularly the G1 phase and G1/S transition.