Addressing the needs for cultural adaptation of DARE-keepin' it REAL among Brazilian students: strategies to improve implementation.

Background: The widely implemented prevention program in Brazil, PROERD (a translated version of the DARE-kiR program), showed no evidence of effect in preventing drug use in a recent trial. The lack of cultural adaptation and instructors' deviations from the curriculum were identified as potential reasons for its ineffectiveness. This study aims to identify points of inadequacy of the PROERD program for the Brazilian culture, suggesting strategies for revising the curriculum to improve implementation.

The Influence of Ovarian-Derived Extracellular Vesicles in Reproduction.

In this chapter, we explore the multifaceted roles of extracellular vesicles (EVs) in ovarian biology, focusing on their contributions to folliculogenesis, oocyte competence, corpus luteum function, and immune response regulation. EVs, particularly those derived from follicular fluid (ffEVs), are crucial mediators of cell-to-cell communication within the ovarian follicle, influencing processes such as meiotic progression, stress response, and hormonal regulation. We review preexisting literature, highlighting key findings on the molecular cargo of EVs, such as miRNAs and proteins, and their involvement in regulating the function of the follicle cells.

Elastic static power, its correlation with acute respiratory distress syndrome severity: A Bayesian post-hoc analysis of the Mechanical Power Day cross-sectional trial.

Objective: The relationship between different power equations and the severity of acute respiratory distress syndrome (ARDS) remains unclear. This study aimed to evaluate various power equations: total mechanical power, total elastic power (comprising elastic static and elastic dynamic power), and resistive power, in a cohort of mechanically ventilated patients with and without ARDS. Bayesian analysis was employed to refine estimates and quantify uncertainty by incorporating a priori distributions.

Assessing postoperative maxillary advancement stability in patients with cleft lip and palate.

This study aims to evaluate the post-surgical stability of patients with cleft lip and palate that underwent maxillary advancement surgery. The study was conducted by means of cephalometric analysis of the soft tissues in digital radiographs acquired preoperatively, immediate postoperatively and six months after surgery using Dolphin Imaging 11.5 software.

Bioengineering Innovations in Global Dental Infection Control: Applications and Adaptations in Clinical Settings.

Introduction And Aims: Dental practices pose a high risk of microbial contamination due to frequent exposure to bodily fluids like saliva and blood. Bioengineering innovations have emerged as vital tools to enhance infection control in dental settings. This review aims to assess the global applications and effectiveness of these innovations, particularly focusing on antimicrobial biomaterials, sterilization techniques, and personal protective equipment (PPE).

Pathway to care, treatment and disease burden of pulmonary arterial hypertension: a real-world survey of physicians and patients in Latin America.

Objectives: To investigate clinical characteristics, symptom profile, testing practices, treatment patterns and quality of life (QoL) among patients with pulmonary arterial hypertension (PAH) in Latin America.

Design: Data from the Adelphi Real World PAH Disease Specific Programme, a cross-sectional survey with retrospective data collection.

Setting: University/teaching hospital, regional centres, private practices and government institutions in Argentina, Brazil, Colombia and Mexico.

Phytoremediation Assessment of in Zinc-Contaminated Oxisols: Tolerance and Accumulation Dynamics.

This study assessed the phytoremediation potential of grown in Oxisol contaminated with varying zinc concentrations. was cultivated in soil with Zn levels from 0 to 1920 mg kg. Growth parameters, Zn concentrations in plant parts, bioaccumulation, and translocation factors were measured.

Artificial Intelligence Models Could Enhance the Diagnostic Accuracy (DA) of Fecal Immunochemical Test (FIT) in the Detection of Colorectal Adenoma in a Screening Setting.

Background/aim: This study evaluated the diagnostic accuracy (DA) for colorectal adenomas (CRA), screened by fecal immunochemical test (FIT), using five artificial intelligence (AI) models: logistic regression (LR), support vector machine (SVM), neural network (NN), random forest (RF), and gradient boosting machine (GBM). These models were tested together with clinical features categorized as low-risk (lowR) and high-risk (highR).

Patients And Methods: The colorectal neoplasia (CRN) screening cohort of 5,090 patients included 222 CRA patients and 264 non-CRA patients.

Changes in blowfly (Diptera: Calliphoridae) wing morphology during succession in rat carcasses across forest and grassland habitats in South Brazil.

Succession is one of the most extensively studied ecological phenomena, yet debates persist about the importance of dispersal and external factors in driving this process. We aimed to quantify the influence of these factors by investigating how wing-related traits evolve across succession of blowfly (Diptera: Calliphoridae) communities in South Brazil. Rat carrion was placed in both forest and grassland habitats, and the associated blowfly communities were documented throughout the decomposition process.

Mindfulness interventions and quality of life in anxiety-related disorders: A systematic review and meta-analysis.

Mindfulness-based interventions (MBIs) effectively treat anxiety symptoms across different anxiety and related disorders (ARDs), including panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. In this systematic review and meta-analysis, we investigate whether MBIs also lead to improvements in the quality of life (QoL) of patients with ARDs. A systematic review was performed through electronic search in PUBMED, PsycINFO, Embase, Web of Science, and Clinical Trials databases.

Orofacial pain models induce impairment in spatial learning and working memory in rodents: a systematic review and meta-analysis.

Orofacial pain is one of the most common causes of chronic pain leading to physical and cognitive disability. Several clinical and pre-clinical studies suggest that chronic pain results in cognitive impairment. However, there is a lack of meta-analyses examining the effects of orofacial pain models on behavioral learning and memory in rodents.

The presence of sexed sperm in bovine oviduct epithelial cells alters the protein profile related to stress and immune response.

Although sperm sexing technology has progressed considerably in the last decade, there are still challenges to fully understand the reason for the low fertility of sexed sperm. Thus, we aimed to evaluate the effect of sexed and non-sexed sperm on the proteome of bovine oviduct epithelial cells (BOECs). Semen from six Nellore bulls was used and one ejaculate from each bull was collected and separated into three fractions: non-sexed, sexed for X-sperm and sexed for Y-sperm.

System justification, subjective well-being, and mental health symptoms in members of disadvantaged minority groups.

Although system justification-believing that the societal status quo is legitimate and desirable-is positively associated with subjective well-being and mental health outcomes for members of advantaged groups, the picture is more complicated for members of disadvantaged minority groups. According to system justification theory, believing that the social system is legitimate and desirable is a way of coping with one's own and fellow in-group members' state of disadvantage. At the same time, it is also a potential stressor, insofar as it implies that there are deficiencies of the individuals and groups who "fail" to succeed in a fair system.

Automatic segmentation of cardiac structures can change the way we evaluate dose limits for radiotherapy in the left breast.

Purpose: Radiotherapy is a crucial part of breast cancer treatment. Precision in dose assessment is essential to minimize side effects. Traditionally, anatomical structures are delineated manually, a time-consuming process subject to variability.

Health literacy and likelihood of death in community-dwelling older people.

Objectives: To investigate the correlation between health literacy and the likelihood of death in ten years among community-dwelling older people; and identify whether health literacy exerts an influence on the likelihood of death in this population.

Methods: A cross-sectional study was conducted with 200 community-dwelling older people. Data were collected on sociodemographic characteristics, health-related characteristics, health literacy and the likelihood of death in ten years.

Impact of ultra-processed foods on excess weight and dyslipidemia in schoolchildren.

Objective: To analyze the impact of the association between the consumption of ultra-processed foods (UPF), excess weight, and dyslipidemia in schoolchildren.

Methods: This is a cross-sectional study in which 420 schoolchildren aged 6 to 10 years from public schools in the municipality of Rio das Ostras, Brazil, were evaluated. Food consumption was assessed using the Previous Day Food Questionnaire (PDFQ-3), and physical activity (PA) was assessed using the Previous Day Physical Activity and Food Questionnaire (PDPAFQ).

Investigating the Links Between Food Addiction, Emotional Dysregulation, Impulsivity and Quality of Life in Brazilian and Canadian College Students: A Network Analysis.

Introduction: Food addiction (FA) has been associated with emotional dysregulation, impulsivity and reduced quality of life, but its interrelationships remain underexplored. This cross-sectional descriptive study aimed to examine these connections using network analysis.

Methods: Data were collected from 1777 university students in Brazil and Canada through an online survey.

Development and Validation of a Stability-Indicating High-Performance Liquid Chromatography Method Coupled With a Diode Array Detector for Quantifying Haloperidol in Oral Solution Using the Analytical Quality-by-Design Approach.

This study developed a stability-indicating HPLC-DAD method for quantifying haloperidol in oral solution using analytical quality-by-design principles. Haloperidol stability was tested under acidic, alkaline, oxidative, and photolytic stress conditions. The analytical quality-by-design approach began by defining the analytical target profile and identifying critical material attributes and critical method parameters via risk analysis.

Interaction Between Sclerostin and Mast Cells in Fibro-Osseous Lesions of the Jaws.

Objective: To assess the sclerostin, β-catenin, and tryptase expression in fibro-osseous lesions (FOL) of the jaws.

Subjects And Methods: Immunohistochemistry analysis was performed for these proteins on FOL and non-lesional bone. The sclerostin-positive cells were scored from 0 (no expression) to 3 (high expression).

Detection and Phylogenetic Analysis of Emerging Human-Associated Gemykibivirus-2 in Molossus molossus Bat From Brazil.

We detected an emerging human-associated gemykibivirus-2 (HuGkV-2) in rectal swab sample from Molossus molossus bat from Brazil. Phylogenetic analysis further revealed well-supported relationships between our sequence and those associated with human infections. This study underscores the necessity of ongoing monitoring of HuGkV-2 to elucidate potential spillback events, its role in human infections, and its public health implications.

Quality assessment and umbrella review of systematic reviews about dance for people with Parkinson's disease.

Objective(s): To determine (1) the quality of systematic reviews about dance-based intervention in individuals with Parkinson's disease (PD) and (2) standard evidence for dance-based intervention efficacy based on the categories of The International Classification of Functioning, Disability, and Health (ICF) from the World Health Organization's (WHO).

Methods: The data source included MEDLINE, PUBMED, Embase, Scopus, CENTRAL (Cochrane Library), CINAHL, PEDro, SPORTDiscus, APA PsycNet (APA PsycINFO), LILACS, SciELO, and AMED. Pairs of independent reviewers screened titles, abstracts, and full texts of eligible studies by using the software Covidence.

Performance and quality of eggs of laying hens fed with Moringa Oleifera leaf flour.

The objective of this study was to evaluate the performance of commercial laying hens fed with different levels of Moringa oleifera leaf meal in their diet. For this purpose, 150 laying hens of the Dekalb White lineage, at 62 weeks of age, and with an initial average weight of 1.458 kg ± 8.