Gatekeeping Through Remote Family Physician Consultations in Tertiary University Hospital During the COVID-19 Pandemic: A Cross-Sectional Study.

: To explore the potential of gatekeeping for specialized consultations and patient care via remote interactions with family physicians. This cross-sectional study was conducted at a tertiary hospital between November 2020 and December 2021, when specialized consultations were canceled due to the COVID-19 pandemic. Patients who were evaluated for remote consultation with family physicians were included.

Blood-Based Biomarkers for Identifying Disease Activity in AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder.

Importance: The temporal dynamics of serum glial fibrillary acidic protein (sGFAP) and serum neurofilament light chain (sNfL) as biomarkers of disease activity for neuromyelitis optica spectrum disorder (NMOSD) remain underexplored.

Objective: To determine optimal timing for assessing sGFAP and sNfL, establish cutoff values differentiating between attacks and remissions in NMOSD, and evaluate these findings across independent cohorts.

Design, Setting, And Participants: This retrospective, longitudinal, multicenter cohort study was conducted among patients with aquaporin-4 antibody (AQP4-IgG)-positive NMOSD.

Chia Oil Nanoemulsion Using Chia Mucilage as a Wall Material: An Alternative for Cracker Fat Substitution.

Crackers are bakery products that have shown an increase in consumption. One way to make crackers more nutritious is to add bioactive compounds, such as chia oil which is rich in polyunsaturated fatty acids. As these compounds are highly unsaturated, encapsulation techniques, such as nanoemulsion, allow the addition of them in foods, guaranteeing the preservation of their properties.

Fermi Polaron in Atom-Ion Hybrid Systems.

Atom-ion hybrid systems are promising platforms for the quantum simulation of polaron physics in certain quantum materials. Here, we investigate the ionic Fermi polaron, a charged impurity in a polarized Fermi bath, at zero temperature using quantum Monte Carlo techniques. We compute the energy spectrum, residue, effective mass, and structural properties.

Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method.

Purpose: To generate consensus and provide expert clinical practice statements for the management of adult sepsis in resource-limited settings.

Methods: An international multidisciplinary Steering Committee with expertise in sepsis management and including a Delphi methodologist was convened by the Asia Pacific Sepsis Alliance (APSA). The committee selected an international panel of clinicians and researchers with expertise in sepsis management.

Polymorphisms in nanog are associated with oral leukoplakia: case-control study.

To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case-control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG, through real-time polymerase chain reaction (PCR). Pearson's chi-squared and Fisher's exact statistical tests were used, with a significance of 5%.

Multimodality imaging of pediatric ascariasis.

Ascariasis is a prevalent intestinal helminthic infection caused by Ascaris lumbricoides, commonly known as roundworm. While the disease may remain asymptomatic when the parasites are confined to the intestinal lumen of the small bowel, symptoms and complications can arise when the helminths invade the biliary tree or pancreatic ducts. In cases of severe infection, a mass of roundworms can lead to intestinal complications, such as bowel obstruction.

Indole Derivatives as Promising Anti-Dengue Agents: A Review of Recent Advances.

Dengue, a mosquito-borne disease transmitted by Aedes mosquitoes, is a significant global health concern. Despite extensive research, effective treatments remain limited. The indole nucleus, known for its diverse pharmacological properties, has emerged as a promising scaffold for anti-dengue drug discovery.

GC-MS and HPLC-HRMS Metabolite Profiling and Biological Activities of Blanchetia heterotricha Extracts.

Blanchetia heterotricha is a species popularly used for its medicinal properties. However, few scientific records report the investigation of its chemical composition and biological activity. Herein, a metabolomics and multivariate statistical analysis approach was used to assess the chemical composition, antioxidant, and antimicrobial activity of B.

Lateral Brow-Eyelid Contour After Traditional Blepharoplasty Versus Blepharoplasty With Brassiere Sutures Using Three-Dimensional Imaging.

Purpose: This study aims to compare the lateral brow-eyelid contour following traditional blepharoplasty versus blepharoplasty with brassiere sutures using 3D imaging.

Methods: This prospective, randomized, comparative, parallel-group trial involved 56 female patients with dermatochalasis. Patients with an odd number of letters in their first names underwent traditional upper blepharoplasty (group A), while the rest underwent blepharoplasty with orbicularis oculi muscle fixation (group B).

Impact of Congested Match Schedules on Countermovement Jump Metrics in Elite Volleyball Players.

Rebelo, A, Loturco, I, Pereira, JR, Martinho, DV, Valente-dos-Santos, J, and Broek, GV. Impact of congested match schedules on countermovement jump metrics in elite volleyball players. J Strength Cond Res XX(X): 000-000, 2024-The aim of this study was to assess the impact of a congested match schedule on various countermovement jump (CMJ) metrics recorded across the braking, transfer, propulsive, and flight phases of the CMJ.

Genetic and Clinical-epidemiologic Profile of hRSV in Pediatric Patients in Southern Brazil: A Four-year Hospital Surveillance Study.

Background: Respiratory syncytial virus (hRSV) infections primarily cause acute respiratory illness and pediatric hospitalizations. We examined the hRSV molecular epidemiology in a pediatric cohort over a 4-year period and described the interrelationship with clinical data.

Methods: A cross-sectional study was conducted from 2014 to 2017 on children with acute respiratory illness.

An insect virus differentially alters gene expression among life stages of an insect vector and enhances bacterial phytopathogen transmission.

Unlabelled: transmits Liberibacter asiaticus (CLas) between citrus plants which causes the expression of huanglongbing disease in citrus. flavi-like virus (DcFLV) co-occurs intracellularly with CLas in populations in the field. However, the impact(s) of DcFLV presence on the insect vector and its interaction with the CLas phytopathogen remain unclear.

Impact of low-dose aspirin on the prevalence of anemia in elderly patients: a systematic review and meta-analysis.

Background: Aspirin is largely used for cardiovascular prevention. While its adverse effect on bleeding is well-documented, the prevalence of anemia remains uncertain. We conducted a meta-analysis on how low-dose aspirin affects hemoglobin and other hematologic parameters in the elderly.

Immunometabolic reprogramming in macrophages infected with active and dormant : differential modulation of respiration, glycolysis, and fatty acid utilization.

Dormancy is an adaptation in which cells reduce their metabolism, transcription, and translation to stay alive under stressful conditions, preserving the capacity to reactivate once the environment reverts to favorable conditions. Dormancy and reactivation of () are closely linked to intracellular residency within macrophages. Our previous work showed that murine macrophages rely on the viable but not cultivable (VBNC-a dormancy phenotype) fungus from active , with striking differences in immunometabolic gene expression.

Short-time collective dynamics of an ionic liquid: A computer simulation study with non-polarizable and polarizable models, and ab initio molecular dynamics.

Molecular dynamics (MD) simulation is used to study the intermolecular dynamics in the THz frequency range of the ionic liquid 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)imide, [C2C1im][FSI]. Non-polarizable and polarizable models for classical MD simulation are compared using as quality criteria ab initio molecular dynamics (AIMD) and experimental data from far-infrared (FIR) spectroscopy and previously published data of inelastic x-ray scattering (IXS). According to data from IXS spectroscopy, incorporating polarization in the classical MD simulation has relatively little effect on the dispersion curve (excitation frequency vs wavevector) for longitudinal acoustic modes.

Comparative analysis of sleep physiology using qualitative and quantitative criteria for insomnia symptoms.

Despite decades of research, defining insomnia remains challenging due to its complex and variable nature. Various diagnostic systems emphasize the chronic nature of insomnia and its impact on daily functioning, relying heavily on patient self-reporting due to limitations in objective measures like polysomnography (PSG). Discrepancies between subjective experiences and objective PSG results highlight the need for more nuanced approaches, such as electroencephalogram (EEG) spectral analysis, which reveals distinct patterns of high-frequency activity in individuals with insomnia.

Direct-detection of glyphosate in drinking water a scalable and low-cost laser-induced graphene sensor.

The use of pesticides has significantly increased and proliferated following the technological advancements established by the green revolution, aimed at boosting agricultural productivity. The extensive use of man-made chemicals as fertilizer and pesticides has consequently led to large-scale application, which has led to a number of environmental and human health problems. This study has helped to develop a laser-induced graphene (LIG) sensor for the detection of the most widely used herbicide in the world, glyphosate.

Metabolic acidosis with elevated anion gap and euglycemic ketoacidosis in pregnant and postpartum women with severe Covid-19.

Background/objectives: Pregnant and postpartum women have a higher risk for developing severe Covid-19 and other clinical and obstetric complications. This study aims to evaluate the frequency of metabolic acidosis with elevated anion gap and describe a case series of euglycemic ketoacidosis (EKA) in pregnant and postpartum women with severe confirmed or suspected Covid-19.

Materials And Methods: Observational retrospective study carried in a reference intensive care unit from May 2020 to June 2022.

K. Koch in the Treatment of Skin Inflammation: A Comprehensive Evaluation of Its Therapeutic Properties.

is a plant widely cultivated for food and medicinal purposes. species have been reported as anti-inflammatory, antibacterial, anxiolytic, and antinephritic agents. This study aimed to evaluate the anti-inflammatory potential of the ethanolic extract (EE) from the aerial parts of and its most promising fraction in models of acute and chronic inflammation, including a psoriasis-like mouse model.

Single-Step Deposition of Chalcopyrite (CuFeS) Thin Films.

Thin films of chalcopyrite, CuFeS, are promising candidates for use as absorber layers in photovoltaic cells due to their low band gap and high absorbance. These films are typically deposited in two or three steps, always involving an annealing process. In this work, the CuFeS film was deposited on a glass substrate in a single deposition step using the cathodic cylindrical plasma deposition (CCyPD) technique.

Innovative Emulsifiers in Cosmetic Products: A Patent Review (2013-2023).

The cosmetics industry, characterized by innovation and dynamism, is constantly undergoing research, often guided by market trends. Although it covers various sectors, emulsifiers have had a notable impact on its development. Numerous products depend on these components, and continuous research has led to the creation of ever-better products.

Electrostatic Orientation of Optically Asymmetric Janus Particles.

Janus micro- and nanoparticles, featuring unique dual-interface designs, are at the forefront of rapidly advancing fields such as optics, medicine, and chemistry. Accessible control over the position and orientation of Janus particles within a cluster is crucial for unlocking versatile applications, including targeted drug delivery, self-assembly, micro- and nanomotors, and asymmetric imaging. Nevertheless, precise mechanical manipulation of Janus particles remains a significant practical challenge across these fields.