Multicenter research in dialysis centers in Brazil: recruitment and implementation of the SARC-HD study.

Introduction: Multicenter research initiatives in Brazilian dialysis centers are scarce. We described the recruitment and implementation phases of the SARC-HD study, aimed at investigating sarcopenia and its impact on adverse clinical outcomes.

Methods: The SARC-HD is a cohort study being conducted with patients on hemodialysis in Brazil.

Public resources on the Brazilian Food and Nutrition Security agenda from 2000 to 2022.

To analyze the time trend of federal public resources invested in the Brazilian Food and Nutrition Security agenda from 2000-2022. A time series study was carried out with data collected from a publicly accessible system on the Federal Government's planning and budget. We analyzed the budget actions and their resources indicated by the Budget Allocation and the Settled Amount.

Characterization of patients treated at a rare disease referral service: a descriptive study, 2016-2021.

Objective: To analyze the first referral service for rare diseases accredited by the Brazilian Ministry of Health, focusing on referral from the primary healthcare network through to diagnosis.

Methods: This is a descriptive study with patients treated between 2016 and 2021 at a referral hospital service located in Curitiba, Paraná, Brazil. Clinical and epidemiological data were obtained from medical records, as were the results of genetic tests at the hospital's clinical analysis laboratory.

DIAGNOSIS AND TREATMENT OF MICROSCOPIC COLITIS: POSITION PAPER ON BEHALF OF THE BRAZILIAN FEDERATION OF GASTROENTEROLOGY.

Background: Microscopic colitis (MC) is a chronic inflammatory condition of the colon, primarily characterized by watery diarrhea, with normal or near-normal endoscopic findings. It encompasses two main subtypes: lymphocytic colitis and collagenous colitis.

Objective: This position paper from the Brazilian Federation of Gastroenterology aims to review current evidence on the diagnosis and management of MC in Brazil, emphasizing the need for standardization across the country's healthcare systems.

TRANSLATION, CROSS-CULTURAL ADAPTATION, AND VALIDATION OF THE IBD DISK FOR USE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES IN THE BRAZILIAN POPULATION.

Background: The inflammatory bowel disease (IBD) disk is a simple and quick method to assess the level of disability experienced by patients with IBD. It has been already translated and validated in European countries, however it was not yet translated and validated to use in Brazil.

Objective: This study was performed to translate and validate a Brazilian version of the IBD-Disk.

The Patterns of P53, E-Cadherin, β-Catenin, CXCR4 and Podoplanin Expression in Oral Squamous Cell Carcinoma Suggests a Hybrid Invasion Model: an Immunohistochemical Study on Tissue Microarrays.

Purpose: Oral squamous cell carcinoma (OSCC) is a significant public health challenge associated with high mortality rates primarily due to its invasive and metastatic behavior. This study aimed to evaluate the expression patterns of five critical biomarkers: β-catenin, E-cadherin, podoplanin (PDPN), CXCR4, and p53 in OSCC tissues and to investigate their correlations with clinicopathologic features and patient outcomes.

Methods: We conducted an immunohistochemical analysis utilizing tissue microarrays (TMAs) from 95 patients diagnosed with primary OSCC.

Environmental Dissemination of SARS-CoV-2: An Analysis Employing Crassphage and Next-Generation Sequencing Protocols.

This study aimed to investigate the dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in water samples obtained during the coronavirus disease 2019 pandemic period, employing cross-assembly phage (crAssphage) as a fecal contamination biomarker and next-generation sequencing protocols to characterize SARS-CoV-2 variants. Raw wastewater and surface water (stream and sea) samples were collected for over a month in Rio de Janeiro, Brazil. Ultracentrifugation and negatively charged membrane filtration were employed for viral concentration of the wastewater and surface water samples, respectively.

Aroeira (Myracrodruon urundeuva) and Malva (Herissantia crispa) have forage potential for ruminant nutrition in arid regions.

The Caatinga biome has a wide variety of plants which, despite their irregular distribution, are frequently used to feed animals. This study aimed to evaluate the gas production kinetics of Caatinga plants: Malva (Herissantia crispa), Aroeira (Myracrodruon urundeuva), Marmeleiro (Croton sonderianus), and Bamburral (Hyptis suaveolens). Buffel grass (Cenchrus ciliaris), a cultivated forage, was used as a control.

Evaluating the Immunoprotective and Diagnostic Potential of Schistosoma mansoni Epitopes from Sm050890 and Sm141290 Proteins Identified Through Reverse Vaccinology.

Purpose: Schistosomiasis remains a parasitic disease affecting millions of people worldwide, requiring interventions like vaccination. In previous work, our group used reverse vaccinology to identify two epitopes from the Schistosoma mansoni proteins, Sm050890 (44-58) and Sm141290 (225-239). This study evaluated the immune response profile and protection induced by peptides, as a mixture of immunogens, in murine vaccination trials.

Is surgical treatment better than non-surgical treatment for proximal humeral fracture in elderly people? A meta-analysis and meta-regression.

Purpose: This systematic review, meta-analysis, and meta-regression aims to determine whether surgical treatment for proximal humeral fractures is superior to non-surgical treatment regarding pain, functionality, complications, and new surgery rates.

Methods: We systematically reviewed clinical trials from PubMed (MEDLINE), EMBASE, Web of Science, Scopus, and Cochrane up to April 2024. Data comparing surgical or conservative of proximal humeral fractures were retrieved for outcomes of pain, functionality, adverse events, and new surgeries.

Relationship between periodontitis and systemic diseases: A bibliometric and visual study.

To provide a comprehensive and updated mapping of observational studies assessing the relationship between periodontitis and systemic diseases through a bibliometric and visual analysis. A search was conducted using the Web of Science database, covering the period 1989 to 2024. The Medical Subject Headings (MeSH) from the US National Library of Medicine was used to categorize systemic conditions, focusing on terms unrelated to stomatognathic diseases.

Open-label evaluation of oral trehalose in patients with neuronal ceroid lipofuscinoses.

The neuronal ceroid lipofuscinoses (NCLs) are incurable pediatric neurodegenerative diseases characterized by accumulation of lysosomal material and dysregulation of autophagy. Given the promising results of treatment with trehalose, an autophagy inducer, in cell and animal models of NCL, we conducted an open-label, non-placebo-controlled, non-randomized 12-month prospective study in NCL patients receiving oral trehalose (4 g/day). All were treated with a commercially available formulation for 6 months, followed by a 6-month washout.

The effects of compassionate care on oral health outcomes: A scoping review.

Purpose: To access and synthesize the existing literature about the effects of compassionate care on oral health outcomes.

Methods: A scoping review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify articles from six electronic databases: MEDLINE via the PubMed interface, Embase, Age-Line, Scopus, CINAHL, and Cochrane.

Results: Among 30 studies reporting on compassion in dental treatment, only two reported on the effects of compassionate care on oral health outcomes.

Genetic characterization of paternal lineages by Y-STR in three sample populations in Northeastern Brazil.

Genetic markers of the Y chromosome are powerful tools for investigating paternal ancestry and are widely used in population and forensic genetics. However, in order to obtain statistics with a higher degree of certainty using these markers, it is necessary to obtain haplotypic frequencies from a representative database, as well as knowing the diversity and structure of the population. The aim of this study was to investigate the genetic diversity of a sample of 1114 unrelated men from three states in the Northeast of Brazil: Paraíba, Pernambuco and Ceará, through the analysis of 23 Y-STRs and to contribute to the expansion of the Brazilian database on these markers.

Genetic Analysis of Retinal Cell Types in Neuropsychiatric Disorders.

Importance: As an accessible part of the central nervous system, the retina provides a unique window to study pathophysiological mechanisms of brain disorders in humans. Imaging and electrophysiological studies have revealed retinal alterations across several neuropsychiatric and neurological disorders, but it remains largely unclear which specific cell types and biological mechanisms are involved.

Objective: To determine whether specific retinal cell types are affected by genomic risk for neuropsychiatric and neurological disorders and to explore the mechanisms through which genomic risk converges in these cell types.

Early warning system using primary health care data in the post-COVID-19 pandemic era: Brazil nationwide case-study.

Syndromic surveillance using primary health care (PHC) data is a valuable tool for early outbreak detection, as demonstrated by the potential to identify COVID-19 outbreaks. However, the potential of such an early warning system in the post-COVID-19 era remains largely unexplored. We analyzed PHC encounter counter of respiratory complaints registered in the database of the Brazilian Unified National Health System from October 2022 to July 2023.

Integrative use of DNA barcode and morphology reveal high level of diversity in the ornamental fish on the lower Amazon basin.

The Amazon basin is the world's largest hydrographic basin, in terms of both its total area and its species diversity, with more than 2,700 species of fish. Despite this diversity, the data available on the fish fauna of the Amazon basin are still relatively scant and incomplete, in particular from the streams and floodplain lakes of the lower Amazon, which may contain a large proportion of the still undescribed species of the basin. Many of these species are expected to be of interest to the ornamental fish market.

Nutritional Profiling of Wild Edible Plants: Quantification of Macronutrients and Minerals via Energy Dispersive X-ray (EDX) Fluorescence Spectroscopy.

The wild edible plants offer a valuable resource for food and human nutrition. The current study aimed to analyze the proximate composition and ethno-medicinal profiles of twenty selected wild edible plants from the Malakand District, Pakistan. The proximate composition (moisture, ash, crude protein, crude fat, and dietary fiber) was analyzed following Association of Official Agricultural Chemists (AOAC) protocols.

Mental health in the Tupinambá community of Serra do Padeiro, southern Bahia, Brazil: community and struggle as sources of health.

This work presents concepts and practices linked to mental health in the Tupinambá Indigenous community of Serra do Padeiro in southern Bahia, Brazil. This qualitative cartographic research mapped existing processes and relationships in the Tupinambá territory. Data production techniques were participant observation, semi-structured interviews, field diary, and bibliographic studies.

Sociodemographic profiles of Indigenous households in the 1991, 2000, and 2010 censuses.

This article analyzes the sociodemographic composition of the Indigenous population in Brazil in the 1991, 2000, and 2010 demographic censuses, in addition to investigating inequalities in access to basic sanitation and electricity based on the 2010 Census. A methodology is proposed that classifies households with Indigenous residents as "homogeneous", "mixed" with an Indigenous in the category "household head", and mixed with a non-Indigenous in the category "household head". Regional and situational differences overlapped with differences by type of household and location, with better conditions in urban than rural areas and in the Southeast and South.

Excess weight and associated factors among Xavante Indigenous adults, Central Brazil.

Considered an important public health problem among Indigenous peoples in Brazil, obesity is a risk factor for Noncommunicable Diseases (NCDs) and conditions. The present study aimed to describe the occurrence of excess weight, obesity, and associated factors in Xavante Indigenous adults, through a nutritional survey carried out in the population ≥ 15 years of age living in the Pimentel Barbosa and Wedezé Indigenous Lands, Mato Grosso, Central Brazil, during the period of June to August 2011. Eight of the 10 villages in the territory were investigated.