On the consequences of childbirth: obstetrics/gynaecology, comparative anatomy and racial theories in 19th century France and Brazil.

The following paper is centred on an analysis of comparative studies of the human pelvis developed over the 19th century by mostly French natural scientists, physical anthropologists, students of the human anatomy and doctors engaged in the initial stages of the emerging fields of gynaecology and obstetrics. As this paper will argue, there was considerable overlap between these specialisations, producing a fundamentally masculine, Eurocentric and racialised knowledge that had an enormous impact in establishing racially informed gynaecological and obstetric practices. This paper argues that comparative pelvic anatomy studies originated from the belief that African and Black women had specifically different pelves and genitalia and served to stratify women of different races and promoted racially oriented obstetric and gynaecological treatments.

Evaluating amyloid-beta aggregation and toxicity in transgenic Caenorhabditis elegans models of Alzheimer's disease.

Alzheimer's disease (AD) is the leading cause of dementia in the elderly, clinically characterized by memory loss, cognitive decline, and behavioral disturbances. Its pathogenesis is not fully comprehended but involves intracellular depositions of amyloid beta peptide (Aβ) and neurofibrillary tangles of hyperphosphorylated tau. Currently, pharmacological interventions solely slow the progression of symptoms.

Evaluating polyglutamine protein aggregation and toxicity in transgenic Caenorhabditis elegans models of Huntington's disease.

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by a repeat of the cytosine-adenine-guanine trinucleotide (CAG) in the huntingtin gene (HTT). This results in the translation of a mutant huntingtin (mHTT) protein with an abnormally long polyglutamine (polyQ) repeat. The pathology of HD leads to neuronal cell loss, motor abnormalities, and dementia.

Effect of adapted ice cream on nutritional status and oral mucositis in cancer patients undergoing chemotherapy: protocol study for a randomized controlled trial.

Background And Aims: Chemotherapy is one of the treatments of choice for patients with hematological or head and neck neoplasms. However, chemotherapy promotes elevate occurrence of adverse events and many of them directly impact nutritional status and patients' quality of life, which may include a low treatment tolerance. Suggested mechanisms include inflammation and oxidative stress as contributing factors to adverse effects of chemotherapy.

Body fat is related with poor motor skills and physical fitness in socially assisted children and adolescents regardless of age, sex, and body mass index.

Objective: To analyze the relationship between body fat, motor skills, and physical fitness in children and adolescents.

Methods: 216 children and adolescents (143 males and 73 females, aged 5-15 years) from a social project composed this study. Body mass and height were measured to calculate the body mass index (BMI).

New potential susceptibility factors contributing to tomato bacterial spot disease.

The label-free shotgun proteomics analysis carried out in this study aimed to understand the molecular mechanisms that contribute towards tomato susceptibility to Xanthomonas euvesicatoria pv. perforans (Xep). To achieve this, comparative proteomics was performed on susceptible inoculated plants with the bacterium and the control group (saline solution) at 24 and 48 h after inoculation (hai).

SURVEY OF Salmonella spp., Escherichia coli and Staphylococcus aureus IN ARDEIDS: INVESTIGATION OF POTENTIAL RESERVOIRS.

Ardeids are wild birds well adapted to urban and periurban environments. However, the association of wildlife with humans and livestock increases the chances of transmission of microorganisms between wild animals, domestic animals and humans. The present study aimed to investigate the occurrence of Salmonella spp.

Neuropsychiatric manifestations in systemic lupus erythematosus and Sjogren's disease.

Introduction: Autoimmune diseases often present in a systemic manner, affecting various organs and tissues. Involvement of the central and peripheral nervous system is not uncommon in these conditions and is associated with high morbidity and mortality. Therefore, early recognition of the neuropsychiatric manifestations associated with rheumatologic diseases is essential for the introduction of appropriate therapies with the objective of providing a better quality of life for individuals.

Pharmacogenetic Testing in Admixed Populations: Frequency of the AMR PGx Working Group Tier 1 Variant Alleles in Brazilians.

This article examines the frequency distribution of Tier 1 pharmacogenetic variants of the Association for Molecular Pathology Pharmacogenomics Working Group Recommendations in two large (>1.000 individuals) cohorts of the admixed Brazilian population, and in patients from the Brazilian Public Health System enrolled in pharmacogenetic trials. Three Tier 1 variants, all in DPYD, were consistently absent, which may justify their non-inclusion in genotyping panels for Brazilians; 13 variants had frequency < 1.

Six-month safety and efficacy outcomes from the randomized-controlled arm of the WRAPSODY Arteriovenous Access Efficacy (WAVE) trial.

Stenosis within the arteriovenous fistula (AVF) of hemodialysis patients leads to vascular access dysfunction and inadequate hemodialysis. Percutaneous transluminal angioplasty (PTA) is the standard therapy for stenosis. However, rates of restenosis and loss of access patency remain high.

Insights into the use of DNA content in head and neck squamous cell carcinoma as a method for patient stratification and targeted therapy: Revisiting old concepts and exploring new possibilities.

Background: This review aimed to emphasize the implications of DNA content in head and neck squamous cell carcinoma (HNSCC), focusing on its predictive value, role in patient stratification, and potential as a therapeutic target for this malignancy.

Methods: A narrative review of the literature was conducted through electronic database searches.

Results: In conventional HNSCC, aneuploid tumors are associated with increased lymph node metastasis, locoregional recurrences, poor response to radiotherapy and chemotherapy, and worse prognosis.

Current level, sources, and risk of human exposure to PAHs, PBDEs and PCBs in South American outdoor air: A critical review.

This study provides comprehensive overview of the current level, sources and human exposure risk to hazardous polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs) in South American outdoor air. Research documents were obtainable for only 6 countries within the target period (2014 - 2024). For all contaminants, urban concentrations exceeded that of rural/remote locations.

ALTERNATIVE BIOLOGICAL MODELS FOR EVALUATION OF THE TOXIC, GENOTOXIC AND MUTAGENIC POTENTIAL OF Ectatomma brunneum Smith VENOM.

The venom of Ectatomma brunneum is considered promising for drugs development. Therefore, it is important to evaluate its toxic potential and genetic instability using biological assays. To this end, toxicity assays were performed with Artemia salina, cytotoxicity and genotoxicity with Allium cepa and mutagenicity with Ames.

Indobufen versus aspirin in patients with indication for antiplatelet therapy: A systematic review and meta-analysis.

Introduction: Aspirin is commonly recommended for individuals who have experienced stroke or myocardial infarction (MI). Indobufen, a cyclooxygenase-1 inhibitor, has been studied as a potential alternative. We conducted a meta-analysis and trial sequential analysis (TSA) to compare indobufen with aspirin in patients requiring antiplatelet therapy.

Safety and efficacy of satralizumab in patients with generalised myasthenia gravis (LUMINESCE): a randomised, double-blind, multicentre, placebo-controlled phase 3 trial.

Background: Evidence from preclinical studies suggests that IL-6 signalling has the potential to modulate immunopathogenic mechanisms upstream of autoantibody effector mechanisms in patients with generalised myasthenia gravis. We aimed to assess the safety and efficacy of satralizumab, a humanised monoclonal antibody targeting the IL-6 receptor, in patients with generalised myasthenia gravis.

Methods: LUMINESCE was a randomised, double-blind, placebo-controlled, multicentre, phase 3 study at 105 sites, including hospitals and clinics, globally.

Long-term human influence on the demography and genetic diversity of the hyperdominant Bertholletia excelsa in the Amazon Basin.

The Amazon rainforest is characterized by a limited number of hyperdominant trees that play an oversized role in its ecosystems, nutrient cycle, and rainfall production. Some of these, such as the Brazil nut, appear to have been intensively exploited and dispersed by Indigenous populations since their earliest arrival in this part of South America around 13,000 years ago. However, the genetic diversity-and geographic structure-of these species remains poorly understood, as does their exact relationship with past human land use.

Small forest patches and landscape-scale fragmentation exacerbate forest fire prevalence in Amazonia.

Over recent decades, forest fire prevalence has increased throughout the tropics, necessitating improved understanding of the landscape-scale drivers of fire occurrence. Here, we use MapBiomas land-cover and fire scar data to evaluate relationships between forest fragmentation, land-use, and forest fire prevalence in a typically consolidated Amazonian agricultural frontier: Portal da Amazonia, Mato Grosso, Brazil. Using zero-/zero-one-inflated Beta regressions, we investigate effects of forest patch (area, shape, surrounding forest cover) and landscape-scale variables (forest edge length, land-cover composition) on forest fire occurrence and density between 1985 and 2021.

Natural infection and diversity of hemotropic mycoplasmas in free-ranging Geoffroy's cat (Leopardus geoffroyi) and margay cat (Leopardus wiedii) populations in Southern Brazil.

Hemoplasma infection significantly impacts felines health, yet there is a research gap regarding free-ranging wild small felids. Therefore, this study aimed to investigate the occurrence of hemoplasma in Leopardus geoffroyi and Leopardus wiedii in southern Brazil. For this purpose, we conducted molecular research for Mycoplasma spp.

Physiological and behavioral effects of titanium dioxide nanoparticle exposure on stingless bee foragers.

Bee population decline is associated with various stressors, including exposure to pollutants. Among these, titanium dioxide (TiO), an emerging nanoparticle (NP) pollutant, potentially affects living organisms, including bees. This study evaluates the impact of TiO NPs ingestion (1.

Three-dimensional kinematics in patients with anterior shoulder instability - A systematic review with meta-analysis.

Anterior Shoulder Instability (ASI) is a common orthopedic condition often resulting in altered shoulder kinematics. Understanding the biomechanics of the unstable shoulder is critical to determine the most appropriate treatment. This study aims to conduct the first systematic review and meta-analysis of three-dimensional (3D) shoulder kinematic studies in ASI patients.

Healthcare, socioeconomic and obstetric factors associated with the excess of cesarean sections in 880,000 births from the city of Rio de Janeiro, Brazil.

Objective: A study conducted in Rio de Janeiro aimed to identify the factors contributing to the high rate of cesarean deliveries in the city, which is over three times higher than the World Health Organization recommended. However, the city has a role in strategies and policies to empower primary care and to organize delivery care.

Methods: We conducted a cross-sectional study using the Live Birth Information System from 2012 to 2021.

Forensic characterization of Brazilian gemstones: A pilot study employing raman spectroscopy and multivariate analysis.

Forensic gemstone analysis faces many challenges. One of the most critical aspects of gemological research is the classification of a gemstone. It is necessary to understand the mineral species, purity, origin, and identification of treatments to identify and classify a gem correctly, as well as assign a monetary value to it.