Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021.

Background And Objective: Esophageal cancer (EC) is the seventh most prevalent cancer globally and the sixth leading cause of cancer-related mortality. This study aimed to provide an updated stratified assessment of rates in EC incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021 by sex, age, and Socio-demographic Index (SDI) at global, regional, and national levels, as well as to project the future trends of EC both globally and regionally.

Methods: Data about age-standardized rates (ASRs) of incidence (ASIR), mortality (ASDR), probability of death (ASPoD) and DALYs (ASDALYRs) of EC were obtained from the 2021 Global Burden of Disease (GBD) study.

Quality, topics, and demographic trends of animal systematic reviews - an umbrella review.

Background: Animal systematic reviews are critical to inform translational research. Despite their growing popularity, there is a notable lack of information on their quality, scope, and geographical distribution over time. Addressing this gap is important to maintain their effectiveness in fostering medical advancements.

Breast cancer patterns by age groups in Brazil: insights from population-based registries data.

Background: Breast cancer (BC) has exhibited varied epidemiological trends based on distinct age categories. This research aimed to explore the incidence and mortality rates of BC within pre-defined age groups in the Brazilian population.

Methods: BC incidence trends were assessed from 2010 to 2015 using Brazilian Population-Based Cancer Registries, employing age-standardized ratios and annual average percentage change (AAPC).

Open government data in health sector: a systematic literature review open government data in health sector.

Background: Open government data (OGD) in the health sector consolidates transparency, access to information, and collaboration between the government and different sectors of society. It is an essential instrument for health systems and researchers to generate initiatives, drive innovations, and qualify decision-making, whether in health emergencies or supporting the creation of more effective public policies. This review aimed to identify OGD initiatives in healthcare and their possible applications.

Thermal ablation of margins for recurrence prevention after endoscopic mucosal resection: a systematic review and meta-analysis.

Background And Aims: Endoscopic mucosal resection (EMR) of large colorectal lesions can be challenging, and residual lesions after EMR can progress to colorectal cancer. We aimed to assess the efficacy and safety of adding thermal ablation of margins [using argon plasma coagulation (APC) or snare tip soft coagulation (STSC)] in reducing recurrence rates after EMR.

Methods: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) identified from PubMed, Cochrane Library, and Embase.

Laser therapy in Molar-Incisor Hypomineralization (MIH) teeth treatment of hypersensitivity: a systematic review.

This review investigated the effects of hypersensitivity treatment on molar-incisor hypomineralization (MIH) using laser therapy, combined or in conjunction with other therapeutic modalities. The review was conducted according to the PICOS strategy (Population, Intervention, Comparison, and Outcome) and was performed in March 2024 using the Web of Science, PubMed, Scopus and Embase. The RoB 2 tool was employed to evaluate the risk of bias.

Mucosal-adapted bacteriophages as a preventive strategy for a lethal Pseudomonas aeruginosa challenge in mice.

Pseudomonas aeruginosa is an emergent threat due to the antimicrobial resistance crisis. Bacteriophages (phages) are promising agents for phage therapy approaches against P. aeruginosa.

Core-genome guided novel therapeutic targets identification and chimeric vaccine designing against Rickettsia rickettsii.

Rocky Mountain Spotted Fever, caused by the gram-negative intracellular bacteria Rickettsia rickettsii, is a serious tick-borne infection with a fatality rate of 20-30%, if not treated. Since it is the most serious rickettsial disease in North America, modified prevention and treatment strategies are of critical importance. In order to find new therapeutic targets and create multiepitope vaccines, this study integrated subtractive proteomics with reverse vaccinology.

Spatiotemporal expansion of dengue in Brazilian Amazon between 2001 and 2021.

Dengue remains a significant public health concern in Brazil, with all federative units registering occurrences of the disease within their territories despite constant measures to control the Aedes aegypti vector. This study aimed to evaluate the profile of notified dengue cases in the Brazilian Legal Amazon from 2001 to 2021, analyzing National System of Notifiable Diseases (SINAN) data on the disease to assess the risks for its occurrence. Subsequently, statistical analyses were conducted to identify incidence and lethality rates.

The fastest nonprofessional age group IRONMAN triathletes in the world originate from Europe.

It is well known that elite athletes of specific ethnicities and/or nationalities dominate certain sports disciplines (e.g., East Africans in marathon running).

Adenosinergic Signalling in Cervical Cancer Microenvironment.

Despite the emergence of the first human papillomavirus vaccine, the incidence of cervical cancer is still responsible for more than 350,000 deaths yearly. Over the past decade, ecto-5'-nucleotidase (CD73/5'-NT) and extracellular adenosine (ADO) signalling has been the subject of many investigations to target cancer progression. In general, the adenosinergic axis has been linked to tumourigenic effects.

Bioengineering chitosan-antibody/fluorescent quantum dot nanoconjugates for targeted immunotheranostics of non-hodgkin B-cell lymphomas.

B-cell non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy, capable of invading the brain, meninges, and nerve roots of the brain and spine, leading to high lethality. Herein, we designed and developed novel nanostructures for the first time by biofunctionalizing chitosan with two specific antibodies (i.e.

Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting.

Introduction: Healthcare systems face several challenges, with microbial infections being one of the main concerns. Therapeutic drug monitoring (TDM) is a strategy that has been encouraged to optimize antimicrobial regimens, particularly those with significant toxicity and narrow therapeutic indices, such as amikacin (AMK). We aimed to evaluate AMK concentrations of patients in a non-routine TDM setting and compare the performance of immunoassay and chromatography methods for routine clinical use.

Presence of multidrug-resistant bacteria on ready-to-use laryngoscope blades and handles: a cross-sectional study.

Background: The presence of microorganisms in laryngoscopes emphasizes the risk to patient safety during orotracheal intubations.

Methods: Cross-sectional study was carried out in university hospital in the inpatient, emergency, intensive care and surgical center sectors. Microorganisms were recovered from the blades using a filter membrane and from the handles using swab.

Obstructive Sleep Apnoea-Associated Factors in Children and Adolescents Diagnosed by Polysomnography: A Scoping Review.

Purpose: This scoping review aimed to map research on factors associated with obstructive sleep apnoea (OSA) in children and adolescents undergoing overnight polysomnography (PSG) and questionnaire-based diagnostic assessments.

Methods: Searches were conducted in three electronic databases up to May 2023, including nine observational studies, including 3482 individuals.

Results: Among the included studies, nine reported on sex, six on obesity, five on tonsillar hypertrophy, three on mouth breathing, two on allergic rhinitis, and three on smoking exposure.

Copper Prevention Values in Brazilian Subtropical Soils.

The Brazilian National Environmental Council (CONAMA) Resolution 420/2009 establishes soil quality guideline values for copper, as the prevention value (PV). It defines the maximum concentrations of chemical substances permitted in the soil. Thus, the aim of the present research was to evaluate the effectiveness of the copper PV adopted at the national level by conducting exposure assays with enchytraeids (Enchytraeus crypticus, Enchytraeus bigeminus and Enchytraeus dudichi) and springtails (Folsomia candida, Proisotoma minuta and Sinella curviseta) in two Brazilian subtropical soils: a Latosol and an Argisol.

Computational condensed matter science contributions to addressing water emerging contaminant pollution: A comprehensive review.

The study of emerging contaminants (ECs) in water resources has garnered significant attention due to their potential risks to human health and the environment. This review examines the contribution from computational approaches, focusing on the application of machine learning (ML) and molecular dynamics (MD) simulations to understand and optimize experimental applications of ECs adsorption on carbon-based nanomaterials. Condensed matter physics plays a crucial role in this research by investigating the fundamental properties of materials at the atomic and molecular levels, enabling the design and engineering of materials optimized for contaminant removal.

Gene expression and immunohistochemistry analysis of ADAMTS-1 and its substrates in odontogenic keratocyst.

Background: Considering the significant participation of the microenvironment in the local aggressiveness of odontogenic keratocysts, this study aims to evaluate the expression of ADAMTS-1 and its substrates, versican, aggrecan and brevican in this locally invasive odontogenic cyst.

Methods: Immunohistochemistry and polymerase chain reaction (PCR) were conducted on 30 cases of odontogenic keratocysts (OKCs) and 20 dental follicles (DFs).

Results: The immunohistochemical expression of these proteins was predominantly cytoplasmic and granular across all samples.

Psychometric properties of the health literacy questionnaire tested in Vietnamese adults with chronic diseases.

Background: The Health Literacy Questionnaire (HLQ) is an increasingly used health literacy instrument that has been translated into many languages. The HLQ has 44 items and comprises 9 scales assessing the multidimensional construct of health literacy. This study reports the HLQ reliability and construct validity tested in people with chronic diseases living in Vietnam.

Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature.

Non-invasive, low intensity focused ultrasound is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported.

Clinical characteristics of the Ala21Val variant in the myelin proteolipid protein 1 (PLP1) gene associated with Pelizaeus-Merzbacher disease in a Brazilian male patient.

Here, we report the case of a 29-year-old male with classic Pelizaeus-Merzbacher disease (PMD) harboring the PLP1 variant NM_000533.5:c.62 C > T, leading to an NP_000524.

Birth weight and head circumference for 22-29 weeks gestation neonates from an international cohort.

Objective: Size at birth is a key indicator of in utero growth. Our objective was to generate sex-specific percentiles for birth weight and head circumference in neonates born between 22 and 29 weeks gestation from pregnancies without hypertension or diabetes and assess differences between vaginal and caesarean births and between singletons and twins.

Methods: We used data from 12 countries participating in the International Network for Evaluating Outcomes in Neonates database from 2007 to 2021.

Application of Automated face coding (AFC) in older adults: a pilot study.

Objectives: The study aimed to assess the prevalence and nature of emotional expressions in care-dependent older adults using an automated face coding (AFC) software. By examining the seven fundamental emotions, the study sought to understand how these emotions manifest and their potential implications for dental care in this population.

Methods: Fifty care-dependent older adults' (mean-age: 78.