Immunohistochemical Expression of Vascular Endothelial Growth Factor (VEGF) in Primary Canine Mast Cell Tumors and Related Regional Lymph Node Metastasis.

Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and has been identified as an autocrine growth factor for neoplastic cells of several tumors. The aim of this study was to evaluate VEGF expression in canine mast cell tumors and their respective lymph node metastases. For this purpose, 28 patients with mast cell tumors and confirmed regional lymph node metastasis were selected.

Application of Genomic Selection in Beef Cattle Disease Prevention.

Genomic applications in beef cattle disease prevention have gained traction in recent years, offering new strategies for improving herd health and reducing economic losses in the livestock industry. Advances in genomics, including identification of genetic markers linked to disease resistance, provide powerful tools for early detection, selection, and management of cattle resistant to infectious diseases. By incorporating genomic technologies such as whole-genome sequencing, genotyping, and transcriptomics, researchers can identify specific genetic variants associated with resistance to pathogens like bovine respiratory disease and Johne's disease.

Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers-Metabolic Hormones.

The extent of endocrine changes in response to various levels of heat stress and subsequent recovery is not well understood. Two cohorts of 12 Black Angus steers were housed in climate-controlled rooms (CCR) and subjected to three thermal periods: PreChallenge (5 d), Challenge (7 d) and Recovery (5 d). PreChallenge and Recovery provided thermoneutral conditions.

Standardization for Data Generation and Collection in the Dairy Industry: Addressing Challenges and Charting a Path Forward.

Standards for data generation and collection are important for integration and for achieving data-driven actionable insights in dairy farming. Data integration and analysis are critical for advancing the dairy industry, enabling better decision-making, and improving operational efficiencies. This commentary paper discusses the challenges of and proposes pathways for standardizing data generation and collection based on insights from a multidisciplinary group of stakeholders.

Heat Stress in Dairy Cows: Impacts, Identification, and Mitigation Strategies-A Review.

Heat stress in animals affects productivity, health, and reproduction, with particularly pronounced effects in dairy cows. Identifying heat stress requires understanding both physiological and environmental indicators, such as increased heart rate, respiratory rate, and rectal temperature, which reflect the animal's thermal condition within its environment. Thermoregulation in cows involves behavioral and physiological adjustments to maintain homeothermy, aiming to stabilize their internal thermal state.

Increasing Cattle Herd Size or Density in C Grass-Legume Meadows Reduces Dietary Quality.

Animal density is a grazing management decision implemented by managers that may reduce animal diet quality. Over three years, we collected herd-level cattle samples with varying animal numbers and densities across C grass-legume meadows near Powell, WY, USA. Paddocks ranged in size from 3 to 72 ha, cattle groups ranged from 80 to 370 animals, animal units (AUs; defined as heifers = 0.

Assessing and Improving Animal Welfare Using Applied Ethology.

The papers in this Special Issue, entitled "Editorial Board Members' Collection Series: Behaviour, Applied Ethology and Welfare of Farmed Animals", bring to the forefront empirical data and theoretical discussions that contribute to the discussion of contemporary issues, from environmental enrichment to improvements in animal welfare, the intensification of animal rearing systems, and innovations like virtual fencing and dietary adjustments to improve animal health and welfare in organic systems [...

Impact of Hypocaloric Diets on Weight Loss and Body Composition in Obese Dogs: A Meta-Analysis.

Canine obesity is a complex, multifactorial condition marked by excessive body fat accumulation due to a sustained positive energy balance. Over the past decade, its global prevalence has risen significantly in most industrialized nations. Despite the availability of numerous commercial diets designed for obesity management in dogs, these products exhibit considerable variability in nutrient composition, and there is currently no standardized guideline on optimal macronutrient levels for effective weight loss.

The Wildcat That Lives in Me: A Review on Free-Roaming Cats () in Brazil, Focusing on Research Priorities, Management, and Their Impacts on Cat Welfare.

Domestic cats () currently occupy the 38th place in the Global Invasive Species Database. Free-roaming cats potentially have broad-ranging impacts on wildlife, occupying most terrestrial environments globally as house pets, strays, or feral animals. In Australia, for example, cats are responsible for the decline in many vertebrate populations and extinction of several native mammals.

The Role of Nutrition Across Production Stages to Improve Sow Longevity.

Modern hyperprolific sows are increasingly susceptible to health challenges. Their rapid growth rates predispose them to locomotor disorders, while high metabolic demands, reduced backfat thickness, and increased protein accretion heighten their vulnerability to heat stress and dystocia. Additionally, prolonged farrowing negatively affects the oxidative and inflammatory status of these females.

Neonatal Abandonment and Hydrocephalus in Antillean Manatees (): Is There a Causal Relationship?

Manatees are semi-social animals, with the mother-calf relationship being considered long-lasting for the species. However, some events lead to the separation of this pair. Orphaned manatee calves can be adopted by other females of the same species.

Reproduction and Development in Fish: Solving Bottlenecks in Modern Aquaculture.

The aquaculture industry is home to the fastest-growing activity in the agriculture sector worldwide and is one of the leading sectors in global food production [...

Short Supply of High Levels of Guanidine Acetic Acid, Alters Ovarian Artery Flow and Improves Intraovarian Blood Perfusion Area Associated with Follicular Growth in Sheep.

Guanidinoacetic acid (GAA), a precursor of creatine, has a recognized effect on ruminant performance when used as a dietary supplement. However, its impact on reproductive response remains to be elucidated. Therefore, this study aimed to contribute initially to this area by supplementing the diets of ewes with a high dose of GAA, evaluating its effects on reproductive response.

Phenotypic Presentation of Children with Joint Hypermobility: Preclinical Signs.

Introduction: Joint hypermobility (JH) is mobility beyond the normal range of motion. JH can be an isolated finding or a characteristic of a syndrome. Characteristics related to the sitting position with atypical body positions, such as sitting in splits (S), with the foot on the head (F), in W (W), in a concave shape (C), episodes of dislocations, and subluxations, suggest impacts on body mechanics since childhood, with damage to the conformation of the joints.

Effects of Exergaming on Morphological Variables, Biochemical Parameters, and Blood Pressure in Children and Adolescents with Overweight/Obesity: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.

Objectives: This systematic review with meta-analysis aimed to evaluate the available body of published peer-reviewed studies on the effects of exergaming (EXG) compared to the control group (CG) on morphological variables, biochemical parameters, and blood pressure in children and adolescents with overweight/obesity.

Methods: A systematic literature search was conducted until September 2024 using five databases: PubMed, Medline, CINAHL Complete, Scopus, and Web of Science. PRISMA, TESTEX, RoB 2, and GRADE tools assessed the methodological quality and certainty of evidence.

The Influence of Socio-Affective Relationships Between Adolescents in Educational Experiences of Cooperation-Opposition: A Systematic Review.

Background/objectives: Socio-affective relationships have garnered increasing attention in recent years as a means to enhance coexistence and well-being. Within this context, educational institutions play a pivotal role in shaping peaceful coexistence and promoting well-being among future generations. Physical Education (PE) is particularly significant, because it integrates cooperative-opposition activities, which blend collaboration and competition, fostering socio-emotional development.

NF-κB-Specific Suppression in Cardiomyocytes Unveils Aging-Associated Responses in Cardiac Tissue.

: Aging is associated with structural and functional changes in the heart, including hypertrophy, fibrosis, and impaired contractility. Cellular mechanisms such as senescence, telomere shortening, and DNA damage contribute to these processes. Nuclear factor kappa B (NF-κB) has been implicated in mediating cellular responses in aging tissues, and increased NF-κB expression has been observed in the hearts of aging rodents.

Advancing Hydrogel-Based 3D Cell Culture Systems: Histological Image Analysis and AI-Driven Filament Characterization.

Machine learning is used to analyze images by training algorithms on data to recognize patterns and identify objects, with applications in various fields, such as medicine, security, and automation. Meanwhile, histological cross-sections, whether longitudinal or transverse, expose layers of tissues or tissue mimetics, which provide crucial information for microscopic analysis. : This study aimed to employ the Google platform "Teachable Machine" to apply artificial intelligence (AI) in the interpretation of histological cross-section images of hydrogel filaments.

Structural Disruption of Cilia and Increased Cytoplasmic Tubulin in Biliary Atresia-An Exploratory Study Focusing on Early Postoperative Prognosis Following Portoenterostomy.

Biliary atresia (BA) is a progressive hepatobiliary disease in infants, leading to liver failure and the need for transplantation. While its etiopathogenesis remains unclear, recent studies suggest primary cilia (PC) disruption plays a role. This study investigates correlations between PC and cytoplasmic tubulin (TUBA4A) alterations with hypoxia in patients with the isolated form of BA, focusing on native liver survival.

Rescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy.

The potentiator VX-770 (ivacaftor) has been approved as a monotherapy for over 95 cystic fibrosis (CF)-causing variants associated with gating/conductance defects of the CF transmembrane conductance regulator (CFTR) channel. However, despite its therapeutic success, VX-770 only partially restores CFTR activity for many of these variants, indicating they may benefit from the combination of potentiators exhibiting distinct mechanisms of action (i.e.

Emerging Trends in Non-Invasive Brain Stimulation: The New Kids on the Block.

In the Sustainable Development Goals of the United Nations for 2030, mental health has been identified as a global priority, emphasizing the need to reduce the prevalence, morbidity, and premature mortality associated with mental disorders [...

Analysis of the Climate Impact on Occupational Health and Safety Using Heat Stress Indexes.

Unlabelled: Workers may be exposed to conditions that put their physical and mental integrity at risk, from workplace settings to climate characteristics. Heat stress is a harmful health condition caused by exceeding the human body's tolerance limits, leading to illness and increasing the chance of work accidents. Heat stress indexes, such as the Humidex and the Heat Index (HI), are used to measure these impacts.

Incidence of Tooth Loss in Remote Indigenous Populations of the Amazon Region: A 13-Year Cohort Study Before and After Belo Monte Dam.

Tooth loss among indigenous people in the Amazon emphasizes the need for culturally appropriate oral health interventions. The objective of this study was to analyze the incidence of tooth loss in two remote Amazon indigenous populations. This prospective cohort evaluated a total of 47 indigenous in the permanent dentition at T0 and thirteen years later (T1) from two villages, Arara-Laranjal (n = 28, mean age 16.

Enhancing Post-Training Muscle Recovery and Strength in Paralympic Powerlifting Athletes with Cold-Water Immersion, a Cross-Sectional Study.

(1) Background: The recovery method is important and decisive in the training system. This study aimed to assess the effects of various post-training recovery methods on muscle damage and strength indicators in Paralympic powerlifting athletes. (2) Methods: A crossover study was conducted involving eleven male athletes (25.

The First Report of Environmental Exposure to Barium in 10 Localities Close to Industrial Areas and Ports in the Amazon.

Environmental exposure to metallic contaminants such as barium (Ba) is a worldwide concern, as these metals can even be toxic to the human body. Data on different sources of exposure to Ba and possible routes of entry are important for preventing adverse health effects. Blood Ba levels were evaluated in 10 localities in the cities of Barcarena and Abaetetuba in the Amazon.