Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation.

Inoculation of Bothrops jararaca snake venom (BjV) induces thrombocytopenia in humans and various animal species. Although several BjV toxins acting on hemostasis have been well characterized in vitro, it is not known which one is responsible for inducing thrombocytopenia in vivo. In previous studies, we showed that BjV incubated with metalloproteinase or serine proteinase inhibitors and/or anti-botrocetin antibodies still induced thrombocytopenia in rats and mice.

Biodiversity and Antifungal Activities of Amazonian Actinomycetes Isolated from Rhizospheres of Plants.

Background: Actinobacteria are major producers of antibacterial and antifungal metabolites and are growing their search for substances of biotechnological interest, especially for use in agriculture, among other applications. The Amazon is potentially rich in actinobacteria; however, almost no research studies exist. Thus, we present a study of the occurrence and antifungal potential of actinobacteria from the rhizosphere of , a native South American plant and one that is economically useful in the whole of the Amazon.

Visual Loss after Scoliosis Surgery: What Do Surgeons and Patients Need to Know? Three Case Reports.

Visual deficit after spinal surgery is rare but tragic. The main causes include external eye injury, cortical blindness, central retinal artery occlusion, and ischemic optic neuropathy. In scoliosis surgery, this complication potentially arises from prolonged surgical time, high blood loss, prone position, hydroelectrolytic imbalance, and cerebrospinal fluid loss.

Bilateral Asymmetric Traumatic Dislocation of the Hip: Case Report.

Traumatic hip dislocations are serious traumas, the result of high-energy mechanisms, constituting one of the orthopedic emergencies. The epidemiology of asymmetric bilateral hip dislocation is an extremely rare orthopedic condition. Prompt diagnosis and urgent reduction are essential due to the high risk of future complications.

Radiocarpal Fracture Dislocation: Minimally Invasive Treatment Assisted by Arthoscopic - Case Report.

To measure the life quality, clinical-functional outcomes of a patient who had undergone acute reconstruction of radio scapho capitate (RSC), radio lunate (RLL) ligaments, using brachiorradialis tendon in treatment of radiocarpal fracture dislocation. 21-years-old, man with radiocarpal fracture dislocation in his left wrist, after motorcycle accident. Percutaneous screw fixation of the distal radius and acute reconstruction of the RSC and RLL was performed, assisted by arthroscopy.

Fixation of an Osteochondral Fragment with Autologous Bone Picks in the Knee - A Case Report.

Osteochondral injuries in the knee are uncommon in the immature skeleton and are usually related to sporting activities. Fixation is required depending on the size and location of the fragment. The standard technique is open reduction and internal fixation with metal screws, which are removed in a second procedure after consolidation.

Synovial Chondromatosis of the Shoulder: Report of Two Cases.

Synovial chondromatosis is an uncommon, progressive, benign condition favoring synovial metaplasia resulting from the production of cartilaginous tissue as loose bodies within the joints. In rare cases, it can affect the interior of the shoulder joint and present with pain, edema, and impaired mobility. The diagnosis is challenging, requiring imaging techniques.

Acromioclavicular Luxation with Fracture of the Lateral End of the Clavicle: Case Report.

The present case report is an observational study with a literature review. This case is significant because the injury is rare regarding location and clinical manifestation. A middle-aged male patient sustained a fracture at the acromial end of the clavicle with lateral fragment dislocation after falling from a bicycle.

Popliteal Artery Entrapment Syndrome as a Differential Diagnosis for Knee Pain: A Case Report.

Popliteal artery entrapment syndrome has congenital and functional causes. It mostly affects young people. There are six types of popliteal artery entrapment syndrome.

Noninvasive Management after a Traumatic Anterior Knee Dislocation in a Cruciate Retaining Total Knee Arthroplasty: A Case Report.

The reported case describes a traumatic anterior knee dislocation of a previous asymptomatic knee after a posterior cruciate-retaining primary knee arthroplasty. The described patient accidentally rolled over her knee six years after the surgical intervention. Anterior traumatic dislocation after knee arthroplasty is an uncommon event often leading to prosthetic's components revision due to its associated ligament injuries.

Surgical Treatment of Peripartum Pelvic Ring Injury: Case Report.

During the gestational period, the pubic symphysis dilates for vaginal delivery. However, exacerbated widening may indicate ligament injury and pelvic instability, resulting in significant pain complaints. This uncommon condition is called peripartum pubic symphysis disjunction (PPSD).

Pectoralis Major Rupture in a 15-year-old Teenager: Case Report.

Rupture of the pectoralis major muscle is extremely rare in adolescents. The current literature contains only 5 reports of this condition in patients under 20 years old, with 2 reports in subjects under 16. In the present article, we report the case of a 15-year-old volleyball player who suffered a traumatic rupture of the pectoralis major in a match during the serve movement.

Long-term Outcomes 18 Years after the Arthroscopic Fixation of a Scapular Articular Fracture: A Case Report.

Reduction and fixation of glenoid cavity fractures using arthroscopy cause little surgical trauma, allowing the complementary diagnosis and treatment of potentially associated injuries (either capsular, ligamentous or tendon lesions) with promising outcomes. The authors report a case of Ideberg type III glenoid fracture with a distal clavicle fracture which underwent percutaneous reduction and bone fixation (with Kirschner wires) using an arthroscopic technique. We describe the procedure and the outcomes after 18 years of follow-up.

Common Fibular Nerve Palsy in a Cyclist after Bariatric Surgery - Case Report.

Common fibular nerve (CFN) palsy is the most common mononeuropathy in the lower limb, and several etiologies are described. The CFN is the minor and lateral division of the sciatic nerve; it originates in the lumbar sacral division, and many risks of compression have been described: the behavior of crossing and squatting legs, extra and intraneural compressions, local trauma, and weight loss have been increasingly reported as important and noteworthy causes. The treatment is based on the severity of the nerve condition.

Bilateral Brachial Neuritis after COVID-19: Case Report.

Brachial neuritis, or Parsonage-Turner syndrome, is a rare disease characterized by a sudden, self-limiting pain in the upper limb followed by weakness and atrophy of the shoulder girdle muscles. Bilateral brachial plexus involvement occurs in between 10 and 30% of the patients, but symptoms are usually asymmetrical. The most common etiological factors include infection (25 to 55%) and autoimmune conditions.

Localized Pigmented Villonodular Synovitis in the Shoulder: Report of a Case Treated through Arthroscopy.

Pigmented villonodular synovitis (PVNS) is rare in the shoulder, with few descriptions in the literature. We present the case of a 58-year-old female patient with no history of trauma. The patient reported pain for 2 months with no limb irradiation and presented lifting strength loss and progressive limitation of active and passive mobility.

Ochronotic Arthropathy and Alkaptonuria (Ochronosis): Case Report.

Alkaptonuria (AKU) is a rare genetic condition resulting from a deficiency in the homogentisic acid oxidase enzyme, which is produced by the liver and kidneys, that interferes with the metabolism of the amino acids phenylalanine and tyrosine. Although it may not cause symptoms, AKU can lead to ochronosis, the abnormal accumulation in body tissues of a pigment called alkapton. Over time, this pigment accumulation in the joints may result in secondary osteoarthritis known as ochronotic arthropathy, the most debilitating form of the disease.

Talus Osteonecrosis after Chemotherapy: A Case Report.

This paper described a case of talus osteonecrosis in a 13-year-old female with a diagnosis of T-type acute lymphocytic leukemia, who underwent chemotherapy and treatment with glucocorticoids, attended at the Orthopedics and Traumatology Sector of our institution. After approximately six months of treatment, the patient began to complain of sporadic pain in her left ankle with progressive worsening. Bone scintigraphy and magnetic resonance imaging of the ankles showed the presence of avascular osteonecrosis of the bilateral talar body.

Minimally-invasive Distal Metatarsal Diaphyseal Osteotomy in the Treatment of Plantar Ulcer in the Diabetic Foot: A Case Report.

The diabetic foot consumes a large number of resources and has a profound negative impact on quality of life, representing the major non-traumatic cause of lower limb amputation in adults. The present report describes a diabetic patient with a recurrent plantar ulcer in the topography of the heads of the second, third, and fourth metatarsals. The patient was treated using the distal metatarsal diaphyseal osteotomy (DMDO) technique in these bones, an Akin-type percutaneous osteotomy in the proximal phalanx of the hallux, and debridement.

Combined association of physical activity and depressive symptoms with cardiometabolic risk factors in Chilean adults.

Cardiometabolic risk factors such as obesity, raised blood pressure, high blood glucose and dyslipidemia are emerging health concerns worldwide. Therefore, the aim of this study was to estimate the combined association between physical activity and depressive symptoms with cardiometabolic risk factors in Chilean adults. Data was obtained from the National Health Survey of Chile 2016-2017, with a sample of 5995 adult participants.

Impact of Climate Change on Adolescents' Health Outcomes: An Evidence Gap Map Review.

Background: The evolving impact of climate change on adolescents' health is a pressing global concern. Climate change's effects on their physical, mental, and social well-being worsen unique developmental challenges for adolescents. This study aims to map existing evidence, identify gaps, and highlight research and intervention needs.

Pan-cancer and multiomics: advanced strategies for diagnosis, prognosis, and therapy in the complex genetic and molecular universe of cancer.

The pan-cancer and multi-omics approach is motivated by the genetic and molecular complexity inherent in the varied types of cancer. This method presents itself as a crucial resource for advancing early diagnosis, defining prognoses and identifying treatments that share common bases between different forms of tumors. The aim of this article is to explore pan-cancer analysis in conjunction with multi-omics strategies, evaluating laboratory, computational, clinical procedures and their consequences, as well as examining the tumor microenvironment, epigenetics and future directions of these technologies in patient management.

Embryonic dormancy in Aedes aegypti and Aedes albopictus (Diptera: Culicidae): a survival and dispersal mechanism.

Aedes aegypti and Aedes albopictus are the main vectors of arboviruses such as dengue, Zika virus, and chikungunya. Ae. aegypti is a widely spread mosquito in tropical and subtropical regions, whereas Ae.

Characteristics of advanced practice nurses' clinical competence in primary healthcare settings: a scoping review protocol.

Objective: This scoping review aims to identify the clinical competency characteristics, in terms of knowledge, skills, and attitudes, of advanced practice nurses in primary care settings.

Introduction: Although much has been written about the competencies of advanced practice nurses, more detail about the skills, knowledge, and attitudes that inform their clinical competency in primary health care needs to be ascertained. This will promote the development, implementation, and evaluation of advanced nursing practice in contexts where it is unavailable.

Incidence of oral manifestations in hematological malignancy patients undergoing chemotherapy: prospective cohort study.

Background: Oral manifestations are frequent in patients with hematological malignancies undergoing chemotherapy and may be directly or indirectly related to drug toxicity. Few studies have assessed the chemotherapy and oral manifestations that patients might develop. Therefore, this study aimed to evaluate the incidence of oral manifestations in patients with hematologic neoplasms during hospitalization and chemotherapy.