Copaiba essential oil carried in a self-nanoemulsifying drug delivery system improves adjuvant-induced arthritis in rats.

Objectives: Copaiba essential oil (CEO) is obtained through the distillation of copaiba balsam and has been used in the traditional medicine to treat inflammatory conditions. However, the highly lipophilic nature of CEO restricts its pharmaceutical use. This study evaluated the effect of CEO, carried in a self-nanoemulsifying drug delivery system (SNEDDS), on articular and systemic inflammation and liver changes in Holtzman rats with Freund's adjuvant-induced arthritis.

Spatiotemporal analysis of visceral leishmaniasis in Belo Horizonte, Brazil: a historical perspective (1994-2018).

Background: In the Americas, visceral leishmaniasis (VL) results from the zoonotic transmission of Leishmania infantum. VL has a high occurrence rate in the Metropolitan Region of Belo Horizonte (BH), Minas Gerais, Brazil, and has rapidly spread throughout the municipality since it was first recorded in 1994. This research analysed a historical perspective over 25 y of human VL occurrence in BH.

The interplay between individual capacities and pair performance according to the experience in Acrobatic Gymnastics.

The interplay between individual capacities and group performance provides insights for different tasks and contexts. So far, little is known about the individual capacities of base and top gymnasts and mechanical efficiency during pair tasks of Acrobatic Gymnastics. This work aims to investigate: (1) the effect of the pair experience in the mechanical efficiency during a pair task; (2) the effect of the individual training experience in the gymnasts' individual capacities, and (3) the contribution of individual capacities and pair mechanical efficiency to the performance of a partner-assisted flight task.

Translation, cross-cultural adaptation, and psychometric properties of the Finnish version of the Malocclusion Impact Questionnaire (MIQ).

Objectives: This study aimed to translate and adapt the Malocclusion Impact Questionnaire (MIQ) into Finnish; to estimate its psychometric properties when applied to Finnish adolescents; and to estimate the effect of demographic characteristics on the perceived impact of malocclusion.

Methods: The Finnish version of MIQ (MIQ-Fi) was established through translation, back-translation, and a pilot study. Psychometric properties were estimated using factorial validity (confirmatory factor analysis [CFA]), convergent validity (Average Variance Extracted [AVE]), and reliability (αordinal and ω).

Emergent Carotid Stenting During Thrombectomy in Tandem Occlusions Secondary to Dissection: A STOP-CAD Secondary Study.

The optimal endovascular management of cervical carotid dissection causing tandem occlusion remains uncertain. We investigated the impact of emergent carotid stenting during endovascular treatment (EVT) for acute ischemic stroke (AIS) in patients with tandem occlusion secondary to cervical carotid artery dissection. This was a secondary analysis of patients treated with EVT for AIS due to occlusive carotid artery dissection and tandem occlusion included in the retrospective international Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection (STOP-CAD) study.

Gas-phase and water-mediated mechanisms for the OCS + OH reaction.

We report a computational study of the gas-phase and water-mediated mechanisms for the oxidation of carbonyl sulfide (OCS) by the hydroxyl radical. To achieve reliable results, we employ a dual-level strategy within interpolated single-point energies (VTST-ISPE) at the CCSD(T)/aug-cc-pVTZ//M06-2X/aug-cc-pVTZ level of theory. In the gas-phase mechanism, we have determined the rate constants by kinetic Monte Carlo simulation in the interval of temperatures of 250-550 K.

Thrombolysis for Ischemic Stroke Beyond the 4.5-Hour Window: A Meta-Analysis of Randomized Clinical Trials.

Background: A minority of patients with stroke qualify for intravenous thrombolysis (IVT) within 4.5-hour window. The safety and efficacy of IVT beyond this period have not been well studied.

Reporting completeness and methodological quality of guidelines for nutritional care of critically ill patients: A meta-research utilizing Reporting Items for practice Guidelines in HealTh Care (RIGHT) and Appraisal of Guidelines for Research & Evaluation (AGREE II).

Studies have demonstrated that the quality and transparency of reporting Clinical Practice Guidelines (CPGs) in healthcare are low. This meta-research aimed to evaluate the adherence of nutrition CPGs for critically ill adults to the reporting RIGHT checklist and its association with the methodological quality assessed by AGREE II, along with other potential publication-related factors. A systematic search for CPGs until December 2024 was conducted.

Global Epidemiology and Implications of I148M Variant in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-analysis.

Background & Aims: rs738409 variant is a risk factor for onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to assess its global prevalence, clinical and histological characteristics, and long-term outcomes in patients with MASLD.

Methods: PubMed and Embase databases were searched until December 30, 2023, for observational studies on genotyped adults with MASLD.

Dynamic nonlinear control strategies for resilient heterogeneous vehicle platooning and handling Byzantine attacks in communication networks.

This paper addresses the challenges of maintaining stability in heterogeneous vehicle platooning under the influence of communication disruptions caused by Byzantine attacks within a leader-follower framework. To enhance resilience, we propose a nonlinear control strategy tailored for a third-order heterogeneous dynamic model, integrating leader-follower interconnections with adaptable control gains. Utilizing a constant time headway spacing policy with gap adjustments, we derive control gains that secure internal platoon stability.

Simulation and techno-economic analysis of energy cane pyrolysis for bio-oil production using Aspen Plus.

This work investigates the energy cane pyrolysis by process simulation in Aspen Plus, evaluating which variety maximizes bio-oil yield with further economics to evaluate process feasibility. Three cultivars were selected: two natural, and , and one, IACSP955000, generated by a breeding program. Firstly, 100 kg/h of wet biomass entered a stoichiometric reactor (RSTOIC) at 450 °C and 40 bar, generating biochar, bio-oil and gases.

Internal Breast Lift: A New Method for Performing Internal Mastopexy.

Background: Mastopexy combined with implant placement is a complex cosmetic surgery due to the dual nature of the procedure. Various mammoplasty techniques and implant types add to its intricacy. This study aimed to evaluate the effectiveness of an internal breast lift in correcting pseudoptosis, grade 1 breast ptosis, and asymmetries, thereby offering a safer alternative with reduced morbidity and avoiding the creation of an inverted T scar.

Evolutionary dynamics of the B chromosomes in the fish species Valenciennes, 1837 of the Paraná River Basin.

The fish species has an interesting B chromosome system, with three morphological types as acrocentric, metacentric, and submetacentric. However, most cytogenetic studies on this species are restricted to the natural population of the Mogi Guaçu River. Given this, the present work aimed to study the structure karyotypic profile as well as the occurrence of supernumeraries in in several localities in the Paraná River basin, where this species is abundant.

Health policy to address disease-related malnutrition: a scoping review.

Background: Health policies promote optimal care, yet policies that address disease-related malnutrition (DRM) are lacking. The purpose of this study was to conduct a scoping review to identify literature on existing and planned policy to address DRM in children or adults and explore the settings, contexts and actors of DRM policy.

Methods: A search strategy comprising DRM and policy keywords was applied to eight databases on 24 February 2023.

Optimizing Superhydrophobic Coatings: The Role of Catalysts, Additives, and Composition on UV and Thermal Stability of Inverse Vulcanization Polymers.

Inverse vulcanization (IV) enables the production of sustainable polymer from sulfur waste, offering hydrophobic, fluorine-free, and superhydrophobic coatings. However, these materials need adhesion improvements for enhanced durability. This study has developed an epoxy-, fluorine-, and metal-free superhydrophobic coating using the spray-coating of carbon nanofibers (CNFs), silica nanoparticles, and IV polymers on glass.

Mental health outcomes in dementia caregivers: a systematic review of yoga-based interventions.

Unlabelled: Mind-body interventions have been explored to enhance the psychological well-being of dementia caregivers; however, the specific effects of yoga practice remain underexamined.

Objective: The aim of this study was to investigate the benefits of yoga on quality of life (QoL), life satisfaction, psychological well-being, attention, self-compassion, perceived stress, anxiety, depression, and caregiver burden for dementia caregivers.

Methods: A comprehensive search was conducted on September 11, 2024, in databases including SciELO, PubMed, BVSalud, Web of Science, Embase, and PsycINFO, focusing on the effects of yoga for informal dementia caregivers compared to passive or active control groups through randomized and non-randomized trials.

Healing the Open Apex: A Case Report on Innovative Apexogenesis of a Maxillary Molar Using Bio-C Repair.

Preserving pulp vitality in developing permanent teeth is paramount. This approach facilitates continued root formation, ultimately leading to apical closure, enhanced root strength, and improved overall tooth integrity. This case report details the management of a 17-year-old female patient presenting with dental caries on the right permanent maxillary molar.

Parasitism by Shimbori, 2023 (Hymenoptera: Braconidae) of three species of Guenée, 1852: effects of preferential instar and host diet.

Unlabelled: A recently discovered koinobiont parasitoid species, Shimbori, 2023, proved to be a promising biological control agent for larvae of (Walker, 1858), (Stoll, 1782), and (J.E. Smith, 1797), all well-known pests that cause critical damage to soybean and corn crops.

The Effect of Task Cognitive Difficulty on Perceptual-Cognitive Indicators: Evidence on the Relationship Between Challenge Point Framework (CPF) and Cognitive Development in Table Tennis Beginners.

Introduction: Motor learning, in addition to influencing the practice of physical activity, affects cognitive skills related to prediction and decision. One key principle in sports training is designing exercise programs that optimize cognitive-motor performance, based on the Challenge Point Framework (CPF). The aim of this study is to investigate the effect of different levels of work difficulty on cognitive-perceptual indicators in table tennis beginners.

A novel imatinib analogue inhibitor of chronic myeloid leukaemia: design, synthesis and characterization-explanation of its folded conformation.

Chronic myeloid leukaemia (CML) is primarily treated using imatinib mesylate, a tyrosine kinase inhibitor (TKI) targeting the BCR::ABL1 oncoprotein. However, the development of drug resistance and adverse side effects necessitate the exploration of alternative therapeutic agents. This study presents the synthesis and characterization of a novel imatinib analogue, 3-chloro--(2-methyl-5-((4-(pyridin-2-yl)pyrimidin-2-yl)amino)phenyl)benzamide (PAPP1).