The problem of multiple adjustments in the assessment of minimal clinically important differences.

Introduction: Anthropometric, demographic, genetic, and clinical features may affect cognitive, behavioral, and functional decline, while clinical trials seldom consider minimal clinically important differences (MCIDs) in their analyses.

Methods: MCIDs were reviewed taking into account features that may affect cognitive, behavioral, or functional decline in clinical trials of new disease-modifying therapies.

Results: The higher the number of comparisons of different confounders in statistical analyses, the lower values will be significant.

Comparison of Nurses' Workload and Multiple Organ Failure of Patients Hospitalized in the COVID-19 and Non-COVID-19 Intensive Care Units.

Background: Measuring nurses' workload and related factors in intensive care units and reviewing their staffing is very important during COVID-19. This study aims to compare nurses' workload and multiple organ failure of patients hospitalized during the COVID-19 in intensive care units and non-COVID-19 intensive care units.

Materials And Methods: An observational study was conducted with 768 patients hospitalized in intensive care units and Zanjan City (Iran) intensive care units in 2021.

Erratum: Retraction notice to "A deep learning approach based on graphs to detect plantation lines" [Heliyon Volume , Issue 11, 15 June 2024, e31730].

[This corrects the article DOI: 10.1016/j.heliyon.

Consensus on the lung cancer management after third-generation EGFR-TKI resistance.

Lung cancer is the most prevalent malignant tumour in the Asia-Pacific region. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers. Among these, the rate of mutations in Asian patients with lung adenocarcinoma is 40-60%.

Transcriptomic effects of alginate hydrogel applied to the production of bovine embryos.

-produced blastocysts are exposed to different stimuli when compared with ones. This includes the culture of embryos in a sturdy petri-dish, while embryos develop in a soft and dynamic structure. Here we hypothesized that a softer environment could differently modulate the produced embryos To that aim, presumptive zygotes were produced by fertilization and divided into three groups: 1) Cultured in a regular Petri dish - Control (CON); 2) Cultured on top of an alginate hydrogel surface (TOP); 3) Encapsulated inside an alginate hydrogel sphere (ENC) and cultured.

Prototype analysis of a low-power, small-scale wearable medical device.

Wearable and portable devices are gaining significant popularity across consumer electronics as well as in medical and industrial fields. To ensure that these devices are both comfortable and appealing to users, they need to have low battery consumption and be compact in both size and weight. The EGluco project is focused on developing a wearable device for non-invasive blood glucose monitoring.

Impact of strategic public health interventions to reduce tuberculosis incidence in Brazil: a Bayesian structural time-series scenario analysis.

Background: Despite government efforts, tuberculosis (TB) remains a major public health threat in Brazil. In 2023, TB incidence was 39.8 cases per 100,000 population, far above the WHO's target of 6.

Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 cells with gut tropism.

Activated CD4 T cells located at mucosal surfaces orchestrate local effector immune mechanisms. When properly polarized, these cells contribute to block infections at early stages and may be essential to restrain the local growth of mucosal tumors, playing a critical role in host protection. How CD4 T cells simultaneously integrate gut-homing instructions and Th polarization signals transmitted by TLR activated dendritic cells (DCs) is unknown.

Design of Natterins-based peptides improves antimicrobial and antiviral activities.

The biochemical analysis of animal venoms has been intensifying over the years, enabling the prediction of new molecules derived from toxins, harnessing the therapeutic potential of these molecules. From the venom of the fish , using methods for predicting antimicrobial and cell-penetrating peptides, two peptides from Natterins with promising characteristics were synthesized and subjected to and analysis. The peptides were subjected to stability tests and antimicrobial assays, cytotoxicity in murine fibroblast cells, antiviral assays against the Chikungunya virus, and the toxicity on was also evaluated.

Impact of thrombocytopenia on failure of endoscopic variceal treatment in cirrhotic patients with acute variceal bleeding.

Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment (EVT). Thrombocytopenia is the most common hemostatic abnormality in liver cirrhosis. However, it is still unclear about whether thrombocytopenia increases the failure of EVT in cirrhotic patients with AVB.

High red luminescence intensity under sunlight exposure of a PMMA polymer doped with a tetrakis Eu β-diketonate complex containing a benzimidazolium counterion.

New tetrakis Eu and Gd β-diketonate complexes containing benzimidazolium (Bzim) as the counterion were synthesized by the one-pot method. The Bzim[Eu(tta)]·HO complex was further incorporated into a poly(methyl methacrylate) matrix (PMMA) at 1, 5, and 10% (w/w), which revealed highly desirable photonic features. The Eu and Gd complexes were characterized by elemental and thermal analyses, in addition to ESI-MS spectrometry, FTIR, and Raman spectroscopy.

Investigations into the growth and formation of biofilm by at temperatures encountered during infection.

The genus comprises unique atypical spirochete bacteria that includes the etiological agent of leptospirosis, a globally important zoonosis. Biofilms are microecosystems composed of microorganisms embedded in a self-produced matrix that offers protection against hostile factors. Leptospires form biofilms in rice fields and unsanitary urban areas, and while colonizing rodent kidneys.

Photoelectrochemical Performance of Brookite Titanium Dioxide Electrodeposited on Graphene Foam for Portable Biosensors.

We discuss the photoelectroanalytical performance of a brookite-phase titanium dioxide (TiO) platform electrodeposited onto graphene foam (GF) at low temperatures. The scalable electrosynthesis process eliminates the need for thermal annealing, which is impractical for carbon-based electrodes. Films resulting from a 10 min electrodeposition (TiO-10/GF) exhibit enhanced photocurrents, reaching 170 μA cm -twice the value for TiO films on traditional screen-printed carbon electrodes (82 μA cm ).

Carbon Dot-Laponite Hybrid Nanocomposites as Selective Turn-Off Sensors for Hg Detection and Photoluminescence Quenching Mechanism.

Motivated by the importance of Hg detection in water due to its harmful effect on the environment and human health, we investigated a recently developed nanocomposite based on carbon dots (CDs) and LAPONITE as an optical chemical sensor using photoluminescence emission. While several studies have reported the Hg detection using CDs' photoluminescence emission, there is a lack of in-depth investigation into the quenching mechanisms involved in turn-off sensors. In this study, we propose a Stern-Volmer analysis at three different temperatures (288, 298, and 303 K).

How Dendrimers Impact Fibrin Clot Formation, Structure, and Properties.

Polyamidoamine (PAMAM) dendrimers, with their unique structural versatility and tunable surface functionalities, have emerged as promising nanomaterials for a wide range of biomedical applications. However, their in vivo use raises concerns, as unintended interactions between dendrimers and blood components could disrupt the delicate hemostatic balance and lead to serious complications like bleeding or thrombosis. In this study, we explored the impact of low-generation PAMAM dendrimers on the kinetics of fibrin clot formation, along with their influence on the structure, properties, and resistance to lysis of the resulting clots.

Potassium Persulfate Promoted the One-Pot and Selective -Functionalization of Pyrazoles under Acidic Conditions.

Our research presents selective direct selenylation at the C-4 pyrazole ring using KSO as an oxidant under simple and mild conditions. This elegant synthesis involves the one-pot method under acidic conditions, thus minimizing reaction steps and waste generation. This innovative method allowed us to create a library of 4-selanylpyrazoles in good to excellent yields.

Influence of Sodium Hydroxide Treatment on Fibers for Geotextile Manufacturing.

The conservation of soil, a finite natural resource, demands effective measures. Within this context, the instability of soil masses on steep slopes poses significant risks to human life and environmental infrastructure, highlighting the need for developing erosion control strategies rooted in soil bioengineering principles. The objective of this study was to investigate the mechanical properties of fibers subjected to biodegradation and treated with sodium hydroxide (NaOH) for geotextile manufacturing.

Deep Multitask Learning-Driven Discovery of New Compounds Targeting .

Visceral leishmaniasis caused by is a severe and often fatal disease prevalent in low- and middle-income countries. Existing treatments are hampered by toxicity, high costs, and the emergence of drug resistance, highlighting the urgent need for novel therapeutics. In this context, we developed an explainable multitask learning (MTL) pipeline to predict the antileishmanial activity of compounds against three species, with a primary focus on .

The London money market and non-British bank lending during the first globalisation: evidence from Brazil.

This study examines the relationship between the London money market (LMM) and the credit provision of non-British overseas banks in peripheral economies during the first wave of globalisation. Using monthly data between 1889 and 1913, we find a positive relationship between the amount of credit authorised by the German in Brazil and the spread between the London market and floating rate. Our results suggest that increased demand for foreign bills and/or decreased borrowing costs in the LMM leads to an increase in credit supply.

Long-term Outcomes of Geriatric Medicine Teaching Strategies: Comparing no Content, Traditional Lecture, and Flipped Classroom 2 Years Postintervention.

Background: The long-term effects of use of the flipped classroom to teach geriatric medicine are still underexplored.

Objective: To investigate whether different educational interventions on geriatrics (i.e.

Association of Pedagogical Training with the Social Skills of Medical Tutors in Problem-Based Learning Curriculum.

Background: Satisfactory interaction between tutor and student is fundamental to the success of problem-based learning, and social skills (SS) are essential in this context. The factors associated with a better repertoire of teachers' SS are still unclear. Therefore, we aimed to assess tutors' SS and investigate which factors might be related to a better repertoire of SS.

Potential use of beet-pulp concentrate supplementation in athletic horse.

The aim of this two-phase study was to evaluate the use of beet pulp concentrate (BPC) in athletic horses. On the first trial the effects of supplementation with 820g of BPC for 12 weeks were assessed and a crossover postprandial curves of blood biomarkers were determined in five adult Arabian mares. Differences were found in T-chol, HDL-chol, TPP and MCHC (p < 0.

Factors Associated With the Presence and Severity of Nutritional Impact Symptoms in Individuals With Head and Neck Cancer Before Treatment.

As head and neck cancer (HNC) affects regions directly related to the digestive tract, it is consistently associated with nutritional impact symptoms (NISs), which further reduce food intake and affect nutritional status. Early identification of patients with NIS can assist therapy. This is a cross-sectional study with HNC patients from a cancer reference hospital.

Umbilical vein remodeling is associated with pregestational maternal overweight.

Introduction: Excess weight during pregnancy is a condition that can affect both mother and fetus, through the maternal-fetal interface, which is constituted by the placenta and umbilical cord. The umbilical vein is responsible for transporting oxygen and nutrients to the fetus, and its proper functioning depends on the integrity of its structure. The remodeling of the umbilical vein represents one of the causes of inadequate transport of nutrients to the fetus, being potentially harmful.

A Randomized, Placebo-controlled Clinical Study Evaluating a Dietary Supplement for Hair Growth.

Objective: The desire for improved hair appearance, hair growth and strength are common drivers of supplementation for women experiencing thinning hair. This study examined the effect and safety of a gummy supplement containing B vitamins, zinc and botanical ingredients to improve hair growth, strength and perceived hair quality outcomes.

Methods: Healthy females (n=65) ages 18 to 60 with thinning hair were enrolled.