Dementia Care Research and Psychosocial Factors.

Background: Recognizing Alzheimer's disease (AD) early is essential for enhancing patient outcomes. Therefore this research focused on exploring indicators of AD by investigating the role of declining financial capacity (FC) in predicting objetive cognitive impairment (OCI).

Method: We analyzed participants without OCI in Mini-mental state examination (MMSE, Table 1) or Clinical Dementia Rating-Sum of Boxes (CDR-SB, Table 2) scores from the ADNI database.

Dementia Care Research and Psychosocial Factors.

Background: Several studies have shown that financial capacity constitutes a vital component of instrumental activities of daily living. However, there is insufficient research investigating the relationship between financial impairment, brain volume changes and cognitive decline in Alzheimer's disease (AD). Here, we examine the association between brain volume changes and financial capacity in cognitively unimpaired (CU) and mild cognitively impaired (MCI) individuals.

Dementia Care Research and Psychosocial Factors.

Background: Caregivers of people with dementia (PwD) often experience the burden of caregiving and depressive symptoms that may be associated. PwD who experience a higher occurrence of neuropsychiatric symptoms often cause a greater burden on their caregivers due to the difficulty in managing these symptoms. Caregivers may transfer their feelings of frustration and exhaustion with caregiving through the way they communicate with the PwD.

Dementia Care Research and Psychosocial Factors.

Background: Although primary progressive aphasia (PPA) is considered a rarer form of dementia, individuals living with PPA are increasingly identified by healthcare professionals. Research investigating speech-language assessment and intervention in PPA has been conducted primarily in monolingual speakers and little is known about clinical decision-making of speech-language pathologists (SLPs) working with bilinguals with PPA.

Methods: A comprehensive survey containing questions regarding clinician confidence, prioritization, and ratings of basic competency for Volkmer, Cartwright, Ruggero et al.

Dementia Care Research and Psychosocial Factors.

Background: Caregivers of people with dementia (PwD), assuming the responsibility for another life, can become physically and emotionally overwhelmed, leading to increased psychiatric symptoms such as anxiety and depression. Similarly, the level of neuropsychiatric symptoms in PwD is associated with caregiver burden. Faced with this burden and the challenges of managing dementia, caregivers may potentially channel their feelings of frustration and exhaustion from caregiving into the way they communicate with the person with dementia.

Dementia Care Research and Psychosocial Factors.

Background: The number of people with dementia (PWD) is increasing worldwide, and especially in low- and middle-income countries (LMIC). Dementia's burden extends beyond mortality and healthcare costs. In LMIC, dementia indirect costs are proportionally higher.

Dementia Care Research and Psychosocial Factors.

Background: Low- and middle-income countries (LMIC) share characteristics, such as low education, that increase the risk of dementia among their population. Critically, around 70% of the cases of dementia in LMICs are underdiagnosed. Understanding factors contributing to older adults' cognitive performance may support healthcare professionals from these countries in their decision-making process when screening for cognitive decline in their communities.

Dementia Care Research and Psychosocial Factors.

Background: Amyloid and tau pathologies are the hallmarks of Alzheimer's disease (AD). Previous research indicated notable connections between financial capacity and AD biomarkers. Here, we aimed to understand whether financial capacity is affected by the cerebral accumulation of tau and amyloid.

Dementia Care Research and Psychosocial Factors.

Background: Informal care of older adults impacts the lives of millions worldwide. Critically, low- and middle-income countries have the highest proportion of dementia costs related to informal care. Research suggests that older adults' cognitive decline is associated with burden among caregivers, which corroborates the worsening in caregivers' quality of life and mental health.

Dementia Care Practice.

Background: Cognitive impairment is frequently undetected or undiagnosed in the early stages. To increase the rates of detecting cognitive impairment, the Early Detection program of the Davos Alzheimer's Collaborative System Preparedness (DAC-SP) implemented digital cognitive assessments (DCA) in primary care and other non-specialty settings.

Methods: The DAC-SP Early Detection program was initiated in 2021 in seven healthcare systems across six countries.

Dementia Care Practice.

Background: Early symptoms of cognitive impairment are frequently undetected. The Davos Alzheimer's Collaborative System Preparedness (DAC-SP) Early Detection program implemented a digital cognitive assessment (DCA) in primary care and other non-specialty settings to increase the rate of detection of cognitive impairment.

Methods: The DAC-SP Early Detection program was initiated in 2021 in seven healthcare systems across six countries.

Nine high-intensity sweeteners in beverages in a single LC-MS/MS analysis.

With the increasing demand for reduced sugar or sugar-free products by consumers with chronic non-communicable diseases and individuals seeking weight control, foods and beverages with high-intensity sweeteners (HIS) tend to become more common in the market. Therefore, monitoring HIS concentrations added to industrialised products is an important issue. Thus, an analytical method using LC-MS/MS was established and validated in order to allow the simultaneous determination of nine of these compounds in beverages marketed in Brazil.

Dementia Care Practice.

Background: Dementia syndromes are chronic health conditions that lead to significant cognitive decline and functional impairment, including acts of civil life. Concerning the latter, a guardianship petition maybe needed when patients or family are at risk.

Methods: Retrospective cross-sectional study of documentary research on 72 electronical guardianship proceedings involving adults with dementia.

Dementia Care Practice.

Background: Caregiver burden is the result of dealing with the dependency of the subject who needs attention and care. Caregivers of people with neuropsychiatric disease could experience emotional, physical and financial stress. The literature shows that the caregiver burden can negatively impact both, the caregiver and the patient.

Dementia Care Practice.

Introduction: Patients with severe cognitive impairment, with the progression of the disease, show behavioral impairments, loss of functionality and, in many cases, swallowing changes (dysphagia). Dysphagia comes with serious complications that can cause health damage, such as malnutrition, dehydration and serious lung damage secondary to aspirations. Eating process goes beyond nutritional intake, as it has a social, cultural, behavioral, physical and cognitive component.

Technology and Dementia Preconference.

Background: Anti-amyloid therapy appears to have an increased effect on reducing cognitive decline in amyloid- and tau-positive individuals. However, clinical trials inclusion criteria require solely amyloid positivity. Herein, we developed a machine-learning prediction model to identify tau positivity in amyloid-positive individuals using clinical variables.

Dementia Care Practice.

Introduction: Dementia numbers are increasing rapidly with a substantial contribution from low and middle-income countries. There's a limited number of reports in Brazil, mostly modest initiatives from south-eastern, more developed regions. With a population of approximately 1.

HDAC6: Tumor Progression and Beyond.

Histone Deacetylase 6 (HDAC6) is an intriguing therapeutic target in cancer re-search, distinguished as the only HDAC family member predominantly located in the cyto-plasm. HDAC6 features two catalytic domains and a unique ubiquitin-binding domain, which sets it apart from other HDACs. Beyond its role in histone deacetylation, HDAC6 targets vari-ous nonhistone substrates, such as α-tubulin, cortactin, Heat Shock Protein 90 (HSP90), and Heat Shock Factor 1 (HSF1).

Technology and Dementia Preconference.

Background: Screen failure due to amyloid negativity is yet a problem in clinical trials for anti-amyloid drugs. In this context, clinical characteristics of patients presenting with cognitive decline may decrease the screen failure ratio by increasing the odds of selecting individuals with brain amyloid pathology. Herein, we aimed at estimating amyloid and tau positivity in individuals using clinical variables in a machine learning model of prediction.

Lichen novelties from Corvo Island (Azores, Portugal).

Background: Corvo is a small and remote island in the western group of the Azores Archipelago, Portugal. The Island's lichen biodiversity was largely understudied, with only 17 species documented to date.

New Information: This study reports 68 new records of lichen species on Corvo Island, representing an addition of two classes, eight orders, 18 families and 43 genera.

Hospital-level volume in extracorporeal membrane oxygenation cases and death or disability at 6 months.

Objective: Extracorporeal membrane oxygenation (ECMO) is a high-risk procedure with significant morbidity and mortality and there is an uncertain volume-outcome relationship, especially regarding long-term functional outcomes. The aim of this study was to examine the association between ECMO centre volume and long-term death and disability outcomes.

Design Setting And Participants: This is a registry-embedded observational cohort study.

3D-Printed PCL-Based Scaffolds with High Nanosized Synthetic Smectic Clay Content: Fabrication, Mechanical Properties, and Biological Evaluation for Bone Tissue Engineering.

Background: The 3D printing of macro- and mesoporous biomimetic grafts composed of polycaprolactone (PCL) infused with nanosized synthetic smectic clay is a promising innovation in biomaterials for bone tissue engineering (BTE). The main challenge lies in achieving a uniform distribution of nanoceramics across low to high concentrations within the polymer matrix while preserving mechanical properties and biological performance essential for successful osseointegration.

Methods: This study utilized 3D printing to fabricate PCL scaffolds enriched with nanosized synthetic smectic clay (LAP) to evaluate its effects on structural, chemical, thermal, mechanical, and degradative properties, with a focus on in vitro biological performance and non-toxicity.

Vascular injury in glomerulopathies: the role of the endothelium.

In glomerulopathies, endothelial dysfunction and the presence of histological vascular lesions such as thrombotic microangiopathy, arteriolar hyalinosis, and arteriosclerosis are related to a severe clinical course and worse renal prognosis. The endothelial cell, which naturally has anti-inflammatory and anti-thrombotic regulatory mechanisms, is particularly susceptible to damage caused by various etiologies and can become dysfunctional due to direct/indirect injury or a deficiency of protective factors. In addition, endothelial regulation and protection involve participation of the complement system, factors related to angiogenesis, the renin-angiotensin system (RAS), endothelin, the glycocalyx, the coagulation cascade, interaction between these pathways, interactions between glomerular structures (the endothelium, mesangium, podocyte, and basement membrane) and interstitial structures (tubules, arterioles and small vessels).

Post-Degradation Recovery of CsPbI Quantum Dot Solar Cells.

The stability of perovskite quantum dot solar cells is one of the key challenges of this technology. This study reveals the unique degradation behavior of cesium lead triiodide (CsPbI) quantum dot solar cells. For the first time, it is shown that the oxygen-induced degradation and performance loss of CsPbI quantum dot photovoltaic devices can be reversed by exposing the degraded samples to humidity, allowing the performance to recover and even surpass the initial performance.