UPPER DIGESTIVE ENDOSCOPY IN CAPTIVE COATIS (, LINNAEUS, 1766).

This study aimed to perform upper digestive endoscopy in clinically healthy coatis (), based on descriptions in domestic dogs and cats. In addition, research was carried out for r in stomach samples. Five adult male coatis, weighing between 2.

ANTIBODIES TO SPP. IN THREE SPECIES OF FREERANGING OPOSSUM ( SPP.) IN FLORIDA, USA, AND BRAZIL.

The opossum has been recognized as an intermediate host for many parasites including spp., which is a protozoan that infects various mammals, including many wildlife species. A limited number of reports using serology, histopathology, and molecular assays have documented the presence of in opossums.

ASSESSMENT OF ECHOCARDIOGRAPHIC PARAMETERS IN HEALTHY FREE-RANGING GIANT ANTEATERS ().

The aim of this study was to conduct Doppler echocardiography on healthy free-ranging anteaters () and to evaluate the relationship between echocardiographic parameters of diagnostic importance and animal body weight (BW). This work utilized 8 anesthetized adult animals and 4 manually restrained pups. The echocardiographic examinations were performed with the animal in left lateral recumbency.

ILAE neuroimaging task force highlight: The utility of multimodal neuroimaging in diagnostic and presurgical workup of drug-resistant focal epilepsy.

The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy, consistent with ILAE's educational mission. In patients with drug-resistant focal epilepsy who are candidates for surgical intervention, the identification of structural abnormalities is a strong predictor of favorable postoperative seizure outcomes. When conventional imaging is insufficient, the integration of multimodal neuroimaging data with structural, metabolic, and functional imaging modalities is often helpful.

The burden of migraine in Mexico: a database analysis of migraine-related visits to emergency departments in Mexico's ministry of health (MMoH) hospitals.

Background: The burden of migraine in Mexican Emergency Department (ED) settings remains understudied. This study aimed to determine the frequency of migraine-related ED visits within the ED Mexican Ministry of Health's (MMoH) database and analyze their demographics and treatment patterns.

Research Design And Methods: This retrospective study analyzed MMoH database of ED visits between 2013 and 2022.

Direct and Volatile Potential Applications of Essential Oils for Post-Harvest Fungi Control.

Around one third of food production is lost globally, significantly impacting food security, primarily due to post-harvest deterioration from phytopathogenic fungi. This study aimed to assess the antifungal properties of essential oils (EOs) from Syzygium aromaticum, Origanum vulgare L., Cymbopogon martini, Cymbopogon citratus, Mentha spicata, and Mentha piperita against three fungi affecting tropical fruits: Lasiodiplodia theobromae, Alternaria alternata, and Fusarium solani.

Pelvic floor muscle training with feedback or biofeedback for urinary incontinence in women.

Background: Pelvic floor muscle training (PFMT), compared to no treatment, is effective for treating urinary incontinence (UI) in women. Feedback and biofeedback are additional resources that give women more information about their pelvic floor muscle contraction. The extra information could improve training performance by increasing capability or motivation for PFMT.

Silicon amendment to the crop increases the potential of Aphidius platensis to control the invasive pest aphid Melanaphis sorghi.

Background: The efficacy of integrated pest management programs can be affected by interactions between different pest control methods. Silicon (Si) amendments increase plant resistance to phytophagous insects; however, such amendments may also affect higher-trophic level species, causing either negative or positive impacts on the biological control of pests in treated crops. To evaluate the effect of Si amendment on the potential for control of the pest aphid Melanaphis sorghi (Theobald) by the parasitoid Aphidius platensis (Bréthes), the key biological parameters and the fertility life tables of both species were assessed in the laboratory at both 23 ± 1 °C and 29 ± 1 °C without Si application and in a greenhouse trial, with the insects reared on plants grown in soil with and without the application of Si (800 kg of Si per hectare).

Effect of 12-week dietary nitrate supplementation on carotid arterial stiffness in postmenopausal females.

Menopause is associated with reduced nitric oxide (NO) bioavailability, a key contributor to increased arterial stiffness and, consequently, greater risk of cardiovascular disease (CVD)-related mortality in postmenopausal females. Even though dietary nitrate has been shown to increase NO bioavailability in postmenopausal females acutely, previous studies showed no impact of dietary nitrate supplementation on arterial stiffness in postmenopausal females. Their findings were likely limited by the acute and/or short-term design.

Optimal Mating Combination for Directed Breeding in a Racially Composite Cattle Population.

Evaluating optimal mating combinations in large populations poses significant combinatorial and computational challenges. To address this, we propose a method to optimise mating combinations in composite cattle populations, incorporating heterosis and genetic variability. Leveraging integer linear programming, our approach maximises expected offspring merit, outperforming random mating systems.

Intestinal polyps and chronic schistosomiasis.

Intestinal polyps have been described in association with chronic schistosomiasis, and must be differentiated from malignant tumors and appropriately managed. This uncommon condition may be very rarely detected in people from non-endemic areas of this zoonosis, who were occasionally infected during some travel period. The lesions are more frequently described in men, and predominating in the colon.

First report of the emerging pathogenic yeast in commercially relevant fish from southeastern Brazil.

The emerging fungal pathogen () has been increasingly detected in environmental and animal samples, although studies in this regard are still scarce, especially in fisheries contexts. This study reports the first-time detection of in a commercially relevant fish species belonging to the Sciaenidae family ( sp.), indicating its potential emergence as a pathogen in Brazil.

There and turn back again: the application of phage serine integrases in eukaryotic systems.

Serine integrases (Ints) have gained prominence and have been extensively used in Synthetic Biology due to their ability to modify DNA sequences. Ints are recombinases encoded by the phage genome and have been used to unidirectionally catalyze an insertion, excision, or inversion of a specific DNA sequence between the two attachment sites () (bacterial attachment site) and (phage attachment site). The entire process is highly specific and accurate; therefore, Ints are widely used in genetic engineering and have been extensively studied due to their unique site-specific recombination properties and potential genome editing applications.

Progression in Fibrotic Interstitial Lung Diseases: Prevalence and Indicators in the Initial Evaluation in a Brazilian Multicentric Cohort.

Objective: This retrospective study aimed to determine the prevalence of progression in fibrotic interstitial lung disease (ILD) and the findings at diagnosis most associated with progression after two years of follow-up in a large Brazilian cohort.

Methods: This was a retrospective multicenter observational study in Brazil. Progression was defined after two years of follow-up.

Vaccination versus antimicrobials to prevent Porcine Proliferative Enteropathy: associated costs and effects on piglets' growth, health, and serological performance.

Introduction: This study evaluated vaccination and prophylactic use of antimicrobials as strategies to prevent Porcine Proliferative Enteropathy (PPE) during nursery and growth-finishing phases.

Methods: Three hundred weaned piglets (~ 29 days old) were distributed into groups: NVMED - no vaccinated against but in-feed medicated with antimicrobials (amoxicillin, florfenicol, lincomycin, spectinomycin and tilmicosin); VMED - vaccinated and in-feed medicated; VNMED - vaccinated but no in-feed medicated. Piglets were vaccinated at weaning (Porcilis Ileitis, MSD Animal Health).

Somatic mutations in Brazilian patients with paroxysmal nocturnal hemoglobinuria: a comprehensive analysis.

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disease characterized by acquired abnormalities in the phosphatidylinositol glycan class A () gene.

Methods: This study analyzed gene using polymerase chain reaction (PCR) followed by Sanger sequencing of 31 Brazilian patients with PNH, including 23 with classical PNH and 8 with subclinical PNH (aplastic anemia and a PNH clone).

Results: A diverse spectrum of acquired variants was identified, encompassing insertions, deletions, and single-base substitutions.

Characterization of Immunoglobulin Heavy Locus Rearrangements in Molecular Subtypes of Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

Biased VDJ recombination has been previously described in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), although its causes are not yet fully understood. This study assesses differential features in 565 clonotypes from BCP-ALL molecular subsets against 560 clonotypes from bone marrow donors. Leukemia clonotypes were enriched for segments in the KMT2A rearranged and B-other subtypes, while was enriched in TCF3::PBX1.

Revisiting the druggable genome using predicted structures and data mining.

Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this method tends to be time- and resource-consuming. The discoverable target space is also constrained by existing compound libraries and phenotypic assay conditions.

Antimicrobial activity and biocompatibility of alpha-silver tungstate nanoparticles.

The growing global threat posed by microorganisms resistant to conventional antimicrobials underscores the urgent need for novel agents to control infections. The aim of this study was to evaluate the antimicrobial activity and biocompatibility of alpha-silver tungstate (α-AgWO) nanoparticles (NPs) synthesized by the ultrasonic method. The NPs were characterized, and their antimicrobial activity was assessed against , , and using the broth microdilution method, determining the minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC).

The social burden of antimicrobial resistance: what is it, how can we measure it, and why does it matter?

Antimicrobial resistance (AMR) is a growing global health threat, which is increasingly quantified in terms of its human health and economic burden. In this article, we highlight that for policy and planning purposes the social burden of AMR is as important to attend to as health and economic burdens, requiring systematic consideration and measurement of multiple dimensions. We provide a conceptual and empirical overview of four dimensions of the social burden of AMR: the distribution of AMR among and between populations; the lived experiences of AMR by patients and carers; how and by whom AMR interventions are shouldered; and how AMR can change society.

Leveraging machine learning on the role of hospitalizations in the dynamics of dengue spread in Brazil: an ecological study of health systems resilience.

Background: The alarming rise in dengue cases and fatalities worldwide necessitates an in-depth analysis of essential public health functions (EPHFs) to fortify the resilience of health systems in the face of upcoming surges. This study focuses on the resilience of Brazil's health system in managing dengue from 2010 to 2024, leveraging machine learning techniques to correlate EPHF variables with dengue outcomes.

Methods: Utilizing public data from DATASUS and IBGE, we evaluated indicators such as healthcare workforce, health facilities, and dengue-specific data.

Raman spectroscopy for forensic pen ink investigation: a review.

The performance of Raman spectroscopy (RS) has improved in recent years due to the significant advantages of its use in various fields, such as archaeology, medicine, foods, and forensics. An aspect of great relevance in forensic investigation is preserving criminal evidence, and nondestructive techniques for analysis are needed. RS has great potential for characterizing pen inks in questioned documents, and it has even been considered promising for trace intersection and dating investigations.