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Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny.

J Endocrinol

March 2015

Laboratory of Endocrine PhysiologyLaboratory of NeurophysiologyBiology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551-030, BrazilCarlos Chagas Filho Biophysic InstituteFederal University of Rio de Janeiro, Rio de Janeiro 21949-900, Brazil.

Postnatal nicotine exposure leads to obesity and hypothyroidism in adulthood. We studied the effects of maternal nicotine exposure during lactation on thyroid hormone (TH) metabolism and function in adult offspring. Lactating rats received implants of osmotic minipumps releasing nicotine (NIC, 6 mg/kg per day s.

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