Large and long-term photon energy storage in diazetidines [2+2] photocycloaddition.

We report a series of -functionalized phenylbenzoxazoles that offer remarkable energy storage, exceeding 300 J g, for the first time among intermolecular cycloaddition-based molecular solar thermal energy storage systems. The [2 + 2] photocycloaddition of phenylbenzoxazoles generates diazetidine cycloadducts that store energy for up to 23 years in the solid state and release energy upon triggered cycloreversion. The solid-state phase transition contributes to increasing overall energy storage densities, and the dearomative cycloaddition process is revealed to be critical for maximizing the intrinsic energy storage capacities.

Emerging solid-state cycloaddition chemistry for molecular solar thermal energy storage.

Recently discovered designs of solid-state molecular solar thermal energy storage systems are illustrated, including alkenes, imines, and anthracenes that undergo reversible [2 + 2] and [4 + 4] photocycloadditions for photon energy storage and release. The energy storage densities of various molecular designs, from 6 kJ mol to 146 kJ mol (or up to 318 J g), are compared and summarized, along with effective strategies for engineering their crystal packing structures that facilitate solid-state reactions. Many promising molecular scaffolds introduced here highlight the potential for achieving successful solid-state solar energy storage, guiding further discoveries and the development of new molecular systems for applications in solid-state solar thermal batteries.

Visible light activated energy storage in solid-state Azo-BF switches.

We present here a group of Azo-BF photoswitches that store and release energy in response to visible light irradiation. Unmodified Azo-BF switches have a planar structure with a large π-conjugation system, which hinders isomerization when in a compacted state. To address this challenge, we modified the switches with one or two aliphatic groups, which altered the intermolecular interactions and arrangement of the photochromes in the solid state.

Autohydrolysis of Diglycine-Activated Succinic Esters Boosts Cellular Uptake.

Rapid cellular uptake of synthetic molecules remains a challenge, and the motif frequently employed to generate prodrugs, succinic ester, unfortunately lowers the efficacy of the desired drugs due to their slow ester hydrolysis and low cell entry. Here we show that succinic ester-containing diglycine drastically boosts the cellular uptake of supramolecular assemblies or prodrugs. Specifically, autohydrolysis of the diglycine-activated succinic esters turns the nanofibers of the conjugates of succinic ester and self-assembling motif into nanoparticles for fast cellular uptake.

Intramitochondrial co-assembly between ATP and nucleopeptides induces cancer cell apoptosis.

Mitochondria are essential intracellular organelles involved in many cellular processes, especially adenosine triphosphate (ATP) production. Since cancer cells require high ATP levels for proliferation, ATP elimination can be a unique target for cancer growth inhibition. We describe a newly developed mitochondria-targeting nucleopeptide (MNP) that sequesters ATP by self-assembling with ATP inside mitochondria.

Low effective coverage of family planning and antenatal care services in Ethiopia.

Objective: To assess the quality and effective coverage (EC) of family planning (FP) and antenatal care (ANC) services in Ethiopia.

Design: Secondary analyses of the 2014 Ethiopia Service Provision Assessment Plus Survey and 2016 Ethiopia Demographic and Health Survey data.

Setting And Participants: Women using FP and ANC.