Chronic treatment with nandrolone decanoate reduces left ventricular contractile response even when combined with strength training.

Introduction: The use of anabolic steroids is widely adopted for aesthetic purposes and sports performance. In supraphysiological doses, they can impair various physiological systems. However, we know little about their effects on the heart, especially when combined with strength training.

Fluorescence images of skin lesions and automated diagnosis using convolutional neural networks.

In recent years, interest in applying deep learning (DL) to medical diagnosis has rapidly increased, driven primarily by the development of Convolutional Neural Networks and Transformers. Despite advancements in DL, the automated diagnosis of skin cancer remains a significant challenge. Emulating dermatologists, deep learning approaches using clinical images acquired from smartphones and considering patient lesion information have achieved performance levels close to those of specialists.

Plasma Omega-3 Fatty Acids Are Not Associated with Muscle Strength, Regardless of Age or Protein Intake: National Health and Nutrition Examination Survey 2011-12.

Background & Aims: Muscle strength is a key predictor of both quality of life and mortality. Although numerous studies have investigated the relationship between omega-3 (ω-3) intake and muscle strength, the evidence remains inconclusive. Furthermore, it is unclear whether this association is influenced by protein intake.

In vitro evaluation of the antimicrobial effect of ZnO:9Ag nanoparticle and antibiotics on standard strains of Leptospira spp.

Silver nanoparticles are recognized for potent antimicrobial properties against pathogenic bacteria, crucial in addressing the severity of leptospirosis, where an ideal treatment is lacking. This study focuses on assessing the antimicrobial efficacy of silver-doped zinc oxide nanoparticles (ZnO:9Ag) on standard Leptospira spp. strains (six species and ten serovars).

Newly Isolated LAMA1607 for Enhanced Biological Phosphorus Removal: A Genomic and Functional Characterization.

Background: Enhanced biological phosphorus removal (EBPR) systems utilize phosphorus-accumulating organisms (PAOs) to remove phosphorus from wastewater since excessive phosphorus in water bodies can lead to eutrophication. This study aimed to characterize a newly isolated PAO strain for its potential application in EBPR systems and to screen for additional biotechnological potential. Here, sequencing allowed for genomic analysis, identifying the genes and molecules involved, and exploring other potentials.

Biodiversity and Antifungal Activities of Amazonian Actinomycetes Isolated from Rhizospheres of Plants.

Background: Actinobacteria are major producers of antibacterial and antifungal metabolites and are growing their search for substances of biotechnological interest, especially for use in agriculture, among other applications. The Amazon is potentially rich in actinobacteria; however, almost no research studies exist. Thus, we present a study of the occurrence and antifungal potential of actinobacteria from the rhizosphere of , a native South American plant and one that is economically useful in the whole of the Amazon.

Biosurfactant Production using URM 1150 and its Application in the Bioremediation of Coast Environments Impacted by Oil Spills.

Background: This study aimed to produce, characterize, and apply a biosurfactant as a bioremediation tool for oil-contaminated coastal environments.

Methods: The biosurfactant was produced in a medium containing 5.0% corn steep liquor and 1.

Impact of Vanessa's Law on the Reporting of Serious Adverse Events: A Retrospective Study Among Antiplatelet Users in a Tertiary-Care Cardiology Centre.

Background: Antiplatelet drugs, such as clopidogrel, ticagrelor, prasugrel, and acetylsalicylic acid, may be associated with a risk of adverse events (AEs). Vanessa's Law was enacted to strengthen regulations to protect Canadians from drug-related side effects (with mandatory reporting of serious adverse events [SAEs]).

Objective: To determine whether Vanessa's Law has led to an increase in SAE reporting among antiplatelet users.

Properties of Compounds Citral and Geraniol on : Activity in Vitro and Cytotoxicity.

Background: Avian trichomoniasis is an important disease that causes bird mortality, both wild and captive, around the world. This study evaluated the in vitro cytotoxicity, antioxidant, and antiparasitic activity of citral (3.7-Dimetil-2.

Implementation of the ProMisE classifier and validation of its prognostic impact in Brazilian endometrial carcinomas.

Purpose: Molecular classification of endometrial cancer (EC) has emerged as a key approach to individualize therapy and define prognostic outcomes. This study aimed to implement the traditional ProMisE classification in a Brazilian population, compared with a molecular setting of ProMisE biomarkers, and evaluate its impact on patients' prognosis.

Patient And Methods: A prospective cohort of 114 patients with primary EC treated at Barretos Cancer Hospital (BCH) between October 2020 and December 2022 was conducted.

Influence of the Chemical Structure of Perylene Derivatives on the Performance of Honey-Gated Organic Field-Effect Transistors (HGOFETs) and Their Application in UV Light Detection.

Electronics based on natural or degradable materials are a key requirement for next-generation devices, where sustainability, biodegradability, and resource efficiency are essential. In this context, optimizing the molecular chemical structure of organic semiconductor compounds (OSCs) used as active layers is crucial for enhancing the efficiency of these devices, making them competitive with conventional electronics. In this work, honey-gated organic field-effect transistors (HGOFETs) were fabricated using four different perylene derivative films as OSCs, and the impact of the chemical structure of these perylene derivatives on the performance of HGOFETs was investigated.

Ochronotic Arthropathy and Alkaptonuria (Ochronosis): Case Report.

Alkaptonuria (AKU) is a rare genetic condition resulting from a deficiency in the homogentisic acid oxidase enzyme, which is produced by the liver and kidneys, that interferes with the metabolism of the amino acids phenylalanine and tyrosine. Although it may not cause symptoms, AKU can lead to ochronosis, the abnormal accumulation in body tissues of a pigment called alkapton. Over time, this pigment accumulation in the joints may result in secondary osteoarthritis known as ochronotic arthropathy, the most debilitating form of the disease.

Association of Current and Long-Term Estradiol Use with Carotid Intima Media Thickness Among Transgender Women: A Cross-Sectional Study.

Purpose: Epidemiologic studies suggest that the transgender population has a higher burden of cardiovascular (CV) disease. We aimed to assess CV risk and investigate the relationship between estradiol (E2) or ethinylestradiol (EE) use and carotid intima media thickness (cIMT) in transgender women.

Methods: This is a cross-sectional analysis nested into a transgender-specific cohort in Rio de Janeiro, Brazil, from August 2015 to February 2018.

Factors Associated with Transgender-Based Discrimination Among and Transgender Women in Rio de Janeiro, Brazil.

Purpose: Transgender-based discrimination is associated with poor mental health, unemployment, and poverty. and transgender women (trans women) frequently experience transgender-based discrimination, but associated factors are understudied. Our objective was to identify the factors associated with transgender-based discrimination among trans women from Brazil.

A novel ensemble ARIMA-LSTM approach for evaluating COVID-19 cases and future outbreak preparedness.

Background: The global impact of the highly contagious COVID-19 virus has created unprecedented challenges, significantly impacting public health and economies worldwide. This research article conducts a time series analysis of COVID-19 data across various countries, including India, Brazil, Russia, and the United States, with a particular emphasis on total confirmed cases.

Methods: The proposed approach combines auto-regressive integrated moving average (ARIMA)'s ability to capture linear trends and seasonality with long short-term memory (LSTM) networks, which are designed to learn complex nonlinear dependencies in the data.

New insights into the putative role of leucine-rich repeat proteins of and their participation in host cell invasion: an analysis.

Pathogenic are spirochetes that cause leptospirosis, a worldwide zoonotic disease. Leptospirosis affects humans and animals, with approximately 1 million human infections and 60,000 deaths per year. The diversity of leptospiral strains and serovars allied to the fact that pathogenesis is not yet fully understood, make the development of an effective vaccine against leptospirosis a challenge.

Olmesartan-Induced Enteropathy: A Rare Case of Chronic Diarrhea.

The case involves a 63-year-old hypertensive man, taking antihypertensive medication (olmesartan) for the previous two years, who sought medical attention due to voluminous diarrhea, with several episodes per day and weight loss of 10 kg. He was submitted to a series of diagnostic procedures without elucidation and empirical treatment with unsuccessful outcome. After hospitalization for clinical stabilization and for presenting with duodenal atrophy, obtained by duodenal biopsy associated with negative markers for celiac disease, the patient was diagnosed with suspected olmesartan-induced enteropathy, showing rapid improvement of diarrhea after the drug was withdrawn, with weight regain in 6 months and normalization of the duodenal histological picture after 10 months.

Navigation Experience in Latin-American Spine Surgeons: A Survey.

Study Design: This is a cross-sectional survey.

Objectives:  This study aimed to evaluate the availability and knowledge of navigation technologies for educational purposes and patient management in spine surgeons in Latin America.

Methods: A cross-sectional study was conducted among Latin American Spine Association members using a comprehensive 16-question survey to evaluate their knowledge and practices regarding navigation in spinal surgery.

Disparities in PrEP use and unmet need across PEPFAR-supported programs: doubling down on prevention to put people first and end AIDS as a public health threat by 2030.

Background: In 2023, an estimated 1.3 million people newly acquired HIV. In the same year, 3.

Effect of Graphene-Based Coating 3D Printing Process on the Remanence and Corrosion of Sintered NdFeB Magnets.

This study describes a 3D fused deposition modeling (FDM) printing process using a graphene-impregnated polylactic acid (G-PLA) filament to create a new type of rigid, plastic, nonconductive, and anticorrosion layer. Therefore, the possibility of 3D printing a plastic layer using FDM methods is demonstrated herein. A commercial magnet such as N35 NdFeB can be used to produce an efficient shielding film by additive manufacturing.

Snaplage residue as a fiber source for finishing beef cattle under grazing: effects on residue characteristics, cattle behavior and performance, and carcass traits.

The snaplage residue presents itself as a potential alternative roughage source in finishing systems, owing to its high fiber concentration which aids in maintaining rumen health. Nevertheless, the performance of animals will hinge on both the allowance and the nutritive value it offers. This study aimed to evaluate different stocking rates of heifers grazing snaplage residue as an exclusive source of fiber on finishing phase performance.