The dual role of circHIPK3 in cancer and its implications for multiple drugs resistance: a systematic review and computational approach.

Background: circHIPK3 role in cancer as oncogene or tumor suppressor is still debated, therefore, this study aimed to understand the dual role of this circRNA in different cancers. Furthermore, all available evidence of circHIPK3 interactions with sponged-miRNA and RBPs in oncological diseases were systematically gathered to better understand the its functional role in cancer.

Methods: PubMed, BioMedCentral, Web of Science, Embase and Scopus databases were searched for articles published until October 2024, following the PRISMA guideline.

Four-year associations of wish-to-die trajectories with changes in the frailty of European citizens aged 50 and over.

Background: A death wish is a passive ideation about thoughts that suggest dying is better than continuing to live. We investigated the associations of different wish-to-die (WTD) trajectories with changes in frailty over a four-year period in European citizens aged 50 and over.

Methods: A longitudinal analysis was conducted with 27,350 participants (13,921 women) from 17 European countries, all aged ≥50 years, who responded to waves 6 and 8 of the Survey of Health, Ageing, and Retirement in Europe (SHARE) project.

Canopy functional trait variation across Earth's tropical forests.

Tropical forest canopies are the biosphere's most concentrated atmospheric interface for carbon, water and energy. However, in most Earth System Models, the diverse and heterogeneous tropical forest biome is represented as a largely uniform ecosystem with either a singular or a small number of fixed canopy ecophysiological properties. This situation arises, in part, from a lack of understanding about how and why the functional properties of tropical forest canopies vary geographically.

Functional composition of the Amazonian tree flora and forests.

Plants cope with the environment by displaying large phenotypic variation. Two spectra of global plant form and function have been identified: a size spectrum from small to tall species with increasing stem tissue density, leaf size, and seed mass; a leaf economics spectrum reflecting slow to fast returns on investments in leaf nutrients and carbon. When species assemble to communities it is assumed that these spectra are filtered by the environment to produce community level functional composition.

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36 TeV with the ATLAS Detector at the LHC.

This Letter presents a search for highly ionizing magnetic monopoles in 262  μb^{-1} of ultraperipheral Pb+Pb collision data at sqrt[s_{NN}]=5.36  TeV collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion data.

When the wild things are: Defining mammalian diel activity and plasticity.

Circadian rhythms are a mechanism by which species adapt to environmental variability and fundamental to understanding species behavior. However, we lack data and a standardized framework to accurately assess and compare temporal activity for species during rapid ecological change. Through a global network representing 38 countries, we leveraged 8.

as a Potential Anti-Inflammatory and Anti-Biofilm Agent Against Anaerobic Infections: An In Vitro Study.

This study evaluates the antimicrobial activity of the glycolic extract of against anaerobic pathogens, along with its cytotoxicity, genotoxicity, anti-inflammatory activity, antioxidant effects, and phytochemical composition. Phytochemical analysis was conducted using high-performance liquid chromatography and liquid chromatography-mass spectrometry, while the antioxidant effect was assessed through a DPPH assay. Antimicrobial action was tested on planktonic cultures and biofilms of , , , and .

Volumetric Evaluation of Alveolar Ridge Preservation Using Dense PTFE (d-PTFE) Membranes Intentionally Exposed to the Oral Cavity After Immediate Implant Placement-A Retrospective Study.

Tooth loss causes alveolar bone resorption, which may hinder the ability of implant placement. Socket preservation with immediate implant placement is one of the methods used to reduce bone resorption. In this retrospective study, we evaluated the influence of the use of dense polytetrafluoroethylene (d-PTFE) membranes on alveolar preservation after tooth extraction and with the installation of immediate dental implants.

Depression, reduced physical activity and the risk of heart disease: a prospective cohort of European middle-aged and older adults.

Objective: To assess the impact of depression and physical activity (PA) of different intensities on the incidence of heart disease.

Methods: A prospective cohort study with 20 645 European middle-aged and older adults (mean baseline age 63 years; 55.1% women; median follow-up 9.

Molecular and biochemical analyses of germination of cowpea (Vigna unguiculata L.) seeds inhibited by n-propyl gallate reveal a key role of alternative oxidase in germination Re-establishment.

n-Propyl gallate (PG) is a phenolic compound that influences enzymatic processes, mostly involving AOX, PTOX, LOX, POD, and PPO. Here, analyses of different PG concentrations (1, 2.5, and 5 mM) during cowpea seed germination at 16, 32, and 48h showed that 2.

Food-related properties and composition of cocoa honey (Theobroma cacao L.): An integrated investigation.

Cocoa (Theobroma cacao L.) is a tropical fruit used in chocolate production, with a huge portion of its byproducts, such as cocoa honey, being discarded, contributing to the over 52,000 tons of waste generated by the cocoa chain. Cocoa honey is a yellow liquid that drips from cocoa beans, rich in sugars, organic acids, vitamins, and minerals, making it highly susceptible to microbial fermentation.

Canine Multicentric Lymphoma: Diagnostic, Treatment, and Prognostic Insights.

Lymphoma accounts for 24% of all documented canine neoplasms and 85% of hematological malignancies, while multicentric lymphoma corresponds to 84% of all canine lymphomas. Canine lymphomas of B-cell origin account for 60% to 80% of lymphomas. Similar to humans, the histologic grade, architecture, as well as immunophenotype determination, are crucial.

Role of atrial natriuretic peptide and oxytocin in gastric emptying delay induced by right atrial stretch in rats.

Fluid volume and osmolality balance are maintained by complex neuroendocrine and liquid-salt intake behavior, cardiovascular and renal mechanisms, and gastrointestinal adjustments. Mechanical stretching of the right atrium [atrial stretch (AS)] enhances central venous pressure and heart rate while decreasing gastric emptying (GE) of liquid in rats. We evaluated the effect of AS on GE and plasma levels of atrial natriuretic peptide (ANP), oxytocin (OT), and corticosterone (CORT) to determine whether ANP contributes to the OT-mediated GE delay of liquids due to AS in awake rats.

Simultaneous Unbinned Differential Cross-Section Measurement of Twenty-Four Z+jets Kinematic Observables with the ATLAS Detector.

Z boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of Z boson production characterize the event properties using a small number of observables and present the results as differential cross sections in predetermined bins.

Glioprotective Effects of Resveratrol Against Glutamate-Induced Cellular Dysfunction: The Role of Heme Oxygenase 1 Pathway.

Resveratrol, a natural polyphenol, has shown promising neuroprotective effects in several in vivo and in vitro experimental models. However, the mechanisms by which resveratrol mediates these effects are not fully understood. Glutamate is the major excitatory neurotransmitter in the brain; however, excessive extracellular glutamate levels can affect neural activity in several neurological diseases.

Arbovirus exposure and subclinical myocardial dysfunction in an Indigenous population in Northeast Brazil: a cross-sectional study.

Background: Human activities, such as urbanization and climate change, have facilitated the spread of arbovirus-carrying vectors, disproportionately affecting vulnerable traditional Indigenous communities.

Objective: To explore the relationships between subclinical myocardial dysfunction, assessed by global longitudinal strain (GLS), and comprehensive arbovirus serology in an Indigenous population, while also describing the serological and epidemiological profile of dengue, chikungunya, and Zika viruses.

Methods: This ancillary study is part of the first phase (2016-2017) of the Project of Atherosclerosis among Indigenous Populations (PAI), a cross-sectional study involving participants from two Indigenous communities with different degrees of urbanization and a highly urbanized city in Northeast Brazil.

Floodplain forests drive fruit-eating fish diversity at the Amazon Basin-scale.

Unlike most rivers globally, nearly all lowland Amazonian rivers have unregulated flow, supporting seasonally flooded floodplain forests. Floodplain forests harbor a unique tree species assemblage adapted to flooding and specialized fauna, including fruit-eating fish that migrate seasonally into floodplains, favoring expansive floodplain areas. Frugivorous fish are forest-dependent fauna critical to forest regeneration via seed dispersal and support commercial and artisanal fisheries.

Comparative Nutritional Profile of Publicly Procured Foods for School Meals in Federal Schools in Northeastern Brazil Pre- and Post-COVID-19 Pandemic.

Unlabelled: School meals play a critical role in supporting students' biopsychosocial growth, development, learning, academic performance, and the establishment of healthy eating habits. In public institutions, food procurement is conducted through formal public procurement processes. However, emphasizing cost-effectiveness in bidding criteria, such as prioritizing the lowest product price, may inadvertently encourage the acquisition of foods high in critical nutrients.

The effects of teleconnections on water and carbon fluxes in the two South America's largest biomes.

Ecosystem services provided by terrestrial biomes, such as moisture recycling and carbon assimilation, are crucial components of the water, energy, and biogeochemical cycles. These biophysical processes are influenced by climate variability driven by distant ocean-atmosphere interactions, commonly referred to as teleconnections. This study aims to identify which teleconnections most significantly affect key biophysical processes in South America's two largest biomes: The Amazon and Cerrado.

Tracing the Dispersal Pathway of HIV-1 Subtype C to Bahia: Phylogenetic Connections to Southern Brazil.

The HIV-1 epidemic in Brazil is predominantly characterized by subtype B, except in the southern states, where subtype C (HIV-1C) is more prevalent. Continuous monitoring of this profile is essential to maintain an accurate understanding of the molecular landscape of the HIV epidemic in Brazil. In this study, we isolated and sequenced seven new HIV-1C strains from the state of Bahia, located in the Northeast region of Brazil.

Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study.

Arthropod-borne viral diseases are acute febrile illnesses, sometimes with chronic effects, that can be debilitating and even fatal worldwide, affecting particularly vulnerable populations. Indigenous communities face not only the burden of these acute febrile illnesses, but also the cardiovascular complications that are worsened by urbanization. A cross-sectional study was conducted in an Indigenous population in the Northeast Region of Brazil to explore the association between arboviral infections (dengue, chikungunya, and Zika) and cardiac biomarkers, including cardiotrophin 1, growth differentiation factor 15, lactate dehydrogenase B, fatty-acid-binding protein 3, myoglobin, N-terminal pro-B-type natriuretic peptide, cardiac troponin I, big endothelin 1, and creatine kinase-MB, along with clinical and anthropometric factors.

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

The effect of frailty on the relationship between cognition and depression symptoms in older people. A differential analysis by European regions.

This study aimed to investigate the moderating effect of frailty on the relationship between cognition and symptoms of depression in individuals aged ≥65 and to explore differences between four European regions (West, North, South, and East). A cross-sectional analysis was conducted with 29,094 participants (16,365 women) from 27 countries, aged ≥65 years, who responded to wave 8 of the SHARE project. The variables analysed were depression (12-item EURO-D scale), frailty, and a general cognition index (CogId).

Exploring multi-media geochemical relationships in the southeastern Amazonian basin: A way forward to define source and background levels of potentially toxic elements in lake sediments.

Understanding geochemical source-sink relationships is an important aspect for developing background values of potentially toxic elements (PTEs) in a lake basin. This approach was studied in the Araguaia belt of Amazonia, Brazil. A total of 96 sediments (from 13 sediment core, low-altitude lateritic plateaus; LA2-LA14), 36 surface soils, and 19 catchment crusts/rocks were collected in 2022-2023 and chemical analysis of these samples was performed in the fine fraction (<177 μm) using XRF and ICP-MS.