Eeg Microstates and Balance Parameters for Stroke Discrimination: A Machine Learning Approach.

Electroencephalography microstates (EEG-MS) show promise to be a neurobiological biomarker in stroke. Thus, the aim of the study was to identify biomarkers to discriminate stroke patients from healthy individuals based on EEG-MS and clinical features using a machine learning approach. Fifty-four participants (27 stroke patients and 27 healthy age and sex-matched controls) were recruited.

Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis.

The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a major challenge to global health. Targeting the main protease of the virus (Mpro), which is essential for viral replication and transcription, offers a promising approach for therapeutic intervention. In this study, advanced computational techniques such as molecular docking and molecular dynamics simulations were used to screen a series of antiviral compounds for their potential inhibitory effect on the SARS-CoV-2 Mpro.

Coordinated conformational changes in P450 decarboxylases enable hydrocarbons production from renewable feedstocks.

Fatty acid peroxygenases have emerged as promising biocatalysts for hydrocarbon biosynthesis due to their ability to perform C-C scission, producing olefins - key building blocks for sustainable materials and fuels. These enzymes operate through non-canonical and complex mechanisms that yield a bifurcated chemoselectivity between hydroxylation and decarboxylation. In this study, we elucidate structural features in P450 decarboxylases that enable the catalysis of unsaturated substrates, expanding the mechanistic pathways for decarboxylation reaction.

Molar Incisor Hypomineralization and Periodontitis in Adolescents: A Population-Based Study.

Aim: To investigate the association between molar incisor hypomineralization (MIH) and periodontitis in adolescents.

Methods: A population-based study was undertaken of Brazilian adolescents aged 18 and 19 years (n = 2515). MIH was assessed according to Ghanim's criteria.

Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007 and 2022.

Objectives: Health research that significantly impacts global clinical practice and policy is often published in high-impact factor (IF) medical journals. These outlets play a pivotal role in the worldwide dissemination of novel medical knowledge. However, researchers identifying as women and those affiliated with institutions in low- and middle-income countries (LMICs) have been largely under-represented in high-IF journals across multiple fields of medicine.

Effect of photobiomodulation as preventive treatment of diabetic foot ulcer: randomised, controlled, double-blind, clinical trial protocol.

Introduction: The prevention of diabetic foot ulcer (DFU) involves the classification of risk, systemic care, regular examinations, foot care, therapeutic education and adjunct treatments. Photobiomodulation (PBM) has been successfully administered for the healing of DFU and its preventive effects have drawn the interest of researchers.

Methods And Analysis: The purpose of the study is to assess the effect of PBM for the prevention of DFU through a randomised, controlled, double-blind, clinical trial.

Transvestibular Chondrolarynoplasty-Experimental Study in Cadavers.

Background: The neck, and specifically the prominence of the thyroid cartilage, can be considered a marker of male gender, which is often unwanted by transgender women. Chondrolaryngoplasty is traditionally performed using an open transcervical approach, which, while effective, leaves visible scars that can compromise patient satisfaction. Recent advancements, such as the transoral endoscopic vestibular approach (TOEVA), have emerged as promising alternatives, eliminating external scars and improving esthetic outcomes.

Influence of sintering temperature and aging on the color and translucency of zirconia.

Statement Of Problem: Translucent zirconias are promising materials for monolithic prostheses. However, information on their optical behavior after sintering and aging protocols is scarce.

Purpose: The purpose of this in vitro study was to evaluate the color and translucency of zirconia subjected to different sintering temperatures and aging.

Repercussions of abuse by caregivers in the elderly population with dementia: a scoping review.

Due to the ageing population throughout the world, the rates of older adults suffering from dementia are increasing, requiring a closer look at this population. As a result, the aim of this scoping review is to gather data from the scientific literature on the repercussions of abuse of elderly people with dementia by their caregivers. For this review, Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews was used as a guideline to structure the review topics.

The PRO-AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department.

Background: Existing risk scores assessing geriatric vulnerability in the emergency department (ED) have shown limited predictive power, especially in diverse populations. We investigated the relationship of a quick and easy-to-administer geriatric vulnerability scoring system with functional decline and mortality in older patients admitted to multiple hospitals through the ED in the United States (US) and Brazil (BR).

Method: Federated, international, multicenter observational study of hospitalized ED patients aged ≥ 65 from US and BR.

Influence of alginate extraction conditions from the brown seaweed Dictyota mertensii on the functional properties of a novel glycerol plasticized alginate film.

Alginate films were prepared from the brown seaweed Dictyota mertensii using glycerol as a plasticizer. The effects of extraction conditions-time, temperature, and NaCO concentration-on the optical, barrier, and mechanical properties of the films were investigated using a central composite design (CCD). ANOVA and F tests confirmed the models' statistical significance at p ≤ 0.

Bioactive arabinoxylan oligomers via colonic fermentation and enzymatic catalysis: Evidence of interaction with toll-like receptors from in vitro, in silico and functional analysis.

Dietary fibers (DF) from plant-based foods promote health benefits through their physicochemical properties and fermentation by the gut microbiota, often studied in relation to changes in gut microbiota profile and production of gut microbiota-derived metabolites. Here, we characterized structural motifs (i.e.

Characterization of the polysaccharide schizophyllan and schizophyllan-chitosan hydrogel formation by diffusing-wave spectroscopy.

Schizophyllan (SPG) is a semi-flexible, triple-helical polysaccharide with attractive properties as an efficient viscosifying compound and biological response modifier. We report microrheological characterization of schizophyllan as dispersed in solution and the changes associated when crosslinked with chitosan over an extended frequency range using diffusing wave spectroscopy (DWS). A SPG with high molecular weight (M = 1.

Strength training improves heart function, collagen and strength in rats with heart failure.

Background/objectives: Myocardial infarction (MI) frequently leads to cardiac remodeling and failure with impaired life quality, playing an important role in cardiovascular deaths. Although physical exercise is a well-recognized effective non-pharmacological therapy for cardiovascular diseases, the effects of strength training (ST) on the structural and functional aspects of cardiac remodeling need to be further documented. In this study, we aimed to investigate the role of a linear block ST protocol in the rat model of MI.

Comparative Analysis of Conversion and Crosslinking Degree in Bulk-Fill, Monochromatic, and ORMOCER composites.

Bulk-fill, monochromatic, and ORMOCER composites were introduced in restorative dentistry with the aim of reducing clinical time and/or alleviating contraction stresses at the interface between the tooth and restoration. While the conversion and immediate properties of these materials are comparable to conventional composites, studies evaluating their long-term properties and the structure of the polymer matrix are lacking. The objective of this study was to evaluate the degree of conversion and, indirectly, the crosslink density of conventional, bulk-fill, monochromatic, and ORMOCER resin composites.

Characterisation of periorbital mechanical allodynia in the reserpine-induced fibromyalgia model in mice: The role of the Schwann cell TRPA1/NOX1 signalling pathway.

Fibromyalgia (FM) is a complex and multifaceted condition characterized by a range of clinical symptoms, including widespread pain and a strong association with migraine headaches. Recent findings have underscored the role of oxidative stress and transient receptor potential ankyrin 1 (TRPA1) channel in migraine and FM. However, the precise mechanisms underlying the comorbidity between migraine and FM are unclear.

A systematic review of the genus Tyzzeria Allen, 1936 (Chromista: Apicomplexa), including the molecular phylogenetic position of Tyzzeria parvula (Kotlán, 1933) Klimeš, 1963.

Tyzzeria Allen, 1936 is a coccidian genus traditionally associated with Anseriformes, although there are descriptions of Tyzzeria spp. from junglefowls, snakes, skinks and mice. In this sense, the current study performs a taxonomic review of Tyzzeria spp.

Interaction of normelinonine F and related N-methyl-β-carbolines derivatives with bovine serum albumin. Spectroscopic profiles, multivariate analysis and theoretical calculations.

β-carbolines (βCs) represent a large family of bioactive alkaloids, including norharmane and normelinonine F, known for their diverse pharmacological activities. The effects of these alkaloids may depend, among other factors, on their delivery, accumulation in different subcellular compartments, and interactions with biomacromolecules such as serum albumins. In this study, we investigated the pH dependence of the interactions between bovine serum albumin (BSA) and four βCs (norharmane, normelinonine F, and their corresponding N(9)-methyl derivatives) using UV-vis and fluorescence spectroscopy, combined with multivariate analysis and molecular docking.

Microfibrillated cellulose-based colorimetric sensor strips for detecting total iron in water.

Microfibrillated cellulose (MFC), a sustainable material derived from biomass, stands out as an environmentally friendly alternative for developing chemical sensors owing to its advantageous properties, including high porosity, surface area, and available surface functional groups. Herein, we propose a simple and low-cost strategy for developing cellulose-based strips for the colorimetric detection of total iron in water. The strips were prepared by functionalizing MFC casting membranes with 1-(2-Thiazolylazo)-2-naphthol (TAN), which was then characterized by structural and morphological techniques.

Probing the interaction of mannose-binding lectin with healthy and sickle cell anemia red blood cells and its role in cellular biomechanics.

Mannose-binding lectin (MBL) is an important glycoprotein of the human innate immune system. Furthermore, individuals with sickle cell anemia (SCA) and MBL deficiency seem more susceptible to vaso-occlusive crises, suggesting an MBL role on HbSS red blood cells (RBCs). This study investigated the interaction of MBL with HbA (healthy) and HbSS RBCs using optical tweezers (OT) and atomic force microscopy (AFM).

Genome assemblies and other genomic tools for understanding insect adaptation.

Insects, the most diverse group of animals, exhibit remarkable adaptability, playing both crucial and problematic roles in ecosystems. Recent advancements in genomic technologies, such as high-throughput sequencing, have provided unprecedented insights into the genetic foundations of insect adaptation. This review explores key methodologies, including de novo and reference-guided genome assemblies, and highlights cutting-edge technologies like second and third-generation sequencing, and hybrid techniques.

Immune regulation of host energy metabolism and periodicity of malaria parasites.

The synchronization of parasites as they replicate within red blood cells of their vertebrate host remains largely unexplored. Understanding this synchronization could reveal how parasites optimize their lifecycle to maximize transmission, evade the immune response and maximize energy acquisition. Rhythmic replication fulfils some criteria of an endogenous oscillator with time of day cues potentially provided by temperature, oxygen levels, hormones and/or nutrient availability.

A systematic review of the molecular mechanisms related to anthelmintic resistance in Haemonchus contortus: A contemporary narrative.

Haemonchus contortus is a gastrointestinal parasite that affects ruminants (cattle, sheep, etc.), having a significant welfare impact worldwide. The rise of anthelmintic resistance poses a growing challenge to adequate control, compromising the success of treatments.

Impact of mandibular overdentures on maxillary resorption and its association with masticatory function: A prospective longitudinal study with 3 years of follow-up.

Objective: This longitudinal clinical study monitored annually the maxillary and mandibular bone remodeling and masticatory function in complete denture (CD) wearers rehabilitated with implant-retained mandibular overdentures (MO) over three years and combined radiographic and masticatory function data to assess the correlation between bone remodeling and masticatory function.

Design: Thirty-nine MO wearers were monitored annually to assess changes in: i) residual ridge in the anterior and posterior maxillary region; ii) posterior height and posterior area index (PAI) in the mandible; and iii) masticatory function. Bone remodeling was measured through linear and angular measurements using panoramic radiographs.