Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy.

Background: Females with hypertrophic cardiomyopathy present at a more advanced stage of the disease and have a higher risk of heart failure and death. The factors behind these differences are unclear. We aimed to investigate sex-related differences in clinical and genetic factors affecting adverse outcomes in the Sarcomeric Human Cardiomyopathy Registry.

Third age fitness: the connective materiality of a major movement in Brazil.

Since 2006, simple outdoor gyms have been installed on public squares all over Brazil. From the beginning, they were mainly conceived as for use by older people - especially women - within an international movement of 'healthy cities'. Based on an ethnography in Rio de Janeiro, our aim is to show in particular the politico-commercial dimensions of the fitness equipment.

Comparative Genomic Analysis Reveals the Emergence and Dissemination of Different serovar Gallinarum biovar Gallinarum Lineages in Brazil.

serovar Gallinarum biovar Gallinarum is a pathogenic bacterium that causes fowl typhoid (FT), affecting chicken flocks worldwide. This study aimed to evaluate the emergence, dissemination and genomic profile of Gallinarum lineages from Brazil. Twelve whole-genomes sequences (WGS) of different .

ZBP1 senses DNA triggering type I interferon signaling pathway and unfolded protein response activation.

The innate immune system promptly detects and responds to invading pathogens, with a key role played by the recognition of bacterial-derived DNA through pattern recognition receptors. The Z-DNA binding protein 1 (ZBP1) functions as a DNA sensor inducing type I interferon (IFN) production, innate immune responses and also inflammatory cell death. ZBP1 interacts with cytosolic DNA via its DNA-binding domains, crucial for its activation.

Genetic determinants of COVID-19 severity and mortality: Alu 287 bp polymorphism and , , expression in hospitalized patients.

Background: The angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are central human molecules in the SARS-CoV-2 virus-host interaction. Evidence indicates that may influence expression. This study aims to determine whether ACE1, ACE2, and TMPRSS2 mRNA expression levels, along with the ACE1 Alu 287 bp polymorphism (rs4646994), contribute to the severity and mortality of COVID-19.

Corrigendum: Modeling extracellular matrix through histo-molecular gradient in NSCLC for clinical decisions.

[This corrects the article DOI: 10.3389/fonc.2022.

Determinants of variations in sleep patterns across Brazil: Exploring geographic influences.

Objective: To examine the influence of latitude, longitude, sunrise, and daylight, in conjunction with individual and behavioral factors, on sleep duration, wake time, and bedtime in a country with the world's broadest latitude range, yet characterized by homogeneity in language, cultural traits, and consistent time zones.

Methods: Participants (n = 1440; 18-65y) were part of a virtual population-based survey (2021-22). Sleep patterns were spatially represented through maps using Multilevel B-spline Interpolation.

Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer.

Platelet-derived growth factor alpha (PDGFRA) plays a significant role in various malignant tumors. PDGFRA expression boosts thyroid cancer cell proliferation and metastasis. Radiorefractory thyroid cancer is poorly differentiated, very aggressive, and resistant to radioiodine therapy.

Synthetic data in generalizable, learning-based neuroimaging.

Synthetic data have emerged as an attractive option for developing machine-learning methods in human neuroimaging, particularly in magnetic resonance imaging (MRI)-a modality where image contrast depends enormously on acquisition hardware and parameters. This retrospective paper reviews a family of recently proposed methods, based on synthetic data, for generalizable machine learning in brain MRI analysis. Central to this framework is the concept of domain randomization, which involves training neural networks on a vastly diverse array of synthetically generated images with random contrast properties.

Variability of in buffaloes.

The buffalo population raised in Brazil tend to show loss of genetic variability over generations, with significant estimates of inbreeding depression. Besides mating genetically distant individuals, other tools can be used to maintain/increase the genetic variability of the population, such as the use of genotypes. The gene promotes the creation of crossing-over points across the genome, with each allele promoting the creation of a different hotspot.

ACCREDIT: Validation of clinical score for progression of COVID-19 while hospitalized.

Unlabelled: COVID-19 is no longer a global health emergency, but it remains challenging to predict its prognosis.

Objective: To develop and validate an instrument to predict COVID-19 progression for critically ill hospitalized patients in a Brazilian population.

Methodology: Observational study with retrospective follow-up.

Assessment of upper extremity functional capacity in following osteosynthesis for upper limb fractures using a novel method for determining total reachable workspace.

Objective: This study aimed to assess reachable workspace (RWS) in patients post-osteosynthesis of shoulder, elbow, or wrist fractures and explore correlations with self-reported function and kinesiophobia.

Design: An observational case-control study compared patients with fractures to a control group, utilizing questionnaires and 3D kinematic data.

Participants: The sample included 66 individuals who had undergone osteosynthesis: 21 with shoulder fractures, 10 with elbow fractures, and 22 with wrist fractures.

Integrated systems improve soil microclimate, soybean photosynthesis and growth.

This study aimed to compare the conventional soybean ( L.) cultivation method with integrated systems in an Latossolo Vermelho Acriférrico típico and how these systems affect soil cover biomass production, initial nutrient concentration in plant residues, soil respiration and microclimate, as well as soybean growth, physiology and productivity. A comparative analysis of microclimate and soil respiration, plant physiology, and growth was conducted between a conventional soybean monoculture (soybean grown without plant residues on the soil from the previous crop) and soybean grown in soil containing maize residues.

Awake Craniotomy in Neurosurgery: A Bibliometric Analysis of the Top 100 Most-Cited Articles and Review of Technological Advancements.

Awake craniotomy (AC) is a critical neurosurgical technique for maximizing tumor resection in eloquent brain regions while preserving essential neurological functions like speech and motor control. Despite its widespread adoption, no prior bibliometric analysis has evaluated the most influential research in this field. This study analyzed the top 100 most-cited articles on AC to identify key trends, influential works, and authorship demographics.

Injectable thermosensitive antibiotic-laden chitosan hydrogel for regenerative endodontics.

Injectable biomaterials, such as thermosensitive chitosan (CH)-based hydrogels, present a highly translational potential in dentistry due to their minimally invasive application, adaptability to irregular defects/shapes, and ability to carry therapeutic drugs. This work explores the incorporation of azithromycin (AZI) into thermosensitive CH hydrogels for use as an intracanal medication in regenerative endodontic procedures (REPs). The morphological and chemical characteristics of the hydrogel were assessed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier transform infrared spectroscopy (FTIR).

Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD): From Diagnostic Approach to Treatment - A Narrative Review.

Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD) is characterized by persistent or recurrent unwanted genital arousal, causing significant distress to the affected individual. Classified as a sexual dysfunction, PGAD/GPD is predominantly described in women and severely affect their quality of life with psychological repercussions. Despite its morbidity, PGAD/GPD remains unfamiliar to healthcare professionals.

Mixture of auxinic herbicides for the control of spp. and its phytotoxic effects on soybean sown in sequence.

The combination of auxin-mimicking herbicides from different chemical groups offers an alternative for controlling fleabane ( spp.) in soybean pre-sowing, but care is needed to avoid phytotoxicity. This study evaluated the effectiveness of auxinic herbicide mixtures in controlling spp.

Microencapsulated phenolic compounds from organic coffee husk: Impacts on human gut microbiota and in vitro prebiotic potential.

This research investigated the influence of the microencapsulation of phenolic compounds (PCs) from organic coffee husk with whey protein concentrate (WPC) and maltodextrin on the abundance of intestinal bacterial populations and their metabolic activity during in vitro fecal fermentation. The microencapsulated PCs were gradually metabolized during fecal fermentation, resulting in significant transformations and an increase in PCs in the fermentation media. The metabolism of PCs by the fecal microbiota occurred concurrently with the consumption of sugars, production of organic acids, and reduction in pH in the media.

Nanoencapsulation reduces the perception of carvacrol odor, enhances the control of Botrytis cinerea growth and preserves grape quality.

Botrytis cinerea is the causal agent of gray mold, which is one of the most widespread and destructive fungal diseases that compromises the productivity and quality of grapes produced throughout the world. This work aimed to verify, for the first time, the impact of unencapsulated carvacrol and encapsulated in Eudragit® nanocapsules (Eud-Carv NCs) and chia mucilage (Chia-Carv NCs) on mycelial growth and spore germination of B. cinerea.

Chitosan suspension enriched with phenolics extracted from pineapple by-products as bioactive coating for liposomes: Physicochemical properties and in vitro cytotoxicity.

The physicochemical stability of liposomes (L) loaded with bioactive compounds can be improved by coating them with chitosan, to give chitosomes (Ch). In addition, crosslinked chitosan can be obtained by using sodium tripolyphosphate (TPP). This study aimed to prepare L enriched with bioactive compounds extracted from pineapple by-products (PB) without coating or coated with chitosan or crosslinked chitosan-enriched with PB bioactive compounds, to obtain Ch and TPP-Ch, respectively.

Compositional analysis of baru (Dipteryx alata Vogel) pulp highlighting its industrial potential.

Baru (Dipteryx alata Vogel), a fruit native to the Brazilian Cerrado, has gained scientific interest due to its nutritional potential and commercial value. Its edible seed, of high commercial value, represents around 5 % of the fruit. On the other hand, its pulp, a byproduct of the baru processing industry, is normally discarded, generating a huge volume of waste with reported antioxidant properties.

Impact of ultrasonic pretreatment on pumpkin seed protein: Effect on protease activities, protein structure, hydrolysis kinetics and functional properties.

Adding value to food by-products, such as pumpkin seeds, is an important strategy for the complete utilization of plant foods and advancing sustainability goals. This study aimed to maximize the production of bioactive peptides from pumpkin seed protein (PSP) by combining ultrasonic (US) pretreatment (40 kHz, 23.8 W/L) with enzymatic hydrolysis.

Effect of nutrition warning, brand, and claims on the perception of product healthiness by Brazilian consumers.

In response to the rise of Non-communicable Diseases, public policies, such as Front-of-package (FOP) nutrition labeling, have been implemented to clarify information on food labels and promote healthier eating habits. Brazil adopted black magnifier warning label in 2020, which consists of a black rectangle with a magnifier glass followed by the expression "High in" for three critical nutrients: added sugar, saturated fat and/or sodium. This study aims to evaluate the effect of black magnifier warning label, brand, and claims on Brazilian consumers' perceived healthiness.