Variations and Opportunities in Postnatal Management of Hemolytic Disease of the Fetus and Newborn.

Importance: Preventive efforts in pregnancy-related alloimmunization have considerably decreased the prevalence of hemolytic disease of the fetus and newborn (HDFN). International studies are therefore essential to obtain a deeper understanding of the postnatal management and outcomes of HDFN. Taken together with numerous treatment options, large practice variations among centers may exist.

Newborn screening in Brazil: realities and challenges.

Neonatal screening is a critical public health initiative introduced worldwide to detect severe congenital disorders early in life. This study provides an updated overview of public neonatal screening in Brazil, highlighting the transition from initial pilot projects to a robust national program. Through the analysis of recent data up to 2023, we discuss the coverage and regional efficiencies of the program.

Pathogenic Aspergillus spp. and Candida spp. in coastal waters from southern Brazil: an one health approach.

Aspergillus and Candida are ubiquitous fungi included in the group of high priority in the World Health Organization list of fungal pathogens. They are found in various ecosystems and the environmental role in increasing the resistance to antifungals has been shown. Thus, we aimed to determine the occurrence of Aspergillus spp.

Candida albicans migrates itself from the vagina to the uterus and ovaries in estrogenized mice.

Vulvovaginal candidiasis (VVC) represents the second cause of vaginal infections in childbearing-age women. It mainly affects the vulva and vagina; however, other organs can be compromised, with consequences that are not well known yet. To evaluate the ability of Candida albicans, inoculated into the vaginal lumen of mice, to migrate to the uterus and ovaries.

Expanding the evidence for cross-species viral transmission from trophic interactions of parasitoid wasps and their hosts.

Parasitoid wasps act as natural biological control agents for several harmful insect species. However, there is a lack of information regarding the exogenous RNA viruses that infect parasitoids and may contribute to the success of their parasitism strategies. This study aimed to investigate the presence, abundance, and replication of known exogenous viruses in two parasitoid wasp species and their corresponding preys.

Presence of polyketide synthases and nonribosomal peptide synthetase in culturable bacteria associated with Aplysina fulva and Aplysina caissara (Porifera).

Culture-dependent and -independent studies have provided access to symbiont genes and the functions they play for host sponges. Thus, this work investigates the diversity, presence of genes of pharmacological interest, biological activities and metabolome of the bacteria isolated from the sponges Aplysina caissara and Aplysina fulva collected on the southwestern Atlantic Coast. The genes for Polyketide Synthases types I and II and Nonribosomal Peptide Synthetases were screened in more than 200 bacterial strains obtained, from which around 40% were putatively novel.

A systematic review of salivary gland hypofunction and/or xerostomia induced by non-surgical cancer therapies: prevention strategies.

Purpose: This systematic review aimed to assess the updated literature for the prevention of salivary gland hypofunction and xerostomia induced by non-surgical cancer therapies.

Methods: Electronic databases of MEDLINE/PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials (RCT) that investigated interventions to prevent salivary gland hypofunction and/or xerostomia. Literature search began from the 2010 systematic review publications from the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) up to February 2024.

Sleep disorders in individuals with dentofacial deformities: a preliminary study on the relationship with sex and serotonin levels.

Purpose: It has been suggested that dentofacial deformities (DFD) can impair sleep quality. This pilot study aimed at evaluating sleep disorders in individuals with DFD before orthognathic surgery, correlating the clinical findings with salivary biomarker levels.

Methods: This cross-sectional study enrolled ten males and ten females with DFD diagnoses under orthodontic treatment preceding orthognathic surgery.

Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis.

The progression of periodontal disease (PD) involves the action of oxidative stress mediators. Antioxidant agents may potentially attenuate the development of this condition. Thus, we aimed to evaluate the effects of different doses of humic acid (HA), extracted from biomass vermicomposting, on redox status and parameters related to PD progression in rats.

Retinal Sensitivity in KCNV2-Associated Retinopathy.

Purpose: The purpose of this study was to analyze the retinal sensitivity under photopic, mesopic, and scotopic conditions in a cohort of patients affected with KCNV2-associated retinopathy.

Methods: Cross-sectional evaluation of molecularly confirmed individuals was conducted. Data were obtained prospectively.

Persisting Gaps in Cytomegalovirus Prevention and Management After Solid Organ Transplantation in a Resource-Limited Setting.

Background: Cytomegalovirus (CMV) infection remains among the leading complications after solid organ transplantation (SOT). Large international surveys mainly focused on high-income countries, detected considerable variability in the management of this infection after SOT. Limited data are available from resource-limited settings.

Genetic investigation of hydrogenases in suggests that redox balance via hydrogen cycling enables high ethanol yield.

Unlabelled: is an anaerobic and thermophilic bacterium that has been genetically engineered for ethanol production at very high yields. However, the underlying reactions responsible for electron flow, redox equilibrium, and how they relate to ethanol production in this microbe are not fully elucidated. Therefore, we performed a series of genetic manipulations to investigate the contribution of hydrogenase genes to high ethanol yield, generating evidence for the importance of hydrogen-reacting enzymes in ethanol production.

biofilms: implications for survival, transmission, and disease management.

Leptospirosis is a zoonotic disease caused by bacteria, affecting humans and a broad range of wild and domestic animals in diverse epidemiological settings (rural, urban, and wild). The disease's pathogenesis and epidemiology are complex networks not fully elucidated. Epidemiology reflects the One Health integrated approach of environment-animal-human interaction, causing severe illness in humans and animals, with consequent public health burdens.

Acoustic Characteristics of Voice and Speech in Post-COVID-19.

Background/objectives: The aim of this paper was to compare voice and speech characteristics between post-COVID-19 and control subjects. The hypothesis was that acoustic parameters of voice and speech may differentiate subjects infected by COVID-19 from control subjects. Additionally, we expected to observe the persistence of symptoms in women.

Relation Between COVID-19 Infection and Vaccine and Menstrual Cycle Changes of Portuguese Adolescents in Higher Education.

Unlabelled: In a period globally known as long COVID, several post-acute infection sequelae and vaccination effects have been discussed.

Objectives: This study aimed to identify the effects of COVID-19 infection and vaccines on the menstrual cycle of adolescents attending higher education and to verify the association between personal health factors and changes in their menstrual cycle after contact with the virus SARS-CoV-2 via infection or via the vaccine.

Methods: A cross-sectional study was conducted using a questionnaire for data collection, applied online to Portuguese higher education adolescents aged between 18 and 24.

Death Anxiety Among Users and Non-Users of Psychedelics.

This study is a survey-type, cross-sectional study conducted in Brazil ( = 517), with online data collection taking place from April to June 2022. The main objective of this study was to evaluate the death anxiety in users and non-users of psychedelics. To this end, we also assessed the validity and reliability of the Death Anxiety Scale in Brazil.

Self-Reported Delayed Adverse Events and Flare Following COVID-19 Vaccination Among Patients With Autoimmune Rheumatic Disease (AIRD) in Malaysia: Results From the COVAD-2 Study.

Objectives: To determine the prevalence of self-reported delayed adverse events (DAEs), major AEs, and flares following COVID-19 vaccinations among patients with autoimmune rheumatic diseases (AIRDs) in Malaysia.

Methodology: An electronically validated survey from the COVID-19 vaccination in autoimmune diseases (COVAD) study group was distributed in July 2021 to patients with autoimmune diseases and healthy controls (HCs). The survey collected data on DAEs (any AE that persisted or occurred after 7 days of vaccination), any early or delayed major adverse events (MAEs), and flares following COVID-19 vaccination.

Surface Modifications and Antifungal Efficacy of Origanum Oil Incorporation in Denture-based Materials: An Study.

Aim: This study aimed to assess if the addition of origanum oil to denture materials could decrease microorganisms counts and biofilm formation without changing their mechanical/surface properties.

Materials And Methods: A total of 66 resilient denture liner discs (SoftConfort, Dencril Comércio de Plásticos Ltda, SP, Brazil) were prepared with fixed dimensions of 10 × 3 mm for biofilm assay ( = 36) and 12 × 2 mm for sorption-solubility tests ( = 30) containing three oil concentrations - 0, 2.5 and 5%, thereby = 12 per each group samples for biofilm assay and = 10 per each group for sorption-solubility test respectively.

Country-specific key lifestyle factors and health outcomes for resource allocation in the general population: a network analysis across 29 countries.

Background: We aimed to identify the central lifestyle, the most impactful among lifestyle factor clusters; the central health outcome, the most impactful among health outcome clusters; and the bridge lifestyle, the most strongly connected to health outcome clusters, across 29 countries to optimise resource allocation for local holistic health improvements.

Methods: From July 2020 to August 2021, we surveyed 16 461 adults across 29 countries who self-reported changes in 18 lifestyle factors and 13 health outcomes due to the pandemic. Three networks were generated by network analysis for each country: lifestyle, health outcome, and bridge networks.

The canine blood-brain barrier in health and disease: focus on brain protection.

This review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the gene. The BBB is critical in maintaining central nervous system homeostasis and brain protection against xenobiotics and environmental drugs that may be circulating in the blood stream. We revise key anatomical, histological and functional aspects of the canine BBB and examine the role of the gene mutation in specific dog breeds that exhibit reduced P-gp activity and disrupted drug brain pharmacokinetics.

Special Collection: XIX Brazilian Meeting on Organic Synthesis (BMOS).

In this guest editorial, Paulo H. Schneider, Diogo S. Lüdtke, and Eufrânio N.

Special Collection: The XXI Brazilian Meeting on Inorganic Chemistry.

This article is an editorial about The XXI Brazilian Meeting on Inorganic Chemistry (BMIC). The XXI Brazilian Meeting on Inorganic Chemistry is one of the most important inorganic chemistry events in Latin America. This editorial introduces the event and the papers featured in the special issue celebrating BMIC in Chemistry An Asian Journal.

Body composition differences in older adults with and without Alzheimer's disease: A systematic review and meta-analysis of observational studies.

Background: Research on body composition and fat distribution in Alzheimer's disease (AD) has presented conflicting findings.

Objective: Compare body composition and anthropometric measurements in older adults with and without AD.

Methods: A systematic review and meta-analysis were conducted following Cochrane guidelines and PRISMA standards.

Effect of Pilates Intervention on the Physical Conditioning of a Ballet Dancer: A Single Case Study.

Objective: The purpose of this case study was to report the effect of an 8-week Pilates intervention on a ballet dancer's strength, balance, and endurance.

Clinical Features: A healthy 24-year-old ballet dancer (50 kg, 1.66 meters, 12 years of practice and who had no previous experience with Pilates) presented for care.