New insight on the acute CCl-induced hepatotoxicity model in rats.

The CCl-induced hepatotoxicity model is a traditional preclinical assay applied to evaluate potential hepatoprotective compounds. However, several studies have used it with inappropriate dose and exposure time, generating both weak response or irreversible liver injury, as well as lack of representative liver and plasma biomarkers. Therefore, this study aims to determine the best dose and exposure time of CCl in Wistar rats, permitting a proper evaluation of potential hepatoprotective effect.

Prioritizing questions and topics for the development of guidelines and consensus-based recommendations supported by ILAE: A scoping review and proposal of prioritization criteria.

Clinical practice guidelines (CPGs) and consensus-based recommendations (CBRs) require considerable effort, collaboration, and time-all within the constraints of finite resources. Professional societies, such as the International League Against Epilepsy (ILAE), must prioritize what topics and questions to address. Implementing evidence-based care remains a crucial challenge in clinical practice.

Transfusion Practices in Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Objectives: Balancing oxygen requirements, neurologic outcomes, and systemic complications from transfusions in traumatic brain injury (TBI) patients is challenging. This review compares liberal and restrictive transfusion strategies in TBI patients.

Data Sources: Electronic databases were searched from inception to October 2024.

The photochemical inheritance of Eduardo Lissi and Juan Grotewold and the intersystem crossings with other inheritances.

In 1963, Eduardo Lissi and Juan Grotewold started a chemical kinetics and photochemistry group at the School of Sciences at the University of Buenos Aires (Facultad de Ciencias Exactas y Naturales, FCEN, UBA). Political circumstances in Argentina and in Chile were a great determinant of the evolution, dispersion, and re-encounters of the group members. The initial graduate students in the group developed their own research groups working in various Countries and on a variety of projects.

TccP4: a novel effector identified in the strain 1551-2 required for attaching and effacing lesion formation on infected Nck-null cells.

is a pathogen that causes sporadic cases and outbreaks of diarrhea. The main virulence feature of this bacterium is the attaching and effacing (AE) lesion formation on infected intestinal epithelial cells, which is characterized by the formation of pedestal-like structures that are rich in F-actin. The Brazilian 1551-2 strain can recruit F-actin using both the Nck-dependent and the Nck-independent pathways, the latter of which uses an adaptor protein named Tir-cytoskeleton coupling protein (TccP/EspF).

Associations between colonization with Helicobacter pylori and risk of gastrointestinal tract cancers: An umbrella review of meta-analyses.

Background: Several studies have investigated the association between Helicobacter pylori colonization and gastrointestinal malignancies. However, inconsistent results have been found, leaving no clear consensus.

Materials And Methods: Umbrella review of meta-analyses of observational studies aiming to understand the association between Helicobacter pylori colonization and gastrointestinal cancers in humans.

Riga-Fede Disease in a Child With Neuropsychomotor Impairment: A Case Report.

Riga-Fede disease (RFD) is a rare, benign condition marked by traumatic ulceration on the tongue's ventral side in infants. It arises from friction between the tongue and lower incisors during sucking, potentially worsening into a keratinized lesion if the cause is not addressed. This report details the case of a 1-year-6-month-old male with hydrocephalus, cleft palate, corpus callosum dysgenesis, neuropsychomotor developmental delay, and tracheostomy and gastrostomy needs.

Potentially paraneoplastic glomerulopathies in a Brazilian cohort: a retrospective analysis.

Introduction: Glomerular diseases can be associated with solid or hematopoietic malignancies. The prevalence of these associations varies according to the studied glomerular disease. This study aimed to evaluate the frequency and type of neoplasms in patients with glomerular diseases as well as their clinical, laboratory, and histopathological features and the relationship with immunosuppressive therapy.

Brazilian Dialysis Survey 2023.

Introduction: The annual Brazilian Dialysis Survey (BDS) supports and contributes to the development of national health policies. Objective: To report the 2023 epidemiological data from the BDS of the Brazilian Society of Nephrology (BSN).

Methods: A survey was carried out in a voluntary sample of Brazilian chronic dialysis centers using an online questionnaire covering clinical and epidemiological aspects of patients on chronic dialysis, and characteristics of dialysis centers.

Comprehensive analysis of flower extracts: phytochemical composition and toxicity in zebrafish embryos.

(L.) R. Br.

Key takeaways: Gynecologic cancer breakthroughs at ESMO Congress 2024.

The "Key Takeaways: Gynecological cancer breakthroughs at ESMO Congress 2024" aims to include the most original and potentially practice-changing research in gynecologic oncology presented during the Annual Congress of the European Society of Medical Oncology, held in Barcelona, Spain, September 13 to 17, 2024. The scientific program encompassed a wide range of topics across various fields within oncology, and we selected 13 studies presented during the conference considered highly significant in the field of gynecologic oncology.

Impact of load and movement on arteriovenous fistula flow.

Introduction: Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis. Whether acute arm movement impacts arteriovenous fistula (AVF) blood flow is unknown.

Methods: In this cross-sectional analysis, we evaluated AVF blood flow using an ultrasound device at resting and after three muscle movements for proximal (elbow flexion, shoulder adduction and abduction) or distal AVF (fist extension and flexion, fingers squeeze), without and with a 2 kg load.

Expression of Plasma Levels of miRNA-181b and miRNA-21 in Patients With Abdominal Aortic Aneurysms and Their Effect on Clinical Outcome After Endovascular Treatment.

Introduction: Abdominal aortic aneurysms (AAA) are major causes of morbidity and mortality in the elderly population. Endovascular aneurysm repair (EVAR) is associated with lower complications rates than conventional treatment; however, rigorous follow-up with contrast imaging is required to confirm aneurysmal sac exclusion. The main objective of this study was to quantify and evaluate miRNA expression response to EVAR based on serum dosages at the 6-month follow-up.

Molecular Interactions of the Antimicrobial Peptide Tritrpticin with Mixed Nanoaggregates: A Fluorescence Spectroscopy Study.

Introduction: Tritrpticin (TRP3) is a peptide belonging to the cathelicidin family and has a broad spectrum of antimicrobial activity. However, this class of biomolecules can be easily degraded in the body, making it necessary to use an efficient transport system. The ability to form stable nanostructures from the interaction of glycyrrhizin saponin with the pluronic polymer F127 was demonstrated, forming mixed biopolymeric micelles, highly promising as drug carriers.

Citrate in autosomal dominant polycystic kidney disease: biomarker or therapeutic agent?

Purpose Of Review: This review highlights the latest findings regarding hypocitraturia in autosomal dominant polycystic kidney disease (ADPKD), from both experimental and clinical studies, exploring the underlying pathophysiology and potential therapeutic approach.

Recent Findings: Experimental studies have shown that the lodging of microcrystals in the tubules can trigger cyst formation and growth in polycystic kidney disease (PKD). ADPKD patients are prone to developing hypocitraturia in early stages, which could predispose to calcium microcrystal formation.

Manifestations of the archaic in character within the analytic field: From memories in behaviour to chronic and acute enactments.

The objective of this paper is to discuss the ways in which primitive aspects of the mind, in particular, the archaic elements of character, become manifest within the analytic field. After a review of the concept, it is proposed that a "normal" character manifests through memories in behaviours/feelings, which seek the object to satisfy their needs. The characterological structure keeps primitive traumatic inscriptions under control.

From primordial inscription to word representation.

This work seeks to examine two aspects of the passage from the somato-sensory function to the psyche, in an attempt to explore in greater detail the construction of mental representations. The first aspect is the primordial inscription, which ends in the formation of a pictogram. This is an attempt to represent the "thing".

The work of the human mind: Time and symbolization (in honour of Dana's work and thought).

In order to honour the work of Dana Birksted-Breen I will attempt to show how the reading of her work has impacted on my own thinking and changed it or modified it. I would like to begin by highlighting one of Dana's claims in . I will focus on two areas: (1) the development of symbolic capacity and its connection with temporality, and (2) the concept of reverie as a .

An isolated extra-articular procedure can be indicated for patients with minor instabilities and intact graft after anterior cruciate ligament reconstruction.

Background: Some patients submitted to isolated ACL reconstruction may have symptomatic postoperative rotational instability. The objective of this study was to evaluate a population with mild rotatory instability after ACL reconstruction, which was submitted to an isolated extra-articular procedure.

Methods: Patients submitted to an isolated extra-articular procedure after ACL reconstruction were retrospectively evaluated.

Molecular and functional convergences associated with complex multicellularity in Eukarya.

A key trait of Eukarya is the independent evolution of complex multicellular (CM) in animals, plants, fungi, brown algae and red algae. This phenotype is characterized by the initial exaptation of cell-cell adhesion genes followed by the emergence of mechanisms for cell-cell communication, together with the expansion of transcription factor gene families responsible for cell and tissue identity. The number of cell types (NCT) is commonly used as a quantitative proxy for biological complexity in comparative genomics studies.