130 results match your criteria: "Brain and Mind Research Institute and Department of Neurology.[Affiliation]"
Antiplatelet therapy after intracerebral haemorrhage.
Lancet Neurol
December 2024
Department of Neurosurgery, Mount Sinai Health System, New York, NY, USA.
Diagnosis of Incident Cancer After Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized Trial.
Neurology
November 2024
From the Clinical and Translational Neuroscience Unit (B.B.N., C.Z., A.P., M.B., H.K.), Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York; Department of Neurology (B.B.N.), Memorial Sloan Kettering Cancer Center, New York, NY; Department of Neurology (B.R.M., C.S.), University of Minnesota, Minneapolis; Division of Hematology and Oncology (M.C.), Department of Medicine, University of Vermont Larner College of Medicine, Burlington; Department of Neurology (S.E.K.), University of Pennsylvania School of Medicine, Philadelphia; Department of Neurology (D.T., W.L.), Department of Epidemiology (W.L.), and Department of Biostatistics (R.K.), University of Washington, Seattle; Department of Biostatistics (J.E.), Medical University of South Carolina, Charleston; Ochsner Neuroscience Institute (R.M.Z., J.T.), Ochsner Health, New Orleans, LA; Department of Neurology and Rehabilitation Medicine (J.P.B.), University of Cincinnati College of Medicine, OH; Sunnybrook Research Institute (D.J.G.), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, and Division of Neurology (D.J.G.), Department of Medicine, University of Toronto, Ontario, Canada; Department of Neurology (M.B.), Inselspital, Bern University Hospital and University of Bern, Switzerland; and Department of Neurology (M.S.V.E.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY.
Objectives: The objective of this study was to estimate the incidence, timing, and type of new cancer diagnosis among patients with cryptogenic stroke.
Methods: We used data from the ARCADIA trial, which enrolled patients with cryptogenic stroke and atrial cardiopathy. Participants were prospectively followed, and serious adverse events were assessed every 3 months or sooner if investigators were alerted between visits to an event.
Mobile Stroke Units-Time for Legislation and Remuneration.
JAMA Neurol
December 2024
Department of Neurology, University of Cincinnati, Cincinnati, Ohio.
Association between atherosclerotic disease and cervical artery dissection in a population-based cohort of older people.
Ann Clin Transl Neurol
December 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, New York, USA.
Article Synopsis
- The study investigates the link between traditional vascular risk factors and cervical artery dissection, particularly focusing on older patients.
- Using data from Medicare beneficiaries, the research identifies several risk factors, including hypertension, alcohol use, and coronary artery disease, that are associated with an increased likelihood of developing cervical artery dissection.
- The findings suggest that older individuals with certain vascular conditions are at a higher risk, indicating the need for further research on these associations.
Cancer and left atrial enlargement in patients with ischemic stroke.
J Stroke Cerebrovasc Dis
December 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, USA; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:
Article Synopsis
- Cancer increases the risk of atrial fibrillation, but its relationship with atrial cardiopathy—linked to a higher ischemic stroke risk—was studied to see if it’s also significant.
- A study of 1,104 patients hospitalized for acute ischemic stroke found that while 10% had active cancer and 47% had atrial cardiopathy, no significant association was found between active cancer and atrial cardiopathy overall or in patients with embolic stroke of undetermined source (ESUS).
- Even when considering any history of cancer, results showed no strong link to atrial cardiopathy, indicating cancer may not significantly influence this specific heart condition in stroke patients.
Heart failure and stroke: The underrepresentation of the heart failure with preserved ejection fraction subtype in randomized clinical trials of therapeutic anticoagulation.
J Neurol Sci
November 2024
Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece.
Heart failure (HF) is an important comorbidity for patients with ischemic stroke, present in 11 %-18 % of patients, and may also independently increase the risk of first-ever and recurrent ischemic stroke. HF is categorized based on ejection fraction (EF) into HF with reduced (HFrEF), mildly-reduced (HFmrEG) and preserved ejection fraction (HFpEF), with the efficacy of HF therapies differing between the three subcategories. Despite this classification, the incidence, recurrence rates and outcomes of ischemic stroke do not appear to differ significantly between the three subtypes, even when considering the concurrent presence of atrial fibrillation.
View Article and Find Full Text PDFCongenital Heart Disease, Atrial Fibrillation, and Ischemic Stroke Risk.
J Am Heart Assoc
September 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine New York NY.
Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke: A Post Hoc Analysis of the ARCADIA Randomized Clinical Trial.
JAMA Neurol
September 2024
Department of Neurology, University of Minnesota, Minneapolis.
Article Synopsis
- About 10% to 15% of ischemic strokes are linked to cancer, especially cryptogenic strokes, which pose a higher risk for recurrent strokes and major bleeding; however, there’s limited data on the best antithrombotic treatments for these patients.
- The study aimed to evaluate the effectiveness of apixaban versus aspirin in preventing serious complications in cancer patients who had a cryptogenic stroke.
- In a post hoc analysis of 1015 patients from the ARCADIA trial, it was found that 13.5% had a history of cancer, and those patients faced a greater risk of adverse outcomes compared to those without a cancer history.
Mortality in acute ischemic stroke patients with new cancer diagnosed during the index hospitalization versus after discharge.
J Stroke Cerebrovasc Dis
October 2024
Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Switzerland; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, New York, USA. Electronic address:
Article Synopsis
- Early diagnosis of occult cancer in acute ischemic stroke (AIS) patients might lead to quicker treatment and better outcomes, prompting this study to compare mortality rates based on when cancers were diagnosed.
- The research analyzed data from AIS patients treated between 2015 and 2020, finding that out of 3894 patients, 1.5% were diagnosed with new cancer within a year, with a nearly even split between those diagnosed during hospitalization and after discharge.
- Results indicated no significant difference in long-term mortality between the two groups, suggesting that the timing of cancer diagnosis does not impact survival rates, highlighting the need for larger studies to verify these findings.
Factors impacting D-dimer levels in patients with acute ischemic cerebrovascular events.
J Stroke Cerebrovasc Dis
August 2024
Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA; Graduate School for Health Sciences, University of Bern, Switzerland. Electronic address:
Article Synopsis
- The study aimed to understand how time from symptom onset affects D-dimer levels in patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA), as this knowledge may help identify other thrombotic conditions.
- A total of 2467 AIS patients and 708 TIA patients were analyzed, finding that D-dimer levels were higher in AIS patients compared to TIA patients, with distinct fluctuations in D-dimer levels over time in AIS patients.
- The research concluded that while D-dimer levels in AIS patients change significantly after symptoms begin, TIA patients do not show these time-dependent variations, indicating the need for further studies to better utilize D-dimer as a biomarker in acute stroke cases.
Atrial fibrillation and short-term outcomes after cancer-related ischemic stroke.
Eur Stroke J
June 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.
Introduction: Atrial fibrillation (AF) and cancer are each associated with worse outcomes in patients with acute ischemic stroke (AIS). Few studies have evaluated the impact of AF on outcomes of cancer-related stroke.
Patients And Methods: We conducted a retrospective cross-sectional study using the 2016-2019 National Inpatient Sample, identifying all hospitalizations with diagnosis codes for cancer and AIS.
Association between elevated fibrosis-4 index of liver fibrosis and risk of hemorrhagic stroke.
Eur Stroke J
June 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.
Background: Cirrhosis is associated with an increased risk of hemorrhagic stroke. Liver fibrosis, typically a silent condition, is antecedent to cirrhosis. The objective of this study was to test the hypothesis that elevated Fibrosis-4 (FIB-4) index, indicating a high probability of liver fibrosis, is associated with an increased risk of hemorrhagic stroke.
View Article and Find Full Text PDFPrevalence of right-to-left shunt in stroke patients with cancer.
Int J Stroke
October 2024
Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Article Synopsis
- Cancer patients have a higher risk of acute ischemic stroke (AIS) and may have a cardiac right-to-left shunt (RLS), but the relationship between RLS and cancer in AIS is unclear.
- In a study of 2,236 AIS patients, only 4.6% had active cancer, and RLS was found less frequently in these patients compared to those without cancer.
- The findings suggest that arterial causes could be more significant than paradoxical embolism in cancer-related strokes, indicating a need for further research on treatment options like patent foramen ovale (PFO) closure for these patients.
Intravenous thrombolysis in patients with recent intake of direct oral anticoagulants: A target trial analysis after the liberalization of institutional guidelines.
Eur Stroke J
December 2024
Stroke Research Center Bern, Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland.
Article Synopsis
- The study evaluated the safety and efficacy of using intravenous thrombolysis (IVT) with alteplase in patients on direct oral anticoagulants (DOACs) without strict guidelines on plasma levels or last intake time.
- Researchers included 98 DOAC patients from their stroke registry, comparing outcomes between those who received IVT and those who did not.
- Results showed no symptomatic intracranial hemorrhage in IVT patients, and those who received IVT had better functional outcomes, indicating a need for further randomized controlled trials.
Leveraging the Capabilities of AI: Novice Neurology-Trained Operators Performing Cardiac POCUS in Patients with Acute Brain Injury.
Neurocrit Care
October 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, 525 East 68th Street, F610, New York, NY, 10065, USA.
Background: Cardiac point-of-care ultrasound (cPOCUS) can aid in the diagnosis and treatment of cardiac disorders. Such disorders can arise as complications of acute brain injury, but most neurologic intensive care unit (NICU) providers do not receive formal training in cPOCUS. Caption artificial intelligence (AI) uses a novel deep learning (DL) algorithm to guide novice cPOCUS users in obtaining diagnostic-quality cardiac images.
View Article and Find Full Text PDFImpact of tobacco smoking on disease-specific outcomes in common neurological disorders: A scoping review.
J Clin Neurosci
April 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA. Electronic address:
Although the association of smoking with the risk of incident neurological disorders is well established, less is known about the impact of smoking and smoking cessation on outcomes of these conditions. The objective of this scoping review was to synthesize what is known about the impact of smoking and smoking cessation on disease-specific outcomes for seven common neurological disorders. We included 67 studies on the association of smoking and smoking cessation on disease-specific outcomes.
View Article and Find Full Text PDFAssociation Between Hematoma Volume and Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis.
Stroke
March 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY (W.H., J.H.K., V.L., C.I., H.K., S.B.M.).
Background: Nontraumatic intracerebral hemorrhage (ICH) is independently associated with a long-term increased risk of major arterial ischemic events. While the relationship between ICH location and ischemic risk has been studied, whether hematoma volume influences this risk is poorly understood.
Methods: We pooled individual patient data from the MISTIE III (Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation Phase 3) and the ATACH-2 (Antihypertensive Treatment of Acute Cerebral Hemorrhage-2) trials.
Acute ischaemic stroke in active cancer versus non-cancer patients: stroke characteristics, mechanisms and clinical outcomes.
Eur J Neurol
April 2024
Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Article Synopsis
- The study compares demographics, clinical characteristics, and outcomes of acute ischemic stroke (AIS) patients with active cancer (AC) to those without cancer using data from a registry spanning 2003 to 2021.
- Among 6686 AIS patients, 365 had active cancer, and these patients were generally older and less likely to receive reperfusion therapies, showing a higher risk for death and cerebrovascular recurrence at 12 months.
- The findings suggest that AIS patients with active cancer have a more challenging prognosis, indicating the potential benefit of antithrombotic medications at discharge to lower the risks associated with their condition.
Classification of traumatic injury to the dural venous sinus using CT venography.
J Neuroimaging
March 2024
Department of Neurology, School of Medicine, University of California San Francisco, San Francisco, California, USA.
Background And Purpose: Cerebral venous sinus thrombosis (CVST) is an underrecognized cause of morbidity in acute traumatic brain injury (TBI). Radiologic diagnosis is challenging in the setting of concurrent extra-axial injury and a lack of standardized diagnostic criteria. The prevalence of traumatic thrombosis versus compression is unknown.
View Article and Find Full Text PDFPatent Foramen Ovale Management for Secondary Stroke Prevention: State-of-the-Art Appraisal of Current Evidence.
Stroke
January 2024
Department of Neurology, University of California, Los Angeles (J.L.S.).
Patent foramen ovale (PFO) is frequently identified in young patients with ischemic stroke. Randomized controlled trials provide robust evidence supporting PFO closure in selected patients with cryptogenic ischemic stroke; however, several questions remain unanswered. This report summarizes current knowledge on the epidemiology of PFO-associated stroke, the role of PFO as a cause of stroke, and anatomic high-risk features.
View Article and Find Full Text PDFPlateauing atrial fibrillation burden in acute ischemic stroke admissions in the United States from 2010 to 2020.
Int J Stroke
June 2024
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Background: Utilization of oral anticoagulants for acute ischemic stroke (AIS) prevention in patients with atrial fibrillation (AF) increased in the United States over the last decade. Whether this increase has been accompanied by any change in AF prevalence in AIS at the population level remains unknown. The aim of this study is to evaluate trends in AF prevalence in AIS hospitalizations in various age, sex, and racial subgroups over the last decade.
View Article and Find Full Text PDFAssociation between left atrial volume index and infarct volume in patients with ischemic stroke.
Front Neurol
November 2023
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, United States.
Background: Left atrial volume index (LAVI) is one marker of atrial myopathy, which is increasingly being recognized as a cause of cardioembolic stroke even in the absence of atrial fibrillation. Cardiac embolism is associated with larger strokes than other stroke mechanisms. The purpose of this study was to examine the association between LAVI and total brain infarct volume in patients with ischemic stroke.
View Article and Find Full Text PDFUsage of mineralocorticoids and isotonic crystalloids in subarachnoid hemorrhage patients in the United States.
J Stroke Cerebrovasc Dis
January 2024
Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Background: The usage rates of mineralocorticoids (fludrocortisone) to treat hyponatremia and isotonic crystalloids (saline and balanced crystalloids) to maintain intravascular volume in patients with aneurysmal subarachnoid hemorrhage (aSAH) patients across the United States are unknown.
Methods: We surveyed National Institute of Neurologic Disorders and Stroke (NINDS) StrokeNet sites in 2023, which are mostly large, tertiary, academic centers, and analyzed subarachnoid hemorrhage encounters from 2010 to 2020 in the Premier Healthcare Database that is representative of all types of hospitals and captures about 20 % of all acute inpatient care in the United States.
Results: Although mineralocorticoids are used by 70 % of the NINDS StrokeNet sites, it is used in less than 20 % of the aSAH encounters in the Premier Database.
Association of liver fibrosis with cognitive decline in Parkinson's disease.
J Clin Neurosci
January 2024
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA. Electronic address:
Background: Cognitive decline is a common but variable non-motor manifestation of Parkinson's disease. Chronic liver disease contributes to dementia, but its impact on cognitive performance in Parkinson's disease is unknown. We assessed the effect of liver fibrosis on cognition in Parkinson's disease.
View Article and Find Full Text PDFAntiplatelet therapy and outcomes after aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis.
Clin Neurol Neurosurg
December 2023
Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA. Electronic address:
Background: The efficacy of antiplatelet therapy (APT) after aneurysmal subarachnoid hemorrhage (aSAH) remains unclear. We performed a systematic review and meta-analysis to summarize the associations of APT use after aSAH with outcomes.
Methods: We searched published medical literature to identify cohort studies involving adults with aSAH.