11,267 results match your criteria: "Brain Imaging in Astrocytoma"
Sci Rep
November 2024
Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil.
Neurosurg Clin N Am
January 2025
Department of Neurosurgery, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX 77030, USA. Electronic address:
This article discusses the evidence supporting the resection of glioblastoma beyond the borders of contrast-enhancing tumor. While several techniques for this have been described, including a so-called FLAIRectomy, lobectomy, or via the use of adjuncts such as fluorescence or intraoperative MRI, the optimal extent of additional resection has yet to be established. Many authors have noted a survival benefit with supramarginal resection without significant additional morbidity.
View Article and Find Full Text PDFSovrem Tekhnologii Med
November 2024
MD, PhD, Associate Professor, Head of the Department of Neurosurgery; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.
Unlabelled: is to assess the effectiveness and safety of stereotactic photodynamic therapy (sPDT) with 5-aminolevulinic acid (5-ALA) in patients with recurrent malignant supratentorial gliomas in functionally relevant brain areas.
Materials And Methods: In a retrospective single-center study the results of sPDT with 5-ALA in 10 patients (6 of 10 were male), aged 30 to 62 years (median: 51.5 years; 95% CI: 38-59 years) with recurrent malignant brain gliomas after standard therapy who underwent surgery during the period of 2020-2023 were analyzed.
Sci Rep
November 2024
Department of Neurosurgery, Zhongnan Hospital of Wuhan University, No.125 Donghu Road, WuChang, Wuhan, 430062, China.
Comprehensive and non-invasive preoperative molecular diagnosis is important for prognostic and therapy decision-making in adult-type diffuse gliomas. We employed a deep learning method for automatic segmentation of brain gliomas directly from conventional magnetic resonance imaging (MRI) scans of the tumor core and peritumoral edema regions based on available glioma MRI data provided in the BraTS2021. Three-dimensional volumes of interest were segmented from 424 cases of glioma imaging data retrospectively obtained from two medical centers using the segmentation method and radiomic features were extracted.
View Article and Find Full Text PDFCNS Oncol
December 2024
UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision & Imaging Biomarkers, University of California Los Angeles, Los Angeles, CA 90024, USA.
A radio-pathomic machine learning (ML) model has been developed to estimate tumor cell density, cytoplasm density (Cyt) and extracellular fluid density (ECF) from multimodal MR images and autopsy pathology. In this multicenter study, we implemented this model to test its ability to predict survival in patients with recurrent glioblastoma (rGBM) treated with chemotherapy. Pre- and post-contrast T-weighted, FLAIR and ADC images were used to generate radio-pathomic maps for 51 patients with longitudinal pre- and post-treatment scans.
View Article and Find Full Text PDFActa Neurochir (Wien)
November 2024
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Purpose: Extent of resection, MGMT promoter methylation status, age, functional level, and residual tumor volume are established prognostic factors for overall survival in glioblastoma patients. Preoperative tumor volume has also been investigated, but the results have been inconclusive. We hypothesized that the surface area and the shape were more representative of the tumor's infiltrative capacities, and thus, the purpose of this study was to assess the prognostic value of tumor size and shape in patients with glioblastoma.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Radiotherapy, Cancer Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
PLoS One
November 2024
Department of Biomedical Data Intelligence, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Oncoimmunology
December 2024
ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany.
Background: Human glioblastoma multiforme (GBM) is a highly aggressive tumor with insufficient therapies available. Especially, novel concepts of immune therapies fail due to a complex immunosuppressive microenvironment, high mutational rates, and inter-patient variations. The intratumoral heterogeneity is currently not sufficiently investigated.
View Article and Find Full Text PDFOncol Rep
January 2025
Department of Anatomy and Cell Biology, College of Medicine, Chung‑Ang University, Seoul 06974, Republic of Korea.
Adv Mater
December 2024
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, 94720, USA.
Hyaluronic acid (HA), the primary component of brain extracellular matrix, is increasingly used to model neuropathological processes, including glioblastoma (GBM) tumor invasion. While elastic hydrogels based on crosslinked low-molecular-weight (LMW) HA are widely exploited for this purpose and have proven valuable for discovery and screening, brain tissue is both viscoelastic and rich in high-MW (HMW) HA, and it remains unclear how these differences influence invasion. To address this question, hydrogels comprised of either HMW (1.
View Article and Find Full Text PDFInt J Nanomedicine
November 2024
Department of Medical Imaging, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, People's Republic of China.
Purpose: Radiotherapy (RT) is currently recognized as an important treatment for glioblastoma (GBM), however, it is associated with several challenges. One of these challenges is the radioresistance caused by hypoxia, whereas the other is the low conversion efficiency of the strongly oxidized hydroxyl radical (•OH), which is produced by the decomposition of water due to high-energy X-ray radiation. These factors significantly limit the clinical effectiveness of radiotherapy.
View Article and Find Full Text PDFGlioblastoma recurrence is a major hindrance to treatment success and is driven by the invasion of glioma stem cells (GSCs) into healthy tissue that are inaccessible to surgical resection and are resistant to existing chemotherapies. Tissue-level fluid movement, or interstitial fluid flow (IFF), regulates GSC invasion in a manner dependent on the tumor microenvironment (TME), highlighting the need for model systems that incorporate both IFF and the TME. We present an accessible method for replicating the invasive TME in glioblastoma: a hyaluronan-collagen I hydrogel composed of human GSCs, astrocytes, and microglia seeded in a tissue culture insert.
View Article and Find Full Text PDFCurr Med Imaging
November 2024
Department of Computer Science, King Abdullah I School of Graduate Studies and Scientific Research, Princess Sumaya University for Technology, Amman, Jordan.
The most common primary malignant brain tumor is glioblastoma. Glioblastoma Multiforme (GBM) diagnosis is difficult. However, image segmentation and registration methods may simplify and automate Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) scan analysis.
View Article and Find Full Text PDFEur J Pharmacol
December 2024
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; Coimbra Chemistry Centre, Institute of Molecular Sciences-IMS, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal. Electronic address:
Pitavastatin is commonly prescribed to treat hypercholesterolemia through the regulation of cholesterol biosynthesis. Interestingly, it has also demonstrated a great potential for treating brain tumors, although the detailed cytotoxic mechanism, particularly in glioblastoma, remains incompletely understood. This work explores the activity of pitavastatin in 2D and 3D glioblastoma models, in an attempt to provide a more representative and robust overview of its anticancer potential in glioblastoma.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
November 2024
Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Background: The hyperintensity area surrounding the residual cavity on postoperative fluid-attenuated inversion recovery (FLAIR) image is a potential site for glioblastoma (GBM) recurrence. This study aimed to develop a nomogram using quantitative metrics from subregions of this area, prior to chemoradiotherapy (CRT), to predict early GBM recurrence.
Methods: Adult patients with GBM diagnosed between October 2018 and October 2022 were retrospectively analyzed.
Neurosurg Focus
November 2024
1Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida.
Objective: Maximizing safe resection in neuro-oncology has become paramount to improving patient survival and outcomes. Laser interstitial thermal therapy (LITT) offers similar survival benefits to traditional resection, alongside shorter hospital stays and faster recovery times. The extent of ablation (EOA) achieved using LITT is linked to patient outcomes, with greater EOA correlating with improved outcomes.
View Article and Find Full Text PDFPET Clin
January 2025
Division of Nuclear Medicine, Department of Radiology, Fox Chase Cancer Center, Philadelphia, PA, USA.
MR imaging is currently the main imaging modality used for the diagnosis and post therapeutic assessment of glioblastomas. Recently, several innovative PET radioactive tracers have been investigated for the evaluation of glioblastomas (GBM). These radiotracers target several biochemical and pathophysiological processes seen in tumors.
View Article and Find Full Text PDFJAMA Oncol
December 2024
Mayo Clinic, Rochester, Minnesota.
Eur Radiol Exp
October 2024
Brain Tumor Center, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Anticancer Res
November 2024
Department of Radiotherapy, University Medical Center Schleswig-Holstein/Lübeck, Lübeck, Germany.
Background/aim: Presurgical tumor volume progression in glioblastoma (GBM) may be a predictor of survival. This study aims to evaluate the potential impact of preoperative tumor growth and other clinical as well as laboratory parameters on overall survival (OS) of GBM patients.
Patients And Methods: We retrospectively analyzed 98 adult patients with GBM who received two magnetic resonance imaging (MRI) scans between 2013 and 2023, before primary surgery and concurrent Stupp chemoradiotherapy.
Sci Transl Med
October 2024
Division of Oncology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.
Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis, and their presence correlates with worse outcomes for patients with glioma.
View Article and Find Full Text PDFTurk Neurosurg
November 2024
Health Sciences University, Izmir Bozyaka Education and Research Hospital, Department of Neurosurgery, Izmir, Türkiye.
Aim: To investigate the relationship between tumor volume and serum microsomal prostaglandin E2 (mPGE2) levels in patients with astrocytic tumors.
Material And Methods: The study included patients with astrocytic tumors who were treated at our clinic between August 2015 and December 2016. Preoperative and postoperative contrast-enhanced cranial magnetic resonance imaging (MRI) scans were performed (within the first 24 h), and preoperative and postoperative residual tumor volumes were calculated.
Neurosurg Rev
October 2024
Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Medicina (Kaunas)
October 2024
Department of Radiology, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, Latvia.