18 results match your criteria: "Brazil (M.S.B.); and Center for Healthcare Advancement and Outcomes[Affiliation]"
Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma.
N Engl J Med
August 2024
From Clinica São Germano (V.H.) and Hospital das Clínicas and Instituto do Câncer do Estado de São Paulo, Universidade de São Paulo (G.A.M.), São Paulo, Centro de Pesquisa e Ensino em Saúde de Santa Catarin, Florianópolis (A.C.R.A.), and Universidade da Região de Joinville and Centro de Hematologia e Oncologia, Joinville (M.P.L.) - all in Brazil; Medical University of Lodz, Lodz (P.R.), Medical University of Lublin, Lublin (M.H., M.M.), and the Medical University of Silesia, Katowice (S.G.) - all in Poland; Gorodskaya Klinicheskaya Bol'nitsa Imeni Saint Petersburg Botkina, Moscow (V.Z.); the Royal North Shore Hospital (C.W.) and Liverpool Hospital (A.B.), Sydney, Royal Prince Alfred Hospital and University of Sydney, Camperdown, NSW (P.J.H.), and Pindara Private Hospital, Gold Coast, QLD (H.S.) - all in Australia; the Department of Hematooncology, University Hospital Ostrava, and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic (R.H.); Sungkyunkwan University and Samsung Medical Center, Seoul, South Korea (K.K.); Institut Català d'Oncologia-L'Hospitalet de Llobregat-Barcelona, Barcelona (A.M.S.B.), Institut Català d'Oncologia and Josep Carreras Research Institute, Hospital Germans Trias i Pujol, Badalona (A.O.), and Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca, Centro de Investigación del Cáncer, Ciberonc, Salamanca (M.-V.M.) - all in Spain; Cross Cancer Institute, Edmonton (I.S.), and GSK, Mississauga (H.B.) - both in Canada; the Hematology Unit, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori," IRST IRCCS, Meldola (C.C.), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli," Bologna (M.C.) - both in Italy; Christchurch Hospital, Christchurch, New Zealand (P.G.); National and Kapodistrian University of Athens, Athens (M.D.); the First Affiliated Hospital of Soochow University, Suzhou, China (C.F.); University Hospitals of Leicester NHS Trust, Leicester (M.G.), GSK, Stevenage (A.M., S.M.), and GSK, London (L.E.) - all in the United Kingdom; University of Kansas Cancer Center, Fairway (A.-O.A.); the Department of Hematology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel (M.E.G.); Rocky Mountain Cancer Centers-Denver-Midtown, Denver (R. Rifkin); Matsuyama Red Cross Hospital, Matsuyama, Japan (T.F.); GSK, Upper Providence, PA (N.P., X.Z., R. Rogers, S.R.-G., J.O.); and GSK, Durham (M.N.), and GSK, Research Triangle Park (E.L.) - both in North Carolina.
Background: Belantamab mafodotin had single-agent activity in patients with relapsed or refractory multiple myeloma, a finding that supports further evaluation of the agent in combination with standard-care therapies.
Methods: In this phase 3, open-label, randomized trial, we evaluated belantamab mafodotin, bortezomib, and dexamethasone (BVd), as compared with daratumumab, bortezomib, and dexamethasone (DVd), in patients who had progression of multiple myeloma after at least one line of therapy. The primary end point was progression-free survival.
Increased Progression-Free Survival with Cabozantinib Versus Placebo in Patients with Radioiodine-Refractory Differentiated Thyroid Cancer Irrespective of Prior Vascular Endothelial Growth Factor Receptor-Targeted Therapy and Tumor Histology: A Subgroup Analysis of the COSMIC-311 Study.
Thyroid
March 2024
Department of Medical Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Article Synopsis
- Lenvatinib and sorafenib are common first-line treatments for advanced thyroid cancer that doesn't respond to iodine therapy, but many patients become resistant to these drugs.
- The COSMIC-311 phase 3 study found that cabozantinib provided significant clinical benefits for patients who progressed on previous treatments, showing better progression-free survival (PFS) and response rates compared to placebo.
- The study involved 258 patients with various thyroid cancer histologies, revealing 16.6 months of median PFS for cabozantinib versus just 3.2 months for placebo in those who had previously used sorafenib, indicating cabozantinib's effectiveness.
Coronary Computed Tomography Angiography Versus Invasive Coronary Angiography in Stable Chest Pain: A Meta-Analysis of Randomized Controlled Trials.
Circ Cardiovasc Imaging
November 2023
Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.B., R.C.).
Background: The efficacy of coronary computed tomography angiography (CCTA) versus invasive coronary angiography (ICA) among patients with stable chest pain has been studied in several trials with conflicting results.
Methods: We performed a systematic review and meta-analysis comparing CCTA first versus direct ICA among patients with stable chest pain, who were initially referred to ICA. PubMed, EMBASE, and Cochrane Central were searched for randomized controlled trials comparing the 2 strategies.
Efficacy of Ozone Therapy in the Treatment of Tinnitus: A Systematic Review.
Int Tinnitus J
March 2022
Department of Otolaryngology, University of Brasilia, Brazil.
Background: Tinnitus is a frequent complaint in otorhinolaryngology. The symptoms of tinnitus those are severe enough to significantly affect the quality of life. Numerous therapeutic interventions and studies claim success in the treatment of tinnitus, but the cure remains undefined.
View Article and Find Full Text PDFCardiac MRI for Patients with Increased Cardiometabolic Risk.
Radiol Cardiothorac Imaging
April 2021
Department of Medicine, Cardiology Service (C.P., R.S., E.A.H.) and Department of Radiology (P.G.P., R.L.), Walter Reed National Military Medical Center, Bethesda, Md; Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, Md (C.P., R.S., P.G.P., R.L., E.A.H.); PeaceHealth Medical Group, Bellingham, Wash (K.S.); University Hospital, University of São Paulo School of Medicine, São Paulo, Brazil (M.S.B.); Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brazil (M.S.B.); and DASA São Paulo, São Paulo, Brazil (M.S.B.).
Cardiac MRI (CMR) has rich potential for future cardiovascular screening even though not approved clinically for routine screening for cardiovascular disease among patients with increased cardiometabolic risk. Patients with increased cardiometabolic risk include those with abnormal blood pressure, body mass, cholesterol level, or fasting glucose level, which may be related to dietary and exercise habits. However, CMR does accurately evaluate cardiac structure and function.
View Article and Find Full Text PDFSpatially Weighted Calcium Score Beyond Power of Zero: Worth the Effort?
Circ Cardiovasc Imaging
January 2021
Division of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX (K.N.).
More Evidence Supporting Fluorodeoxyglucose Positron Emission Tomography for Diagnosing Prosthetic Valve Infective Endocarditis.
Circulation
October 2018
Departments of Medicine and Radiology, Cardiovascular Imaging Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.B.).
Impact of Coronary Remodeling on Fractional Flow Reserve.
Circulation
February 2018
Department of Cardiology, Imperial College of London, UK (P.W.S.)
Not Every Coronary Artery Calcium Is the Same: Implications of Novel Measurements for Clinical Practice?
Circ Cardiovasc Imaging
October 2017
From the Preventive Medicine Center Hospital Israelita Albert Einstein & School of Medicine, Faculdade Israelita de Ciência da Saúde Albert Einstein, São Paulo, Brazil (M.S.B.); Center for Clinical and Epidemiological Research, University Hospital & São Paulo State Cancer Institute, University of São Paulo, Brazil (M.S.B.); and Center for Healthcare Advancement and Outcomes, Baptist Health South Florida, Miami, Florida (K.N.).
Response by Hulten et al to Letter Regarding Article, "Coronary Computed Tomography Angiography in the Evaluation of Chest Pain of Suspected Cardiac Origin".
Circulation
January 2017
From Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.V., R.B.); Cardiology Service, Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD (E.H.); Center for Clinical and Epidemiological Research, University Hospital and Sao Paulo State Center Institute-University of São PauloSão Paulo, Brazil (M.S.B.); and Preventive Medical Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B.).
Presence of Late Gadolinium Enhancement by Cardiac Magnetic Resonance Among Patients With Suspected Cardiac Sarcoidosis Is Associated With Adverse Cardiovascular Prognosis: A Systematic Review and Meta-Analysis.
Circ Cardiovasc Imaging
September 2016
From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Background: Individuals with cardiac sarcoidosis have an increased risk of ventricular arrhythmia and death. Several small cohort studies have evaluated the ability of late gadolinium enhancement (LGE) by cardiac magnetic resonance imaging (MRI) to predict adverse cardiovascular events. However, studies have yielded inconsistent results, and some analyses were underpowered.
View Article and Find Full Text PDFEuropean Society of Cardiology-Recommended Coronary Artery Disease Consortium Pretest Probability Scores More Accurately Predict Obstructive Coronary Disease and Cardiovascular Events Than the Diamond and Forrester Score: The Partners Registry.
Circulation
July 2016
From the Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute, University of São Paulo School of Medicine, Sao Paulo, Brazil (M.S.B.); Cardiovascular Imaging Program, Departments of Medicine and Radiology; Brigham and Women's Hospital; Harvard Medical School, Boston, MA (M.S.B., E.H., M.D.C., R.B.); Preventive Medicine Center, Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B.); Cardiology Service, Department of Internal Medicine, Walter Reed National Military Medical Center, Bethesda, MD (E.H.); Department of Medicine, University of Chicago, Chicago, IL (T.S.P.); Cardiac MR PET CT Program, Department of Radiology, Division of Cardiac Imaging, Massachusetts General Hospital; Harvard Medical School, Boston (U.H., S.A.); Baptist Health South Florida, Miami, FL (K.N.); and Department of Radiology, University of Texas Southwestern, Dallas (S.A.).
Article Synopsis
- The study aimed to compare the effectiveness of the Diamond-Forrester (DF) score against two CAD consortium scores for predicting obstructive coronary artery disease (CAD) in patients.
- The study involved 2,274 patients undergoing coronary computed tomographic angiography, and the results showed that the DF score significantly overestimated the prevalence of obstructive CAD, while the CAD consortium scores provided better accuracy and discrimination.
- The findings suggest that using the CAD consortium scores could potentially reduce unnecessary testing for CAD and better identify patients who truly need further evaluation.
Coronary Computed Tomography Angiography in the Evaluation of Chest Pain of Suspected Cardiac Origin.
Circulation
May 2016
From Center for Clinical and Epidemiological Research, University Hospital & São Paulo State Cancer Institute, University of São Paulo School of Medicine, Brazil (M.S.B.);Preventive Medicine Center, Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B.);Cardiology Service, Department of Internal Medicine, Walter Reed National Military Medical Center, Bethesda, MD (E.A.H.); andCardiovascular Imaging Program, Departments of Medicine and Radiology; Brigham and Women's Hospital; Harvard Medical School, Boston, MA (V.V., R.B.).
Clinical Outcomes After Evaluation of Stable Chest Pain by Coronary Computed Tomographic Angiography Versus Usual Care: A Meta-Analysis.
Circ Cardiovasc Imaging
April 2016
From the Center for Clinical and Epidemiological Research, University Hospital and State of São Paulo Cancer Institute (ICESP) (M.S.B.) and Heart Institute (C.E.R.), University of São Paulo, São Paulo, Brazil; Preventive Medicine Center, Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B.); Department of Medicine (Cardiology Service), Walter Reed National Military Medical Center, Bethesda, MD (E.A.H.); Division of Cardiovascular Medicine, Department of Medicine, University of Michigan, Ann Arbor (V.L.M.); and Non-Invasive Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (M.C., M.D.C., R.B.).
Background: Limited data exist on how noninvasive testing options compare for evaluating patients with suspected stable coronary artery disease. In this study, we have performed a meta-analysis of randomized controlled trials comparing the use of coronary computed tomographic angiography (CTA) with usual care.
Methods And Results: We systematically searched databases for randomized clinical trials comparing coronary CTA with usual care for the evaluation of stable chest pain with follow-up for cardiovascular outcomes.
Changes in Whole-Plant Metabolism during the Grain-Filling Stage in Sorghum Grown under Elevated CO2 and Drought.
Plant Physiol
November 2015
Laboratory of Plant Physiological Ecology, Department of Botany, Institute of Biosciences, University of Sao Paulo, 05508-090 Sao Paulo, Brazil (A.P.D.S., A.C.G., M.S.B.); andDepartment of Molecular Genetics (J.-C.C., A.P.A.) and Center for Applied Plant Sciences (J.-C.C.), The Ohio State University, Columbus, Ohio 43210
Projections indicate an elevation of the atmospheric CO2 concentration ([CO2]) concomitant with an intensification of drought for this century, increasing the challenges to food security. On the one hand, drought is a main environmental factor responsible for decreasing crop productivity and grain quality, especially when occurring during the grain-filling stage. On the other hand, elevated [CO2] is predicted to mitigate some of the negative effects of drought.
View Article and Find Full Text PDFCoronary artery disease detected by coronary computed tomographic angiography is associated with intensification of preventive medical therapy and lower low-density lipoprotein cholesterol.
Circ Cardiovasc Imaging
July 2014
From the Noninvasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Boston, MA (E.H., M.S.B., A.S., D.O., M.P.C., W.O., M.L.S., F.F.R., J.K., J.H., M.F.D.C., R.B.); Cardiology Service, Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD (E.H.); Center for Clinical and Epidemiological Research, Division of Internal Medicine, University of São Paulo, São Paulo, Brazil (M.S.B.); Cardiac MR PET CT Program, Department of Radiology, Division of Cardiac Imaging (S.A., T.J.B., U.H., B.B.G.), and Division of Cardiology (Q.A.T.), Massachusetts General Hospital, Harvard Medical School, Boston; Center for Wellness and Prevention Research, Baptist Health South Florida, Miami (K.N.); and Cleveland Clinic Foundation, OH (R.H.).
Background: Coronary computed tomographic angiography (CCTA) is an accurate test for the identification of coronary artery disease (CAD), yet the impact of CCTA results on subsequent medical therapy and risk factors has not been widely reported.
Methods And Results: We identified consecutive patients aged >18 years without prior CAD who underwent CCTA from 2004 to 2011 and had complete data on medications before and after CCTA. CCTA results were categorized as no CAD, <50% stenosis, and ≥50% stenosis.
CXCR3 controls T-cell accumulation in fat inflammation.
Arterioscler Thromb Vasc Biol
July 2014
From the Division of Cardiovascular Medicine (V.Z.R., E.J.F., T.C., G.K.S., E.H.C.T., P.L.), Division of Gastroenterology, Department of Medicine (C.O., D.E.C.), and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (Y.S.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Lipid Clinic Cardiopulmonary Division, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil (V.Z.R., R.D.S.); Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China (E.H.C.T.); Center for Clinical and Epidemiological Research, Division of Internal Medicine, University Hospital, University of São Paulo Medical School, São Paulo, Brazil (M.S.B.); and Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (A.D.L.).
Objective: Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine (C-X-C motif) receptor 3 (CXCR3) participates in T-cell accumulation in AT of obese mice and thus in the regulation of local inflammation and systemic metabolism.
Approach And Results: Obese wild-type mice exhibited higher mRNA expression of CXCR3 in periepididymal AT-derived stromal vascular cells compared with lean mice.
The mechanism of synthesis of a mixed-linkage (1-->3), (1-->4)beta-D-glucan in maize. Evidence for multiple sites of glucosyl transfer in the synthase complex.
Plant Physiol
August 1999
Instituto de Botanica, Secao de Fisiologia e Bioquimica Plantas, Caixa Postal 4005, CEP-01061970, Sao Paulo, SP Brazil (M.S.B.).
We examined the mechanism of synthesis in vitro of (1-->3), (1-->4)beta-D-glucan (beta-glucan), a growth-specific cell wall polysaccharide found in grasses and cereals. beta-Glucan is composed primarily of cellotriosyl and cellotetraosyl units linked by single (1-->3)beta-linkages. The ratio of cellotriosyl and cellotetraosyl units in the native polymer is strictly controlled at between 2 and 3 in all grasses, whereas the ratios of these units in beta-glucan formed in vitro vary from 1.
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