549,839 results match your criteria: "Brazil; Hospital Beneficencia Portuguesa de Sao Paulo[Affiliation]"
Arq Neuropsiquiatr
January 2025
The University of Tokyo Hospital, Department of Neurology, Tokyo, Japan.
The pioneers of neurology in Japan were professors Hiroshi Kawahara and Kinnosuke Miura. Kawahara published the first description of progressive bulbar palsy and wrote the first neurology textbook in Japan. Miura, on the other hand, published studies about amyotrophic lateral sclerosis, in addition to participating in the founding of the Japanese Society of Neurology.
View Article and Find Full Text PDFArq Neuropsiquiatr
January 2025
Universidade Federal do Rio Grande do Norte, Hospital Universitário Onofre Lopes, Serviço de Neurologia, Natal RN, Brazil.
Background: The movement disorder known as hemifacial spasm is characterized by involuntary contractions of the muscles that are innervated by the facial nerve. The treatment of choice for this condition is botulinum toxin injections.
Objective: To analyze the botulinum toxin dosage in patients undergoing treatment for hemifacial spasm during a 14-year period.
Arq Neuropsiquiatr
January 2025
Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Centro de Estudos em Paramiloidose Antônio Rodrigues de Mello, Rio de Janeiro RJ, Brazil.
Background: Tafamidis is a kinetic stabilizer that binds to the transthyretin (TTR) gene, inhibiting its dissociation. It is the only disease-modifying treatment for hereditary TTR amyloidosis with peripheral neuropathy (ATTRv-PN) available in the National Therapeutic Form (Formulário Terapêutico Nacional, FTN, in Portuguese) of the Brazilian Unified Health System (Sistema Único de Saúde, SUS, in Portuguese).
Objective: To assess if the efficacy and safety of tafamidis in the Brazilian real-world experience are comparable to the results of clinical trials.
Vaccine
January 2025
Instituto Butantan, Sao Paulo, Brazil.
Developing Countries Vaccine Manufacturers Network (DCVMN) is an alliance of vaccine developers, manufacturers, and marketing authorization holders (MAHs) from low- and middle-income countries (LMICs) that plays a vital role in ensuring equitable, inclusive, accountable, and timely access to affordable, high-quality vaccines in these countries. Besides research and development, this network promotes manufacturing and global supply chains for effective strengthening of regulatory and pharmacovigilance activities. Traditionally, vaccine safety surveillance systems in LMICs rely on spontaneous reporting.
View Article and Find Full Text PDFEnzyme Microb Technol
January 2025
Departamento de Biocatálisis, ICP-CSIC, C/Marie Curie 2, Campus UAM-CSIC, Cantoblanco, Madrid 28049, Spain. Electronic address:
Supports coated with amino-hexyl and amino octyl have been prepared from glyoxyl agarose beads and compared in their performance with octyl-agarose to immobilize lipases A and B from Candida antarctica (CALA and CALB). Immobilization courses were similar using all supports, but enzyme release was more difficult using the amino-alkyl supports suggesting a mixed interfacial activation/ionic exchange immobilization. The enzyme activity and specificity (using p-nitrophenyl propionate, triacetin and both isomers of methyl mandelate) greatly depended on the support.
View Article and Find Full Text PDFFood Chem
January 2025
Group of Alternative Analytical Approaches (GAAA), Bioenergy Research Institute (IPBEN), Institute of Chemistry, São Paulo State University (UNESP), Araraquara, 14800-060 São Paulo State, Brazil; National Institute of Alternative Technologies for Detection Toxicological Assessment and Removal of Micropollutants and Radioactive Substances (INCT-DATREM), Araraquara, 14800-060 São Paulo State, Brazil. Electronic address:
Non-conventional food plants (or non-conventional edible plants) have the potential to serve as an excellent nutritional alternative while promoting the circular economy. Given the nutritional potential of non-conventional food plants, this study aimed to investigate and determine the composition of these plants using inductively coupled plasma optical emission spectroscopy (ICP OES) combined with chemometric techniques. In this context, the following non-conventional food plant species were evaluated: serralha (Sonchus oleraceus), two species of ora-pro-nóbis, Pereskia grandifolia and Pereskia aculeata, peixinho (Nematanthus gregarius), alfavaca (Ocimum basilicum), taioba (Xanthosoma sagittifolium), capeba (Pothomorphe umbellata), tranchagem (Plantago major), and bardana (Arctium lappa).
View Article and Find Full Text PDFSci Total Environ
January 2025
Graduate Program in Biodiversity and Nature Conservation, Federal University of Juiz de Fora (UFJF), Minas Gerais State, Brazil; Plant Ecology Laboratory, Department of Botany, Federal University of Juiz de Fora, Juiz de Fora (UFJF), Minas Gerais State, Brazil. Electronic address:
Research about patterns of aboveground carbon stock (AGC) across different tropical forest types is central to climate change mitigation efforts. However, the aboveground carbon stock (AGC) quantification for Brazilian cloud forest ecosystems along the altitudinal gradient is still scarce. We aimed to evaluate the effects of abiotic and biotic on AGC and the AGC distribution between species and families of tree communities along an altitudinal Brazilian Atlantic cloud forest gradient of the Mantiqueira Mountain Range, Southeastern Brazil.
View Article and Find Full Text PDFArch Oral Biol
December 2024
University of Brasília, Brasília, Laboratory of Oral Histopathology, Health Sciences Faculty, Brazil. Electronic address:
Objective: This in vitro study aimed to analyze the effects of ionizing radiation on immortalized human osteoblast-like cells (SaOS-2) and further assess their cellular response in co-culture with fibroblasts. These analyses, conducted in both monoculture and co-culture, are based on two theoretical models of osteoradionecrosis - the theory of hypoxia and cellular necrosis and the theory of the radiation-induced fibroatrophic process.
Design: SaOS-2 cells were exposed to ionizing radiation and evaluated for cell viability, nitric oxide (NO) production, cellular morphology, wound healing, and gene expression related to the PI3K-AKT-mTOR pathway.
Clin Neurol Neurosurg
January 2025
Department of Medicine, Federal University of Piauí, Teresina, Brazil.
Introduction: Intravenous tirofiban (IT) is shown to be potentially effective in acute ischemic stroke (AIS) patients submitted to mechanical thrombectomy, despite its safety and efficacy are not well established. However, there is a lack of evidence on the effects of IT on endovascular thrombectomy (EVT) in patients with AIS due to large artery atherosclerosis (LAA).
Objectives: To assess the safety and efficacy of IT in AIS patients due to LAA submitted to EVT.
J Craniofac Surg
November 2024
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL.
Giant cell tumors (GCTs) are benign but locally aggressive bone neoplasms that primarily affect skeletally mature individuals. They are characterized by a tendency for recurrence and being associated with significant morbidity. Traditional treatment has focused on surgical resection; however, the role of medical therapies, such as Denosumab, a bone anti-resorptive drug, which has been Food and Drug Administration (FDA)-approved for unresectable GCTs since 2013, recently has gained prominence.
View Article and Find Full Text PDFEpidemiol Serv Saude
January 2025
Universidade Federal da Bahia, Instituto de Saúde Coletiva, Salvador, BA, Brasil.
Objective: To describe the sociodemographic profile and access to social assistance and health services among trans people and travestis experiencing homelessness in Salvador, the capital city of Bahia state.
Methods: This was a cross-sectional study involving 24 (4.5%) participants who identified as trans people or travestis out of a total of 529 people, aged 18 or older, living in public spaces or institutional shelters included in the survey.
Epidemiol Serv Saude
January 2025
Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brasil.
Objective: To assess adherence to and completeness of vaccination schedules against human papillomavirus (HPV) and hepatitis A and B among transgender women and travestis in São Paulo, capital city of São Paulo state.
Methods: This was a secondary data analysis of the multicenter TransOdara study. Data were collected from 403 transgender women and travestis aged 18 years or older, recruited through respondent-driven sampling between December 2019 and October 2020.
Epidemiol Serv Saude
January 2025
Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, SP, Brasil.
Objective: To analyze the social network of mothers, fathers or guardians of transgender children or adolescents.
Methods: This was a qualitative study, based on the theoretical framework of social network, with a focus on the primary network. The study was conducted in Brazil through online interviews between August and October 2021.
Dental Press J Orthod
January 2025
Federal University of Rio de Janeiro, School of Dentistry, Department of Orthodontics (Rio de Janeiro/RJ, Brazil).
Introduction: It is known that the stability of the results obtained with orthodontic treatment depends, in addition to the functional and aesthetic aspects, also on the adequate planning of the retention devices, the patient's compliance with this new phase, and the physiological changes that the human body experiences over the years, throughout the craniofacial aging process.
Objective: This article discusses the importance of the orthodontic retention phase and the influence of diagnosis, planning and execution of corrective treatment of malocclusions, in order to achieve the expected success.
Methods: Throughout the text, different types of retainers and approaches during this phase will be presented, with the aim of ensuring the stability of the results obtained after correcting problems in the vertical, transverse and anteroposterior directions.
Dental Press J Orthod
January 2025
Federal University of Minas Gerais, School of Dentistry, Department of Restorative Dentistry (Belo Horizonte/MG, Brazil).
Objective: To evaluate the quality of YouTube™ and TikTok™ videos as educational tools for patients with cleft lip and palate (CLP) as regards their care, and multidisciplinary treatment.
Methods: Videos were searched on YouTube™ and TikTok™ using four keywords. The reliability and quality of the first 60 videos for each keyword and platform were analyzed.
Dental Press J Orthod
January 2025
Paraíba State University, Dentistry Program (Campina Grande/PB, Brazil).
Introduction: Malocclusion is a public health problem. The evidence of its impact on quality of life is contradictory and requires further studies.
Objective: The aim of this study was to estimate the prevalence of severe malocclusion and its impact on oral health-related quality of life in schoolchildren aged 12-15 years.
Rev Bras Enferm
January 2025
Universidade da Integração Internacional da Lusofonia Afro-Brasileira. Redenção, Ceará, Brazil.
Rev Bras Enferm
January 2025
Universidade Federal de Santa Catarina, Colégio de Aplicação. Santa Catarina, Santa Catarina, Brazil.
Objective: To analyze the new roles of community health workers as outlined in the 2017 National Primary Care Policy (PNAB) from the perspectives of both nurses and community health workers.
Methods: This qualitative study involved nurses and community health workers from Family Health teams, conducted through semi-structured interviews via videoconference between August 2021 and April 2022. The data were analyzed using thematic content analysis.
Rev Bras Enferm
January 2025
Universidade Federal de Minas Gerais. Belo Horizonte, Minas Gerais, Brazil.
Objective: To analyze the reach and engagement on the history of nursing on social media of the Memory Center of the School of Nursing, Federal University of Minas Gerais (CEMENF/UFMG), in light of Pierre Lévy.
Methods: Documentary study carried out on CEMENF's Instagram and on the YouTube of the School of Nursing of UFMG, from September to December 2021. The findings were analyzed according to Pierre Lévy's concepts.
Rev Bras Enferm
January 2025
Universidade Federal de Mato Grosso do Sul. Campo Grande, Mato Grosso do Sul, Brazil.
Objective: To map studies on clinical simulation training directed at first responders during pediatric emergencies, focusing on interaction with families.
Methods: A scoping review based on the guidelines of the JBI Manual for Evidence Syntheses and reported according to the PRISMA-ScR checklist, covering eight databases and gray literature, without time or language restrictions.
Results: The ten selected studies indicated that most publications were from the United States.
Rev Bras Enferm
January 2025
Universidade Federal de São João del-Rei. Divinópolis, Minas Gerais, Brazil.
Objective: to develop a bundle for the safety of psychiatric patients during hospitalization.
Methods: a methodological study conducted in two stages. In the first, a comprehensive literature review was developed through a scoping review and conducted to examine evidence on the safety of psychiatric patients during hospitalization.
Cad Saude Publica
January 2025
Instituto de Economia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
In 2021, the sole paragraph of article 40 of the Industrial Property Law (LPI) was declared unconstitutional. As a result, some companies filed lawsuits seeking an extension of the term of validity of their pharmaceutical patents. This article aims to estimate the possible economic consequences of the extension of the term of patents in spending on medicines for centralized procurement and the private market.
View Article and Find Full Text PDFCad Saude Publica
January 2025
Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
This study aimed to evaluate the overall excess mortality and COVID-19 mortality in the regions of Brazil, in 2020, by sex and age group. An ecological study was carried out to calculate the overall excess mortality, by sex and age group, using the expected number of deaths in a non-pandemic context and the deaths observed in 2020. Data on deaths were extracted from the Brazilian Mortality Information System, in addition to population data from the Brazilian Institute of Geography and Statistics.
View Article and Find Full Text PDFCad Saude Publica
January 2025
Universidade Federal de Alagoas, Maceió, Brasil.
This study aimed to investigate the presence of mental illness in victims of soil instability in neighborhoods affected by rock salt extraction from a mining company located in the city of Maceió, Alagoas, Brazil. It is a quantitative, descriptive-analytical, and cross-sectional study. The sample was intentional and non-probabilistic and consisted of 158 participants, with a 0.
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