Evaluating 36 years of fishing sustainability in a large reservoir.

Various fishing activities are common economic practices in large hydroelectric reservoirs, such as Itaipu. Consequently, the Itaipu company has monitored artisanal commercial fishing since the formation of its reservoir. In this study, we used long-term monitoring data to evaluate the sustainability of this fishing activity in the Itaipu Reservoir, one of the largest reservoirs in the Neotropical region.

Results of Endoscopic Treatment of Recurrent Malignant Biliary Obstruction in Patients with Self-Expanding Metal Stents.

Background And Aim: Endoscopic biliary drainage with placement of a self-expanding metal stent (SEMS) is the preferred palliative treatment of malignant biliary obstruction. Recent advances in the treatment have prolonged survival, thus, increasing the chance of recurrent biliary obstruction (RBO) after SEMS placement. The aim of this study was to compare different endoscopic approaches in patients with a SEMS and RBO, regarding clinical success and time to RBO.

Exploring the therapeutic potential of α-(Phenylselanyl) acetophenone in tumor necrosis Factor-α-Induced depressive-like and hyperalgesic behavior in mice.

Chronic pain and depression exhibit a high comorbidity, are challenging to manage, and their pathophysiology mechanisms are intricated and closely related to the up-regulation of pro-inflammatory response and oxidative stress. Chronic pain and depression often coexist and present significant management challenges. Their underlying pathophysiological mechanisms are complex and closely linked to the up-regulation of pro-inflammatory responses and oxidative stress.

The Association Between Physical Activity and Markers of Obesity in Children Living With Obesity.

Purpose: The purpose of this study is to describe the association between the volume and intensity of accelerometer-assessed physical activity (PA) and markers of obesity.

Method: Forty-seven children (20 girls) took part in this investigation. Children wore accelerometers on their nondominant wrists for 7 days.

Investigating chemical changes, material properties, and off-gas emissions in sewage sludge through thermal plasma treatment.

This study aimed to investigate the thermal plasma treatment of sewage sludge as an alternative waste management solution. Samples were collected from a sewage treatment facility in São Paulo, Brazil, and subjected to thermal treatments in a furnace at temperatures of 400, 600, 800, and 900 °C to assess moisture content, mass loss, and ash composition. Subsequently, the samples were processed in a thermal plasma reactor operating at an average power of 30 kW.

Leveraging Antarctic psychrotolerant fungi for PAH biodegradation, unveiling key factors influencing the process.

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, detected even in remote regions such as the Antarctic, Arctic, and Tibetan Plateau. Thus, understanding their biodegradation processes at low temperatures is crucial. Therefore, the potential of fungal strains from the Antarctic to biodegrade PAHs was explored.

Syringic acid protective role: Combatting oxidative stress induced by UVB radiation in L-929 fibroblasts.

Neglecting proper skin care and repeated exposure to ultraviolet (UV) radiation can have serious consequences, including skin burns, photoaging and even the development of skin cancer. UV radiation-induced damage is mediated by highly unstable and reactive molecules, named reactive oxygen species (ROS). To counteract ROS, the skin has an endogenous antioxidant system.

Prediction of marbling score in ribeye quartered at the 5th- 6th rib of French beef using the Q-FOM™ beef assessment camera.

In the Meat Standards Australia (MSA) and Guaranteed Global Grading (3G) grading schemes, beef marbling is scored visually in the chiller by accredited graders from 100 to 1190 marble score points in increments of 10. This study aimed to evaluate a hand-held camera (Q-FOM™ Beef) for determining MSA marbling scores of carcasses quartered between the 5th and 6th rib. The carcasses were scored by two accredited graders, including an expert grader (i.

Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial.

Background: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition emerging in early childhood, characterized by core features such as sociocommunicative deficits and repetitive, rigid behaviors, interests, and activities. In addition to these, disruptive behaviors (DB), including aggression, self-injury, and severe tantrums, are frequently observed in pediatric patients with ASD. The atypical antipsychotics risperidone and aripiprazole, currently the only Food and Drug Administration-approved treatments for severe DB in patients with ASD, often encounter therapeutic failure or intolerance.

Karyotype Evolution of Suliformes and Description of a ♂Z1Z1Z2Z2/♀Z1Z2W Multiple Sex Chromosome System in boobies (Sula spp.).

Our comprehension of avian karyotypes still needs to be improved, especially for Suliform birds. To enhance understanding of chromosomal evolution in this order, we conducted conventional and molecular cytogenetic analysis in five species, named Sula dactylatra, S. leucogaster, S.

Oral Cyclophosphamide for Patients With Metastatic Castration-Resistant Prostate Cancer in a Scenario of Limited Health Care Resources.

Purpose: Prior noncontemporary studies showed that oral cyclophosphamide is an active treatment of metastatic castration-resistant prostate cancer (mCRPC). However, cyclophosphamide is currently underutilized in routine clinical practice given the lack of survival benefit and the emergence of more effective treatments.

Methods: We retrospectively reviewed our institutional database to identify patients with mCRPC treated with cyclophosphamide.

Inequalities and Inclusion in Genomics Applied to Healthcare: A Latin American Perspective.

Integrating genomics into healthcare within the precision medicine (PM) framework poses distinct challenges in resource-limited regions like Latin America and the Caribbean (LAC). These challenges arise partly from the lack of PM models tailored for low- and middle-income countries. To address this, healthcare authorities in LAC should adopt predictive models to estimate costs and infrastructure needed for PM programs.

Supratotal Resection Versus Gross Total Resection for Isocitrate Dehydrogenase-Wildtype Glioblastoma and Grade 4 Isocitrate Dehydrogenase-Mutant Astrocytoma: Meta-Analysis of Individual Patient Data.

Background And Objectives: IDH-wildtype glioblastoma multiforme (GBM) and grade 4 IDH-mutant astrocytoma are challenging to manage in oncology. This study explores the contrast between gross total resection (GTR) and supratotal resection (SupTR) for IDH-wildtype GBM and grade 4 IDH-mutant astrocytoma, aiming to summarize their influence on crucial clinical outcomes.

Methods: This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.

Influence of LaO Addition on CuO/CeO Catalysts for the Water-Gas Shift Reaction.

CuO/CeO and CuO/CeO-LaO catalysts, synthesized with varying CeO and LaO molar ratios (1:1, 1:2, and 2:1), were prepared via the hydrothermal method and tested in the water-gas shift reaction (150-350 °C). LaO addition altered structural properties, reducing surface area and copper dispersion. XANES and in situ XRD confirmed metallic Cu species during reduction and reaction.

Can Focusing on One Deep Learning Architecture Improve Fault Diagnosis Performance?

Machine learning approaches often involve evaluating a wide range of models due to various available architectures. This standard strategy can lead to a lack of depth in exploring established methods. In this study, we concentrated our efforts on a single deep learning architecture type to assess whether a focused approach could enhance performance in fault diagnosis.

Genetic diversity, population structure in a historical panel of Brazilian soybean cultivars.

Soybean [Glycine max (L.) Merrill] is one of the most widely grown legumes in the world, with Brazil being its largest producer and exporter. Breeding programs in Brazil have resulted from multiple cycles of selection and recombination starting from a small number of USA cultivar ancestors in the 1950s and 1960s years.

Family perceptions of prolonged hospitalization for children with complex chronic conditions: Between losses and adaptations in an uncertain future.

The aim of this study was to understand the family perception and emotional impacts on caregivers of children with chronic conditions who remained hospitalized in intensive care units for an extended period. A qualitative, descriptive-exploratory study, grounded in symbolic interactionism, was conducted with 10 primary caregivers of children with long-term experience in a Brazilian intensive care unit. Interviews were conducted, either remotely or in person, and were analyzed using thematic content analysis supplemented by lexical analysis.

A novel machine learning-based cancer-specific CVD risk score among patients with breast, colorectal, or lung cancer.

Background: Cancer patients have up to a 3-fold higher risk for cardiovascular disease (CVD) than the general population. Traditional CVD risk scores may be less accurate for them. We aimed to develop cancer-specific CVD risk scores and compare them with conventional scores in predicting 10-year CVD risk for patients with breast cancer (BC), colorectal cancer (CRC), or lung cancer (LC).

The Adverse Health Effects of Air Pollution from Sugarcane Burning: A Scoping Review of Observational and Experimental Evidence.

Background: Sugarcane burning is an agricultural practice that is implemented to increase sugar yields. However, sugarcane burning produces air pollutants associated with adverse health outcomes. This review summarizes the current knowledge of the defined exposures and health effects associated with sugarcane burning and identifies research gaps.

Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer: The ALEXANDRA/IMpassion030 Randomized Clinical Trial.

Importance: Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- to 18-month life expectancy. Until recently, one strategy for treating early-stage triple-negative breast cancer was chemotherapy after surgery. However, it was not known whether the addition of immune therapy to postsurgery chemotherapy would be beneficial.

Genetic diversity and selection signatures in sheep breeds.

Natural and artificial selection in domesticated animals can cause specific changes in genomic regions known as selection signatures. Our study used the integrated haplotype score (iHS) and Tajima's D tests within non-overlapping windows of 100 kb to identify selection signatures, in addition to genetic diversity and linkage disequilibrium estimates in 9498 sheep from breeds in Ireland (Belclare, Charollais, Suffolk, Texel, and Vendeen). The mean observed and expected heterozygosity for all the sheep breeds were 0.

Evaluating key predictors of anatomical complexity in mandibular incisors: insights from CBCT analysis considering premolar anatomy, sex, and age.

Understanding the impact of premolar root anatomy, sex, and age on incisor complexity can aid in developing tailored diagnostic and therapeutic strategies. This study evaluated if the anatomical complexity of mandibular premolars, sex and age can predict the anatomical complexity in mandibular incisors. Using CBCT scans, 3944 mandibular incisors from 493 patients were analyzed.