Less cytotoxic phthalocyanine derivative promotes in vitro wound healing compared to chlorhexidine.

The use of adjunct chemical substances in the early postoperative period of periodontal surgical procedures is recommended due to the potential risk of trauma in the operated area. Chlorhexidine digluconate mouthwash is widely used but can cause adverse effects. Phthalocyanine derivatives are being studied as an alternative, demonstrating good antimicrobial activity, especially in the self-activated form, which does not require additional light or chemicals.

Scientific and Technological Prospecting on Polymeric Particles Containing Extracellular Matrix Peptides for the Treatment of Duchenne Muscular Dystrophy.

Duchenne muscular dystrophy is a neuromuscular disease with an overall incidence of between 1 in 5,000 newborn males. Carriers may manifest progressive muscle weakness, resulting from the progressive degeneration of skeletal muscles, generating cardiac and respiratory disorders. Considering the lack of effective treatments, different therapeutic approaches have been developed, such as protein synthesis and extracellular matrix derivatives that can be used to improve muscle regeneration, maintenance, or repair.

Food consumption and cardiovascular risk in children and adolescents living with HIV: a systematic review.

The aim of this systematic review was to summarize the dietary intake of children and adolescents living with HIV and its association with cardiovascular risk factors. PubMed/MEDLINE, Scopus, Web of Science, BIREME and LILACS were searched for original observational studies. The studies were extracted between June and August 2021, in addition to a manual search of references.

Clinical, pathological, and oncological outcomes in unclassified renal cell carcinoma compared to clear cell renal cell carcinoma.

Purpose: This study aims to assess the impact of unclassified renal cell carcinoma (uRCC) on clinical, pathological, and oncological outcomes compared with clear cell renal cell carcinoma (ccRCC).

Materials And Methods: We analyzed the data of 48 uRCC and 688 ccRCC cases, collected from a histopathological database at a single center from July 2011 to August 2019. uRCC cases were confirmed according to the 2016 World Health Organization classification.

: A Model Eukaryotic Organism for Astrobiological Studies on Microbial Interactions with Martian Soil Analogs.

The exploration of our solar system for microbial extraterrestrial life is the primary goal of several space agencies. Mars has attracted substantial attention owing to its Earth-like geological history and potential niches for microbial life. This study evaluated the suitability of the polyextremophilic fungal strain LaBioMMi 1217 as a model eukaryote for astrobiology.

Chiral Oxazoline-Triazole-Benzothiazole Molecular Triads: Photoactive Sensors for Enantioselective Carbohydrate Recognition in Solution.

Understanding the mechanism of drug action in biological systems is facilitated by the interactions between small molecules and target chiral biomolecules. In this context, focusing on the enantiomeric recognition of carbohydrates in solution through steady-state fluorescence emission spectroscopy is noteworthy. To this end, we have developed a third generation of chiral optical sensors for carbohydrates, distinct from all of those previously presented, which interact with carbohydrates to form non-covalent probe-analyte interactions.

Biologic Augmented Scaffold-based cartilage repair: Addressing Complications and Enhancing Outcomes.

Cartilage repair remains a significant challenge due to the tissue's limited innate regenerative capacity. Despite advances in techniques such as microfracture, autologous chondrocyte implantation (ACI), and osteochondral grafting, long-term outcomes are often compromised by complications, including suboptimal tissue integration, graft resorption, and mechanical instability. Recently, biologically augmented scaffold-based cartilage repair has emerged as a promising approach for full-thickness osteochondral lesions.

Oral Hyaluronic Acid in Osteoarthritis and Low Back Pain: A Systematic Review.

Background: Hyaluronic acid (HA) has been largely used in clinical practice for rheumatic diseases. However, the effects of oral HA on these diseases are poorly understood.

Aim: To review articles evaluating oral HA's effects on rheumatic patients.

Interest, uptake, and feasibility trial of a real-life digital health intervention to improve lifestyle in Brazil.

Objective: Promoting healthy lifestyle behaviors is essential for preventing and managing chronic and mental health conditions. This study aims to present a digital health platform accessible via PC or smartphone, , designed to foster lifestyle change among the Brazilian population. It evaluates interest, uptake, acceptability, usability, adherence, and retention over 12 weeks.

Epidemiology of Methicillin-resistant Colonization in Neonates within Neonatal Intensive Care Units: A Systematic Review and Meta-analysis.

Introduction: Methicillin-resistant (MRSA) colonization in neonatal intensive care units (NICUs) is a significant global health concern, leading to severe infections, extended hospital stays, and substantial economic burdens on health-care systems. To develop effective infection control strategies, we need to fill existing gaps in our understanding of MRSA epidemiology in neonates. The aim of this systematic review is to provide an extensive analysis of the proportion of MRSA colonizations in NICUs.

IgM against Merozoite Surface Protein 1-Block 2 Haplotypes as New Tools for Infections.

Introduction: The tools to distinguish relapse from reinfection are needed in malaria-endemic areas. We evaluated seroprevalence against sets of specific peptides to the block 2 region of -merozoite surface protein-1 (PvMSP1) to detect parasite clones.

Methods: We applied amplicon deep sequencing (ADS) of block 2 region of the MSP-1 gene () to determine cocirculating parasite clones within eight -infected individuals.

Prevalence and location of myofascial trigger points in dogs with osteoarthritis.

Introduction: This study was designed to determine the prevalence of myofascial pain and the location of myofascial trigger points (MTPs) in dogs with osteoarthritis.

Methods: Thirty-five dogs were selected and examined for the presence of MTPs using palpation. Assessments were performed independently by two examiners.

REFRAMING FEMINIST IDEAS, CHALLENGING STATE INCORPORATION: Activism Against Violence and the Feminicídio Law in Brazil.

Feminist debates on how the state incorporates and reshapes feminist categories of violence reveal unintended consequences, such as the depoliticization of these ideas. Through a case study of the Feminicídio Law in Brazil, I examine feminist writings on , following its state incorporation as a criminal category, to address the killing of women based on gendered reasons. Drawing on materialist feminist discourse analysis, I challenge the notion that institutionalization necessarily leads to depoliticization.

Impact of the COVID-19 pandemic on small vulnerable newborns: an interrupted time series analysis in Peru and Brazil.

Background: We examined COVID-19's impact on the number of small vulnerable newborns (SVN) at national and regional levels in Peru and Brazil.

Methods: Using national birth registries, we examined monthly numbers of preterm (PT), low birthweight (LBW), and small for gestational age (SGA) newborns. We analysed COVID-19's impact on SVN using two interrupted time series models.

Investigating novel pharmacological strategies for treatment-resistant depression: focus on new mechanisms and approaches.

Introduction: A substantial number of patients exhibit treatment-resistant depression (TRD), posing significant challenges to clinicians. The discovery of novel molecules or mechanisms that may underlie TRD pathogenesis and antidepressant actions are highly needed.

Areas Covered: Using the PubMed database, the authors searched for emerging evidence of novel approaches for TRD based on experimental and human studies.

Unraveling the relationship between facial neuropathic conditions and pain, sleep, chronotypes, bruxism, and psychosocial factors.

Objective: This cross-sectional study evaluated associations between sleep disorders, pain, bruxism, and chronotypes in patients with trigeminal neuralgia (TN) or post-herpetic neuralgia (PHN) in orofacial area.

Methods: Ninety-four subjects (25 TN, 14 PHN, 55 controls) were evaluated for pain, sleep, chronotype, anxiety, depression, oral behaviors, and lifestyle by validated instruments. Bruxism was assessed by self-report.

Trans-ancestry genome wide association study of childhood body mass index identifies novel loci and age-specific effects.

Over the past 30 years, obesity prevalence has markedly increased globally, including among children. Although genome-wide association studies (GWAS) have identified over 1,000 genetic loci associated with obesity-related traits in adults, the genetic architecture of childhood obesity is less well-characterized. Moreover, most childhood obesity GWAS have been restricted to severely obese children, in relatively small sample sizes, and in primarily European ancestry populations.

An updated systematic review with meta-analysis and meta-regression of the factors associated with human visceral leishmaniasis in the Americas.

Background: Human visceral leishmaniasis (VL) is a systemic disease with high case-fatality rates and a widespread distribution. Continuous evaluation of the risk factors for VL is essential to ensure the effective implementation of prevention and control measures. The present study reviews the factors associated with VL in the Americas.

The association of previous and current non-chronic low back pain with daily physical activity in middle- and older-aged adults.

Background: Low back pain (LBP) is a leading cause of years lived with disability. However, the association of non-chronic LBP with levels of daily physical activity (PA) remains poorly explored. This study investigated the association between previous and current non-chronic LBP with daily PA and compliance with PA recommendations in middle and older-aged adults.

Global seroprevalence of Toxoplasma gondii in pregnant women: a systematic review and meta-analysis.

Background: Toxoplasmosis in pregnancy is associated with serious and irreversible maternal and fetal detrimental consequences. Also, different seroprevalence of Toxoplasma gondii in pregnancy is reported in many countries. The present systematic review and meta-analysis study aimed to determine the global seroprevalence of Toxoplasma gondii in pregnant women.

Benefits of the Global Integration Method (Método de Integração Global - MIG) in functional priorities of parents of Brazilian children and adolescents with autism spectrum disorder.

Background: Understanding the priorities of parents of children and adolescents with autism spectrum disorder (ASD) is crucial for implementing evidence-based programs. This study aims to identify the functional priorities of parents of Brazilian children and adolescents with ASD, analyze variations in priorities according to the levels of support and age groups of the participants, and categorize the goals according to the categories of the International Classification of Functioning, Disability, and Health (ICF). Additionally, this study aimed to evaluate changes in parents' performance and satisfaction with functional priorities after intervention with the Global Integration Method (Métodode Integração Global - MIG).