Consensus statement regarding storage and reuse of previously reconstituted neuromodulators.

Background: Legacy recommendations suggest that vials of botulinum toxin be used within 24 hours of reconstitution and in a single patient. Current standard of care is consistent with storage after reconstitution and use of a single vial for several patients.

Objective: To develop expert consensus regarding the effectiveness and safety of storage and reuse of botulinum toxin.

Fields of anhidrotic effects of abobotulinumtoxinA in patients with compensatory hyperhidrosis.

Background: Botulinum toxin type A can be used to treat compensatory hyperhidrosis (CHH), which presents areas of different intensity of sweating. More information about the anhidrotic effects is needed.

Objective: To evaluate the fields of anhidrotic effects (FAEs) resulting from different doses (5 and 10 U), dilution, and depths of injection of abobotulinumtoxinA in patients with CHH.

Fields of muscular and anhidrotic effects of 2 botulinum toxin-A commercial preparations: a prospective, double-blind, randomized, multicenter study.

Background: Longevity of effects and dose equivalence of different botulinum toxin type A (BoNT-A) preparations need to be better clarified because BoNT-A units are manufacturer-specific. These points are of particular importance for new brands emerging in the market.

Objective: To assess the field of muscular and anhidrotic effects of 2 commercial preparations of BoNT-A (incobotulinumtoxinA: Xeomin [XEO]; abobotulinumtoxinA: Dysport [DYS]) administered to the upper third of the face.

Management of complications of injectable silicone.

Soft tissue augmentation is a common procedure, and a wide variety of injectable fillers are used. Liquid injectable silicone (LIS) was the first highly popularized injectable filler. LIS is a permanent filler and can be used in the correction of facial furrows and wrinkles.

Triple combination as adjuvant to cryotherapy in the treatment of solar lentigines: investigator-blinded, randomized clinical trial.

Background: Post-inflammatory hyperpigmentation is a frequent concern when treating solar lentigines.

Objectives: To assess the safety and efficacy of a triple combination cream with fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.

Superficial dermabrasion versus topical tretinoin on early striae distensae: a randomized, pilot study.

Background: Striae distensae (SD) is a common skin condition, with a prevalence ranging from 40% to 90%, depending on the population studied.

Objectives: To evaluate the efficacy of superficial dermabrasion and compare it with that of topical tretinoin cream in the treatment of narrow and early SD.

Materials And Methods: Prospective, single-center, randomized, open-label study.

A comparative study of the anatomy of adipose tissue in areas with and without raised lesions of cellulite using magnetic resonance imaging.

Background: Cellulite is considered a noninflammatory phenomenon characterized by alterations to the skin surface, with depressed and raised lesions. Few studies have evaluated subcutaneous fat in patients with cellulite, and there is no information about the anatomy of raised lesions.

Methods: Sixty women with raised cellulite lesions were evaluated using magnetic resonance imaging (MRI).

Fields of effects of 2 commercial preparations of botulinum toxin type A at equal labeled unit doses: a double-blind randomized trial.

Importance: This article provides new data on a controversial issue, the influence of doses on the diffusion characteristics of 2 botulinum toxins type A. OBJECTIVE To assess the fields of effect of abobotulinumtoxinA and onabotulinumtoxinA at the same labeled unit dose (1:1 U) comparing sweat gland and muscle activity.

Design, Setting, And Participants: A prospective, single-center, randomized, double-blind study was conducted at the Brazilian Center for Studies in Dermatology in Porto Alegre, Brazil.

Epidemiology of melasma in Brazilian patients: a multicenter study.

Background: Melasma is an acquired, irregularly patterned, light to dark-brown hypermelanosis, with symmetric distribution mostly over the face. The aim of this study was to evaluate clinical characteristics and factors related to melasma in Brazilian patients.

Methods: This was a cross-sectional, multicenter study performed in Brazil.

Evaluation of self-esteem and depression symptoms in depressed and nondepressed subjects treated with onabotulinumtoxinA for glabellar lines.

Background: Botulinum toxin type A (BoNT-A) injection has become the most popular cosmetic nonsurgical procedure, and it has been suggested that BoNT-A injections may improve emotional states when frown lines are treated.

Objectives: To evaluate symptoms of depression and self-esteem before and after onabotulinumtoxinA (ONA) injections in the glabella in subjects with and without depression.

Methods: Twenty-five subjects with depression were allocated into one group and 25 subjects without depression were matched to those according to demographic characteristics.

Noninvasive treatment of cellulite utilizing an expedited treatment protocol with a dual wavelength laser-suction and massage device.

Background: Over the past few years, noninvasive devices based on radiofrequency and/or lasers and light sources technologies are being used for the treatment of cellulite.

Objectives: To evaluate the effects of an expedited treatment for cellulite and body measures.

Methods: Fifteen female subjects aged from 20 to 42 years were enrolled.

Double-blind, randomized, controlled clinical trial to compare safety and efficacy of a metallic cannula with that of a standard needle for soft tissue augmentation of the nasolabial folds.

Background: Injection-related side effects and complications are likely to occur during or after filler injections; they are mainly caused by the injection technique.

Objective: To assess safety and efficacy of a metallic cannula to inject hyaluronic acid (HA) filler in the nasolabial folds and to compare the safety of this cannula with that of a standard needle.

Methods: This was a prospective, randomized, phase II, double-blinded study that included 25 participants with Grade 2 to 3 for bilateral nasolabial folds according to the Modified Fitzpatrick Wrinkle Scale (MFWS).

Field effect of two commercial preparations of botulinum toxin type A: a prospective, double-blind, randomized clinical trial.

Background: The dose equivalence of commonly used commercial preparations of botulinum toxin type A, Dysport (abotulinumtoxinA [ABO] 500 U, Ipsen Biopharm Limited, Wrexham, United Kingdom) and Botox (onabotulinumtoxinA [ONA] 100 U, Allergan, Irvine, CA), remains unclear.

Objective: We sought to evaluate the field effect for ABO and ONA at dose equivalences of 2.5:1.

A bipolar radiofrequency, infrared, vacuum and mechanical massage device for treatment of cellulite: a pilot study.

Cellulite has a complex and multifactorial etiology. Synergistic action on treating cellulite has gained support in the treatment of cellulite. This study evaluated safety and efficacy of a bipolar radiofrequency, infrared, vacuum and mechanical massage device for cellulite treatment and reduction of body measures.

Cosmeceuticals for cellulite.

Cellulite is characterized by alterations to the skin surface, presenting as dimpled or puckered skin of the buttocks and posterior and lateral thighs. It mainly affects women. Cellulite occurrence is believed to be due to structural, inflammatory, morphological and biochemical alterations of the subcutaneous tissue.

Poly-L-lactic acid for neck and chest rejuvenation.

Background: Poly-L-lactic acid (PLLA) has been widely used in the enhancement of facial contours, but its use in nonfacial areas is rarely cited.

Objectives: To demonstrate the efficacy and safety of PLLA for neck and chest rejuvenation.

Methods: Thirty-six patients with different degrees of cutaneous flaccidity, atrophy, and wrinkles in the neck and chest were treated with PLLA.