Assessing Radiation-Induced Enzyme Activation in Aedes aegypti: Potential Challenges for SIT-Based Vector Management.

This study characterizes the Aedes aegypti population from Fernando de Noronha Island, Pernambuco, Brazil, prior to implementing the Sterile Insect Technique (SIT). The main objective was to assess changes in glutathione S-transferase (GST) enzyme activity, previously linked to cypermethrin resistance in this population, in 2010. GST activity was measured in both male and female mosquitoes, masse produced in lab, after exposure to ionizing radiation.

Changes in phosphorus due to pyrolysis and in the soil-plant system amended with sewage sludge biochar compared to conventional P fertilizers: a global meta-analysis.

Phosphorus (P) plays an essential role for plant growth, but conventional P sources used in agriculture are finite and non-renewable. As a result, there is a growing need to explore alternative P sources such as sewage sludge (SS) - a P-rich solid waste and valuable renewable resource that is often mismanaged globally. Pyrolysis is a promising technique for managing SS.

Validation of a novel tool for automated tooth modelling by fusion of CBCT-derived roots with the respective IOS-derived crowns.

Objectives: To validate a novel artificial intelligence (AI)-based tool for automated tooth modelling by fusing cone beam computed tomography (CBCT)-derived roots with corresponding intraoral scanner (IOS)-derived crowns.

Methods: A retrospective dataset of 30 patients, comprising 30 CBCT scans and 55 IOS dental arches, was used to evaluate the fusion model at full arch and single tooth levels. AI-fused models were compared with CBCT tooth segmentation using point-to-point surface distances-reported as median surface distance (MSD), root mean square distance (RMSD), and Hausdorff distance (HD)- alongside visual assessments.

Clinical evaluation of the accuracy of two face scanners with different scanning technologies.

Objectives: This study compared the clinical accuracy of two different stationary face scanners, employing progressive capture and multi-view simultaneous capture scanning technologies.

Methods: Forty dentate volunteers participated in the study. Soft tissue landmarks were marked with a pen on the participants' faces to measure the distances between them.

Influence of the addition of gum arabic and xanthan gum in the preparation of sodium alginate microcapsules coated with chitosan hydrochloride on the survival of Lacticaseibacillus rhamnosus GG.

The microencapsulation of Lactocaseibacillus rhamnosus GG in a matrix of sodium alginate, xanthan gum, gum arabic and chitosan hydrochloride is a promising strategy for protecting this probiotic during passage through the gastrointestinal tract. This study evaluated the influence on the viability of Lactocaseibacillus rhamnosus GG encapsulated with these polymers by external ionic gelation with vibratory extrusion and the microcapsules that showed the best results of capsulation efficiency, viability, size and morphology were analyzed by Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA) and exposure to environmental stress conditions and gastrointestinal simulation. The result revealed encapsulation efficiency values above 95 % for all formulations and survival rate higher than 6 log CFU/mL for most analyzed groups.

Prenatal toxicity of L-mimosine in Wistar rats.

L-Mimosine is the main active component of the plant Leucaena leucocephala. Due to its metal-chelating mechanism, it interacts with various metabolic pathways in living organisms, making it a potential pharmacological target, although it also leads to toxicity. The present study aimed to investigate the transplacental passage of L-mimosine and its effects on embryofetal development.

Gingivitis- and periodontitis-associated microbiota in bovine deciduous incisor teeth - a preliminary study.

As ruminants are frequently affected by periodontal diseases, understanding their microbial communities is crucial. In this pilot study, we analyzed subgingival biofilm samples of young cattle across different states: clinically healthy (n=5), gingivitis (n=5), and periodontitis (n=5) using 16S rRNA gene sequencing and co-occurrence network analysis. The findings revealed that Proteobacteria was the predominant phylum across all conditions, with Fusobacteriota constituting 27.

Clinical aspects and characterization of Pseudomonas aeruginosa isolated from patients infected with SARS-CoV-2.

Aims: This study aimed to identify and characterize Pseudomonas aeruginosa isolates from patients infected and uninfected with SARS-CoV-2, focusing on their phenotypic characteristics and antimicrobial resistance profiles.

Main Methods: A total of 100 P. aeruginosa isolates were obtained from patients admitted to a hospital in Presidente Prudente, SP, in 2021.

Is self-reported symptom duration in individuals with patellofemoral pain an accurate measure? An observational longitudinal study.

Background: Although self-reported symptom duration of individuals with patellofemoral pain (PFP) is usually assessed for clinical and research purposes, its accuracy has never been investigated.

Objectives: We followed up individuals with PFP over 15 months to determine the agreement between self-reported symptom duration and calculated symptom duration.

Methods: Self-reported symptom duration of 39 participants was assessed at baseline and re-assessed at follow-up.

Which aEEG patterns could predict neurodevelopmental outcome in preterm neonates? - A systematic review.

Objective: Amplitude-integrated electroencephalogram (aEEG) enables continuous and simplified bedside monitoring of brain function. This review aims to investigate aEEG's value as a predictor of neurodevelopment outcome in preterm infants.

Methods: PubMed, Embase and Web of Science were systematically searched according to the PRISMA in April 2023 and updated in October 2023.

New series of 3-pyridyl-1,3-thiazoles: In vitro and in vivo anti-Trypanosomatidae profile, in vitro and in silico mechanism of action approach.

Trypanosomatidae diseases, such as Chagas disease and leishmaniasis, are caused by protozoan parasites of the Trypanosomatidae family, namely Trypanosoma cruzi and Leishmania species, respectively. There is an urgent need for new therapies. Both pyridine and thiazole rings are recognized as important scaffolds in medicinal chemistry.

The effect of dairy herd and industry-related factors on Parmigiano Reggiano PDO cheese-making traits evaluated by FT-IR spectroscopy.

Parmigiano Reggiano protected designation of origin (PDO) cheese inherently exhibits variability due to the characteristics of the production system, contributing to heterogeneity in the composition and properties of milk used in the cheese-making process. This variability leads to variations in cheese yield and nutrient recoveries. The direct measurement of these traits is not feasible in routine practice.

Clinicopathological comparison and cytokeratin-10 expression between Lichen planus and oral lichenoid lesions.

Objectives: This study aimed to compare clinicopathological features and immunostaining for cytokeratin-10 between oral lichen planus and oral lichenoid lesions.

Design: This was a retrospective longitudinal study comparing lichen planus and oral lichenoid lesions diagnosed at the Oral Pathological Anatomy Service that analyzed sociodemographic and clinicopathological data and CK10 expression. Chi-square tests, Fisher's exact tests and Mann-Whitney tests or Student's t tests were used when appropriate, and p values < 0.

The Human Footprint and Climate Change Shape Current and Future Scenarios of Visceral Leishmaniasis Distribution in Doce River Basin in Brazil.

The identification of factors that influence the distribution of visceral leishmaniasis (VL) is key for future surveillance and control. This study sought to understand how environmental and climate variables can interfere with VL expansion in the Doce River basin located in Brazil. This ecological study explored the influence of anthropogenic, environmental, and climatic factors on VL expansion.

Thoracic ultrasound for diagnosing pneumopathies in neotropical primates.

Lung ultrasound can be useful for the early diagnosis and treatment of respiratory complications. The combination of air and soft tissue confirms imaging artefacts that can contribute to differentiation between healthy and deteriorated lung tissue. Although non-human primates are often chosen as research models due to their anatomical and physiological similarity to humans, there is a lack of data on the use of lung ultrasound in these individuals.

Effects of individualized resistance training prescription with heart rate variability on muscle strength, muscle size and functional performance in older women.

Introduction: This study aimed to investigate whether individualizing autonomic recovery periods between resistance training (RT) sessions (IND) using heart rate variability (HRV), measured by the root mean square of successive R-R interval differences (RMSSD), would lead to greater and more consistent improvements in muscle strength, muscle mass, and functional performance in older women compared to a fixed recovery protocol (FIX).

Methods: Twenty-one older women (age 66.0 ± 5.

A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil.

Introduction: The prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%-10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data from Brazilian patients with BC.

"": physicians' perceptions on climate change information and adaptation strategies - qualitative study in Portugal.

Background: Climate change presents several challenges to public health and its professionals. This article aims to fill a significant gap in the current literature by understanding physicians' perceptions of their role in educating others about health adaptation to climate change. It also explores their knowledge of health policies related to this issue in Portugal and their perceived influence on the development of adaptation policies at both local and national levels within the health sector.

Sex Differences in Participation and Performance Trends in Time-Limited Ultramarathon Events.

We aimed to analyze sex differences in time-limited ultramarathon participation, while also identifying trends in participation, age, and performance across different formats of events, from 1990 to 2020. This is an exploratory study, using data obtained from the official event web pages. We downloaded information regarding the year of the event, athletes' year of birth, sex, race event, ranking, and mean running speed (km/h).

Hepatocyte nuclear factor 4-α is necessary for high fat diet-induced pancreatic β-cell mass expansion and metabolic compensations.

Aims: This study investigates the role of Hepatocyte Nuclear Factor 4α (HNF4α) in the adaptation of pancreatic β-cells to an HFD-induced obesogenic environment, focusing on β cell mass expansion and metabolic adaptations.

Main Methods: We utilized an HNF4α knockout (KO) mouse model, with CRE-recombinase enzyme activation confirmed through tamoxifen administration. KO and Control (CTL) mice were fed an HFD for 20 weeks.

Production of Cellulose Nanoparticles from Cashew Apple Bagasse by Sequential Enzymatic Hydrolysis with an Ultrasonic Process and Its Application in Biofilm Packaging.

Cellulose nanostructures obtained from lignocellulosic biomass via enzymatic processes may offer advantages in terms of material properties and processing sustainability. Thus, in this study, cellulose nanoparticles with a spherical morphology were produced through the enzymatic hydrolysis of cashew apple bagasse (CAB). CAB was previously subjected to alkaline and acid-alkali pretreatment, and the pretreated solids were labeled as CAB-PTA and CAB-PT-HA, respectively.

Study of the Anti-MYC Potential of Lanostane-Type Triterpenes.

One of the most investigated molecular targets for anticancer therapy is the proto-oncogene , which is amplified and thus overexpressed in many types of cancer. Due to its structural characteristics, developing inhibitors for the target has proven to be challenging. In this study, the anti-MYC potential of lanostane-type triterpenes was investigated for the first time, using computational approaches that involved ensemble docking, prediction of structural properties and pharmacokinetic parameters, molecular dynamics (MD), and binding energy calculation using the molecular mechanics-generalized born surface area (MM-GBSA) method.

Predicting Irida-Silicene: A Novel 2D Silicon Allotrope.

Two-dimensional (2D) silicon-based materials have garnered significant attention for their promising properties, making them suitable for various advanced technological applications. Here, we present Irida-Silicene (ISi), a novel 2D silicon allotrope inspired by Irida-Graphene (IG), which was recently proposed and is entirely composed of carbon atoms. ISi exhibits a buckled structure composed of 3-6-8 membered rings, unlike its planar carbon counterpart.

Sugar Cane ( L.) Waste Synthesized Si,N,S-Carbon Quantum Dots as High-Performance Corrosion Inhibitors for Mild Steel in Hydrochloric Acid.

This work reports the obtention of Si,N,S-CQDs from sugar cane bagasse and their inhibitory action on the mild steel corrosion in 1 mol L HCl solution. The CQDs were successfully obtained and characterized by X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, Dynamic light scattering, Raman, and UV-vis techniques, also showing endogenous self-doping. The anti-corrosive activity of CQDs was investigated by gravimetric tests, potentiodynamic polarization curves, electrochemical impedance measurements, atomic force microscopy, and scanning electron microscopy.