Low ambient temperature decreases cadmium accumulation in the liver and kidneys of the bank vole (Clethrionomys glareolus).

The importance of photoperiod and ambient temperature on the accumulation of cadmium in the liver and kidneys of bank voles was determined in the present study. Males and females, aged 1 month, were given 3.0 micrograms Cd ml-1 drinking water and divided into four groups according to photoperiod (16 h light/8 h dark and 8 h light/16 h dark) and ambient temperature (20 or 5 degrees C); liver and kidneys were removed for cadmium as well as copper, iron and zinc analyses at the end of 6 weeks.

Synthesis and activity of N epsilon-aminocaproyl-L-norleucine derivatives.

Five new derivatives of epsilon-aminocaproyl-L-norleucine were synthesized. Antifibrinolytic and anticaseinolytic activities were tested. All tested compounds were inhibitors of plasmin.

Photoperiodic elevation of testicular zinc protects seminiferous tubules against fluoride toxicity in the bank vole (Clethrionomys glareolus).

Recent work has shown that a high fluoride (F) intake in rodents leads to histopathologic changes in the germinal epithelium of testes and to zinc deficiency in the testis and several other organs. The purpose of the present study was to determine whether an elecvation of testicular zinc concentration during fluoride exposure could protect the testes of bank vole from damage. The elevation of testicular zinc was achieved by exposing the bank voles to a long photoperiod (16 hr light/8 hr dark).

Synthesis and activity of N alpha-(epsilon-aminocaproyl)-alanines and N epsilon-(epsilon-aminocaproyl)-caproic acid.

Four new dipeptides containing epsilon-aminocaproic acid were synthesized. Antibrinolytic, antiacaseinolytic activity and influence on activation of plasminogen by streptokinase were tested.

Postnatal changes in subcellular distribution of copper, zinc and metallothionein in the liver of bank vole (Clethrionomys glareolus): a possible involvement of metallothionein and copper in cell proliferation.

1. Dramatic interdependent changes in the intracellular concentrations of copper (Cu), zinc (Zn) and metallothionein (MT) in the liver of bank voles during the first 30 days of their life were observed. 2.

On metallothionein, cadmium, copper and zinc relationships in the liver and kidney of adult rats.

1. A short-term exposure of adult Wistar rats to Cu (50 micrograms/ml) and Cd (10.0 micrograms/ml drinking water) caused significant changes in the subcellular concentrations of Cd, Cu, Zn and metallothionein (MT) in the liver and kidney; the concentrations were close to the physiological values, however.

The effect of high fluoride intake on tissue trace elements and histology of testicular tubules in the rat.

1. Male Wistar rats were exposed to fluoride (F) at concentrations of 100- and 200 ppm in their drinking water for 6- and 16 weeks. 2.

Seasonal changes in subcellular distribution of zinc, copper, cadmium and metallothionein in the liver of bank vole (Clethrionomys glareolus): a possible essential role of cadmium and metallothionein in the hepatic metabolism of copper.

1. An increase in total Zn concentration in the liver of sexually mature bank voles in spring and summer was primarily accompanied by an increase in Zn levels in the nuclear and mitochondrial-lysosomal fractions, while in immature voles in an analogous situation, Zn tended to concentrate mainly in the post-mitochondrial fraction. 2.

Peptide inhibitors of plasmin.

Seven peptides of the general formula A-Phe-Lys-X or A-Phe-NH-(CH2)5-NH2 where A = Glp or Ala, X = -OH, -NHC7H15 or -OC7H15 were obtained. The peptide H-Ala-Phe-Lys-NHC7H15 markedly inhibits the fibrinolytic activity of plasmin. The antifibrinolytic activity of the peptide Glp-Phe-Lys-OC7H15 is similar to EACA.