Soybean tolerance to waterlogging is achieved by detoxifying root lactate via lactate dehydrogenase in leaves and metabolizing malate and succinate.

Waterlogging is a significant stressor for crops, particularly in lowland regions where soil conditions exacerbate the problem. Waterlogged roots experience hypoxia, disrupting oxidative phosphorylation and triggering metabolic reorganization to sustain energy production. Here, we investigated the metabolic aspects that differentiate two soybean sister lines contrasting for waterlogging tolerance.

Anxiolytic-like Effect of Chrysin on Female Zebrafish is Likely Mediated by α5 subunits of GABAA Receptors.

Chrysin (5,7-dihydroxyflavone) is a natural flavonoid with potential anxiolytic-like effects in preclinical models. Acute treatment with this molecule (0 - 10 mg/kg) produced a biphasic dose-response in the zebrafish light/dark test (LDT), with anxiolytic-like effect at low doses and anxiogenic-like effects at high doses. Chrysin (1 mg/kg) decreased anxiety-like behavior in the zebrafish novel tank test (NTT), but did not prevent the anxiogenic effects of acute stress.

Proteomic characterization and comparison of the infective and adult life stage secretomes from Necator americanus and Ancylostoma ceylanicum.

More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management approaches are limited by modest drug efficacy, the costs associated with frequent mass drug administration campaigns, and the risk of reinfection and burgeoning drug resistance.

Methods for assessing peri-implant marginal bone levels on digital periapical radiographs: a meta-research.

Objectives: This meta-research assessed methodologies used for evaluating peri-implant marginal bone levels on digital periapical radiographs in randomised clinical trials published between 2019 and 2023.

Methods: Articles were searched in four databases. Data on methods for assessing peri-implant marginal bone levels were extracted.

The clinical assessment of lung involvement in patients with Still's disease, results from the multicentre international AIDA Network Still's Disease Registry.

Objectives: To assess the lung involvement in patients with Still's disease, an inflammatory disease assessing both children and adults. To exploit possible associated factors for parenchymal lung involvement in these patients.

Methods: A multicentre observational study was arranged assessing consecutive patients with Still's disease characterized by the lung involvement among those included in the AIDA (AutoInflammatory Disease Alliance) Network Still's Disease Registry.

Predictive value of enhanced corneal biomechanical parameters for ectasia progression.

Purpose: To determine whether corneal biomechanical parameters can predict ectasia progression.

Study Design: Retrospective observational study.

Methods: The baseline corneal biomechanical parameters of 64 eyes of 41 young patients (age, < 25 years at the first visit) who were diagnosed with keratoconus (KC) or suspected KC at Osaka University Hospital and followed up for more than two years were reviewed.

Synthesis and evaluation of the antifungal and antibiofilm potential of aminochalcones.

Candida is a commensal fungus of clinical interest that commonly lives in oral cavity and intestine but can become an opportunist microrganism and cause severe infections. A serie of 10 aminochalcones were designed and synthetized to obtain compounds anti-Candida with potent and broad-spectrum activity. The most active compound J34 demonstrated excellent in vitro activity against Candida albicans, Candida tropicalis, Candida parapsilosis, Candida glabrata and Candida krusei with minimum inhibitory concentration between 1.

Unveiling cross-reactivity: implications for immune response modulation in cancer.

Antigen recognition by CD8+ T-cell receptors (TCR) is crucial for immune responses to pathogens and tumors. TCRs are cross-reactive, a single TCR can recognize multiple peptide-Human Leukocyte Antigen (HLA) complexes. The study of cross-reactivity can support the development of therapies focusing on immune modulation, such as the expansion of pre-existing T-cell clones to fight pathogens and tumors.

Effects of dynamic resistance training on postexercise hypotension and its mechanisms in hypertensive men.

Background: A possible chronic effect of exercise training is the attenuation of the acute decrease in blood pressure (BP) observed after the execution of a session of exercise [i.e. called postexercise hypotension (PEH)].

Rural Environment as a Risk Factor for the Age at Onset of Machado-Joseph Disease.

Background: Machado-Joseph disease (SCA3/MJD) is a neurodegenerative condition caused by a dominant expansion of a CAG repeat (CAGexp). Most of the variability in the age at onset of symptoms (AO) remains unexplained, and environmental influences were scarcely studied.

Objective: The objective was to test if AO of SCA3/MJD carriers can be associated with markers of the rural environment, such as demographic density (DeD), proportion of rural population (PRP), and the consumption of untreated well water (CWW).

Feasibility and Acceptability of a Virtual "Dementia Awareness for Caregivers" Course in Brazil and India.

Objective: To establish whether a virtual dementia awareness course is feasible for caregivers of people with dementia in Brazil and India.

Methods: A pre/posttest single group, multisite feasibility study, mixed methods exploratory design was applied. Primary caregivers of people with dementia in Brazil and India took a 3 to 4-hour course adapted for online delivery, with 10 to 15 caregivers.

Detection and distinction of amino acids and post-translational modifications with gold nanojunctions.

Amino acids are fundamental building blocks of proteins, playing critical roles in medical diagnostics, environmental monitoring, and biomarker identification. The development of nanoscale electronic sensors capable of single-amino-acid recognition has gained significant attention due to their potential for label-free, real-time detection. In this study, we investigate the electronic transport properties of amino acids in two gold-based nanodevices with distinct architectures: a gold nanojunction and a gold-capacitor system.

Long-term outcomes of second-generation drug-eluting stents versus coronary artery bypass graft: a systematic review and meta-analysis of randomized trials and multivariable adjusted data.

Long-term data are limited comparing percutaneous coronary intervention (PCI) with second-generation drug-eluting stents (S-DES) vs coronary artery bypass grafting (CABG) in patients with complex coronary artery disease (CAD). We aimed to conduct a systematic review and meta-analysis comparing these interventions in patients with left main or multivessel CAD. We systematically reviewed PubMed, Embase, and Cochrane for studies that compared PCI with S-DES and CABG in patients with left main or multivessel CAD with a minimum mean follow-up period of 3 years.

Assessment of shock index in healthy cats and in cats presenting to an emergency room with shock.

Objective: To prospectively compare the shock index (SI) in a population of healthy cats with a population of cats presenting to the emergency room (ER) deemed to be in a state of shock.

Design: Prospective cohort study of cats.

Setting: University teaching hospital.

promoter hypermethylation and Lynch Syndrome: When to test for constitutional epimutations of gene?

Lynch syndrome is a genetic condition predisposing to cancer, particularly colorectal cancer and endometrial cancer, due to germline mutations in MisMatch Repair genes. More rarely, Lynch syndrome is the result of a constitutional promoter methylation. This review summarizes the current knowledge about the role of this epigenetic mechanism in the Lynch syndrome.

Gallbladder perforation in a patient undergoing PCNL: Case report and literature review.

Percutaneous nephrolithotripsy (PCNL) is an effective therapeutic approach in cases of lithiasis, which is prone to complications. In this report we present a case of a 52-year-old female patient with recurrent episodes of lithiasis and, after PCNL, evolution with pain and abdominal distension on the 2nd post-operative day due to a perforation of the gallbladder. An exploratory laparotomy was performed, leading to clinical improvement, and the patient was discharged from the hospital on the 7th day after resolving the choleperitoneum.

Application of cold atmospheric plasma for decontamination of toxigenic fungi and mycotoxins: a systematic review.

Introduction: Microbial contamination remains a vital challenge across the food production chain, particularly due to mycotoxins-secondary metabolites produced by several genera of fungi such as , and . These toxins, including aflatoxins, fumonisins, ochratoxins, and trichothecenes (nivalenol, deoxynivalenol, T2, HT-2). These contaminants pose severe risks to human and animal health, with their potential to produce a variety of different toxic effects.

Assessing the impact of HIV self-testing on diagnosis rates in vulnerable groups in belo horizonte, Brazil: A cross-sectional analysis.

Background: In recent years, HIV self-testing (HIVST) has emerged as a promising approach to enhance accessibility and uptake of HIV testing, particularly among populations at high risk for sexually transmitted infections (STIs). Despite its potential benefits, the effectiveness, and challenges of HIVST warrant careful examination to inform public health strategies effectively. This study investigates the effectiveness and challenges of HIV self-testing (HIVST) in populations at high risk for sexually transmitted infections (STIs).

Dynamic signatures: a mathematical approach to analysis.

This study evaluates mathematical tools (principal component analysis, dynamic time warping, and the Kolmogorov-Smirnov hypothesis test) to analyse global and local data from dynamic signatures to reduce subjectivity and increase the reproducibility of handwriting examination using a two-step approach. A dataset composed of 1 800 genuine signature samples, 870 simulated signatures, and 60 disguises (30 formally similar or "autosimulated" and 30 random but different from usual) provided by 30 volunteers was collected. The first step involved global data analysis using principal component analysis and a hypothesis test performed for 62 global characteristics, and associations of these characteristics were analysed through calculations of multivariate distance followed by a hypothesis test.

Challenges in estimating species' age from phylogenetic trees.

Aim: Species age, the elapsed time since origination, can give insight into how species longevity might influence eco-evolutionary dynamics, which has been hypothesized to influence extinction risk. Traditionally, species' ages have been estimated from fossil records. However, numerous studies have recently used the branch lengths of time-calibrated phylogenies as estimates of the ages of extant species.

Systematic Review and Spatiotemporal Assessment of Mercury Concentration in Fish from the Tapajós River Basin: Implications for Environmental and Human Health.

This study reviews the literature on mercury (Hg) pollution in the Tapajós River basin from 1992 to 2022, focusing on the bioaccumulation in fish and the associated health risks to humans via ingesting contaminated species. Variability in Hg bioaccumulation was analyzed from both spatial (sub-basins) and ecological (trophic levels) perspectives. Mercury concentrations in fish muscle tissue and spatial differences in Hg levels were analyzed using nonparametric Kruskal-Wallis ANOVA and mapped with Inverse Distance Weighting.

The trends of lung cancer burden in BRICS from 1990 to 2021 and its projection to 2035.

Background: Lung cancer has become the malignant tumor with the highest morbidity and mortality in the world. This study aims to analyze the burden of lung cancer and risk factors associated with lung cancer in the BRICS from 1990-2021 and to project the burden of lung cancer in the BRICS from 2021-2035.

Methods: The Global Burden of Disease (GBD) 2021 database was searched to collect the incidence, prevalence, mortality, disability-adjusted life years (DALYs), and risk factors of lung cancer in the BRICS.