3 results match your criteria: "Brain Institute of the Rio Grande do Sul (InsCer)[Affiliation]"
Cocaine-use disorder and childhood maltreatment are associated with the activation of neutrophils and increased inflammation.
Acta Neuropsychiatr
April 2024
Laboratory of Immunobiology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Article Synopsis
- Cocaine-use disorder (CUD) in women is linked to early life adversity and results in increased immune responses, particularly in neutrophils, which play a key role in inflammation.
- The study involved collecting blood samples and clinical data from 41 women with CUD and 31 healthy controls, finding that CUD subjects had higher childhood trauma scores and showed elevated levels of cytokines and neutrophil activity.
- Results indicate that CUD is associated with significant neutrophil activation and inflammatory responses, suggesting that childhood trauma may contribute to these immune system changes.
A systematic review and meta-analysis of epigenetic clocks in schizophrenia.
Schizophr Res
August 2022
Developmental Cognitive Neuroscience Lab, School of Medicine, Brain Institute of the Rio Grande do Sul (InsCer), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. Electronic address:
Introduction: Evidence suggests that schizophrenia (SZ) is associated with accelerated biological aging. DNA methylation can be used as an indicator of biological aging by means of epigenetic clock estimates.
Objective: The aim of this systematic review and meta-analysis was to investigate the association between SZ and different epigenetic clocks.
Oxytocin Receptor Exon III Methylation in the Umbilical Cord Blood of Newborns With Prenatal Exposure to Crack Cocaine.
Front Cell Dev Biol
June 2021
Developmental Cognitive Neuroscience Lab, School of Medicine, Brain Institute of the Rio Grande do Sul (InsCer), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Article Synopsis
- - Prenatal cocaine exposure (PCE) can lead to long-term behavioral and cognitive issues in children, but research on its epigenetic impact, especially in humans, is limited.
- - This study analyzed DNA methylation of the Oxytocin Receptor gene in umbilical cord blood from 28 newborns with PCE and 30 non-exposed newborns to see if there were significant differences.
- - Findings showed no significant differences in methylation levels between the two groups, but highlighted that the severity of the mother's cocaine addiction influenced DNA methylation in newborns, pointing to the need for larger studies to further explore these effects.